Article
Plant Sciences
Diana Ionela Stegarus, Ecaterina Lengyel, George Florian Apostolescu, Oana Romina Botoran, Corneliu Tanase
Summary: This study investigated three species of the Stachys genus in terms of aromatic profile, total polyphenol content, antibacterial activity, and antioxidant capacity. Gas chromatography coupled with flame ionization detection was used to explore the herbal alcoholic extracts. The results showed differences in polyphenol content and antioxidant activity among the three Stachys species, with distinctive volatile compounds identified in each. The microbiological results demonstrated antimicrobial capacity, particularly on Gram-positive bacteria, and highlighted the potential to differentiate between Stachys species using plant tissue VOC profiles.
Article
Multidisciplinary Sciences
Shaista Jabeen, Muhammad Fraz Ali, Atta Mohi Ud Din, Talha Javed, Nouriya Salah Mohammed, Sunbal Khalil Chaudhari, Muhammad Ammar Javed, Baber Ali, Lixin Zhang, Mehdi Rahimi
Summary: Managing invasive grasses is essential to mitigate their negative impact on the environment, but these plants can have benefits in certain contexts. This study examined the potential for livestock feed and plant-derived herbicides from invasive grasses, as well as their phytotoxic effects. Results showed that some grass species contained beneficial compounds and inhibited the growth of certain crops. Therefore, it is important to consider the pros and cons of these toxic grasses.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Ya-Rong Wang, Yu-Cheng Dai, Hong-Gao Liu, Josef Vlasak, Peter Buchanan, Yuan Yuan, Ying-Da Wu
Summary: Megasporoporia sensu lato has been intensively studied in China and South America, resulting in the recognition of four genera and 36 species within this genus. This study analyzed more samples and described six new species, as well as provided an identification key to these species.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Agronomy
Ilhem Rajhi, Fabio Hernandez-Ramos, Manef Abderrabba, Med Taieb Ben Dhia, Sameh Ayadi, Jalel Labidi
Summary: The antioxidant and antifungal activities of crude hydro-ethanolic extract from Capparis spinosa L. leaves and their fractions were investigated in this study. It was found that the ethyl acetate fraction had the highest antioxidant capacity, while the diethyl ether fraction showed the best antifungal activity against Aspergillus niger.
Article
Chemistry, Medicinal
Shaza H. Aly, Ahmed M. Elissawy, Dina Salah, Nawal Abdulaziz Alfuhaid, Ola H. Zyaan, Hany I. Mohamed, Abdel Nasser B. Singab, Shaimaa M. Farag
Summary: This study investigates the larvicidal efficacy of three methanolic algal extracts, Cystoseira myrica, C. trinodis, and C. tamariscifolia, against Cx. pipiens. The analysis of the algal samples led to the characterization of twelve compounds belonging to phenolics and terpenoids. Probit analysis was used to determine the lethal concentrations (LC50 and LC90). The highest toxicity was found in C. myrica extract, followed by C. trinodis, and the lowest toxicity was observed in C. tamariscifolia. The elevation of GST and reduction of AChE enzymes confirm the larvicidal activity of the extracts.
Review
Pharmacology & Pharmacy
Zilda Cristiani Gazim, Juliana Silveira Valle, Isabela Carvalho dos Santos, Isabelle Luiz Rahal, Gabriela Catuzo Canonico Silva, Ana Daniela Lopes, Suelen Pereira Ruiz, Maria Graciela Iecher Faria, Ranulfo Piau Junior, Daniela Dib Goncalves
Summary: This study reviews the ethnobotanical, ethnomedicinal, phytochemical, pharmacological, and potential cytotoxic effects of Baccharis dracunculifolia. The plant has a wide range of uses in folk medicine and is the main source of green propolis. The leaves and flowers contain numerous bioactive compounds with antimicrobial, antioxidant, antitumor, analgesic, immunomodulatory, and antiparasitic properties. However, high doses of the aqueous extract showed genotoxic effects, indicating that the toxicity of the plant is dose-dependent.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria-Evelina Bordean, Rodica Ana Ungur, Dan Alexandru Toc, Ileana Monica Borda, Georgiana Smaranda Martis, Carmen Rodica Pop, Miuta Filip, Mihaela Vlassa, Bogdana Adriana Nasui, Anamaria Pop, Delia Cinteza, Florina Ligia Popa, Sabina Marian, Lidia Gizella Szanto, Sevastita Muste
Summary: This study aimed to investigate the antioxidant and antibacterial activities of leaf and stem ethanolic extracts of Artemisia absinthium L. and Artemisia annua L. The results showed that the leaf extract of Artemisia annua L. had the highest total phenolic content and the strongest antioxidant capacity, while both Artemisia annua L. and Artemisia absinthium L. leaf extracts exhibited low minimum inhibitory concentration and minimum bactericidal concentration against various bacteria.
