Journal
JOURNAL OF NATURAL PRODUCTS
Volume 80, Issue 4, Pages 1178-1181Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.6b00888
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Funding
- NIAID/NIH Contract [HHSN272200700055C]
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Two new antimicrobial agents, neryl ferulate (1) and neryl p-coumarate (2), were identified using bioassay-guided isolation from the leaves of Eremophila longifolia, which is a medicinal plant used by some Australian Aboriginal communities. Although gradual autoxidation of the nerol subunit hindered the initial attempts to purify and characterize 1 and 2, it was found that the autoxidation could be stopped through storage under argon at -20 degrees C. Biological evaluation showed that neryl ferulate (1) had moderate activity against various Gram-positive bacteria, while neryl p-coumarate (2) was active only against Enterococcus faecium.
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