Journal
JOURNAL OF NATURAL PRODUCTS
Volume 80, Issue 6, Pages 1944-1947Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.7b00190
Keywords
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Funding
- National Natural Science Foundation of China [31570340]
- Beijing Nature Science Foundation [7174284]
- Chinese National S&T Special Project on Major New Drug Innovation [2011ZX09307-002-01]
- Fundamental Research Funds for the Central Research Institutes for Public Welfare
- Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Agricultural Sciences [502-17]
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Trichoderpyrone (1), a unique polyketide with a cyclopentenone-pyrone hybrid skeleton, was isolated from the plant endophytic fungus Trichoderma gamsii. The structure of 1 was determined by detailed analysis of NMR data together with comparison of chemical shift values of similar fragments. The relative and absolute configurations were established by NOESY correlations and CD experiment. Trichoderpyrone (1) displayed weak cytotoxic activities against A549, HepG2, and HeLa cancer cell lines. 1 might originate from a hybrid biosynthetic pathway through two nonreduced (NR) polyketide megasynthetases.
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