Article
Neurosciences
Dhaval Shukla, Bhushan Diwakar Thombre, Priya Baby, Jayanthi Palaninathan, Sivakami Subramanian, P. Prathyusha, Indira Devi Bhagavatula
Summary: The purpose of this study was to develop the GOSE mobile application and validate its effectiveness compared to the traditional interview method. The study found high agreement between the two methods, suggesting that the mobile application can accurately measure GOSE scores. This application has the potential to expedite the assessment process for TBI patients in both clinical practice and research.
Article
Critical Care Medicine
David A. Zuckerman, Joseph T. Giacino, Yelena G. Bodien
Summary: The outcomes of TBI are diverse and not standardized, with dichotomization of outcomes into favorable and unfavorable categories potentially limiting detection of treatment effects and impacting decision-making processes.
JOURNAL OF NEUROTRAUMA
(2022)
Review
Nursing
Ruth Shanahan, Pinar Avsar, Chanel Watson, Zena Moore, Declan Patton, Natalie L. Mcevoy, Ger Curley, Tom O'Connor
Summary: The impact of brain tissue oxygenation (PbtO2) monitoring on long-term neurological outcomes and mortality in patients with traumatic brain injuries is still inconclusive. Further research is needed to determine its efficacy and guide clinical practice.
NURSING IN CRITICAL CARE
(2023)
Review
Biochemistry & Molecular Biology
William Torregrossa, Michele Torrisi, Rosaria De Luca, Carmela Casella, Carmela Rifici, Mirjam Bonanno, Rocco Salvatore Calabro
Summary: Traumatic brain injury is damage to the brain occurring after birth, resulting in deterioration of cognitive, behavioural, and emotional functions. Neuropsychological evaluation can assist clinicians in assessing the patient's condition, reaching differential diagnoses, and developing intervention strategies. However, it is difficult to determine the most suitable assessment tool for different brain injury conditions considering the various rating scales available.
Article
Emergency Medicine
Heather Bick, Tarik Wasfie, Virginia Labond, Jennifer R. Hella, Eric Pearson, Kimberly R. Barber
Summary: The study found that age, GCS, and mode of injury play important roles in leveling trauma patients, especially in elderly patients with traumatic head injury. Age is an independent predictor of mortality and length of stay in these patients.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Critical Care Medicine
Timo Roine, Mehrbod Mohammadian, Jussi Hirvonen, Timo Kurki, Jussi P. Posti, Riikka S. K. Takala, Virginia F. Newcombe, Jussi Tallus, Ari J. Katila, Henna-Riikka Maanpaeae, Janek Frantzen, David Menon, Olli Tenovuo
Summary: We investigated the topology of structural brain connectivity networks and found that both global and local network properties are associated with outcome after mild traumatic brain injury. Higher normalized global efficiency, degree, and strength as well as lower small-worldness are correlated with better outcome. The local network properties of the left putamen and the left postcentral gyrus show the most prominent correlations with outcome.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Critical Care Medicine
Natalie Kreitzer, Sonia Jain, Jacob S. Young, Xiaoying Sun, Murray B. Stein, Michael A. McCrea, Harvey S. Levin, Joseph T. Giacino, Amy J. Markowitz, Geoffrey T. Manley, Lindsay D. Nelson
Summary: Comparing QOLIBRI-OS with SWLS, QOLIBRI-OS showed greater sensitivity in reflecting changes in life quality of traumatic brain injury patients, especially during the recovery process.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Clinical Neurology
Joel Frohlich, Micah A. Johnson, David L. McArthur, Evan S. Lutkenhoff, John Dell'Italia, Courtney Real, Vikesh Shrestha, Norman M. Spivak, Jesus E. Ruiz Tejeda, Paul M. Vespa, Martin M. Monti
Summary: The study found that sedation-induced burst-suppression (SIBS) was positively associated with outcomes at 6 months in patients with moderate-to-severe traumatic brain injury (TBI), but did not predict outcomes at discharge. These results suggest that burst suppression may have neuroprotective effects in acute patients with TBI etiologies.
FRONTIERS IN NEUROLOGY
(2021)
Article
Critical Care Medicine
Lindsay Wilson, Kim Boase, Lindsay D. Nelson, Nancy R. Temkin, Joseph T. Giacino, Amy J. Markowitz, Andrew Maas, David K. Menon, Graham Teasdale, Geoffrey T. Manley
Summary: The Glasgow Outcome Scale-Extended (GOSE) is widely used for assessing global disability and recovery after traumatic brain injury, but achieving consistency in its application is challenging. The manual provides guidance on assessment principles, administering the interview, handling borderline cases, and discussing the properties of GOSE. Recommendations for assessor training, accreditation, and monitoring are also outlined.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Biochemistry & Molecular Biology
Ping K. Yip, Shumaila Hasan, Zhuo-Hao Liu, Christopher E. G. Uff
Summary: Traumatic brain injury (TBI) is a complex disease with varying degrees of severity. This study examined the cellular and molecular changes in fresh brain samples from patients with severe TBI and related them to clinical outcomes. The newly devised YHU grading system was used to classify the cellular and molecular pathophysiology of the injury, which correlated with outcome.
