Article
Infectious Diseases
Trine H. Mogensen, Morten Kelder Skouboe, Ingolf Molle
Summary: Human infection with parvovirus B19 can lead to various clinical manifestations, and treatment can be challenging. This case report presents a 43-year-old man with persistent parvovirus B19 infection and anaemia. The patient showed resistance to standard treatments but responded well to pegylated interferon alfa-2a. This highlights the potential of interferon alfa-2a as a treatment option for persistent parvovirus B19 infection.
LANCET INFECTIOUS DISEASES
(2023)
Article
Virology
Massimo De Paschale, Claudia Pavia, Teresa Cerulli, Debora Cagnin, Maria T. Manco, Luisa Belvisi, Alessia Paganini, Laura Pogliani, Elena Ceriani, Alessandro Porta, Luciana Parola, Paola Mirri, Bianca Osnaghi, Laura Vismara, Pierangelo Clerici
Summary: Parvovirus B19 (B19V) infection in pregnancy is common in Italy, with higher IgG seroprevalence among Italian women compared to non-Italian women. The prevalence of viremia is low and does not lead to significant fetal damage at birth.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Medicine, General & Internal
Toshimitsu Shinzawa, Isao Usui, Kanako Hanawa, Hayato Kajitani, Shintaro Sakurai, Takuya Tomaru, Toshie Iijima, Teruo Jojima, Kazuyuki Kojima, Yoshimasa Aso
Summary: This article reports a case of pancytopenia in a patient after sleeve gastrectomy, which may be related to malnutrition and parvovirus B19 infection.
Article
Medicine, General & Internal
Bijun Xu, Weimin Zhang, Ximing Qian, Shiqiang Wang, Fan He
Summary: Patients may develop severe anemia due to B19V infection after heart transplantation, with diagnosis relying on viral DNA detection and successful treatment achieved with intravenous immunoglobulin.
Review
Immunology
Jinmei Luo, Jingcong Zhang, Wenxing Lai, Shaofang Wang, Laizhi Zhou, Yunfeng Shi, Junhui Ba, Jiajia Hu, Yanhong Wang, Laisheng Li, Ben-Quan Wu
Summary: This study reported a case of a patient with alcoholic hepatitis and hemolytic anemia who developed multiple organ dysfunction syndrome due to B19 infection, which was subsequently transmitted to seven nurses during treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Rhiannon R. Penkert, Melissa Azul, Robert E. Sealy, Bart G. Jones, Jola Dowdy, Randall T. Hayden, Li Tang, A. Catharine Ross, Jane S. Hankins, Julia L. Hurwitz
Summary: Infections of human parvovirus B19 can cause severe anemia in individuals with sickle cell disease. The levels of vitamins A and D are associated with the disease consequences and immune responses to the virus. Maintaining sufficient levels of vitamins A and D may serve as prophylaxis against complications.
Article
Oncology
Li Gong, Jing Tian, Yan Zhang, Zheng Feng, Qiannan Wang, Yan Wang, Fuqin Zhang, Wei Zhang, Gaosheng Huang
Summary: The presence of germinal centers (GCs) in thymomas is closely associated with the pathogenesis of myasthenia gravis (MG), and infection by human parvovirus B19 (B19V) may contribute to the formation of ectopic GCs in thymoma. This study provides new insights into the etiopathogenic mechanism of MG and the role of B19V in thymoma-associated MG.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Virology
Daniela P. Mendes-de-Almeida, Joanna Paes Barreto Bokel, Arthur Daniel Rocha Alves, Alexandre G. Vizzoni, Isabel Cristina Ferreira Tavares, Mayara Secco Torres Silva, Juliana dos Santos Barbosa Netto, Beatriz Gilda Jegerhorn Grinsztejn, Luciane Almeida Amado Leon
Summary: Parvovirus B19 (B19V) infection can cause chronic anemia and transient aplastic crisis in patients with immunosuppression or chronic hemolysis. We report three rare cases of Brazilian adults living with HIV with B19V infection. All cases presented severe anemia and required red blood cell transfusions.
