Article
Biochemistry & Molecular Biology
Long-Qing Li, Ang-Xin Song, Wing-Tak Wong, Jian-Yong Wu
Summary: This study aimed to fractionate the complex exopolysaccharide (EPS) from a medicinal fungus based on molecular weight and found that the lower molecular weight fraction exhibited higher anti-inflammatory activity. The identified EPS-LM-1 consists of mannose, glucose, and galactose residues and significantly inhibited the lipopolysaccharide-induced inflammatory responses, making it a promising candidate for anti-inflammation therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Sha Sha Liu, Chun Qing Li, Fan Dong Kong, Qing Yun Ma, Qing Yi Xie, Li Man Zhou, Du Qiang Luo, You Xing Zhao
Summary: Two new compounds, named fusariumtrin A (1) and climacomontaninate D (2), were isolated from the rice culture of Fusarium sp. LGWB-7, along with eight known compounds. The structures of the new compounds were elucidated through 1D and 2D spectroscopic data analysis as well as mass spectrum. One of the compounds showed cytotoxicity against human tumor cell lines K562, A549, SGC-7901, and Hela with IC50 values of 1.46, 13.97, 9.34, and 6.64 mu M, respectively.
PHYTOCHEMISTRY LETTERS
(2021)
Article
Chemistry, Applied
Yin Chen, Teng Wang, Xing Zhang, Fuming Zhang, Robert J. Linhardt
Summary: A neutral branched heteropolysaccharide Pc0-1 was isolated from the spores of Paecilomyces cicadae parasitizing bamboo cicadas. Pc0-1 has a core structure with glucose, galactose, mannose, and arabinose residues, showing moderate immunostimulating activity by activating macrophages through their mannose receptor (MR) and involving TLR4 and TLR2 recognition.
CARBOHYDRATE POLYMERS
(2021)
Article
Microbiology
Xueyi Zhao, Junfa Chai, Fang Wang, Yanxia Jia
Summary: The spore concentration and mycelial biomass of strain JMF-01 were significantly affected by factors such as the primary inoculum density, initial pH, and medium-to-flask ratio. After optimization, the highest mycelial biomass reached 0.35g, and the highest spore concentration reached 6.49 x 10(8) blastospores/mL. Compared to the unoptimized conditions, the optimized submerged culture showed a 3.46-fold increase in mycelial biomass and a 2.06-fold increase in spore concentration. The optimized submerged culture exhibited high pathogenicity against Myzus persicae, with a mortality rate of 95%.
Article
Biotechnology & Applied Microbiology
Meihua Xie, Ni Ma, Na Bai, Meichen Zhu, Ke-Qin Zhang, Jinkui Yang
Summary: This study elucidates the diverse functions of phospholipase C in Arthrobotrys oligospora, including its role in the development of hyphae, spores, and cell nuclei, responses to stress, formation of traps, and predation of nematodes. The study also highlights the involvement of phospholipase C in the biosynthesis of secondary metabolites and regulation of trap morphogenesis in nematode-trapping fungi.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Fu-Run Wang, Li Yang, Fan-Dong Kong, Qing-Yun Ma, Qing-Yi Xie, You-Gen Wu, Hao-Fu Dai, Ping Chen, Na Xiao, You-Xing Zhao
Summary: Three new humulane-type sesquiterpenoids and three known compounds were isolated from an endophytic fungus derived from Carica papaya leaves. The compounds showed significant inhibition of hepatic glucose production induced by glucagon, with mechanisms involving cAMP accumulation suppression. Determination of their structures and absolute configurations were accomplished through NMR and HRESIMS analysis.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Applied
Glaucia H. Braun, Henrique P. Ramos, Ana C. B. B. Candido, Rita C. N. Pedroso, Katia A. Siqueira, Marcos A. Soares, Gustavo M. Dias, Lizandra G. Magalhaes, Sergio R. Ambrosio, Ana H. Januario, Rosemeire C. L. R. Pietro
Summary: Fractionation of extracts from the marine-derived fungus Paecilomyces sp. 7A22 led to the isolation of harzialactone A (HA), a compound previously found in fungi inhabiting marine environments. Analysis showed that HA exhibited significant activity against promastigotes forms of Leishmania amazonensis and moderate activity against intracellular amastigotes. These findings suggest that HA could be a potential compound for future studies on natural products with activity against Leishmania spp., and further support the idea that marine-derived fungi are a promising source of antiparasitic natural products.
