Article
Biochemistry & Molecular Biology
Alyssa M. West, Katherine M. Holleran, Sara R. Jones
Summary: The serotonin and kappa opioid receptor (KOR) systems play important roles in disorders of negative affect. In this study, the researchers investigated the effects of KOR activation and serotonin reuptake inhibition on serotonin transmission in the substantia nigra pars reticulata (SNr). They found that KOR activation reduced serotonin release and uptake, while serotonin reuptake inhibition increased serotonin release and slowed reuptake. The researchers also demonstrated that short-term activation of KOR altered serotonin responses to reuptake inhibition. These findings highlight the complex interactions between KORs and serotonin in regulating negative affect, and suggest that the KOR system may be a promising target for treating disorders such as anxiety and depression alongside traditional antidepressant treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Xinyi Huang, Chao Li, Chaopeng Li, Zhenyu Li, Xiaohui Li, Jianwei Liao, Tai Rao, Lulu Chen, Lichen Gao, Dongsheng Ouyang
Summary: The study demonstrates the differences in CYP2C19 gene frequency between Chinese and Caucasian populations, and highlights the necessity for individualized treatment with escitalopram in Chinese patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gordana Nedic Erjavec, Mirko Grubor, Maja Zivkovic, Nada Bozina, Marina Sagud, Matea Nikolac Perkovic, Alma Mihaljevic-Peles, Nela Pivac, Dubravka Svob Strac
Summary: Antipsychotic-induced parkinsonism is the most common extrapyramidal side effect caused by the blockage of dopamine receptors. This study found significant associations between HTR6 gene polymorphism and tremor and rigidity induced by haloperidol. Additionally, a combined effect of HTR6 T and SLC6A3 9R alleles on AIP was observed.
Article
Biochemistry & Molecular Biology
Weiwei Xue, Tingting Fu, Shengzhe Deng, Fengyuan Yang, Jingyi Yang, Feng Zhu
Summary: This study explored the allosteric modulation mechanism of hSERT using two MD simulation strategies. The results showed that escitalopram enhanced its binding to the orthosteric site by binding to the allosteric site. Additionally, escitalopram occupying the allosteric site also blocked its dissociation from the orthosteric site. A new conformational coupling between extracellular and intracellular salt bridges was also identified. These findings are important for understanding the allosteric modulations of not only hSERT but also other clinically important therapeutic targets.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Eric M. Schoenfeld, Nishant K. Gupta, Shariful A. Syed, Anna Rozenboym, Sasha L. Fulton, Andrea P. Jackowski, Tarique D. Perera, Jeremy D. Coplan
Summary: The study suggests that bonnet macaques reared under stress, carrying the ?s?-allele and having smaller adolescent hippocampal volume, exhibit reduced neurogenesis in adulthood. The positive impact of ipsilateral hippocampal volume on neurogenesis levels was observed.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Ruihao Wang, Sebastian Moeller, Aynur Akhundova, Harald Marthol, Rainer Kollmar, Martin Koehrmann, Max J. Hilz
Summary: This study examined the recovery of cardiovascular-autonomic dysfunction (CAD) in patients with acute stroke within 72 hours. It was found that CAD recovery was almost complete within this timeframe and was associated with neurological improvement. Early initiation of cardiovascular medication and reducing stress may have contributed to the rapid recovery of CAD.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Osama Y. Alshogran, Laith N. Al-Eitan, Shoroq M. Altawalbeh, Hatem A. Aman
Summary: This study investigated the genetic association of dopamine D4 receptor and serotonin transporter genes with psychiatric symptom susceptibility among hemodialysis patients. The findings suggest that certain genetic polymorphisms may be linked to anxiety symptoms in this patient population.
