Journal
JOURNAL OF NATURAL PRODUCTS
Volume 80, Issue 5, Pages 1584-1593Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.7b00155
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Funding
- CONACyT [219765]
- DGAPA [IN217516, IA 204116]
- PAIP-UNAM [5000-9140]
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A dried infusion prepared from the aerial parts of Salvia circinata did not provoke acute toxicity in mice (LD50 > 5 g/kg). This infusion showed poor hypoglycemic and antihyperglycemic effects (100-570 mg/kg) when tested in normal and hyperglycemic mice using acute and oral glucose tolerance tests, respectively. However, this infusion possessed antihyperglycemic action in vivo during an oral sucrose tolerance test (31.6-316 mg/kg), suggesting the presence of a-glucosidase inhibitors in S. circinata. Fractionation of a nonpolar extract of the aerial parts of the plant yielded a new biflavone (1) and four new neoderodane diterpenoid glucosides (2-5) along with the known compounds amarisolide (6), pedalitin (7), apigenin-7-O-beta-D-glucoside (8), and the flavone 2-(3,4-dimethoxypheny1)-5,6-dihydroxy7-methoxy-4H-chromen-4-one (9). Compounds 1 and 6-9 were active against mammalian alpha-glucosidases; 6 and 7 were also active against a recombinant alpha-glucosidase from Ruminococcus obeum and reduced significantly the postprandial peak during an oral sucrose tolerance test in healthy mice, consistent with their alpha-glucosidase inhibitory activity. Molecular docking and dynamic studies revealed that compounds 6 and 7 might bind to alpha-glucosidases at the catalytic center of the enzyme.
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