NATURAL PRODUCT RESEARCH
(2021)
Article
Plant Sciences
Zeinab Y. Al Subeh, Laura Flores-Bocanegra, Huzefa A. Raja, Joanna E. Burdette, Cedric J. Pearce, Nicholas H. Oberlies
Summary: This article reports a relatively young class of fungal metabolites, macrocyclic alkaloids with a cyclopenta[b]fluorene ring system, which were first discovered in 2013. The structures of these compounds were identified by analyzing high-resolution electrospray ionization mass spectrometry data and one-dimensional and two-dimensional NMR spectra. The relative and absolute configurations of these alkaloids were determined through various spectroscopic techniques. These compounds showed cytotoxic activity against human cancer cell lines.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Plant Sciences
Chang-Zheng Wu, Gang Li, Yu-Han Zhang, Shuang-Zhi Yuan, Ke-Min Dong, Hong-Xiang Lou, Xiao-Ping Peng
Summary: Eleven new pyridone alkaloids and three new tetramic acids were isolated from a marine-derived fungus. The structures and absolute configurations were determined through various analyses. Intriguingly, some of the pyridone alkaloids exhibited interconversions between hydroxy and methoxy groups at C-4 in acidic MeOH solution, and OH-4 could be replaced by various substituent groups in acidic aqueous solution. Additionally, several compounds showed moderate inhibitory effects on NO production in LPS-induced macrophages.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Organic
Xinyang Li, He-Ping Chen, Lin Zhou, Jing Fan, Takayoshi Awakawa, Takahiro Mori, Richiro Ushimaru, Ikuro Abe, Ji-Kai Liu
Summary: Cordycicadins A-D are four novel polyketides isolated from the liquid fermentation of Cordyceps cicadae JXCH1. Their structures were determined using spectroscopic analysis, single-crystal X-ray diffraction, and computational methods. Cordycicadins A and B showed antifeedant activity against silkworm larvae.
Article
Plant Sciences
Tao Zhou, Misaki Katsuragawa, Tian Xing, Keisuke Fukaya, Toru Okuda, Toshiyuki Tokiwa, Etsu Tashiro, Masaya Imoto, Naoya Oku, Daisuke Urabe, Yasuhiro Igarashi
Summary: Three new cyclopeptides were isolated from the culture broth of Cladobotryum varium, including one with potent autophagy-inducing activity. New conditions were established for determining the absolute configurations of Ile residues, and NMR chemical shift prediction and chemical synthesis were used to determine the sequence of Phe residues. Noncovalent interactions were shown to be significant in accurately calculating stable conformers for peptides with multiple aromatic rings.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Microbiology
B. K. Nayak, V Prabhakar, Anima Nanda
Summary: The utility of fungi in the biogenic synthesis of silver nanoparticles is impressive due to the production of biomolecules with minimal toxic residuals. This study found that silver nanoparticles synthesized from wasp nest fungus at different pHs were more prominent at pH 6. The nanoparticles had diverse antimicrobial activities against various bacterial strains and Candida albicans. The combination of AgNPs with methanol solvent extract showed enhanced inhibitory effects.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Yang Yu, Hao Tan, Tianhai Liu, Lixu Liu, Jie Tang, Weihong Peng
Summary: The study revealed that P. penicillatus may induce programmed cell death in M. sextelata after infection, while M. sextelata detoxifies P. penicillatus toxins and forms a melanin barrier against invasion by upregulating specific genes.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Plant Sciences
Yi Li, Lan Jiang, David L. Hawksworth, Yong-Hui Wang, Jiao-Jiao Lu, Yi-Jian Yao
Summary: This study corrected the name application of the economically important Chinese caterpillar fungus Ophiocordyceps sinensis at the molecular level by rediscovering original materials and extracting DNA. It designated an epitype and obtained living cultures from it to unequivocally fix the application of the name.
Article
Biochemistry & Molecular Biology
Fei Cao, Xue-Meng Liu, Xu Wang, Ya-Hui Zhang, Jie Yang, Wan Li, Du-Qiang Luo, Yun-Feng Liu
Summary: Co-culturing marine-derived fungi Penicillium janthinellium with Paecilomyces formosus resulted in the discovery of nine new indole-diterpenes, as well as the analysis of their chemical structures and biological activities, including anti-viral properties.
