Journal
JOURNAL OF NATURAL PRODUCTS
Volume 80, Issue 4, Pages 1028-1033Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.6b01026
Keywords
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Funding
- Chinese Academy of Medical Sciences (CAMS) Initiative for Innovative Medicine [2016-I2M-1-010]
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Three new caffeoylquinic acid derivatives, chrysanthemorimic acids A-C (1-3), and 11 known compounds (4-14) were isolated and characterized from the flowers of Chrysanthemum morifolium. Their structures were confirmed by spectroscopic data as well as by comparison of the experimental and calculated electronic circular dichroism spectra. Chrysanthemorimic acids A-C possess a rare 8-oxa-bicyclo[3.2.1]oct-3-en-2-one ring that is formed through a [5+2] cycloaddition of caffeoylquinic acid with a D-glucose derivative. Compounds 1-3, 6-8, 12, and 13 displayed significant effects against hydrogen peroxide-induced neurotoxicity in SH-SYSY cells at 10 mu M.
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