Review
Immunology
Ram Bhupal Reddy Nagireddy, Anand Kumar, Varun Kumar Singh, Rajniti Prasad, Abhishek Pathak, Rameshwar Nath Chaurasia, Vijaya Nath Mishra, Deepika Joshi
Summary: MOGAD and NMOSD are two distinct autoimmune inflammatory central nervous system diseases, with MOGAD patients typically showing milder symptoms and better response to treatment.
JOURNAL OF NEUROIMMUNOLOGY
(2021)
Article
Neurosciences
Xueshan Dong, Yan Jiang, Ping Yuan, Xiao Fan, Jiannan Ma, Peng Wu, Li Jiang, Xiujuan Li
Summary: This study compared the differences between pediatric patients with acute disseminated encephalomyelitis (ADEM) who tested positive and negative for myelin oligodendrocyte glycoprotein (MOG) antibodies in terms of clinical, radiological, therapeutic, and prognostic factors. The study included 62 patients, with 35 being MOG-seropositive and 27 being MOG-seronegative. MOG-seropositive ADEM children had lower rates of seizures and cranial nerve palsy, and isolated leukocytosis in the blood was more common in these children. The two groups showed no significant differences in MRI lesions and features. MOG-seropositive children were more likely to experience relapses and had slower steroid tapering.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Jasodhara Chaudhuri, Tamoghna Biswas, Gautam Ganguly, Supratim Datta, Alak Pandit, Atanu Biswas
Summary: MOG-Ab-associated diseases in eastern India exhibit diverse clinical phenotypes with age-dependent pattern-specific courses.
ACTA NEUROLOGICA BELGICA
(2021)
Article
Biology
Michela Ada Noris Ferilli, Roberto Paparella, Ilaria Morandini, Laura Papetti, Lorenzo Figa Talamanca, Claudia Ruscitto, Fabiana Ursitti, Romina Moavero, Giorgia Sforza, Samuela Tarantino, Martina Proietti Checchi, Federico Vigevano, Massimiliano Valeriani
Summary: Neuromyelitis Optica Spectrum Disorder (NMOSD) is a rare inflammatory disease in children characterized by recurrent inflammation in the optic nerves and spinal cord, and can also affect other regions of the central nervous system. Early diagnosis is crucial for initiating appropriate treatment.
Review
Clinical Neurology
N. Shor, R. Deschamps, A. Cobo Calvo, E. Maillart, H. Zephir, J. Ciron, C. Papeix, F. Durand-Dubief, A. Ruet, X. Ayrignac, M. Cohen, K. Deiva, D. Laplaud, B. Bourre, B. Audoin, N. Collongues, S. Vukusic, F. Cotton, R. Marignier
Summary: Knowledge of the radiological spectrum of MOGAD is expanding rapidly, with MRI playing a crucial role in diagnosis and prognosis. Differentiating MOGAD from other diseases is essential for appropriate management.
REVUE NEUROLOGIQUE
(2021)
Article
Clinical Neurology
Romina Mariano, Silvia Messina, Adriana Roca-Fernandez, Maria Leite, Yazhuo Kong, Jacqueline A. Palace
Summary: Spinal cord involvement is a key feature of multiple sclerosis, neuromyelitis optica with AQP4 antibodies, and MOG-antibody disease. Quantitative spinal cord MRI was used in a cross-sectional study to differentiate these conditions, showing significant damage in AQP4-antibody disease and multiple sclerosis, while MOG-antibody disease had a predominant central grey matter component. The study also found that relapsing MOG-antibody disease is a more severe phenotype and applied various analyses to discriminate between different diseases.
