Article
Clinical Neurology
Josh W. Faulkner, Alice Theadom, Deborah L. Snell, Matt N. Williams
Summary: This study applied network analysis to investigate post-concussion symptoms after mild traumatic brain injury (mTBI) and found that frustration, blurred vision, and concentration difficulties were central symptoms in two different mTBI samples. These symptoms may play an influential role in the experience and maintenance of post-concussion symptoms.
FRONTIERS IN NEUROLOGY
(2023)
Article
Critical Care Medicine
Emily R. Fisher, Janelle J. Montroy, Gerardo Duque, Charles S. Cox, Linda Ewing-Cobbs
Summary: This study investigated the persistence of PCS and PTSS in children and adolescents following TBI and EI, finding that the two types of symptoms varied among different TBI severity groups. Shared vulnerability factors included female sex, milder TBI, and poorer pre-injury adjustment, while older age was a unique vulnerability factor for PTSS.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Critical Care Medicine
Natalie Le Sage, Jean-Marc Chauny, Simon Berthelot, Patrick Archambault, Xavier Neveu, Lynne Moore, Valerie Boucher, Jerome Frenette, Elaine De Guise, Marie-Christine Ouellet, Jacques Lee, Andrew D. McRae, Eddy Lang, Marcel Emond, Eric Mercier, Pier-Alexandre Tardif, Bonnie Swaine, Peter Cameron, Jeffrey J. Perry
Summary: This study aimed to develop and validate a clinical decision rule (CDR) for the early prediction of persistent post-concussion symptoms (PPCS) in patients with mild traumatic brain injury (mTBI). The study found that the derived rule, called the Post-Concussion Symptoms Rule (PoCS Rule), could effectively stratify the risk of PPCS and assist emergency physicians in planning post-discharge resources.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Medicine, General & Internal
Diego Rivera, Sven Greving, Juan Carlos Arango-Lasprilla, Nicole von Steinbuechel, Marina Zeldovich
Summary: This study analyzed the long-term changes in RPQ symptoms from three to twelve months after TBI and identified factors related to these symptoms. The results showed that the three-factor structure of RPQ remains stable within one year after TBI. Sex, injury cause, and prior psychiatric problems were found to be related to both the factor structure and total score of RPQ.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Aliyah Snyder, Christopher Sheridan, Alexandra Tanner, Kevin Bickart, Molly Sullan, Michelle Craske, Meeryo Choe, Talin Babikian, Christopher Giza, Robert Asarnow
Summary: The study suggests that cardiorespiratory functioning may be altered in youth with persistent post-concussive symptoms (PPCS) and could be related to neurobehavioral outcomes associated with poorer recovery from concussion. Participants with PPCS showed reduced end-tidal CO2 levels and an altered relationship between CO2 levels and respiration rate compared to controls. These findings highlight the potential importance of autonomic nervous system dysregulation in PPCS and its impact on recovery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Jonathan E. Elliott, Nadir M. Balba, Alisha A. McBride, Megan L. Callahan, Kendall T. Street, Matthew P. Butler, Mary M. Heinricher, Miranda M. Lim
Summary: This study examined the effectiveness of different methods for evaluating history of traumatic brain injury (TBI), finding that the Head Trauma Events Characteristics (HTEC) method had the highest sensitivity. It also noted that the results and conclusions may significantly differ depending on the diagnostic method used.
JOURNAL OF NEUROTRAUMA
(2021)
Review
Clinical Neurology
Adriano Mollica, Rachel Greben, Chika Oriuwa, Shan H. Siddiqi, Matthew J. Burke
Summary: This article reviews recent research on neuromodulation for mild traumatic brain injury (mTBI). It suggests that transcranial magnetic stimulation (TMS) shows promise as a potential treatment strategy for post-concussive symptoms, such as depression and headaches, while transcranial direct current stimulation (tDCS) has more mixed results. Further studies are needed to explore new stimulation protocols, personalized approaches, and the role of placebo effects.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Article
Rehabilitation
Toril Skandsen, Jonas Stenberg, Turid Follestad, Migle Karaliute, Simen B. Saksvik, Cathrine E. Einarsen, Hanna Lillehaug, Asta K. Haberg, Anne Vik, Alexander Olsen, Grant L. Iverson
Summary: Personal factors play an important role in predicting postconcussion symptoms in patients with mild traumatic brain injury (MTBI). Factors such as work status, preinjury health problems, and gender were found to be predictors of postconcussion symptoms. Intracranial abnormalities on CT scans were also identified as a risk factor for postconcussion symptoms.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Critical Care Medicine
Karen M. Barlow, Kartik Iyer, Tingting Yan, Alex Scurfield, Helen Carlson, Yang Wang
Summary: Persistent post-concussion symptoms (PPCS) following pediatric mild traumatic brain injury (mTBI) are associated with differential changes in cerebral blood flow (CBF). Our study found that CBF levels were higher in participants with poor recovery and decreased over time, with a greater decrease observed in those with good recovery. These changes in CBF levels predicted outcomes in 77% of children with PPCS, highlighting its potential as a useful predictive biomarker in this population.