Review
Cardiac & Cardiovascular Systems
Heba M. Kalbouneh, Ahmad A. Toubasi, Farah H. Albustanji, Yazan Y. Obaid, Layla M. Al-Harasis
Summary: The study found that SSRIs are effective in preventing and treating depression, improving anxiety, motor function, cognitive function, and dependence in post-stroke patients. However, treating with SSRIs increased the risk of seizures.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Multidisciplinary Sciences
Trent Davidson, David B. Braudt, Robert Keers, Elham Assary, Kathleen Mullan Harris, Jason D. Boardman
Summary: This study re-evaluated one of the most cited and disputed papers in gene-environment interaction literature, using a genome-wide polygenic indicator to examine the genetic determinants of stress sensitivity. The results supported the stress-diathesis perspective and validated the scientific contributions of the original paper.
SCIENTIFIC REPORTS
(2021)
Review
Clinical Neurology
Robertas Strumila, Aiste Lengvenyte, Emilie Olie, Philippe Courtet, Sebastien Guillaume
Summary: The lack of a safe and effective pharmacological treatment for anorexia nervosa is a major challenge in research. Based on the understanding of the neurobiology of anorexia nervosa, the use of escitalopram, a widely available drug, is proposed as a potential option. Escitalopram can boost serotonin levels and decrease dopaminergic transmission, which are two key features in the treatment of anorexia nervosa.
JOURNAL OF PSYCHOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Vadim Yuferov, Eduardo R. Butelman, Matthew Randesi, Wim van den Brink, Peter Blanken, Jan M. van Ree, Mary Jeanne Kreek
Summary: The functional SERT promoter tandem repeat genotype may be associated with heavy cocaine exposure and more rapid escalation of cocaine use, in persons with and without opioid dependence diagnosis.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Neurosciences
Carolin A. Lewis, Karsten Mueller, Rachel G. Zsido, Janis Reinelt, Ralf Regenthal, Hadas Okon-Singer, Erika E. Forbes, Arno Villringer, Julia Sacher
Summary: The study found that acute administration of escitalopram reduces blood-oxygen-level-dependent (BOLD) response during punishment feedback in healthy participants. However, no significant BOLD changes were detected during reward feedback.
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Belen Gonzalez-Herrero, Francesca Morgante, Javier Pagonabarraga, Biba Stanton, Mark J. Edwards
Summary: Recent observations suggest a high co-occurrence of autism spectrum disorder (ASD) in people with functional neurological disorder (FND), but little systematic data is available on their relationship. This study aimed to assess the self-reported autistic traits and prevalence of ASD in individuals with FND and their first-degree relatives. The findings showed that 8% of respondents with FND had a previous diagnosis of ASD and 24% reported a first-degree relative with ASD. Moreover, 69% of respondents exhibited clinically significant ASD and 21% displayed autistic traits. Further research is needed to explore the prevalence and impact of ASD in individuals with FND.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Andrea Bonassi, Ilaria Cataldo, Giulio Gabrieli, Bruno Lepri, Gianluca Esposito
Summary: This study examines how the 5-HTTLPR gene and childhood caregiving behavior influence social expectations on close adult relationships. Results show an interaction effect between genetic groups and maternal overprotection history in predicting avoidance experienced in romantic relationships in adulthood. The findings suggest further evidence of genetic and parental mechanisms involved in regulating social expectations in close relationships.
Article
Health Care Sciences & Services
Kwame Adjei, Georges Adunlin, Askal Ayalew Ali
Summary: This study examined the impact of Sertraline, Fluoxetine, and Escitalopram on psychological distress among adults with depression using MEPS data. The results showed that monotherapy antidepressants were effective in improving psychological distress, with Fluoxetine having the highest improvement rate. However, there were no significant differences in the effectiveness of the three medications.