Review
Ophthalmology
Jaya Sharma, M. Tariq Bhatti, Helen V. Danesh-Meyer
Summary: NMOSD is an inflammatory disease that affects the central nervous system, involving optic nerves and spinal cord. The discovery of AQP4-IgG has improved diagnosis, and timely treatment is crucial for mitigating long-term disability.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Clinical Neurology
Hiroki Masuda, Masahiro Mori, Hirotaka Yokouchi, Akiyuki Uzawa, Tomohiko Uchida, Mayumi Muto, Ryohei Ohtani, Reiji Aoki, Shuichi Yamamoto, Satoshi Kuwabara
Summary: Compared with MOGAD eyes, AQPAD eyes tended to have worse visual outcomes during the first ON episode, with longer time to nadir and treatment, higher logMAR values at several time points, and longer time to recovery of BCVA to 0.7. However, the time to BCVA 1.0 was not significantly different between the two disorders.
JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Christopher C. Glisson
Summary: NMOSD is a group of potentially devastating inflammatory disorders of the central nervous system that primarily affect the optic nerve(s) and spinal cord, leading to severe and irreversible neurological disability. Early diagnosis and pharmacologic intervention are crucial for management.
CURRENT TREATMENT OPTIONS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Masoud Etemadifar, Mehri Salari, Mohammad Reza Etemadifar, Fatemeh Sabeti, Sepand Tehrani Fateh, Zahra Aminzade
Summary: This study aimed to assess the association between NMOSD diagnosis and the presence of centrally located lesions at disease onset. The presence of centrally located lesions was found to be associated with NMOSD diagnosis and had higher sensitivity and specificity.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Review
Clinical Neurology
Michal Boronczyk, Julia Wegrzynek, Agnieszka Boronczyk, Joanna Siuda
Summary: This study reports a new case of MOGAE following SARS-CoV-2 infection and summarizes other MOGAE cases associated with COVID-19 infection from the literature. The cases showed varying degrees of cognitive deterioration and neuroimaging changes, with positive findings of anti-MOG antibodies in the serum. These cases highlight the association between COVID-19 and MOGADs, suggesting a new clinical problem of neurological complications associated with COVID-19.
FRONTIERS IN NEUROLOGY
(2023)
Review
Ophthalmology
Darius Mewes, Joseph Kuchling, Patrick Schindler, Ahmed Abdelrahim Ahmed Khalil, Sven Jarius, Friedemann Paul, Claudia Chien
Summary: Neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease are autoimmune diseases of the central nervous system that require multidisciplinary collaboration for symptom management and diagnosis.
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2022)
Article
Clinical Neurology
Rosa Cortese, Marco Battaglini, Ferran Prados, Alessia Bianchi, Lukas Haider, Anu Jacob, Jacqueline Palace, Silvia Messina, Friedemann Paul, Jens Wuerfel, Romain Marignier, Francoise Durand-Dubief, Carolina de Medeiros Rimkus, Dagoberto Callegaro, Douglas Kazutoshi Sato, Massimo Filippi, Maria Assunta Rocca, Laura Cacciaguerra, Alex Rovira, Jaume Sastre-Garriga, Georgina Arrambide, Yaou Liu, Yunyun Duan, Claudio Gasperini, Carla Tortorella, Serena Ruggieri, Maria Pia Amato, Monica Ulivelli, Sergiu Groppa, Matthias Grothe, Sara Llufriu, Maria Sepulveda, Carsten Lukas, Barbara Bellenberg, Ruth Schneider, Piotr Sowa, Elisabeth G. Celius, Anne-Katrin Proebstel, Ozgur Yaldizli, Jannis Mueller, Bruno Stankoff, Benedetta Bodini, Luca Carmisciano, Maria Pia Sormani, Frederik Barkhof, Nicola De Stefano, Olga Ciccarelli
Summary: The study aimed to differentiate non-acute MOG-antibody disease from AQP4-neuromyelitis optica spectrum disorder and multiple sclerosis using MRI and clinical markers. The findings provide guidance for identifying patients with MOG-antibody disease in clinical practice.
Article
Clinical Neurology
Paula Barreras, Eleni S. Vasileiou, Angeliki G. Filippatou, Kathryn C. Fitzgerald, Michael Levy, Carlos A. Pardo, Scott D. Newsome, Ellen M. Mowry, Peter A. Calabresi, Elias S. Sotirchos
Summary: Rituximab treatment reduces the annualized relapse rate in AQP4-IgG-seropositive NMOSD, especially when administered consistently without gaps in treatment or B-cell reconstitution. In MOGAD patients, although a decrease in relapses was observed after rituximab initiation, this effect appeared to be less pronounced compared to AQP4-IgG-seropositive NMOSD. Severe infections and hypogammaglobulinemia were seen in a significant number of patients, underscoring the importance of close monitoring for infectious complications.