JOURNAL OF NEUROTRAUMA
(2021)
Review
Clinical Neurology
Hakan Ashina, David W. Dodick
Summary: This review discusses the pharmacologic management of post-traumatic headache and the potential therapeutic benefits of targeting calcitonin gene-related peptide signaling. It suggests using a phenotype-guided approach for treatment based on the primary headache phenotype that the clinical features resemble the most. Additionally, advancements are being made in identifying cellular and molecular drivers of headache persistence.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Article
Neurosciences
Jackie L. Gottshall, Amma A. Agyemang, Maya O'Neil, Guo Wei, Angela Presson, Bryson Hewins, Daniel Fisher, Sara Mithani, Pashtun Shahim, Mary Jo Pugh, Elisabeth A. Wilde, Christina Devoto, Kristine Yaffe, Jessica Gill, Kimbra Kenney, J. Kent Werner
Summary: Following mild traumatic brain injury (mTBI), the severity of symptoms reported by individuals is positively correlated with biomarker levels of neurodegeneration. The associations between biomarkers and symptoms do not significantly change when sleep items are included or excluded. The Pittsburgh Sleep Quality Index demonstrates strong correlations with both sleep and non-sleep items of all symptom scales.
Review
Clinical Neurology
Todd J. Schwedt
Summary: Post-traumatic headache is a common and persistent symptom following mild traumatic brain injury, with onset typically within 7 days post-injury. Pathophysiological mechanisms of post-traumatic headache involve structural, functional, metabolic, and neuroinflammatory factors. Effective therapy options are currently lacking, with future research priorities including optimizing diagnostic criteria and understanding pathophysiology.
Article
Medicine, General & Internal
Marjolein van der Vlegel, Suzanne Polinder, Ana Mikolic, Rana Kaplan, Nicole von Steinbuechel, Anne Marie Plass, Marina Zeldovich, Dominique van Praag, Fabian Bockhop, Katrin Cunitz, Isabelle Mueller, Juanita A. Haagsma
Summary: Research has shown that patients with mild traumatic brain injury (mTBI) are at risk for post-concussion (PC) symptoms, with 26.1% experiencing them, and post-traumatic stress disorder (PTSD) symptoms, with 9.8% experiencing them, with the majority experiencing both PC and PTSD symptoms. Patients with PC and/or PTSD symptoms reported lower health-related quality of life (HRQoL), higher rates of rehabilitation, and lower return to work rates.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Eva Keatley, Kathleen Bechtold, Kevin Psoter, Matthew E. Peters, Allen Everett, Vani Rao, Timothy E. Van Meter, Hayley Falk, Frederick K. Korley, Durga Roy
Summary: This study utilized group-based trajectory modeling (GBTM) to identify distinct patterns of symptom recovery following mild traumatic brain injury (TBI) in the first 6 months after injury. The findings identified four distinct trajectories of recovery, which can be helpful for understanding the natural history of recovery and developing targeted interventions.
Review
Medicine, General & Internal
Ioannis Mavroudis, Alin Ciobica, Alina Costina Luca, Ioana-Miruna Balmus
Summary: Post-traumatic headache (PTH) is a common and debilitating consequence of mild traumatic brain injury (mTBI) that can occur over one year after the head impact event. Understanding the pathophysiology and risk factors of PTH is crucial for early identification and management. Risk factors for PTH include history of migraines or headaches, female gender, younger age, greater severity of the head injury, and co-occurring psychological symptoms. PTH can present in various clinical profiles and treatment options include pharmacological interventions and non-pharmacological approaches such as cognitive behavioral therapy and physical therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
W. A. R. Zwaans, J. A. de Bruijn, J. P. Dieleman, E. W. Steyerberg, M. R. M. Scheltinga, R. M. H. Roumen
Summary: The purpose of this study was to examine whether patients tend to overestimate or underestimate their pre-operative pain levels when recalling them in the post-operative phase. The study found that a significant percentage of patients experienced recall bias, leading to misclassification of treatment outcomes.