Article
Biochemistry & Molecular Biology
Nicola Bertazza Partigiani, Susanna Negrisolo, Andrea Carraro, Diana Marzenta, Elisabetta Manaresi, Giorgio Gallinella, Luisa Barzon, Elisa Benetti
Summary: Viral infections can lead to transplant dysfunction and may play a role in rejection. Analysis of protocol biopsies in 106 children at different time points after transplantation showed an increased prevalence of intrarenal viral infection between 6 and 12 months. Specifically, Parvovirus B19 infection was associated with antibody-mediated rejection. Monitoring and treatment of Parvovirus B19 infection in the early post-transplant period is important.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Alessandro Reggiani, Andrea Avati, Francesca Valenti, Erika Fasano, Gloria Bua, Elisabetta Manaresi, Giorgio Gallinella
Summary: In this study, a derived B19V minigenome was designed and produced, which was capable of replication, transcription, and production of NS1 protein in cells, and could complement defective genomes. This provides a valuable tool for studying viral expression and genetics.
Article
Biochemistry & Molecular Biology
Gloria Bua, Pasquale Marrazzo, Elisabetta Manaresi, Chiara Gamberini, Laura Bonsi, Francesco Alviano, Giorgio Gallinella
Summary: Both BM-MSCs and FM-MSCs can be infected by B19V, although they cannot support viral replication, they allow persistence of the virus in the infected cultures. Further studies are needed to understand the potential role of MSCs in B19V transmission and the conditions that can favor a potential reactivation of the virus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Yedong Yu, Chunchun Wei, Junhao Lyu, Xiaoliang Wu, Rending Wang, Hongfeng Huang, Jianyong Wu, Jianghua Chen, Wenhan Peng
Summary: This retrospective study evaluated donor-derived B19V infections in kidney transplantations from January 2016 to December 2020. Results showed 0.4% and 1.5% incidence rates in living and deceased donor kidney transplantations, respectively. While some recipients developed infections, they were effectively controlled with treatment, indicating that routine screening for B19V in donors may not be necessary and kidneys from donors with B19V infection can be accepted for transplantation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Chunlin Xiang, Xiaoxiao Wu, Youkang Wei, Tianlong Li, Xuemei Tang, Yi Wang, Xiaoqin Zhang, Xiaobo Huang, Yiping Wang
Summary: This article reports a rare case of severe septic shock caused by human parvovirus B19 infection after cardiac surgery. The virus can lead to septicemia, rash, fever, and other symptoms, especially in immunocompromised patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Infectious Diseases
Pengrui Cheng, Qian Jian, Zongli Fu, Yi Ma
Summary: This study presented a retrospective case series of adult liver transplant recipients with severe anemia associated with B19V infection, and reviewed the literature on this topic. The results showed that B19V infection should be considered early as a possible cause of severe anemia in adult liver transplant recipients. Most patients achieved long-term recovery from anemia after IVIG-based therapy, but some experienced relapses.