BIOORGANIC CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Yunshan Zhang, Mei Wang, Qiuhua Lu, Qi Li, Mingyan Lin, Jianzhong Huang, Yanguo Hong
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2019)
Article
Oncology
Lang Wu, Jifeng Wang, Qiuyin Cai, Taylor B. Cavazos, Nima C. Emami, Jirong Long, Xiao-Ou Shu, Yingchang Lu, Xingyi Guo, Joshua A. Bauer, Bogdan Pasaniuc, Kathryn L. Penney, Matthew L. Freedman, Zsofia Kote-Jarai, John S. Witte, Christopher A. Haiman, Rosalind A. Eeles, Wei Zheng, Sara Benlloch, Brian E. Henderson, David Conti, Fredrick R. Schumacher, Douglas Easton, Ali Amin Al Olama, Kenneth Muir, Sonja Berndt, Stephen Chanock, Demetrius Albanes, Stephanie Weinstein, Stella Koutros, Fredrik Wildund, Henrik Gronberg, Susan M. Gapstur, Victoria L. Stevens, Catherine M. Tangen, Jyotsna Batra, Judith Clements, Nora Pashayan, Johanna Schleutker, Alicia Wolk, Catharine West, Lorelei Mucci, Geraldine Cancel-Tassin, Karina Dalsgaard Sorensen, Eli Marie Grindedal, David E. Neal, Freddie C. Hamdy, Jenny L. Donovan, Ruth C. Travis, Robert J. Hamilton, Bany S. Rosenstein, Yong-Jie Lu, Graham G. Giles, Adam S. Kibel, Ana Vega, Manolis Kogevinas, Jong Y. Park, Janet L. Stanford, Lisa F. Newcomb, Cezary Cybulski, Borge G. Nordestgaard, Hermann Brenner, Christian Maier, Jeri Kim, Esther M. John, Manuel R. Teixeira, Susan L. Neuhausen, Kim De Ruyck, Azad Razack, Marija Gamulin, Radka Kaneva, Nawaid Usmani, Frank Claessens, Paul A. Townsend, Manuela Gago Dominguez, Monique J. Roobol, Florence Menegaux, Kay-Tee Khaw, Lisa Cannon-Albright, Stephen N. Thibodeau, David J. Hunter, William J. Blot, Elio Riboli
Article
Biochemistry & Molecular Biology
Wei Li, Qian Liu, Shimian Cheng, Shanren Li, Yongbiao Zheng
Article
Mycology
Zhi-Yuan Zhang, Wan-Hao Chen, Xiao Zou, Yan-Feng Han, Jian-Zhong Huang, Zong-Qi Liang, Sunil K. Deshmukh
Article
Engineering, Chemical
Jianxiong Ye, Yuxian Chen, Guanxuan Peng, Xinwei Yang, Jianzhong Huang, Chongrong Ke
INTERNATIONAL JOURNAL OF CHEMICAL REACTOR ENGINEERING
(2020)
Article
Biotechnology & Applied Microbiology
Xue Wang, Yang-Le Gao, Ming-Liang Zhang, Huai-Dong Zhang, Jian-Zhong Huang, Li Li
JOURNAL OF BIOTECHNOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Man Xu, Hongxuan Wu, Peijie Shen, Xianzhang Jiang, Xueduan Chen, Jinxin Lin, Jianzhong Huang, Feng Qi
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Feng Qi, Peijie Shen, Rongfei Hu, Ting Xue, Xianzhang Jiang, Lina Qin, Youqiang Chen, Jianzhong Huang
BIOTECHNOLOGY FOR BIOFUELS
(2020)
Article
Biotechnology & Applied Microbiology
Mengsu Liu, Xinwei Yang, Yang Ren, Huaping Xia, Jianzhong Huang, Chongrong Ke
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Hong Jiang, Wenjing Jia, Mojie Duan, Hong Lin, Jianzhong Huang, Xin Li, Zhengyu Shu
BIOCHEMICAL ENGINEERING JOURNAL
(2020)
Article
Biotechnology & Applied Microbiology
Jiangming Zhu, Wei Yang, Bohua Wang, Qun Liu, Xiaotong Zhong, Quanxiu Gao, Jiezheng Liu, Jianzhong Huang, Baixue Lin, Yong Tao
MICROBIAL CELL FACTORIES
(2020)
Article
Biochemical Research Methods
Lingjun Yu, Fengyu Du, Xusheng Chen, Yongbiao Zheng, Martha Morton, Fengquan Liu, Liangcheng Du
ACS SYNTHETIC BIOLOGY
(2020)
Article
Agriculture, Multidisciplinary
Liu Guo-qing, Sun Guang-ming, Liao Xiu-dong, Huang Jian-zhong, Guo Mei-jin, Zhang Li-yang, Guo Yan-li, Lu Lin, Luo Xu-gang
JOURNAL OF INTEGRATIVE AGRICULTURE
(2020)
Article
Agriculture, Multidisciplinary
Amanda Lynn Miller, Shanren Li, Catherine D. Eichhorn, Yongbiao Zheng, Liangcheng Du
Summary: In this study, the first siderophore, lysochelin, and its biosynthetic gene cluster were identified from Lysobacter enzymogenes. It was found that lysochelin, along with antifungal compounds HSAF and its analogues, are crucial for the disease control activity and survival of Lysobacter under oxidative stresses caused by excess iron. The production of these molecules is greatly affected by iron concentration.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Feifei Wang, Jie Tan, Ruixiang Jiang, Feifei Li, Renqing Zheng, Linjun Yu, Lianzhong Luo, Yongbiao Zheng
Summary: In recent years, the cultivation of wild morel mushroom species has become popular in China due to their high value in terms of edibility and medicinal properties. This study used liquid-submerged fermentation to investigate the secondary metabolites of Morehella importuna and identified several new and known compounds with significant antioxidant activity. These findings shed light on the medicinal value of M. importuna and its potential as a rich source of antioxidants.