Article
Critical Care Medicine
Yelena G. Bodien, Jason Barber, Sabrina R. Taylor, Kim Boase, John D. Corrigan, Sureyya Dikmen, Raquel C. Gardner, Joel H. Kramer, Harvey Levin, Joan Machamer, Thomas McAllister, Lindsay D. Nelson, Laura B. Ngwenya, Mark Sherer, Murray B. Stein, Mary Vassar, John Whyte, John K. Yue, Amy Markowitz, Michael A. McCrea, Geoffrey T. Manley, Nancy Temkin, Joseph T. Giacino
Summary: To assess the effects of traumatic brain injury (TBI), a multi-dimensional Flexible Outcome Assessment Battery (FAB) was designed, which assigns participants to different assessment groups based on a decision-making algorithm and guides test selection throughout recovery. The feasibility of FAB was demonstrated by a high proportion of participants completing the assessment and receiving valid scores. Furthermore, the level of function assessed by FAB at 2 weeks post-injury was associated with the GOSE scores at 6 and 12 months.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Oncology
Delal Akdeniz, Iris Kramer, Carolien H. M. van Deurzen, Bernadette A. M. Heemskerk-Gerritsen, Michael Schaapveld, Pieter J. Westenend, Adri C. Voogd, Agnes Jager, Ewout W. Steyerberg, Stefan Sleijfer, Marjanka K. Schmidt, Maartje J. Hooning
Summary: Lobular and lobular mixed primary breast cancer histology are associated with modestly increased risk of contralateral breast cancer (CBC), and personalized risk assessment needs to consider the histology of the primary cancer as well as the impact of systemic therapy.
Article
Dermatology
Vladica M. Velickovic, Tim Spelman, Michael Clark, Sebastian Probst, David G. Armstrong, Ewout Steyerberg
Summary: This review discusses the development of risk prediction tools for chronic wounds and highlights the importance and challenges of regression-based and machine learning methods. Machine learning may be a powerful adjunct for handling complex risk factors in wound healing.
ADVANCES IN WOUND CARE
(2023)
Article
Multidisciplinary Sciences
Jesus Villar, Jesus M. Gonzalez-Martin, Jose M. Anon, Carlos Ferrando, Juan A. Soler, Fernando Mosteiro, Juan M. Mora-Ordonez, Alfonso Ambros, Lorena Fernandez, Raquel Montiel, Anxela Vidal, Tomas Munoz, Lina Perez-Mendez, Pedro Rodriguez-Suarez, Cristina Fernandez, Rosa L. L. Fernandez, Tamas Szakmany, Karen E. A. Burns, Ewout W. Steyerberg, Arthur S. Slutsky
Summary: Mortality assessment in clinical studies of acute respiratory distress syndrome (ARDS) has not been well-defined. This study aimed to determine the timing of mortality assessment in ICU patients with moderate-to-severe ARDS, and its predictive value for treatment response. Observational cohorts and a randomized trial were analyzed, and it was found that ICU mortality rates closely approximated 28-day mortality rates. ICU mortality assessment within the first week of a trial could serve as an early predictor of treatment response for moderate-to-severe ARDS patients.
SCIENTIFIC REPORTS
(2023)
Article
Psychiatry
Murray J. Stein, Sonia S. Jain, Livia A. Parodi, Karmel Choi, Adam J. Maihofer, Lindsay Nelson, Pratik Mukherjee, Xiaoying T. Sun, Feng He, David Okonkwo, Joseph Giacino, Frederick R. Korley, Mary Vassar, Claudia Robertson, Michael McCrea, Nancy Temkin, Amy Markowitz, Ramon R. Diaz-Arrastia, Jonathan K. Rosand, Geoffrey Manley, TRACK TBI Investigators
Summary: This study found that the polygenic risk for PTSD, as well as for related mental health disorders, is associated with an increased likelihood of PTSD following mTBI. However, the polygenic risk for major depressive disorder and neuroticism did not show significant associations with PTSD. These findings suggest that the risk for PTSD after mTBI is partly influenced by genetics.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Health Care Sciences & Services
Siri L. van der Meijden, Anne A. H. de Hond, Patrick J. Thoral, Ewout W. Steyerberg, Ilse M. J. Kant, Giovanni Cina, M. Sesmu Arbous
Summary: This study aimed to investigate physicians' perspectives and decision-making behavior before implementing an AI-CDS tool for predicting readmission and mortality risk after ICU discharge. The survey results showed that most physicians had positive attitudes towards AI and AI-CDS tools, believing that they could support their work. Physicians expressed a willingness to incorporate a discharge AI-CDS tool into their daily clinical practice and recognized its value in their workflows.