SURGICAL INFECTIONS
(2022)
Review
Medicine, Research & Experimental
Maria Celeste Fatone, Lorenzo Cirasino
Summary: This article provides a practical guide for the therapy of autoimmune hemolytic anemias (AIHA) and discusses the different treatment approaches for primary warm AIHA and AIHA from cold agglutinin disease (AIHA from CAD). The article emphasizes the importance of identifying the type of antibody involved in the disease and excluding a secondary form. Rituximab is highlighted as a central treatment for primary warm AIHA and AIHA from CAD.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Clinical Neurology
J. P. Vieira, J. Sequeira, M. J. Brito
JOURNAL OF CHILD NEUROLOGY
(2017)
Review
Clinical Neurology
Ariana Helena Ribeiro de Barros, Joao Paulo Fiadeiro Sequeira, Ary Severino Lopes de Sousa, Carlos Miguel Chegancas Capela, Rui Manuel Gomes Pedrosa, Manuel Alexandre dos Santos Manita
CLINICAL NEUROPHARMACOLOGY
(2018)
Letter
Clinical Neurology
Sara P. Dias, Joao Sequeira, Manuel Almeida
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2018)
Article
Behavioral Sciences
Pedro C. Bras, Ariana Barros, Soraia Vaz, Joao Sequeira, Diana Melancia, Andreia Fernandes, Ary de Sousa, Sara P. Dias, Ines Menezes Cordeiro, Manuel Manita
EPILEPSY & BEHAVIOR
(2018)
Article
Clinical Neurology
Mar Tintore, Georgina Arrambide, Susana Otero-Romero, Pere Carbonell-Mirabent, Jordi Rio, Carmen Tur, Manuel Comabella, Carlos Nos, Maria Jesus Arevalo, Elisenda Anglada, Rebeca Menendez, Luciana Midaglia, Ingrid Galan, Angela Vidal-Jordana, Joaquin Castillo, Patricia Mulero, Ana Zabalza, Breogan Rodriguez-Acevedo, Marta Rodriguez, Carmen Espejo, Joao Sequeira, Raquel Mitjana, Andrea de Barros, Deborah Pareto, Cristina Auger, Santiago Perez-Hoyos, Jaume Sastre-Garriga, Alex Rovira, Xavier Montalban
MULTIPLE SCLEROSIS JOURNAL
(2020)
Article
Clinical Neurology
S. Batista, C. C. Nunes, J. J. Cerqueira, Ana Martins Silva, J. Correia de Sa, J. Ferreira, M. T. Mendonca, J. Pinheiro, V. Salgado, A. S. Correia, J. Sequeira, A. Costa, L. Sousa
Summary: A retrospective study conducted in Portugal with 275 patients with relapsing-remitting multiple sclerosis showed that therapy with Fingolimod demonstrated sustained effectiveness and safety over 3 years, with a significant decrease in relapse rates. The majority of patients who switched to Fingolimod had no relapses during the 3-year follow-up period.
NEUROLOGICAL SCIENCES
(2021)
Letter
Clinical Neurology
Patricia Faustino, Maria Coutinho, Lia Leitao, Carlos Capela, Marisa Brum, Joana Parra, Joao Sequeira, Ariana Barros, Cristina Araujo, Ana Sousa, Filipa Ladeira
Summary: The study evaluated the seroprotection rate following HBV immunization in MS patients and found that patients under different DMTs had varying levels of protection. Older patients may require additional vaccine doses to achieve seroprotection.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Clinical Neurology
Filipa Ladeira, Tiago Oliveira, Mafalda Soares, Cristina Araujo, Ana Sousa, Marisa Brum, Joao Sequeira, Carlos Capela
Summary: This study found that anti-CD20 drugs are associated with a loss of seroprotection against hepatitis B virus (HBV) in a short-interval follow-up, but varicella-zoster virus (VZV) seroprotection loss occurs rarely. Age, baseline HBsAb titer, and anti-CD20 treatment are risk factors for HBV seroprotection loss. No factors associated with an increased risk of VZV seroprotection loss were identified.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Review
Clinical Neurology
Ariana Barros, Joao Sequeira, Ary de Sousa, Joana Parra, Marisa Brum, Rui Pedrosa, Carlos Capela
CLINICAL NEUROPHARMACOLOGY
(2020)
Article
Clinical Neurology
Isabel Loucao de Amorim, Cristina Pereira, Joao Sequeira, Helena Rocha, Ana Rita Peralta, Ricardo Rego, Carla Bentes, Conceicao Bento, Francisco Sales, Conceicao Robalo, Jose Pimentel
EPILEPTIC DISORDERS
(2020)