Article
Neurosciences
Pranav B. Joshi, Shalin D. Shah, Mayank A. Patel, Sudhir Shah, Shailesh H. Darji, Kailash C. Mirche
Summary: This study analyzed the clinical, laboratory, and imaging features of NMO spectrum disorders (NMOSD) associated with aquaporin 4 antibody (AQP4-Ab) serology status. The results showed differences in age, gender, and prognosis between the AQP4-Ab positive and negative groups. The antibody status may guide the treatment approach during the first attack of NMOSD.
Review
Clinical Neurology
Alessandro Dinoto, Elisa Mantovani, Sergio Ferrari, Sara Mariotto, Stefano Tamburin
Summary: This study aimed to phenotype cerebellar immune-related adverse events (iRAEs). The findings revealed that cerebellar iRAEs are usually multifocal and most associated with exposure to PD-1 inhibitors. The most common associated tumors among the patients were lung cancer, melanoma, and Merkel cell carcinoma. Abnormalities were observed in magnetic resonance imaging and inflammatory cerebrospinal fluid findings.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Rehabilitation
Barbara Seebacher, Markus Reindl, Turhan Kahraman
Summary: This study investigated factors and strategies affecting and enhancing motor imagery (MI) ability in people with multiple sclerosis (pwMS). Cognitive impairment, cognitive fatigue, and disability were found to negatively influence MI ability, while external visual and/or rhythmic-auditory cueing and the use of a theory-based MI framework were identified as strategies to enhance MI ability.
Article
Clinical Neurology
Stefano Ziccardi, Anna Isabella Pisani, Gian Marco Schiavi, Maddalena Guandalini, Francesco Crescenzo, Annalisa Colombi, Angela Peloso, Agnese Tamanti, Maddalena Bertolazzo, Damiano Marastoni, Massimiliano Calabrese
Summary: This study aimed to determine the associations between early clinical/neuroradiological variables and cognitive impairment (CI) after 20 years of multiple sclerosis (MS). The results showed that the number and volume of cortical lesions (CLs) were strongly associated with long-term CI, particularly when the number of CLs was equal to or greater than three. Therefore, the number of CLs could serve as a reliable prognostic marker for CI in MS patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Immunology
Francesca Bosello, Damiano Marastoni, Francesca Benedetta Pizzini, Chiara Zaffalon, Andrea Zuliani, Giulia Turri, Sara Mariotto, Erika Bonacci, Emilio Pedrotti, Massimiliano Calabrese
Summary: Post-infectious immune-mediated neurological complications of Sars-Cov-2, including Myelin Oligodendrocyte Glycoprotein (MOG) antibody-associated optic neuritis and inflammatory demyelinating polyneuropathy, have been observed in a 74-year-old patient. This is the first reported case of both complications occurring in the same patient. This case highlights the association between SarsCov-2 infection and MOG antibody-associated disease.
