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Biochemistry & Molecular Biology
Francisca S. Lins, Thalisson A. de Souza, Luiza C. F. Opretzka, Joanda P. R. E. Silva, Laiane C. O. Pereira, Lucas S. Abreu, Anderson A. Pinheiro, George L. D. dos Santos, Yuri M. do Nascimento, Jose Iranildo Miranda de Melo, Raimundo Braz-Filho, Cristiane F. Villarreal, Marcelo S. da Silva, Josean F. Tavares
Summary: This study isolated five new pregnane glycosides, named dardanols A-E, from the roots of Mandevilla dardanoi in Brazil. These compounds showed anti-inflammatory and cytotoxic activities, contributing to the understanding of the biological potential of the Mandevilla genus.
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Biochemistry & Molecular Biology
Hong-Long Ran, Sheng-Zhuo Huang, Hao Wang, Li Yang, Cui-Juan Gai, Rui-Jun Duan, Hao-Fu Dai, Ya-Li Guan, Wen-Li Mei
Summary: Phytochemical investigation of Strophanthus divaricatus stems resulted in the discovery of four previously undescribed cardiac glycosides, one undescribed C21 pregnane, and eleven known steroids. The structures of these compounds were determined using HRESIMS, 1D and 2D NMR spectra analysis. The absolute configuration of compound 16 was determined through a comparison of experimental and computed ECD spectra. Compounds 1-13 and 15 exhibited potent to significant cytotoxicity against human cancer cell lines K562, SGC-7901, A549 and HeLa, with IC50 values ranging from 0.02 to 16.08, 0.04 to 23.13, 0.06 to 22.31, and 0.06 to 15.13 μM, respectively.
Article
Biochemistry & Molecular Biology
Yu-Bo Wang, Dan Zhao, Shan-Shan Su, Gang Chen, Hai-Feng Wang, Yue-Hu Pei
Summary: Continued phytochemical investigation of Cynanchum taihangense led to the discovery of twelve new seco-pregnane glycosides, along with two known glycosides. Compound 11 showed significant cytotoxicity against THP-1 and PC-3 cell lines, while compounds 3 and 14 exhibited moderate and selective cytotoxicity against HL-60 and THP-1 cell lines.
Article
Chemistry, Applied
Hong-Biao Chu, Nan-Nan Li, Zong-Ping Zhang, Xiao-Yue Hu, Cai-Yun Yu, Lei Hua
Summary: Two new pregnane glycosides were isolated from the underground parts of Hosta ventricosa, showing promising anti-inflammatory activities.
NATURAL PRODUCT RESEARCH
(2021)
Article
Plant Sciences
Ze-min Lin, Yu-ting Liu, Yue-teng Huang, Xiao-qian Yang, Feng-hua Zhu, Wei Tang, Wei-min Zhao, Shi-jun He, Jian-ping Zuo
Summary: The study aimed to evaluate the anti-nociceptive, anti-inflammatory, and anti-arthritic effects of Periploca sepium periplosides (PePs). The results showed that PePs had significant inhibitory effects on acute pain and inflammation, and could alleviate joint swelling and bone erosion, partly by suppressing interferon-gamma and interleukin-17.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Katarzyna Dos Santos Szewczyk, Weronika Skowronska, Aleksandra Kruk, Anna Makuch-Kocka, Anna Bogucka-Kocka, Malgorzata Miazga-Karska, Anna Grzywa-Celinska, Sebastian Granica
Summary: The composition of extracts from the roots and leaves of Eutrema japonicum cultivated in Poland were evaluated using LC-DAD-IT-MS and LC-Q-TOF-MS analyses. The results identified forty-two constituents, including glycosinolates, phenylpropanoid glycosides, flavone glycosides, hydroxycinnamic acids, and other compounds. The extracts were then tested for their cytotoxic effect, impact on probiotic and intestinal pathogenic strains, and anti-inflammatory activity. The 60% ethanol extract from biennial roots (WR2) exhibited the strongest anti-inflammatory, antibacterial, and cytotoxic activities. These findings suggest that E. japonicum extracts have potential as health-promoting supplements.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Junru Deng, Lin Wang, Qingyu Jin, Jia Zeng, Jingwen Xu, Xiangjiu He, Yihai Wang
Summary: Sixteen previously undescribed steroidal sapogenins and two known ones were isolated from the stems of Solanum nigrum L. The structures of these compounds were identified using various analysis techniques. Some of the compounds exhibited inhibition of nitric oxide and anti-inflammatory activity in macrophages. These findings suggest that the stems of S. nigrum have potential as a source of anti-inflammatory agents.
