Journal
JOURNAL OF NATURAL PRODUCTS
Volume 80, Issue 8, Pages 2204-2214Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.7b00042
Keywords
-
Funding
- National Natural Science Foundation of China [81573309]
- Open Project Program of Jiangsu Key Laboratory of Drug Screening [JKLD2015KF-01]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Research and Innovation Project for College Graduates of Jiangsu Province [KYLX15_0661]
Ask authors/readers for more resources
Frutescones H-R (1-11), new sesqui- or monoterpene-based meroterpenoids, were isolated from the aerial parts of Baeckea frutescens. Their structures and absolute configurations were established by means of spectroscopic analyses (HRESIMS, 1D and 2D NMR, and ECD), as well as single-crystal X-ray crystallography of 1, (-)-7, and 9. The anti-inflammatory activities of all isolates were evaluated by measuring their inhibitory effects on NO production in LPS-Baeckea frutescens stimulated RAW 264.7 macrophages, and the structure activity relationships of 1-11 are also discussed. Compound 8 exhibited anti-inflammatory activity with an IC50 value of 0.36 mu M, which might be related to the regulation of the NF-kappa B signaling pathway via the suppression of p65 nuclear translocation and the consequent decrease of IL-6 and TNF-alpha.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available