Article
Radiology, Nuclear Medicine & Medical Imaging
Young Hee Sung, Joong-Seok Kim, Sang-Won Yoo, Na-Young Shin, Yoonho Nam, Tae-Beom Ahn, Dallah Yoo, Kyung Mi Lee, Hyug-Gi Kim, Seong-Beom Koh, Jinhee Kim, Ilsoo Kim, Do-Young Kwon, Younghen Lee, Chulhan Kim, Sun Ju Chung, Sungyang Jo, Seung Hyun Lee, Sang Joon Kim, Minjae Kim, Chul Hyoung Lyoo, Min Seok Baek, Suk Yun Kang, Suk Ki Chang, Sang-Won Jo, Seun Ah Lee, Hyeo-il Ma, Young Eun Kim, Eun Soo Kim, Yun Joong Kim, Hyun Sook Kim, Min-Hee Woo, Hye Jeong Choi, Eung Yeop Kim
Summary: This study compared the diagnostic performance of susceptibility map-weighted imaging (SMwI) using different MRI machines with N-3-fluoropropyl-2-beta-carbomethoxy-3-beta-(4-iodophenyl)nortropane (F-18-FP-CIT) PET in the diagnosis of neurodegenerative parkinsonism. The results showed that SMwI had a high diagnostic sensitivity, specificity, and accuracy, and there was no significant difference between the results of SMwI and F-18-FP-CIT PET. The study demonstrated the generalisability of SMwI for determining nigrostriatal degeneration in patients with parkinsonism in a multi-centre setting.
EUROPEAN RADIOLOGY
(2022)
Article
Neuroimaging
Jang-Hyun Baek, Byung Moon Kim, Dong Joon Kim, Ji Hoe Heo, Hyo Suk Nam, Young Dae Kim, Myung Ho Rho, Pil-Wook Chung, Yu Sam Won, Yeongu Chung
Summary: A machine learning-based prediction model (ML-PM) can accurately determine the occlusion pathomechanism based on common preprocedural findings. A decision flowchart derived from the ML-PM can help clinicians determine the occlusion pathomechanism with high accuracy.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Clinical Neurology
Ji Man Hong, Jin Soo Lee, Yeong-Bae Lee, Dong Hoon Shin, Dong-Ick Shin, Yang-Ha Hwang, Seong Hwan Ahn, Jae Guk Kim, Sung-Il Sohn, Sun U. Kwon, Ji Sung Lee, Byoung Joo Gwag, Angel Chamorro, Dennis W. Choi
Summary: This study evaluated the safety and efficacy of nelonemdaz in patients with acute ischemic stroke. While there was no significant difference in the proportion of patients achieving modified Rankin Scale scores of 0-2 at 12 weeks among the groups, patients treated with nelonemdaz showed a favorable tendency towards achieving these scores without serious adverse effects. A large-scale phase III trial is warranted for further validation.
Article
Clinical Neurology
Seong Ho Jeong, Chan Wook Park, Hye Sun Lee, Yun Joong Kim, Mijin Yun, Phil Hyu Lee, Young H. Sohn, Seok Jong Chung
Summary: The study investigated whether different patterns of striatal dopamine depletion are associated with motor deficits in Parkinson's disease. A total of 404 drug-naive patients with early-stage PD were enrolled and underwent dopamine transporter imaging. Principal component analysis identified three patterns of dopamine depletion: overall deficiency, selective loss in the sensorimotor striatum, and symmetric loss in the striatum. Linear regression analysis revealed that overall deficiency and selective loss were associated with motor deficits, while symmetric loss was not. Mediation analysis showed that dopamine deficiency in the posterior putamen mediated the association between dopamine depletion patterns and motor deficits. These findings suggest that dopamine deficiency in the posterior putamen plays a crucial role in motor deficits in PD.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jang-Hyun Baek, Byung Moon Kim, Sang Hyun Suh, Hong -Jun Jeon, Eun Hyun Ihm, Hyungjong Park, Chang-Hyun Kim, Sang-Hoon Cha, Chi-Hoon Choi, Kyung Sik Yi, Jun-Hwee Kim, Sangil Suh, Byungjun Kim, Yoonkyung Chang, So Yeon Kim, Jae Sang Oh, Ji Hoe Heo, Dong Joon Kim, Hyo Suk Nam, Young Dae Kim
