Article
Neurosciences
Yiyang Zhu, Claire I. C. Warrenfelt, Jill C. Flannery, Clark A. Lindgren
Summary: The study indicates that ASIC channels and extracellular protons play a role in mediating presynaptic homeostatic potentiation (PHP) at the mouse neuromuscular junction (NMJ), with blocking ASICs or changing proton concentration affecting the occurrence of PHP.
Review
Neurosciences
Maria Gurma, Yi-Mei Yang, Lu-Yang Wang
Summary: This article reviews the impact of NMDARs on central synapse function during the early postnatal stage and raises unanswered questions that are crucial for understanding the developing brain in health and diseases.
Article
Multidisciplinary Sciences
Kun-Han Lin, Holger Taschenberger, Erwin Neher
Summary: Glutamatergic synapses display variable strength and diverse short-term plasticity, which is determined by the fraction of docked synaptic vesicles equipped with a mature release machinery rather than the fusion probability. Traditional quantal analysis methods do not accurately reflect the fusion probability, but rather reflect the distribution between mature and immature priming states at rest.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Rounak Chatterjee, Janet L. L. Paluh, Souradeep Chowdhury, Soham Mondal, Arnab Raha, Amitava Mukherjee
Summary: The complexity of synaptic function and plasticity relies on the types of neurons and molecular mechanisms at the synaptic level. Computational models like ASDint and hardware like SyNC enable analysis of ASD mechanisms affecting glutamatergic neuron synapses, expanding neural network models of plasticity. They allow for evaluation of the impact of changed parameters on synaptic function and potential failure of neural networks.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Neurosciences
Tetsuya Hori, Shigeo Takamori
Summary: This review introduces a unique electrophysiological method to monitor glutamate refilling by VGLUTs in a giant model synapse from the calyx of Held in rodent brainstem slices. The current understanding of factors that potentially alter the amount and rate of glutamate refilling in this synapse is discussed, along with open questions from physiological viewpoints.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Pharmacology & Pharmacy
Ya-Ting Wang, Xiao-Le Wang, Si-Tong Feng, Nai-Hong Chen, Zhen-Zhen Wang, Yi Zhang
Summary: The glutamate system plays a crucial role in the pathophysiology of major depressive disorder, with dysfunctional glutamatergic neurotransmission closely linked to depression. Novel modulators targeting the glutamate system could offer potential therapeutic targets for the treatment of depression.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Neurosciences
Elizabeth Nicholson, Dimitri M. Kullmann
Summary: The study demonstrates that acetylcholine release from cholinergic axons is able to trigger heterosynaptic potentiation of glutamatergic signaling to oriens interneurons in the hippocampus, independent of NMDA receptors. This phenomenon is sensitive to postsynaptic Ca2+ chelation and blockers of nicotinic receptors, highlighting the importance of cholinergic signaling in the induction of LTP.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Physiology
Subhash C. Gupta, Rebecca J. Taugher-Hebl, Jason B. Hardie, Rong Fan, Ryan T. LaLumiere, John A. Wemmie
Summary: Chronic drug abuse induces synaptic changes in nucleus accumbens medium spiny neurons that promote craving and drug-seeking behavior. Acid-sensing ion channels (ASICs) may play a critical role in these changes. Disrupting the ASIC1A subunit in drug-naive mice produced synaptic changes similar to those seen during cocaine withdrawal, and these changes were normalized by cocaine. The effects of ASIC1A disruption in mice after cocaine exposure were observed to occur 15 hours, 24 hours, and 4 days later, and returned to baseline levels after 7 days. ASIC1A disruption was found to be cell autonomous and restricted to neurons where the channels are disrupted. Testing also showed that dopamine receptor 1-expressing medium spiny neurons were preferentially affected. Protein synthesis was found to be involved in the synaptic adaptations after ASIC1A disruption.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Neurosciences
Aniello Lombardi, Qiang Wang, Maik C. Stuettgen, Thomas Mittmann, Heiko J. Luhmann, Werner Kilb
Summary: This study investigates the role of short-term synaptic plasticity (STP) in excitatory and inhibitory synapses in the cortical layer 2/3 of mice. The results show that burst stimulation leads to short-term depression (STD) in both excitatory and inhibitory synapses, with stronger depression observed in inhibitory synapses and longer decay time.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Eric Danielson, Karen Perez de Arce, Beth Cimini, Eike-Christian Wamhoff, Shantanu Singh, Jeffrey R. Cottrell, Anne E. Carpenter, Mark Bathe
Summary: This study utilized multiplexed imaging and machine learning techniques to identify novel synaptic subtypes within excitatory and inhibitory synapses, and investigated the differences in protein expression within these subtypes. The results revealed changes in synaptic distribution following synaptic plasticity induction, while the distribution of synaptic subtypes remained unchanged under chronic suppression of neuronal activity.
Article
Neurosciences
Daniel D. Cooper, Bruno G. Frenguelli
Summary: The ability of glutamatergic synaptic strength to change in response to neuronal activity is believed to underlie animal learning from experience. BDNF signaling and MSK1 play a crucial role in the structural and functional adaptations associated with enrichment, potentially allowing for enhanced information storage and establishment of genomic homeostasis.