Article
Psychology, Multidisciplinary
Ashley N. Clausen, Heather C. Bouchard, Kathleen A. Welsh-Bohmer, Rajendra A. Morey
Summary: This study compared the chronic effects of combat-related blast mTBI and subconcussive blast exposure on neuropsychological performance in Veterans. Results showed that Veterans with combat-related blast mTBI exhibited significantly slower processing speed compared to controls, even after controlling for PTSD and depressive symptoms. However, there were no significant differences in cognition between subconcussive and control groups, or between subconcussive and combat-related blast mTBI groups, suggesting that neurocognitive assessment may not be sensitive enough to detect the long-term effects of subconcussive blast exposure.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Critical Care Medicine
Rael T. Lange, Sara M. Lippa, Tracey A. Brickell, Ping-Hong Yeh, John Ollinger, Megan Wright, Angela Driscoll, Jamie Sullivan, Samantha Braatz, Rachel Gartner, Elizabeth Barnhart, Louis M. French
Summary: This study found a significant impact of PTSD on neuropsychological outcomes after MTBI, but no relationship between PTSD and white matter integrity. Concurrent PTSD and MTBI should be considered a risk factor for poor neuropsychological outcomes that requires early intervention.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Critical Care Medicine
Caroline Lindblad, Elisa Pin, David Just, Faiez Al Nimer, Peter Nilsson, Bo-Michael Bellander, Mikael Svensson, Fredrik Piehl, Eric Peter Thelin
Summary: This study conducted a multiplex screening of brain enriched and inflammatory proteins in blood and cerebrospinal fluid (CSF) to investigate their role in BBB disruption, neuroinflammation, and long-term functional outcome in TBI patients. The research found that TBI patients showed upregulation of structural CNS and neuroinflammatory pathways in both CSF and serum, with proteins correlating with BBB integrity and identifying potential independent predictors of clinical outcome. The findings provide substantial support for the idea that neuroinflammatory markers, like complement activation, can predict BBB disruption and long-term outcomes in severe TBI.
Article
Medicine, General & Internal
John K. Yue, Nishanth Krishnan, John H. Kanter, Hansen Deng, David O. Okonkwo, Ava M. Puccio, Debbie Y. Madhok, Patrick J. Belton, Britta E. Lindquist, Gabriela G. Satris, Young M. Lee, Gray Umbach, Ann-Christine Duhaime, Pratik Mukherjee, Esther L. Yuh, Alex B. Valadka, Anthony M. DiGiorgio, Phiroz E. Tarapore, Michael C. Huang, Geoffrey T. Manley
Summary: Neuroworsening is an early indicator of traumatic brain injury severity and a predictor of neurosurgical intervention and unfavorable outcome. Clinicians should be vigilant in detecting neuroworsening to provide immediate therapeutic interventions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Giacomo Querzola, Carlo Lovati, Maria M. Lagana, Alice Pirastru, Francesca Baglio, Leonardo Pantoni
Summary: This study aimed to explore the relationship between the neuropsychological profile and traumatic load in American football players, whether traumatic brain injury has a specific cerebral perfusion pattern, and whether this pattern correlates with neuropsychological performances. The results found that cognitive performances of American football players were associated with field position and career length, with linemen having poorer executive, verbal, and visual performances. Additionally, American football players had reduced cerebral blood flow values in sensory-motor areas, and poorer neuropsychological performances correlated with lower perfusion in specific brain areas.
