Review
Rehabilitation
Gongkai Ye, Emerson Paul Grabke, Maureen Pakosh, Julio C. Furlan, Kei Masani
Summary: The study comprehensively evaluated the clinical benefits and engineering designs of functional electrical stimulation (FES)-rowing in individuals with spinal cord injury, finding that FES-rowing can improve cardiovascular performance and reduce bone density loss. Further randomized controlled trials are needed to determine the optimal setup for FES-rowing that maximizes rehabilitation outcomes.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Engineering, Biomedical
Xiao-Na Xiang, Hui-Yan Zong, Yi Ou, Xi Yu, Hong Cheng, Chun-Ping Du, Hong-Chen He
Summary: The study findings indicate that exoskeleton-assisted walking significantly improves pulmonary function parameters in spinal cord injury patients, showing potential benefits for individuals with lower thoracic neurological levels of SCI. Additionally, robotic exoskeletons help facilitate walking.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2021)
Article
Rehabilitation
Pierre Asselin, Christopher M. Cirnigliaro, Stephen Kornfeld, Steven Knezevic, Rachel Lackow, Michael Elliott, William A. Bauman, Ann M. Spungen
Summary: This study aimed to investigate the effects of overground walking using a powered exoskeleton on soft tissue body composition in individuals with spinal cord injury (SCI). The results showed a significant reduction in total body fat mass, particularly in visceral adipose tissue, suggesting potential health improvements with sustained use of powered exoskeletons in SCI patients.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Clinical Neurology
Alexandra M. Williams, Jasmin K. Ma, Kathleen A. Martin Ginis, Christopher R. West
Summary: The study suggests that a tailored behavioral physical activity intervention is more effective in promoting adaptations in cardiac geometry for individuals with lower level spinal cord injuries.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Rehabilitation
Marc Possover
Summary: The study reported the long-term effects of low-frequency stimulation of pelvic somatic nerves in patients with chronic spinal cord injuries, showing that most patients experienced some degree of recovery after stimulation training. Many patients were able to stand and walk to some extent after long-term follow-up.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Critical Care Medicine
Abdullah A. Alrashidi, Tom E. Nightingale, Katharine D. Currie, Michele Hubli, Maureen J. MacDonald, Audrey L. Hicks, Paul Oh, Beverley Catharine Craven, Andrei Krassioukov
Summary: This study aimed to evaluate the impacts of exercise interventions on cardiovascular disease risk factors in persons with chronic SCI, but the results showed that 24 weeks of exercise intervention did not significantly affect arterial stiffness or cardiometabolic health measures, although ACET increased peak oxygen uptake compared to BWSTT.
JOURNAL OF NEUROTRAUMA
(2021)
Review
Cell Biology
Munehisa Shinozaki, Narihito Nagoshi, Masaya Nakamura, Hideyuki Okano
Summary: Spinal cord injury affects 0.93 million people globally each year, with current rehabilitation methods providing limited functional recovery due to the inability to restore damaged tissues. Despite numerous clinical trials on stem cell therapy, the heterogeneous pathophysiology of spinal cord injuries has not been effectively considered, resulting in challenging trial outcomes. Precision medicine based on patient characteristics in the field of SCI shows great potential, particularly in targeting specific mechanisms for different types of injuries.