Article
Biochemistry & Molecular Biology
Fan Xia, Li-Sha Lin, Yan-Song Ye, Lian Yang, Jin-Hua Zhao, Gang Xu
Summary: Eleven new abietane-type diterpene lactones were isolated from Salvia prattii, including five 11,12-seco-11-nor-abietane diterpenes, four 11,12-seco-abietane diterpenes, and two 20(10 -> 5)-abeo-4,5;11,12-bis-seco-abietane diterpenes. The structures of these compounds were established through various analytical techniques, and bioactivity studies showed that some of these compounds have potent antiplatelet activity.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Ghada A. Ismail, Mohamed E. Mostafa, Ahmed Y. Mubarak, AbelAziz M. Dawidar, Mamdouh Abdel-Mogib
Summary: Six new pregnane glycosides, quadrangulosides A-F (1-6), were discovered in the phytochemical investigation of Caralluma quadrangula aerial parts, along with nine known pregnane glycosides and three known flavone glycosides. The structures of the isolated phyto-constituents were elucidated using spectroscopic 1D-, 2D-NMR, and spectrometric ESI-MS spectra.
Article
Plant Sciences
Yongbo Xue, Andrei I. Savchenko, Kylie A. Agnew-Francis, Jared A. Miles, Tina Holt, Hieng Lu, Sharon Chow, Paul I. Forster, Glen M. Boyle, Benjamin P. Ross, Katja Fischer, Andrei G. Kutateladze, Craig M. Williams
Summary: Cynanchum viminale subsp. australe, also known as caustic vine, is a leafless succulent found in the northern arid zone of Australia. It exhibits livestock toxicity, use in traditional medicine, and potential anticancer activity. This study presents four new compounds, but they showed limited activity in cancer, acetylcholinesterase, and Sarcoptes scabiei bioassays, suggesting they are not responsible for the reported toxicity of this plant species.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Plant Sciences
Joanda P. R. e Silva, Laiane C. O. Pereira, Lucas S. Abreu, Francisca S. V. Lins, Thalisson A. de Souza, Renan F. do Espirito-Santo, Renata P. C. Barros, Cristiane F. Villarreal, Jose I. M. de Melo, Marcus T. Scotti, Vicente C. de O. Costa, Lucas H. Martorano, Fernando M. dos Santos Jr, Raimundo Braz Filho, Marcelo S. da Silva, Josean F. Tavares
Summary: This study reports the isolation of secondary metabolites from the aerial parts of Justicia aequilabris. Three new lignans were discovered, and they showed significant inhibitory activity against nitric oxide production.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Xing-Cheng Shao, Zhen-Hua Chen, Shuang-Shuang Liu, Fei Wu, Hong-Yan Mu, Wen-Hui Wei, Yi Feng, Jian-Ping Zuo, Ji-Quan Zhang, Shi-Jun He, Wei-Min Zhao
Summary: LC-MS guided chemical investigation of the periploside-rich extract of the root barks of Periploca sepium led to the discovery of six new minor pregnane glycosides, among which one compound exhibited significant inhibitory activities against the proliferation of T and B lymphocytes.
BIOORGANIC CHEMISTRY
(2021)
Article
Plant Sciences
Riham A. El-Shiekh, Sahar El-Mekkawy, Samar M. Mouneir, Azza Hassan, Essam Abdel-Sattar
Summary: The study evaluated the anti-rheumatic effects of Russelioside B, a compound found in C. quadrangula, in a rat model of adjuvant-induced arthritis. Results showed significant reductions in inflammatory markers, oxidative stress, and bone degeneration enzymes, indicating the potential of Russelioside B as a new treatment for rheumatoid arthritis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Yu-Xia Jiang, Jia-Ying Yao, Nan Qin, Jun-Jie Tan, Feng Han, Shi-Jin Qu, Shi-Jun He, Chang-Heng Tan
Summary: Six new B-seco limonoids, named fraxinifolines A-F (1-6), along with four known A,D-di-seco ones, were isolated from Tetradium fraxinifolium twigs with leaves. The structures and absolute configurations were determined by analyzing MS, NMR, single-crystal X-ray diffraction and biogenetic pathway. Anti-inflammatory bioassay revealed that limonoids 1-3 exhibited significant immunosuppressive effect on the production of proinflammatory cytokines (IL-1β and/or TNF-α) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells.