JOURNAL OF NEUROIMMUNOLOGY
(2023)
Article
Clinical Neurology
Matteo Gastaldi, Thomas Foiadelli, Giacomo Greco, Silvia Scaranzin, Eleonora Rigoni, Stefano Masciocchi, Sergio Ferrari, Chiara Mancinelli, Laura Brambilla, Margherita Mancardi, Thea Giacomini, Diana Ferraro, Marida Della Corte, Antonio Gallo, Massimiliano Di Filippo, Luana Benedetti, Giovanni Novi, Maurizio Versino, Paola Banfi, Raffaele Iorio, Lucia Moiola, Emanuela Turco, Stefano Sartori, Margherita Nosadini, Martino Ruggieri, Salvatore Savasta, Elena Colombo, Elena Ballante, Sven Jarius, Sara Mariotto, Diego Franciotta
Summary: Longitudinal MOG-IgG titres can predict relapses in patients with MOGAD, and the results can be used to guide treatment decisions.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Cardiac & Cardiovascular Systems
Giovanni Merlino, Yan Tereshko, Sara Pez, Daniele Bagatto, Gian Luigi Gigli, Simone Lorenzut, Massimo Sponza, Alessandro Vit, Vladimir Gavrilovic, Nicola Marotti, Francesco Janes, Francesco Bax, Mariarosaria Valente
Summary: The presence of HMCAS predicts favorable outcomes in patients undergoing MT, and it can reduce hemorrhagic transformation.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Article
Clinical Neurology
Margherita Nosadini, Michael Eyre, Thea Giacomini, Massimiliano Valeriani, Marida Della Corte, Andrea D. Pratico, Pietro Annovazzi, Ramona Cordani, Duccio Maria Cordelli, Giovanni Crichiutti, Gabriella Di Rosa, Valentina Dolcemascolo, Anna Fetta, Elena Freri, Paolo Gallo, Matteo Gastaldi, Tiziana Granata, Luisa Grazian, Raffaele Iorio, Martina Lombardini, Monica Margoni, Sara Mariotto, Sara Matricardi, Federico Melani, Nardo Nardocci, Laura Papetti, Alice Passarini, Francesco Pisani, Chiara Po, Marco Puthenparampil, Francesca Ragona, Salvatore Savasta, Sabrina Siliquini, Irene Toldo, Alessandra Tozzo, Emanuela Claudia Turco, Antonio Varone, Alberto Vogrig, Luigi Zuliani, Samuela Bugin, Sara Rossato, Alessandro Orsini, Gaetano Cantalupo, Maria Margherita Mancardi, Michela Ada Noris Ferilli, Thomas Foiadelli, Stefano Sartori
Summary: This study aimed to identify early factors associated with relapse and outcome in pediatric-onset MOGAD. The study found that early immunotherapy, longer duration of corticosteroid treatment, and abnormal optic nerves on MRI were associated with a lower risk of relapse. Meanwhile, higher disease severity at onset was associated with a greater risk of final disability.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Article
Cell Biology
Marianna Spatola, Omar Chuquisana, Wonyeong Jung, Joseph A. Lopez, Eva-Maria Wendel, Sudarshini Ramanathan, Christian W. Keller, Tim Hahn, Edgar Meinl, Markus Reindl, Russell C. Dale, Heinz Wiendl, Douglas A. Lauffenburger, Kevin Rostasy, Fabienne Brilot, Galit Alter, Jan D. Luenemann
Summary: Using a systems-level approach, we investigated humoral immune responses in 123 patients with MOGAD. Our study revealed that age is a significant factor in determining MOG-antibody-related immune signatures. Moreover, we identified two dominant immunological endophenotypes of MOGAD, with the pro-inflammatory endophenotype associated with clinically active disease. Our findings suggest that FcyR-mediated effector functions control the pathogenicity of MOG-specific IgG and highlight the potential of FcyR-targeting therapies in treating MOGAD.
CELL REPORTS MEDICINE
(2023)
Letter
Clinical Neurology
Daniel Engels, Simone Mader, Stefanie Foerderreuther, Markus Reindl, Joachim Havla, Edgar Meinl, Tania Kuempfel, Lisa Ann Gerdes
ANNALS OF NEUROLOGY
(2023)
Article
Rehabilitation
Kristina Traxler, Eva Baum, Edith Klotz, Markus Reindl, Franz Schinabeck, Barbara Seebacher
Summary: This study aimed to describe changes in balance and mobility in chronic stroke patients following specific task-oriented training (TOT), its combination with talocrural manual therapy (MT-TOT) or no intervention. The feasibility of a full-scale randomized controlled trial (RCT) was explored based on recruitment, retention, adherence rates, adverse events, falls, and acceptability of the interventions. The preliminary results showed the effectiveness of MT-TOT and TOT in improving balance, mobility, ankle dorsiflexion range of motion, falls, and health-related quality of life in stroke patients.
