Journal
JOURNAL OF NATURAL PRODUCTS
Volume 80, Issue 10, Pages 2825-2829Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.7b00136
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Funding
- National Natural Science Foundation of China [81302676, 81321004]
- CAMS Initiative for Innovative Medicine [CAMS-I2M-3-012]
- National Infrastructure of Microbial Resources [NIMR-2016-3]
- National Mega-project for Innovative Drugs [2012ZX09301002-001-016, 2012ZX09301002-003]
- Fundamental Research Funds for the Central Universities [2012N09]
- PUMC Youth Fund [3332013090]
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Three dimeric analogues of bohemamines, dibohemamines D-F (1-3), together with dibohemamine A (4), were isolated from Streptomyces sp. CPCC 200497. Their structures were solved using a combination of mass spectrometry, 1D and 2D NMR spectroscopy, and CD. Dibohemamines D and E were new dimeric analogues of bohemamines, and dibohemamine F was a known compound obtained previously by semisynthesis. Dibohemamine F displayed potent cytotoxicity against cancer cell lines A549 and HepG2 with IC50 values of 1.1 and 0.3 mu M, respectively. Dibohemamines D and E showed moderate cytotoxicity against cancer cell lines A549 and HepG2.
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