Article
Chemistry, Medicinal
Ying Yan, Pan Tang, Xiong Zhang, Dan Wang, Mingyou Peng, Xiaoyan Yan, Zuquan Hu, Lei Tang, Xiaojiang Hao
Summary: In this study, six new seco-pregnane C-21 steroidal glycosides were isolated from the roots of Cynanchum paniculatum and showed significant anti-TMV activities. These compounds possibly inhibit TMV infection by suppressing the expression of NtHsp70-1 and NtHsp70-061.
Article
Plant Sciences
Sudarat Kruakaew, Chonticha Seeka, Thitima Lhinhatrakool, Sanit Thongnest, Jantana Yahuafai, Suratsawadee Piyaviriyakul, Pongpun Siripong, Somyote Sutthivaiyakit
JOURNAL OF NATURAL PRODUCTS
(2017)
Article
Dentistry, Oral Surgery & Medicine
A. Promsong, T. Chuenchitra, K. Saipin, S. Tewtrakul, P. Panichayupakaranant, S. Satthakarn, W. Nittayananta
Article
Chemistry, Medicinal
Pattreeya Tungcharoen, Chatchai Wattanapiromsakul, Pimpimon Tansakul, Seikou Nakamura, Hisashi Matsuda, Supinya Tewtrakul
PHYTOTHERAPY RESEARCH
(2018)
Article
Plant Sciences
Suthasinee Srirod, Supinya Tewtrakul
JOURNAL OF ETHNOPHARMACOLOGY
(2019)
Article
Plant Sciences
Thawiwan Muthachan, Supinya Tewtrakul
JOURNAL OF ETHNOPHARMACOLOGY
(2019)
Article
Chemistry, Medicinal
Pattreeya Tungcharoen, Chatchai Wattanapiromsakul, Pimpimon Tansakul, Seikou Nakamura, Hisashi Matsuda, Supinya Tewtrakul
PHYTOTHERAPY RESEARCH
(2020)
Article
Plant Sciences
Sudarat Kruakaew, Chonticha Seeka, Jantana Yahuafai, Pongpun Siripong, Somyote Sutthiyaiyakit
JOURNAL OF NATURAL PRODUCTS
(2019)
Article
Multidisciplinary Sciences
Prapaporn Chaniad, Supinya Tewtrakul, Teeratad Sudsai, Supat Langyanai, Kantarakorn Kaewdana
Article
Integrative & Complementary Medicine
Sirikorn Thanasakdecha, Supinya Tewtrakul
Summary: This study investigated the wound healing activity of compounds from Kaempferia marginata and developed gel formulations containing KM1. Results showed that gels containing 0.1%, 0.25%, and 0.5% KM1 demonstrated higher cell proliferation and migration activity compared to Aloe vera gel. The gel with KM1 was found to have good physical, chemical, and biological stabilities, suggesting its potential application for wound healing.
JOURNAL OF HERBAL MEDICINE
(2021)
Article
Plant Sciences
Monnapa Thapsut, Suriphon Singha, Chonticha Seeka, Somyote Sutthivaiyakit
Summary: Three unprecedented megastigmanes and twelve known compounds were isolated from the aerial part of Euphorbia heterophylla. The structural elucidation was based on extensive uses of spectroscopic data, and the absolute configuration assignment of compound 1 was determined through NOESY correlations and comparison of experimental and calculated ECD spectra. Selected isolates were evaluated for cytotoxic activity.
PHYTOCHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Sudarat Kruakaew, Suriphon Singha, Ek Sangvichien, Jantana Yahuafai, Somyote Sutthivaiyakit
Summary: In this study, chromatographic purification of the CH2Cl2 extract of Myristica fragrans seeds resulted in the isolation of 19 known compounds, including four dihydrofuran neolignans. The absolute configuration of these compounds was thoroughly investigated and discrepancies between the use of an aromatic quadrant rule and time-dependent density function theory calculation for predicting absolute configurations were found. The antimicrobial and cytotoxic activities of the isolates and reduction products of these neolignans were also studied.
Article
Pharmacology & Pharmacy
Prapaporn Chaniad, Teeratad Sudsai, Abdi Wira Septama, Arnon Chukaew, Supinya Tewtrakul
ADVANCES IN PHARMACOLOGICAL SCIENCES
(2019)
Article
Pharmacology & Pharmacy
Kanidta Kaewkroek, Supinya Tewtrakul, Ruedeekorn Wiwattanapatapee
LATIN AMERICAN JOURNAL OF PHARMACY
(2019)
