Article
Neurosciences
Adam J. Dourson, Zachary K. Ford, Kathryn J. Green, Carolyn E. McCrossan, Megan C. Hofmann, Renita C. Hudgins, Michael P. Jankowski
Summary: The study found that growth hormone (GH) plays an important regulatory role in neonatal pain processing, inhibiting peripheral hypersensitivity through GH receptor (GHr) signaling in primary afferents. After injury, a macrophage-dependent displacement of GH at the injury site was found to regulate neuronal transcription through SRF regulation.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Valentina Dzreyan, Moez Eid, Stanislav Rodkin, Maria Pitinova, Svetlana Demyanenko
Summary: This study investigated the expression and localization of E2F1 after axonal injury and found that axotomy increased the expression of E2F1 in neurons. The study also suggested that E2F1 and downstream targets could be potential molecular targets for the development of neuroprotective agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Qing-Rui Qin, Zhong-Qing Xu, Ting-Ting Liu, Xue-Mei Li, Chun-Yu Qiu, Wang-Ping Hu
Summary: The activation of CCK-8/CCK2R enhances ASIC-mediated electrophysiological activity in DRG neurons and nociception in rats, suggesting that CCK-8/CCK2R could be an important therapeutic target for ASIC-mediated pain.
Article
Pharmacology & Pharmacy
Wen-Long Qiao, Qing Li, Jia-Wei Hao, Shuang Wei, Xue-Mei Li, Ting-Ting Liu, Chun-Yu Qiu, Wang-Ping Hu
Summary: This study found a functional interaction between LPA and P2X3 receptors in rat sensory neurons. LPA enhanced the activity of P2X3 receptors through activation of the LPA(1) receptor and PKC pathway, exacerbating nociceptive behaviors.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Paula G. Socuellamos, Luis A. Olivos-Ore, Maria Victoria Barahona, Pilar Cercos, Marta Perez Pascual, Marina Arribas-Blazquez, Jose Ramon Naranjo, Carmen Valenzuela, Marta Gutierrez-Rodriguez, Antonio R. Artalejo
Summary: Neuropathic pain is a chronic form of pain resulting from damage to neural cells. This study evaluated the analgesic effects of IQM-PC332, a new ligand that modulates ion channels, in rats with neuropathic pain. The results showed that IQM-PC332 reduced mechanical sensitivity and modulated ion currents in nerve cells, indicating its potential as a lead compound for novel analgesics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jingjing Zhang, Lina Rong, Jinping Shao, Yidan Zhang, Yaping Liu, Sen Zhao, Lei Li, Wenli Yu, Mengya Zhang, Xiuhua Ren, Qingzan Zhao, Changlian Zhu, Huan Luo, Weidong Zang, Jing Cao
Summary: The study demonstrates that miR-137-mediated Kv1.2 impairment plays a crucial role in the pathogenesis of nerve injury-induced neuropathic pain, suggesting it as a novel potential therapeutic target for neuropathic pain management.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Biology
Yucheng Xiao, Jonathan W. Theile, Agnes Zybura, Yanling Pan, Zhixin Lin, Theodore R. Cummins
Summary: In this study, the authors demonstrate that I-NaR can be reconstituted in a heterologous system by coexpression of sodium channel alpha-subunits and A-type fibroblast growth factor homologous factors (FHFs). They also identify the N-terminus of FHF as the critical molecule responsible for A-type FHFs-mediated I-NaR. Moreover, knockdown of FHF4A significantly reduces I-NaR amplitude and suppresses excitability in nociceptive sensory neurons.
Article
Neurosciences
Shuang Wei, Ting-Ting Liu, Wang-Ping Hu, Chun-Yu Qiu
Summary: Resveratrol inhibits the electrophysiological activity and nociception mediated by acid-sensing ion channels (ASICs), providing a novel peripheral mechanism underlying its analgesic effect.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Immunology
Shuang Wei, Chun-Yu Qiu, Ying Jin, Ting-Ting Liu, Wang-Ping Hu
Summary: TNF-α rapidly enhances ASIC-mediated functional activity through a p38 MAPK pathway, sensitizing ASICs in primary sensory neurons and exacerbating pain.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Cell Biology
Hyun-jeong Pyo, Xue An, Hana Cho
Summary: This study identifies a new pathway for the modulation of TRPA1 and TRPV1 channels, which are involved in inflammatory and neuropathic pain. The findings show that endogenous anti-inflammatory lipid mediators can selectively inhibit the activity of these channels through specific signaling pathways.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jia-Wei Hao, Ting-Ting Liu, Chun-Yu Qiu, Xue-Mei Li, Wen-Long Qiao, Qing Li, Qing-Rui Qin, Wang-Ping Hu
Summary: This study revealed a novel mechanism by which Resolvin D2 (RvD2) exerts its analgesic effects by targeting P2X3 receptors. RvD2 inhibited P2X3 receptors in rat primary sensory neurons through GPR18, PTX-sensitive G alpha(i/o)-proteins, and intracellular cAMP/PKA signaling, leading to pain relief.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Neurosciences
Alexandru-Florian Deftu, Paul Chu Sin Chung, Cedric J. Laedermann, Ludovic Gillet, Marie Pertin, Guylene Kirschmann, Isabelle Decosterd
Summary: The antidiabetic drug metformin reduces pain hypersensitivity by targeting the E3 ubiquitin ligase NEDD4-2 and modulating the expression of voltage-gated sodium channels. NEDD4-2 is critical for the effect of metformin on the excitability of nociceptive neurons, and this action may contribute to the relief of neuropathic pain.
Article
Cell Biology
Bin Pan, Di Guo, Li Jing, Ke Li, Xin Li, Gen Li, Xiao Gao, Zhi-Wen Li, Wei Zhao, Hu Feng, Meng-Han Cao
Summary: This study reveals the role of lncRNA Pvt1 in the repair of peripheral nerve injury and highlights it as a potential treatment target. The findings show that Pvt1 increases c-Jun expression through sponging miRNA-214, enhancing the proliferation and migration of Schwann cells, and improving the regeneration of injured sciatic nerves and locomotor function in mice.
NEURAL REGENERATION RESEARCH
(2023)
Article
Clinical Neurology
Ristiawan Muji Laksono, Taufiq Agus Siswagama, Fa'urinda Riam Prabu Nery, Walter van der Weegen, Willy Halim
Summary: Experimental study shows that 2 Hz PRF has less physiological impact on healthy neurons compared to 4 Hz, making it a preferred frequency for neuron-targeted therapy in clinical applications.
JOURNAL OF PAIN RESEARCH
(2023)
Article
Neurosciences
Jia-Wei Hao, Wen-Long Qiao, Qing Li, Shuang Wei, Ting-Ting Liu, Chun-Yu Qiu, Wang-Ping Hu
Summary: In this study, it was found that the α2A-AR agonist DEX has an analgesic effect by activating peripheral α2A-AR and suppressing P2X3 receptor activity. This effect is mediated through intracellular G(i/o) proteins and cAMP signaling pathways in neurons.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)