JMIR HUMAN FACTORS
(2023)
Article
Health Care Sciences & Services
Alexandros Rekkas, Peter R. Rijnbeek, David M. Kent, Ewout W. Steyerberg, David van Klaveren
Summary: This study compared easily applicable risk-based methods to find optimal prediction methods for individualized treatment effects. The linear-interaction model showed optimal or close-to-optimal performance in many simulation scenarios. The restricted cubic splines model was optimal for strong non-linear deviations when sample size was larger.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Article
Medicine, General & Internal
Ben Van Calster, Ewout W. W. Steyerberg, Laure Wynants, Maarten van Smeden
Summary: Clinical prediction models should be validated before implementation, as the performance of a model may vary across patient populations and measurement procedures. Validation studies should focus on understanding and quantifying heterogeneity and monitoring performance over time, to ensure that prediction models remain up-to-date and safe for clinical decision-making.
Article
Medicine, General & Internal
Nicole von Steinbuechel, Stefanie Hahm, Holger Muehlan, Juan Carlos Arango-Lasprilla, Fabian Bockhop, Amra Covic, Silke W. Schmidt, Ewout Steyerberg, Andrew I. R. Maas, David Menon, Nada Andelic, Marina Zeldovich, CTR TBI Participants Investigators
Summary: Traumatic brain injury (TBI) is a major cause of death and disability worldwide. This study aims to understand the impact of TBI on various outcome domains, evaluating factors contributing to worsening or improving outcomes. The study used patient-reported outcome measures and identified different trajectory classes for outcome after TBI, including stable good health, persistent impairments, improving health, and deteriorating health. Individuals with persistent impairments and deterioration need special attention and long-term clinical monitoring and therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
John K. Yue, Nishanth Krishnan, John H. Kanter, Hansen Deng, David O. Okonkwo, Ava M. Puccio, Debbie Y. Madhok, Patrick J. Belton, Britta E. Lindquist, Gabriela G. Satris, Young M. Lee, Gray Umbach, Ann-Christine Duhaime, Pratik Mukherjee, Esther L. Yuh, Alex B. Valadka, Anthony M. DiGiorgio, Phiroz E. Tarapore, Michael C. Huang, Geoffrey T. Manley
Summary: Neuroworsening is an early indicator of traumatic brain injury severity and a predictor of neurosurgical intervention and unfavorable outcome. Clinicians should be vigilant in detecting neuroworsening to provide immediate therapeutic interventions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Alexandros Rekkas, David van Klaveren, Patrick B. Ryan, Ewout W. Steyerberg, David M. Kent, Peter R. Rijnbeek
Summary: This study proposes a standardized scalable framework to extend the assessment of treatment effect heterogeneity to the observational setting. The framework consists of five steps: definition of research aim, identification of relevant databases, development of prediction model, estimation of treatment effect within risk strata, and presentation of results. It allows for the evaluation of differential treatment effects across risk strata.
NPJ DIGITAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Anne A. H. de Hond, Vaibhavi B. B. Shah, Ilse M. J. Kant, Ben Van Calster, Ewout W. Steyerberg, Tina Hernandez-Boussard
Summary: The generalizability of predictive algorithms is crucial for their application in clinical practice. This article provides an overview of three types of generalizability, namely temporal, geographical, and domain generalizability, based on existing literature. These types of generalizability are associated with their respective goals, methodology, and stakeholders.
NPJ DIGITAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Shubhayu Bhattacharyay, Pier Francesco Caruso, Cecilia Akerlund, Lindsay D. Wilson, Robert K. Stevens, David W. Menon, Ewout W. Steyerberg, David Nelson, Ari Ercole, CENTER TBI Investigators Participants
Summary: Existing methods to characterise the evolving condition of traumatic brain injury (TBI) patients in the intensive care unit (ICU) do not capture the necessary context for individualising treatment. In this study, the integration of heterogenous data from medical records was used to model the individualised impact of clinical course on 6-month functional outcome. The study showed that static variables accounted for the majority of functional outcome explanation after TBI.
NPJ DIGITAL MEDICINE
(2023)
Proceedings Paper
Computer Science, Interdisciplinary Applications
Siri Lise van der Meijden, Anna van Boekel, Laurens Schinkelshoek, Harry van Goor, Mark de Boer, Ewout Steyerberg, Bart Geerts, Sesmu Arbous
Summary: Currently, postoperative infections are identified through manual chart review. In this study, a validated automated labeling method based on registrations and treatments was used to develop a high-quality prediction model (AUC 0.81) for postoperative infections.
CARING IS SHARING-EXPLOITING THE VALUE IN DATA FOR HEALTH AND INNOVATION-PROCEEDINGS OF MIE 2023
(2023)