NEUROLOGICAL SCIENCES
(2022)
Article
Critical Care Medicine
Jennifer A. Weaver, Alison M. Cogan, Katherine A. O'Brien, Piper Hansen, Joseph T. Giacino, John Whyte, Theresa Bender Pape, Philip van der Wees, Trudy Mallinson
Summary: This study evaluated the hierarchical structure of the Coma Recovery Scale-Revised (CRS-R) rating scale categories and their alignment with the Aspen consensus criteria for determining disorders of consciousness (DoC). The study found that most of the rating scale categories were aligned with the consensus criteria, but there were a few deviations. The study also found a strong correlation between the individual measures and states of consciousness. The findings provide empirical evidence for revising the diagnostic criteria for certain states of consciousness.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Clinical Neurology
Nitin Agarwal, Alexander A. Aabedi, Abel Torres-Espin, Austin Chou, Thomas A. Wozny, Praveen Mummaneni, John F. Burke, Adam R. Ferguson, Nikos Kyritsis, Sanjay S. Dhall, Philip R. Weinstein, Xuan Duong-Fernandez, Jonathan Pan, Vineeta Singh, Debra D. Hemmerle, Jason F. Talbott, William D. Whetstone, Jacqueline C. Bresnahan, Geoffrey T. Manley, Michael S. Beattie, Anthony M. DiGiorgio
Summary: Maintaining an average intraoperative MAP value between 80 and 96 mm Hg is associated with improved outcomes for patients with acute spinal cord injury, while spending 93 minutes or longer outside the MAP range of 76-104 mm Hg leads to worse neurological function at discharge.
NEUROSURGICAL FOCUS
(2022)
Article
Critical Care Medicine
Yelena G. Bodien, Jason Barber, Sabrina R. Taylor, Kim Boase, John D. Corrigan, Sureyya Dikmen, Raquel C. Gardner, Joel H. Kramer, Harvey Levin, Joan Machamer, Thomas McAllister, Lindsay D. Nelson, Laura B. Ngwenya, Mark Sherer, Murray B. Stein, Mary Vassar, John Whyte, John K. Yue, Amy Markowitz, Michael A. McCrea, Geoffrey T. Manley, Nancy Temkin, Joseph T. Giacino
Summary: To assess the effects of traumatic brain injury (TBI), a multi-dimensional Flexible Outcome Assessment Battery (FAB) was designed, which assigns participants to different assessment groups based on a decision-making algorithm and guides test selection throughout recovery. The feasibility of FAB was demonstrated by a high proportion of participants completing the assessment and receiving valid scores. Furthermore, the level of function assessed by FAB at 2 weeks post-injury was associated with the GOSE scores at 6 and 12 months.
JOURNAL OF NEUROTRAUMA
(2023)
Review
Mathematical & Computational Biology
J. Russell Huie, Rohit Vashisht, Anoop Galivanche, Constance Hadjadj, Saam Morshed, Atul J. Butte, Adam R. Ferguson, Conor O'Neill
Summary: Chronic low back pain is a common problem that affects adults in the United States and is often associated with neuropsychiatric disorders and opioid addiction. Developing effective treatments requires identifying the causal relationships, which can be achieved through rigorous causal inference methods using big data and artificial intelligence.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Kira D. A. Rienecker, Katherine Grue, Maria Serena Paladini, Elma S. Frias, Valentina Frattini, Mia C. Borlongan, Austin Chou, Abel Torres-Espin, Karen Krukowski, Adam R. Ferguson, Susanna Rosi
Summary: To protect the health and performance of astronauts during interplanetary space travel, it is important to understand the effects of deep space hazards. Our study is the first to investigate the cumulative and synergistic impacts of ionizing radiation, confinement, and altered gravity on behavior and cognition. We found that these factors have independent effects on behavioral and cognitive performance, with different resilience observed between male and female mice.
SCIENTIFIC REPORTS
(2023)
Article
Psychiatry
Murray J. Stein, Sonia S. Jain, Livia A. Parodi, Karmel Choi, Adam J. Maihofer, Lindsay Nelson, Pratik Mukherjee, Xiaoying T. Sun, Feng He, David Okonkwo, Joseph Giacino, Frederick R. Korley, Mary Vassar, Claudia Robertson, Michael McCrea, Nancy Temkin, Amy Markowitz, Ramon R. Diaz-Arrastia, Jonathan K. Rosand, Geoffrey Manley, TRACK TBI Investigators
Summary: This study found that the polygenic risk for PTSD, as well as for related mental health disorders, is associated with an increased likelihood of PTSD following mTBI. However, the polygenic risk for major depressive disorder and neuroticism did not show significant associations with PTSD. These findings suggest that the risk for PTSD after mTBI is partly influenced by genetics.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Benjamin Pierce, Thomas Kirsh, Adam R. Ferguson, Thomas C. Neylan, Sisi Ma, Erich Kummerfeld, Beth E. Cohen, Jessica L. Nielson
Summary: The study found that individuals with PTSD are more likely to have other psychiatric disorders and experience diminished health and psychosocial functioning. Longitudinal analysis revealed a direct association between PTSD symptoms and depressive symptoms, as well as indirect effects on social functioning through depression.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Biotechnology & Applied Microbiology
J. Russell Huie, Jessica L. L. Nielson, Jorden Wolfsbane, Clark R. R. Andersen, Heidi M. M. Spratt, Douglas S. S. DeWitt, Adam R. R. Ferguson, Bridget E. E. Hawkins
Summary: This study used modern data science tools to understand the complexity of recovery from chronic traumatic brain injury (cTBI) by integrating large-scale data and exploring the relationships between gene expression and behavioral outcomes. The findings demonstrate that the integration of genomics and behavioral domains can reveal the underlying mechanisms of TBI recovery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Clinical Neurology
Nitin Agarwal, Jacob Blitstein, Austin Lui, Abel Torres-Espin, Chalisar Vasnarungruengkul, John Burke, Praveen V. Mummaneni, Sanjay S. Dhall, Philip R. Weinstein, Xuan Duong-Fernandez, Austin Chou, Jonathan Pan, Vineeta Singh, Adam R. Ferguson, Debra D. Hemmerle, Nikos Kyritsis, Jason F. Talbott, William D. Whetstone, Jacqueline C. Bresnahan, Michael S. Beattie, Geoffrey T. Manley, Anthony DiGiorgio
Summary: This study analyzed complications and outcomes in elderly patients with spinal cord injury (SCI) and found that cardiovascular and pulmonary complications were common. It is suggested that caution should be taken in the clinical treatment of elderly SCI patients, and blood pressure control and cardiology consultation are recommended.