Article
Immunology
Ziyi Li, Olivia Ewi Vidjro, Gengni Guo, Yanfeng Du, Yao Zhou, Qian Xie, Jiaxin Li, Keqiang Gao, Li Zhou, Tengfei Ma
Summary: This study found that inhibition of the NLRP3 inflammasome can reduce alcohol intake and anxiety-like behavior by regulating glutamatergic transmission in corticostriatal circuits. These findings provide a potential anti-inflammatory target for treating alcohol use disorders.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Endocrinology & Metabolism
J. Fernandez-Felipe, B. Merino, A. B. Sanz-Martos, A. Plaza, A. Contreras, V Naranjo, L. Morales, J. A. Chowen, V Cano, M. Ruiz-Gayo, N. Del Olmo
Summary: Chronic consumption of both SOLF and UOLF impairs spatial short-term memory, modulates hippocampal synaptic plasticity mechanisms and gene expression of NMDA receptor subunits. PPAR gamma gene expression is specifically down-regulated in adolescent SOLF individuals and up-regulated in adult UOLF mice.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Neurosciences
Anna Longatti, Luisa Ponzoni, Edoardo Moretto, Giorgia Giansante, Norma Lattuada, Maria Nicol Colombo, Maura Francolini, Mariaelvina Sala, Luca Murru, Maria Passafaro
Summary: Rho GTPases, specifically ARHGAP22, play a critical role in regulating actin dynamics and synaptic function in the CNS. Loss of ARHGAP22 leads to RAC1 hyperactivity and synaptic defects in dendritic spine density, molecular composition, and plasticity, resulting in cognitive impairment and reduced anxiety-like behavior in mice. Inhibiting RAC1 activity restores synaptic plasticity in ARHGAP22 KO mice, highlighting the importance of ARHGAP22 in hippocampal excitatory synapse formation and function, as well as in learning and memory behaviors.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Cell Biology
Himawari Hirai, Takeshi Sakaba, Yuki Hashimotodani
Summary: This study demonstrates the presence of associative long-term potentiation at the synapses from the hypothalamic supramammillary nucleus to the dentate granule cells, indicating the involvement of Hebbian plasticity in regulating this subcortical input.
Article
Audiology & Speech-Language Pathology
Carlota Gonzalez Inchauspe, Nadia Pilati, Mariano N. Di Guilmi, Francisco J. Urbano, Michel D. Ferrari, Arn M. J. M. van den Maagdenberg, Ian D. Forsythe, Osvaldo D. Uchitel
Article
Biochemistry & Molecular Biology
Agusto Abel Lempel, Lucia Coll, Alejandro F. Schinder, Osvaldo Daniel Uchitel, Joaquin Piriz
JOURNAL OF NEUROCHEMISTRY
(2017)
Article
Neurosciences
Nadia Pilati, Deborah M. Linley, Haresh Selvaskandan, Osvaldo Uchitel, Matthias H. Hennig, Cornelia Kopp-Scheinpflug, Ian D. Forsythe
JOURNAL OF PHYSIOLOGY-LONDON
(2016)
Article
Geriatrics & Gerontology
Tatiana Itzcovich, Zhengrui Xi, Horacio Martinetto, Patricio Chrem-Mendez, Maria Julieta Russo, Bruno de Ambrosi, Osvaldo D. Uchitel, Martin Nogues, Emanuel Silva, Galeno Rojas, Pablo Bagnatti, Alejandra Amengual, Jorge Campos, Ekaterina Rogaeva, Peter St George-Hyslop, Ricardo Allegri, Gustavo Sevlever, Ezequiel I. Surace
NEUROBIOLOGY OF AGING
(2016)
Article
Neurosciences
Graciela L. Mazzone, Priyadharishini Veeraraghavan, Carlota Gonzalez-Inchauspe, Andrea Nistri, Osvaldo D. Uchitel
Article
Neurosciences
Nicolas Ivan Bertone, Ayelen Ivana Groisman, Graciela Lujan Mazzone, Raquel Cano, Lucia Tabares, Osvaldo Daniel Uchitel
Article
Cell Biology
Francisco J. Urbano, Noelia G. Lino, Carlota M. F. Gonzalez-Inchauspe, Laura E. Gonzalez, Natalia Colettis, Lucas G. Vattino, Amanda M. Wunsch, John A. Wemmie, Osvaldo D. Uchitel
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2014)
Article
Neurosciences
Carina Weissmann, Mariano N. Di Guilmi, Francisco J. Urbano, Osvaldo D. Uchitel
BRAIN RESEARCH BULLETIN
(2013)
Article
Biochemistry & Molecular Biology
Laura E. Gonzalez, Monica L. Kotler, Lucas G. Vattino, Eugenia Conti, Ricardo C. Reisin, Kirk J. Mulatz, Terrance P. Snutch, Osvaldo D. Uchitel
JOURNAL OF NEUROCHEMISTRY
(2011)
Article
Neurosciences
Carlota Gonzalez Inchauspe, Francisco J. Urbano, Mariano N. Di Guilmi, Michel D. Ferrari, Arn M. J. M. van den Maagdenberg, Ian D. Forsythe, Osvaldo D. Uchitel
JOURNAL OF NEUROPHYSIOLOGY
(2012)
Article
Neurosciences
Mariano N. Di Guilmi, Tiantian Wang, Carlota Gonzalez Inchauspe, Ian D. Forsythe, Michel D. Ferrari, Arn M. J. M. van den Maagdenberg, Gerard G. Borst, Osvaldo D. Uchitel
JOURNAL OF NEUROSCIENCE
(2014)
Editorial Material
Neurosciences
Osvaldo D. Uchitel
JOURNAL OF PHYSIOLOGY-LONDON
(2012)
Article
Neurosciences
Osvaldo D. Uchitel, Carlota Gonzalez Inchauspe, Francisco J. Urbano, Mariano N. Di Guilmi
JOURNAL OF PHYSIOLOGY-PARIS
(2012)
Article
Physiology
Lezio S. Bueno-Junior, Rafael N. Ruggiero, Matheus T. Rossignoli, Elaine A. Del Bel, Joao P. Leite, Osvaldo D. Uchitel
PHYSIOLOGICAL REPORTS
(2017)