Summary: This study evaluated the efficacy of EmboTrap II in achieving first-pass recanalization and its impact on clinical outcomes. The results showed a high success rate of achieving first-pass effect with EmboTrap II, which was associated with favorable clinical outcomes in patients with cerebral infarction.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Clinical Neurology
Joan Marti-Fabregas, Pol G. Camps-Renom, Jonathan G. Best, Anna Ramos-Pachon, Marina Guasch-Jimenez, Alejandro Martinez-Domeno, Daniel M. Guisado-Alonso, Beatriz M. Gomez-Anson, Gareth Ambler, Duncan Wilson, Keon-Joo Lee, Jae-Sung Lim, Hee-Joon Bae, Masayuki Shiozawa, Masatoshi Koga, Kazunori G. Toyoda, Michael G. Hennerici, Hugues Chabriat, Eric Jouvent, Debbie Yuen Kwun Wong, Henry Mak, Kui Kai Lau, Young Dae Kim, Tae-Jin Song, Ji-Hoe Heo, Sebastian Eppinger, Thomas Gattringer, Ender Uysal, Derya Selcuk Demirelli, Natan Bornstein, Einor Ben Assayag, Hen A. Hallevi, Jeremy A. Molad, Masashi Nishihara, Jun Tanaka, Hideo Hara, Yusuke B. Yakushiji, Shelagh B. Coutts, Eric A. Smith, Alexandros A. Polymeris, Benjamin Wagner, David A. Seiffge, Philippe A. Lyrer, Nils T. Peters, Stefan T. Engelter, Rustam Al-Shahi Salman, Hans Rudolf Jager, Gregory Y. H. Lip, Martina Goeldlin, Leonidas Panos, Christopher Charles G. Karayiannis, Thanh G. K. Phan, Velandai K. Srikanth, Nicolas Christ, Sarah Gunkel, Felix W. Fluri, Thomas W. Leung, Yannie O. Y. Soo, Winnie Chu, Jill Abrigo, Carmen Barbato, Simone Browning, Robert Simister, Anne-Marie Mendyk, Regis Bordet, Saima Hilal, Bibek Gyanwali, Christopher Chen, Simon Jung, Dilek Necioglu Orken, David Werring, Luis Prats-Sanchez
Summary: This study aimed to investigate the risk of future cerebrovascular events in patients with ischemic stroke (IS) or transient ischemic attack (TIA) and cortical superficial siderosis (cSS), as well as the benefits and safety of antithrombotic drugs for secondary prevention. The study found that cSS was associated with an increased risk of stroke, and the risk of IS was higher than that of intracranial hemorrhage (ICrH) in patients receiving antiplatelet or anticoagulant treatment alone, while the risk of ICrH was higher than that of IS in patients receiving both treatments. Therefore, the study suggests that using antiplatelet or anticoagulant drugs alone is safe in patients with cSS, but combined antithrombotic therapy might be hazardous.
Letter
Clinical Neurology
Kijeong Lee, HyungWoo Lee, Young Dae Kim, Hyo Suk Nam, Hye Sun Lee, Joonsang Yoo, Sunghee Cho, Ji Hoe Heo
Article
Cardiac & Cardiovascular Systems
Minyoul Baik, Hyo Suk Nam, Ji Hoe Heo, Hye Sun Lee, Young Dae Kim
Summary: This study investigated the association between atherosclerotic stenosis and LDL-C or ApoB levels in ischemic stroke patients, and whether there is a difference in the association according to preadmission statin use. The results showed that both LDL-C and ApoB levels were associated with stenosis location, and there was an interaction between pre-admission statin use and LDL-C level. ApoB was consistently associated with symptomatic ICAS, regardless of statin use.
