HIV induces expression of complement component C3 in astrocytes by NF-κB-dependent activation of interleukin-6 synthesis

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

(2016) Hansen Lui et al.   CELL

New insights on the role of microglia in synaptic pruning in health and disease

(2016) Soyon Hong et al.   CURRENT OPINION IN NEUROBIOLOGY

From orphan drugs to adopted therapies: Advancing C3-targeted intervention to the clinical stage

(2016) Dimitrios C. Mastellos et al.   IMMUNOBIOLOGY

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

(2016) H. Lian et al.   JOURNAL OF NEUROSCIENCE

Cerebrospinal fluid biomarkers and HIV-associated neurocognitive disorders in HIV-infected individuals in Rakai, Uganda

(2016) Mahsa Abassi et al.   JOURNAL OF NEUROVIROLOGY

A complement–microglial axis drives synapse loss during virus-induced memory impairment

(2016) Michael J. Vasek et al.   NATURE

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment

(2016) Deanna Saylor et al.   Nature Reviews Neurology

Identifying Neurocognitive Decline at 36 Months among HIV-Positive Participants in the CHARTER Cohort Using Group-Based Trajectory Analysis

(2016) Marie-Josée Brouillette et al.   PLoS One

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

CSF complement 3 and factor H are staging biomarkers in Alzheimer’s disease

(2016) William T. Hu et al.   Acta Neuropathologica Communications

Complement C1q-C3-associated synaptic changes in multiple sclerosis hippocampus

(2015) Iliana Michailidou et al.   ANNALS OF NEUROLOGY

Role of the immune system in HIV-associated neuroinflammation and neurocognitive implications

(2015) Suzi Hong et al.   BRAIN BEHAVIOR AND IMMUNITY

The role of complement in neurological and neuropsychiatric diseases

(2015) Bryan Paul Morgan   Expert Review of Clinical Immunology

Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline

(2015) Q. Shi et al.   JOURNAL OF NEUROSCIENCE

An anticomplement agent that homes to the damaged brain and promotes recovery after traumatic brain injury in mice

(2015) Marieta M. Ruseva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms involved in HIV-1 Tat-mediated induction of IL-6 and IL-8 in astrocytes

(2014) Anantha Ram Nookala et al.   Journal of Neuroinflammation

Complement and HIV-I infection/HIV-associated neurocognitive disorders

(2014) Fengming Liu et al.   JOURNAL OF NEUROVIROLOGY

Evolving Character of Chronic Central Nervous System HIV Infection

(2014) Serena Spudich et al.   SEMINARS IN NEUROLOGY

Versatility of the complement system in neuroinflammation, neurodegeneration and brain homeostasis

(2014) Franca Orsini et al.   Frontiers in Cellular Neuroscience

HIV-1-Related Central Nervous System Disease: Current Issues in Pathogenesis, Diagnosis, and Treatment

(2013) S. Spudich et al.   Cold Spring Harbor Perspectives in Medicine

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

Monocyte Activation Markers in Cerebrospinal Fluid Associated With Impaired Neurocognitive Testing in Advanced HIV Infection

(2012) Anupa Kamat et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Translating the Brain Transcriptome in NeuroAIDS: From Non-human Primates to Humans

(2012) Jessica M. Winkler et al.   Journal of Neuroimmune Pharmacology

Neurologic disorders incidence in HIV+ vs HIV- men: Multicenter AIDS Cohort Study, 1996-2011

(2012) F. J. Mateen et al.   NEUROLOGY

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Persistence of HIV-associated cognitive impairment, inflammation, and neuronal injury in era of highly active antiretroviral treatment

(2011) Jarek Harezlak et al.   AIDS

Brain Cell Reservoirs of Latent Virus in Presymptomatic HIV-Infected Individuals

(2011) Katherine A. Thompson et al.   AMERICAN JOURNAL OF PATHOLOGY

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Significant Effects of Antiretroviral Therapy on Global Gene Expression in Brain Tissues of Patients with HIV-1-Associated Neurocognitive Disorders

(2011) Alejandra Borjabad et al.   PLoS Pathogens

HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

(2010) Robert K. Heaton et al.   JOURNAL OF NEUROVIROLOGY

Regional Heterogeneity and Diversity in Cytokine and Chemokine Production by Astroglia: Differential Responses to HIV-1 Tat, gp120, and Morphine Revealed by Multiplex Analysis

(2010) Sylvia Fitting et al.   JOURNAL OF PROTEOME RESEARCH

Enhanced synaptic connectivity and epilepsy in C1q knockout mice

(2010) Yunxiang Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The complement system in schizophrenia

(2009) K.R. Mayilyan et al.   DRUG NEWS & PERSPECTIVES

Cerebrospinal Fluid Proteomics Reveals Potential Pathogenic Changes in the Brains of SIV-Infected Monkeys

(2009) Gurudutt Pendyala et al.   JOURNAL OF PROTEOME RESEARCH