DISABILITY AND REHABILITATION
(2023)
Article
Rehabilitation
Barbara Seebacher, Elena Bergmann, Carole Geimer, Turhan Kahraman, Markus Reindl, Gudrun Diermayr
Summary: This study investigated the determinants of willingness to adopt telerehabilitation, willingness of technology use, core affect regarding using telerehabilitation, and digital competencies in rehabilitation professionals in Austria and Germany before and during the COVID-19 pandemic. A cross-sectional paper-based and online survey was conducted with three cohorts of rehabilitation professionals. The results showed differences between Austria and Germany and before and during the pandemic for most outcomes. German residency, the pandemic, and a higher educational level were the most important predictors of higher willingness to adopt telerehabilitation, willingness of technology use, digital competencies, and positive core affect.
DISABILITY AND REHABILITATION
(2023)
Review
Clinical Neurology
Roberta Magliozzi, Owain W. Howell, Massimiliano Calabrese, Richard Reynolds
Summary: Growing evidence suggests a central role for meningeal inflammation in driving multiple sclerosis (MS) pathology. The subarachnoid space and associated meningeal spaces play important roles in the entry and diffusion of immune cells and molecules into the brain tissue. Chronic meningeal inflammation is associated with a more severe clinical course of MS.
NATURE REVIEWS NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Emma N. Somerville, Lynne Krohn, Eric Yu, Uladzislau Rudakou, Konstantin Senkevich, Jennifer A. Ruskey, Farnaz Asayesh, Jamil Ahmad, Dan Spiegelman, Yves Dauvilliers, Isabelle Arnulf, Michele T. M. Hu, Jacques Y. Montplaisir, Jean-Francois Gagnon, Alex Desautels, Abubaker Ibrahim, Ambra Stefani, Birgit Hoegl, Gian Luigi Gigli, Mariarosaria Valente, Francesco Janes, Andrea Bernardini, Petr Dusek, Karel Sonka, David Kemlink, Giuseppe Plazzi, Elena Antelmi, Francesco Biscarini, Brit Mollenhauer, Claudia Trenkwalder, Friederike Sixel-Doring, Michela Figorilli, Monica Puligheddu, Valerie Cochen De Cock, Wolfgang Oertel, Annette Janzen, Luigi Ferini-Strambi, Anna Heibreder, Christelle Charley Monaca, Beatriz Abril, Femke Dijkstra, Mineke Viaene, Bradley F. Boeve, Ronald B. Postuma, Guy A. Rouleau, Ziv Gan-Or
Summary: NPC1 gene encodes a lysosomal protein involved in cholesterol transport associated with Niemann-Pick disease type C (NPC). The role of NPC1 in alpha synucleinopathies is unclear. This study aimed to evaluate the association of NPC1 variants with synucleinopathies PD, DLB, and RBD. No variants were associated with any of the synucleinopathies, indicating that NPC1 variants do not play an important role.
NEUROBIOLOGY OF AGING
(2023)
Review
Biochemistry & Molecular Biology
Andrea Bernardini, Gaia Pellitteri, Giovanni Ermanis, Gian Luigi Gigli, Mariarosaria Valente, Francesco Janes
Summary: This critically appraised review examines the pathogenetic interplay between clinical manifestations in RBD patients and the misfolding processes that characterize neurodegeneration. It discusses the evidence for and against RBD as a biomarker of neurodegeneration. The review highlights the current knowledge and areas of uncertainty in the relationship between RBD and neurodegenerative disorders, providing a useful reference for clinicians and future research in this field.
AIMS MOLECULAR SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Adriana Cifu, Francesco Janes, Catia Mio, Rossana Domenis, Maria Elena Pessa, Riccardo Garbo, Francesco Curcio, Mariarosaria Valente, Martina Fabris
Summary: This study found that plasma from CSVD patients affects human cerebral microvascular endothelial cells and activates inflammatory pathways, suggesting the pathogenetic role of neuroinflammation in the early asymptomatic stages of cerebrovascular disease.