Article
Rehabilitation
Steven Knezevic, Pierre K. Asselin, Christopher M. Cirnigliaro, Stephen Kornfeld, Racine R. Emmons, Ann M. Spungen
Summary: The study indicates that training with exoskeletal-assisted walking (EAW) can improve oxygen uptake efficiency and walking velocities, while reducing perceived exertion.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Rehabilitation
Claire Shackleton, Robert Evans, Sacha West, Wayne Derman, Yumna Albertus
Summary: The study found that 24 weeks of robotic locomotor training can maintain hip bone mineral density, while activity-based training significantly reduces it. Both interventions improved arm fat-free soft tissue mass, but had no effect on leg fat-free soft tissue mass. The activity-based training group experienced a significant decrease in visceral adipose tissue and gynoid fat mass.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2022)
Article
Rehabilitation
Anthony F. DiMarco, Robert T. Geertman, Kutaiba Tabbaa, Gregory A. Nemunaitis, Krzysztof E. Kowalski
Summary: This study aimed to investigate the use of spinal cord stimulation (SCS) to improve bowel management in individuals with spinal cord injury (SCI). Results showed that SCS significantly reduced time required for bowel management, increased airway pressure generation, and improved overall quality of life. Importantly, the improvement in bowel management was associated with restoration of intra-abdominal pressure development.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Health Care Sciences & Services
Nicole M. Vecin, David R. Gater
Summary: This manuscript reviews the risk of pressure injuries caused by spinal cord injury and discusses the multidisciplinary approach required to prevent and treat these injuries in the vulnerable population.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Neurosciences
Claire Shackleton, Daniel Hodgkiss, Soshi Samejima, Tiev Miller, Monica A. Perez, Thomas E. Nightingale, Rahul Sachdeva, Andrei V. Krassioukov
Summary: This scoping review evaluated the effectiveness of paired interventions (exercise + spinal neuromodulation) for improving sensorimotor and autonomic functions in individuals with SCI. The results showed that spinal cord stimulation combined with activity-based training can improve walking and voluntary muscle activation, and augment improvements in lower urinary tract, bowel, resting metabolic rate, peak oxygen consumption, and thermoregulatory function.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Yannick Rau, Arndt-Peter Schulz, Roland Thietje, Ludwig Matrisch, Jasper Frese, Sven Hirschfeld
Summary: This study provides recent data on the incidence of spinal cord injuries (SCI) in Germany and highlights the influence of age, gender, and type of lesion on incidence rates. The findings suggest potential directions for future research, particularly regarding the relative reduction in complete injuries among the elderly.
EUROPEAN SPINE JOURNAL
(2023)
Article
Clinical Neurology
Adrian Cathomen, Laura Sirucek, Tim Killeen, Rainer Abel, Doris Maier, Norbert Weidner, Rudiger Rupp, Torsten Hothorn, John D. Steeves, Armin Curt, Marc Bolliger
Summary: This study used URP-CTREE to analyze data from 309 SCI patients, identifying homogeneous outcome cohorts, which were validated by an internal validation group. This method can help design clinical trials with broad inclusion criteria and improve the quality of research design.
NEUROREHABILITATION AND NEURAL REPAIR
(2022)
Review
Multidisciplinary Sciences
Xinli Hu, Yu Xu, Haojie Zhang, Yao Li, Xiangyang Wang, Cong Xu, Wenfei Ni, Kailiang Zhou
Summary: This review summarizes the role of necroptosis in central nervous system trauma and its therapeutic implications, providing important suggestions for researchers conducting in-depth research. The study focuses on the necroptosis signaling pathway, execution, temporal patterns of RIPKs in CNS trauma, association of miRNAs with necroptosis, and different types of CNS trauma cell death. It also highlights potential agents for curtailing necroptosis-related cell death in CNS trauma.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Respiratory System
Mandy Scheermesser, Leah Reicherzer, Swantje Beyer, David Gisi, Spencer Rezek, Thomas Hess, Markus Wirz, Anne-Kathrin Rausch Osthoff