JOURNAL OF NEUROSURGERY-SPINE
(2023)
Article
Critical Care Medicine
Andrea L. C. Schneider, J. Russell Huie, Sonia Jain, Xiaoying R. Sun, Adam Ferguson, Cillian K. Lynch, John T. Yue, Geoffrey Manley, Kevin K. W. K. Wang, Danielle Sandsmark, Christopher Campbell, Ramon Diaz-Arrastia
Summary: Traumatic brain injury (TBI) is a complex condition, and the use of biomarker panels is necessary to capture its heterogeneity. This study found that biomarkers of microvascular injury are associated with TBI severity.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Multidisciplinary Sciences
Catherine R. Jutzeler, Lucie Bourguignon, Bobo Tong, Elias Ronca, Eric Bailey, Noam Y. Harel, Fred Geisler, Adam R. Ferguson, Brian K. Kwon, Jacquelyn J. Cragg, Lukas Grassner, John L. K. Kramer
Summary: The study systematically examined the administration of multiple types and classes of medications in the acute management of traumatic spinal cord injury. It found a high degree of polypharmacy in the acute stages of spinal cord injury, which could potentially affect neurological recovery.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
John K. Yue, Nishanth Krishnan, John H. Kanter, Hansen Deng, David O. Okonkwo, Ava M. Puccio, Debbie Y. Madhok, Patrick J. Belton, Britta E. Lindquist, Gabriela G. Satris, Young M. Lee, Gray Umbach, Ann-Christine Duhaime, Pratik Mukherjee, Esther L. Yuh, Alex B. Valadka, Anthony M. DiGiorgio, Phiroz E. Tarapore, Michael C. Huang, Geoffrey T. Manley
Summary: Neuroworsening is an early indicator of traumatic brain injury severity and a predictor of neurosurgical intervention and unfavorable outcome. Clinicians should be vigilant in detecting neuroworsening to provide immediate therapeutic interventions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Shawn R. Eagle, Ava M. Puccio, Lindsay D. Nelson, Michael McCrea, Joseph Giacino, Ramon Diaz-Arrastia, William Conkright, Sonia Jain, Xiaoying Sun, Geoffrey Manley, David O. Okonkwo
Summary: Obesity is associated with higher symptomatology and blood inflammatory markers in recovery following mTBI. The study found that obese patients had higher concentrations of hsCRP and IL-6 at multiple time points after injury, as well as higher RPQ scores at 6 and 12 months.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
John H. Yue, Firas Kobeissy, Sonia Jain, Xiaoying Sun, Ryan R. L. K. Phelps, Frederick C. Korley, Raquel R. Gardner, Adam Ferguson, J. Russell Huie, Andrea L. C. Schneider, Zhihui Yang, Haiyan E. Xu, Cillian Lynch, Hansen Deng, Miri J. Rabinowitz, Mary R. Vassar, Sabrina Taylor, Pratik L. Mukherjee, Esther J. Yuh, Amy M. Markowitz, Ava O. Puccio, David Okonkwo, Ramon T. Diaz-Arrastia, Geoffrey Manley, Kevin K. W. Wang
Summary: The study investigated the relationship between systemic inflammation and secondary injury in TBI. Inflammatory markers were found to be associated with TBI diagnosis and prognosis. IL-15 and serum amyloid A were identified as priority markers with acceptable discriminatory ability.
NEUROTRAUMA REPORTS
(2023)