Evidence for an early innate immune response in the motor cortex of ALS

Serum C-Reactive Protein as a Prognostic Biomarker in Amyotrophic Lateral Sclerosis

(2017) Christian Lunetta et al.   JAMA Neurology

Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes

(2017) Weihua Zhao et al.   JAMA Neurology

Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS

(2017) Barış Genç et al.   Scientific Reports

Peripheral monocytes are functionally altered and invade the CNS in ALS patients

(2016) Lisa Zondler et al.   ACTA NEUROPATHOLOGICA

Non-neuronal Cells in ALS: Role of Glial, Immune cells and Blood-CNS Barriers

(2016) Fabiola Puentes et al.   BRAIN PATHOLOGY

Neuron-Microglia Interactions in Motor Neuron Degeneration. The Inflammatory Hypothesis in Amyotrophic Lateral Sclerosis Revisited

(2016) Manuel Rodríguez et al.   CURRENT MEDICINAL CHEMISTRY

Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis

(2016) Laura Pasetto et al.   JOURNAL OF NEUROSCIENCE

Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis

(2016) Mohamad J. Alshikho et al.   NEUROLOGY

Immunization with a Myelin-Derived Antigen Activates the Brain's Choroid Plexus for Recruitment of Immunoregulatory Cells to the CNS and Attenuates Disease Progression in a Mouse Model of ALS

(2015) G. Kunis et al.   JOURNAL OF NEUROSCIENCE

Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: Assessed with [11C]-PBR28

(2015) Nicole R. Zürcher et al.   NeuroImage-Clinical

Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice

(2014) Oleg Butovsky et al.   ANNALS OF NEUROLOGY

Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: changes in arginase1 and inducible nitric oxide synthase

(2014) Katherine E Lewis et al.   Journal of Neuroinflammation

Microglia centered pathogenesis in ALS: insights in cell interconnectivity

(2014) Dora Brites et al.   Frontiers in Cellular Neuroscience

eGFP Expression under UCHL1 Promoter Genetically Labels Corticospinal Motor Neurons and a Subpopulation of Degeneration-Resistant Spinal Motor Neurons in an ALS Mouse Model

(2013) M. V. Yasvoina et al.   JOURNAL OF NEUROSCIENCE

Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis

(2013) Amanda Sierra et al.   Frontiers in Cellular Neuroscience

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

(2013) Isaac M. Chiu et al.   Cell Reports

MCP-1/CCR2 signaling-mediated astrocytosis is accelerated in a transgenic mouse model of SOD1-mutated familial ALS

(2013) Motoko Kawaguchi-Niida et al.   Acta Neuropathologica Communications

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS

(2012) Oleg Butovsky et al.   JOURNAL OF CLINICAL INVESTIGATION

AAV2 mediated retrograde transduction of corticospinal motor neurons reveals initial and selective apical dendrite degeneration in ALS

(2012) Javier H. Jara et al.   NEUROBIOLOGY OF DISEASE

Review: Activation patterns of microglia and their identification in the human brain

(2012) D. Boche et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Microglial Activation Correlates with Disease Progression and Upper Motor Neuron Clinical Symptoms in Amyotrophic Lateral Sclerosis

(2012) Johannes Brettschneider et al.   PLoS One

Vascular endothelial growth factor-A (VEGF-A) and chemokine ligand-2 (CCL2) in Amyotrophic Lateral Sclerosis (ALS) patients

(2011) Pawan K Gupta et al.   Journal of Neuroinflammation

Corticospinal Motor Neurons and Related Subcerebral Projection Neurons Undergo Early and Specific Neurodegeneration in hSOD1G93A Transgenic ALS Mice

(2011) P. H. Ozdinler et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

(2011) Thomas Philips et al.   LANCET NEUROLOGY

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

(2011) Laura Ferraiuolo et al.   Nature Reviews Neurology

Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice

(2010) David R. Beers et al.   BRAIN BEHAVIOR AND IMMUNITY

CSF chemokine alterations related to the clinical course of amyotrophic lateral sclerosis

(2010) Takahisa Tateishi et al.   JOURNAL OF NEUROIMMUNOLOGY

Plasma biomarkers associated with ALS and their relationship to iron homeostasis

(2010) Ryan M. Mitchell et al.   MUSCLE & NERVE

Efficacy of thalidomide for the treatment of amyotrophic lateral sclerosis: A phase II open label clinical trial

(2009) Elijah W. Stommel et al.   Amyotrophic Lateral Sclerosis

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

(2009) Hristelina Ilieva et al.   JOURNAL OF CELL BIOLOGY

Immune system alterations in sporadic amyotrophic lateral sclerosis patients suggest an ongoing neuroinflammatory process

(2009) Stefania Mantovani et al.   JOURNAL OF NEUROIMMUNOLOGY

Visualization of Chemokine Receptor Activation in Transgenic Mice Reveals Peripheral Activation of CCR2 Receptors in States of Neuropathic Pain

(2009) H. Jung et al.   JOURNAL OF NEUROSCIENCE

Expression of mutant SOD1G93Ain astrocytes induces functional deficits in motoneuron mitochondria

(2008) Lynsey G. Bilsland et al.   JOURNAL OF NEUROCHEMISTRY

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

(2008) Koji Yamanaka et al.   NATURE NEUROSCIENCE

Organ-specific and differential requirement of TYK2 and IFNAR1 for LPS-induced iNOS expression in vivo

(2007) Ronald Painz et al.   IMMUNOBIOLOGY