Summary: The study aimed to explore how a combined counselling and pulmonary rehabilitation program affects COPD patients' perception of physical activity and motivation for behavior change. Findings revealed four types of individuals with COPD based on their activity perceptions, motivation, and coping strategies. Recognizing and tailoring interventions according to these types are crucial for improving outpatient PR programs.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Article
Surgery
Severin Gloor, Merima Misirlic, Cornelia Frei-Lanter, Pascal Herzog, Phaedra Mueller, Judit Schaefli-Thurnherr, Tenzin Lamdark, Dorothee Schregel, Roland Wyss, Ines Unger, David Gisi, Nicola Greco, Giuseppe Mungo, Markus Wirz, Dimitri Aristotle Raptis, Christoph Tschuor, Stefan Breitenstein
Summary: This study aimed to assess the impact of prehabilitation on postoperative complications in patients undergoing colorectal surgery within an enhanced recovery after surgery (ERAS) protocol. The results showed that routine physiotherapeutic prehabilitation did not provide additional benefits for patients in terms of reducing postoperative complications.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Article
Plant Sciences
Jesse T. Beasley, Julien P. Bonneau, Laura T. Moreno-Moyano, Damien L. Callahan, Kate S. Howell, Elad Tako, Julian Taylor, Raymond P. Glahn, Rudi Appels, Alexander A. T. Johnson
Summary: Traditional breeding efforts for iron and zinc biofortification in bread wheat have been hindered by a lack of genetic variation and negative correlation with yield. Genetic engineering techniques have successfully increased iron and zinc concentrations in bread wheat by expressing the OsNAS2 gene, resulting in higher Fe bioavailability in white flour.
Article
Clinical Neurology
Elizabeth A. Bye, Martin E. Heroux, Claire L. Boswell-Ruys, Monica A. Perez, Mariel Purcell, Julian Taylor, Bonsan B. Lee, Euan J. McCaughey, Jane E. Butler, Simon C. Gandevia
Summary: This study aims to determine the effect of transcutaneous spinal stimulation combined with locomotor training on walking ability in individuals with spinal cord injury. Through a 12-week randomized trial, the study will evaluate the primary and secondary outcomes of walking ability.
Article
Agronomy
Paul Telfer, James Edwards, Julian Taylor, Jason A. Able, Haydn Kuchel
Summary: Assessing adaptation to high temperature stress conditions through performance and responsiveness analysis offers breeders opportunities to select for grain yield stability across diverse environments and genotypes with higher relative yield in stress conditions. Genomic analysis identified 199 QTL, including 60 performance QTL and 139 responsiveness QTL, with potential applications in breeding for heat tolerance in wheat.
THEORETICAL AND APPLIED GENETICS
(2022)
Article
Respiratory System
Anne-Kathrin Rausch Osthoff, Swantje Beyer, David Gisi, Spencer Rezek, Ariane Schwank, Andre Meichtry, Noriane A. Sievi, Thomas Hess, Markus Wirz
Summary: The study aimed to investigate whether embedding a PA counselling program in a comprehensive outpatient PR program could increase daily PA in COPD patients, however, the findings showed that this counselling intervention had no short-term or long-term effects on PA behavior.
BMC PULMONARY MEDICINE
(2021)
Article
Plant Sciences
Yongle Li, Lachlan Lake, Yashvir S. Chauhan, Julian Taylor, Victor O. Sadras
Summary: Water deficit accelerates the flowering of pulses due to increased heat in droughted plants. By studying chickpea, researchers have identified genomic regions and candidate genes associated with the effect of drought on phenology. This understanding can enhance genetic and phenotypic models, leading to more accurate predictions of adaptation to future climates.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Rehabilitation
Fabienne Keller, Lara Allet, Andre Meichtry, Luca Scascighini, Mandy Scheermesser, Markus Wirz, Irina Nast
Summary: This study investigated the ability of Swiss physiotherapists to diagnose and triage patients in a direct access setting and found that their characteristics were associated with correct diagnoses and decision-making. The results showed that improving physiotherapists' screening abilities is important and further research is needed to develop innovative educational concepts and improve training.
