Journal
JOURNAL OF NATURAL PRODUCTS
Volume 80, Issue 2, Pages 565-568Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.6b00935
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Funding
- KAKENHI from the Japan Society for the Promotion of Science [26305001, 26293022]
- Strategic Priority Research Promotion Program of Chiba University
- Grants-in-Aid for Scientific Research [16K05696, 16K14910, 17H03992] Funding Source: KAKEN
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Two new aminocyclitol amide derivatives, nabscessins A (1) and B (2), were isolated from the culture broth of a pathogenic actinomycete species, Nocardia abscessus IFM 10029(T). The structures of nabscessins A and B were elucidated by spectral studies, and the compounds showed antifungal activity against Cryptococcus neoformans, with IC50 values of 32 and 16 mu g/mL, respectively.
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