Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 310, Issue -, Pages 51-59Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2017.06.007
Keywords
Estrogen; EAE; Regulatory B cell; M2-like macrophage/microglia; Microbiota
Categories
Funding
- NIH/NINDS [RO1 NS080890]
- Spondylitis Association of America
Ask authors/readers for more resources
Sex hormones promote immunoregulatory effects on multiple sclerosis. In the current study we evaluated the composition of the gut microbiota and the mucosal-associated regulatory cells in estrogen or sham treated female mice before and after autoimmune encephalomyelitis (EAE) induction. Treatment with pregnancy levels of estrogen induces changes in the composition and diversity of gut microbiota. Additionally, estrogen prevents EAE-associated changes in the gut microbiota and might promote the enrichment of bacteria that are associated with immune regulation. Our results point to a possible cross-talk between the sex hormones and the gut microbiota, which could promote neuroprotection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available