PHYSIOTHERAPY THEORY AND PRACTICE
(2023)
Article
Pediatrics
Irina Benninger, Patricia Lampart, Gabi Mueller, Marika Augutis, Inge Eriks-Hoogland, Sebastian Grunt, Erin Hayes Kelly, Beth Padden, Cordula Scherer, Sandra Shavit, Julian Taylor, Erich Rutz, Anke Scheel-Sailer
Summary: This study aims to understand the needs and research priorities of Swiss children, adolescents, and young adults with spinal cord injury/disorder or spina bifida, as well as their parents. The study found that having fun, maintaining good relationships with family members, and physical functioning were highly important for all young people. Research priorities included physical functioning, prevention of pressure injuries, general health, and bowel management in some subgroups. This study highlights the importance of considering both the perspectives of young people and their caregivers when selecting research topics.
Article
Clinical Neurology
Marta Rios-Leon, Bashak Onal, Juan Carlos Arango-Lasprilla, Marika Augutis, Nora Civicos-Sanchez, Allison Graham, Erin Hayes Kelly, Elisa Lopez-Dolado, Anke Scheel-Sailer, Patricia Subinas-Medina, Julian Taylor
Summary: This study described the health and life domain priorities of youth with pediatric-onset spinal cord injury (SCI) and their parents/caregivers. The results showed that health domains were considered the top overall priorities for 13-25-year-olds, while life domains were the main concerns for 2-12-year-olds. This survey will aid rehabilitation professionals to implement a comprehensive SCI management program for the pediatric population.
JOURNAL OF SPINAL CORD MEDICINE
(2022)
Article
Multidisciplinary Sciences
Krithika Anil, Sara Demain, Jane Burridge, David Simpson, Julian Taylor, Imogen Cotter, Aleksandra Vuckovic
Summary: EEG-based neurofeedback allows voluntary self-modulation of brain activity through mental behaviors. This study aimed to understand neurofeedback learning and the relationship between mental behaviors and neurofeedback success. Results showed that self-efficacy was moderately correlated with neurofeedback success, and affect may be more important than mental strategies for a successful neurofeedback performance.
SCIENTIFIC REPORTS
(2022)
Article
Psychology, Multidisciplinary
Leah Reicherzer, Markus Wirz, Frank Wieber, Eveline S. Graf
Summary: This study identifies obstacles and facilitators of physical activity among individuals with severe disabilities. The main categories that impact physical activity include physical capabilities, psychological capabilities, motivation reflective, motivation automatic, opportunity physical, and opportunity social. The results emphasize the need for comprehensive service models based on interdisciplinary collaborations.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Medicine, General & Internal
Eveline S. Graf, Claudio Perret, Rob Labruyere, J. Carsten Moeller, Markus Wirz
Summary: This article presents a scoping review on physical activity interventions for non-ambulatory people with severe motor impairments due to chronic neurological diagnoses. The review found that such interventions can have health benefits for this population, but the number of studies and their comparability is limited, indicating the need for further research to develop evidence-based recommendations.
ANNALS OF MEDICINE
(2023)
Article
Biology
Mario Fruzangohar, William A. Timmins, Olena Kravchuk, Julian Taylor
Summary: HaploMaker is a novel reference-based haplotype assembly algorithm able to accurately and efficiently phase long haplotypes using both short-read and long Pacific Biosciences reads. Compared to three other common reference-based haplotype assembly tools, HaploMaker showed superior accuracy and capability to phase longer genomic regions in both short-read and long-read scenarios.
Article
Medicine, Research & Experimental
Corina Schuster-Amft, Jan Kool, J. Carsten Moeller, Raoul Schweinfurther, Markus J. Ernst, Leah Reicherzer, Carina Ziller, Martin E. Schwab, Simon Wieser, Markus Wirz
Summary: This study aimed to evaluate the safety and acceptance of a high-intensity technology-assisted training for patients after stroke in the subacute or chronic phase. The results showed that the treatment was safe, with no serious adverse events reported. Patients improved in functional performance assessments, and the efficiency gains of the trainings were significant.
PILOT AND FEASIBILITY STUDIES
(2022)