Article
Biochemistry & Molecular Biology
Heonwoo Lee, Junbeom Jeon, Dawoon Jung, Jung-Im Won, Kiyong Kim, Yun Joong Kim, Jeehee Yoon
Summary: This study proposes RelCurator, a curation system that extracts sentences containing gene and phenotype entities related to specific disease categories from PubMed articles, and provides additional information such as entity tagging and predictions of gene-phenotype relationships. By using a deep learning model, this system can effectively predict gene-phenotype relationships and outperforms other models.
Article
Medicine, General & Internal
Seong Hwa Jang, Hyungjong Park, Jeong-Ho Hong, Joonsang Yoo, Hyung Lee, Hyun Ah Kim, Sung-Il Sohn
Summary: This study aimed to investigate the influence of high-intensity statin therapy compared to moderate-intensity statin therapy during the acute phase on the incidence of END in patients with SSSI. The results showed that early high-intensity statin therapy was associated with a lower incidence of END compared to moderate-intensity statin therapy in patients with SSSI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Hyungwoo Lee, Kijeong Lee, Young Dae Kim, Hyo Suk Nam, Hye Sun Lee, Sunghee Cho, Ji Hoe Heo
Summary: This retrospective observational study of 350 patients with basal ganglia infarction found that degeneration of the substantia nigra (SN) was associated with functional dependence or death at 3 months post-stroke. The presence of SN degeneration was significantly correlated with worse functional outcomes, indicating its potential as a predictive factor for poor stroke prognosis and a target for therapeutic interventions.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Seong Ho Jeong, Su Hong Kim, Chan Wook Park, Hye Sun Lee, Phil Hyu Lee, Yun Joong Kim, Young H. Sohn, Yong Jeong, Seok Jong Chung
Summary: This study investigated the differential effects of hypoperfusion and hyperperfusion in cerebral regions on motor and cognitive symptoms in patients with Parkinson's disease. The results showed that hypoperfusion was associated with motor symptoms and cognitive performance levels, while hyperperfusion was associated with future dementia conversion. These findings suggest that hypoperfusion and hyperperfusion have different effects on motor and cognitive functions in patients with Parkinson's disease.
MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
Hung Youl Seok, Mi-Yeon Eun, Sohyeon Kim, Jae-Joon Lee, Gi Ryeong Oh, Geun Yeong Kim, Sung-Il Sohn
Summary: This study presented a detailed case of reversible cerebral vasoconstriction syndrome (RCVS) in a patient with Guillain-Barre syndrome (GBS), and conducted a literature review to explore the association between these two conditions. The findings showed that RCVS in GBS mainly affected middle-aged women and presented with various neurological symptoms. Neuroimaging revealed reversible vasoconstriction in the cerebral arteries and other complications. While the treatment for GBS is known, specific treatments for RCVS remain unclear.
NEUROLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Jang-Hyun Baek, Ji Hoe Heo, Hyo Suk Nam, Byung Moon Kim, Dong Joon Kim, Young Dae Kim
Summary: This study aimed to evaluate the association between preprocedural D-dimer levels and endovascular and clinical outcomes in patients with acute intracranial large-vessel occlusion. The results showed that preprocedural D-dimer levels were not associated with successful recanalization or thrombus fragmentation, but were positively correlated with the number of passes of the thrombectomy device and the puncture-to-recanalization time. Additionally, higher preprocedural D-dimer levels were associated with unfavorable functional outcomes in these patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jang-Hyun Baek, Ji Hoe Heo, Hyo Suk Nam, Byung Moon Kim, Dong Joon Kim, Young Dae Kim
Summary: The clinical benefit of endovascular treatment for acute stroke can be time-dependent even after first-pass recanalization (FPR). This study found that the association between favorable outcomes and FPR is influenced by the time from groin puncture to recanalization (P-to-R time), with patients having a higher chance of favorable outcomes if the P-to-R time is within 30 minutes.
JOURNAL OF CLINICAL MEDICINE
(2023)