Review
Pharmacology & Pharmacy
Sujogya Kumar Panda, Zilda Cristiani Gazim, Shasank S. Swain, Marisa Cassia Vieira de Araujo Bento, Jessica da Silva Sena, Marie Jeanne Mukazayire, Luc Van Puyvelde, Walter Luyten
Summary: Tetradenia riparia is a popular aromatic medicinal plant in Africa. Its leaves and flower buds contain various compounds with pharmacological potential, including antimicrobial, antioxidant, antitumor, and analgesic activities.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Ghada Abdel-Moez, Bharathi Avula, Hanaa Sayed, Azza Khalifa, Samir Ross, Kumar Katragunta, Ikhlas Khan, Shaymaa Mohamed
Summary: In this study, the chemical characteristics of three edible Amaranthus species were analyzed using non-targeted liquid chromatography-tandem mass spectrometry technique. Forty-one compounds were identified, with amino acids and flavonoid glycosides being the most prevalent. The identified compounds varied in distribution and abundance across the investigated species, providing chemotaxonomic identities.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Parasitology
Fahad A. Al-Hizab, Nouh S. Mohamed, Marion Wassermann, Mahmoud A. Hamouda, Abdelazim M. Ibrahim, Waleed R. El-Ghareeb, Sherief M. Abdel-Raheem, Thomas Romig, Rihab A. Omer
Summary: This study reports the genetic identity of Echinococcus parasites in camels from the Eastern Province of Saudi Arabia, showing a widespread infection and active role of camels in the lifecycles of the parasites. The results also indicate the presence of these parasites in the region for a longer period of time.
PARASITOLOGY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Karolina Lendzion, Agnieszka Gornowicz, Krzysztof Bielawski, Anna Bielawska
Summary: The genus Scorzonera consists of nearly 200 species naturally occurring in Europe, Asia, and northern parts of Africa, and has been used in folk medicine in Asia for centuries. Studies have identified various bioactive compounds in Scorzonera plants with antioxidant, anti-inflammatory, analgesic, and hepatoprotective properties, and potential activity against bacteria and fungi. Despite mild cytotoxicity against cancer cell lines, Scorzonera species show promise for wound healing therapy and treatment of microbial infections in medical products.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Forestry
Martina Zoric, Sasa Kostic, Nebojsa Kladar, Biljana Bozin, Verica Vasic, Marko Kebert, Sasa Orlovic
Summary: The study analyzed the composition of leaf volatile organic compounds (BVOCs) in three common coniferous species and observed specificity in the BVOCs content among the species and their genotypes. Significant differences were found in compounds with positive effects on human health, such as anticancer and anti-inflammatory properties. The variations in BVOCs content within and among species provide a foundation for further research on the forest-human health relationship and sustainable forest management.
Review
Plant Sciences
Yuangui Yang, Zhengcai Ju, Yingbo Yang, Yanhai Zhang, Li Yang, Zhengtao Wang
Summary: This review investigates the identification and evaluation methods of chemical constituents in Panax species, as well as discusses different extraction methods. A total of 219 articles published between 1980 and 2018 are surveyed, focusing on the chemical components of different Panax species in raw and processed forms, as well as potential biomarkers.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Microbiology
Ya-Ning Wang, Xiao-Yong Liu, Ru-Yong Zheng
Summary: This study identified multiple new taxonomic units of Umbelopsis ramanniana through a variety of research methods, enriching the understanding of species within the genus and updating the key for all currently accepted species in the genus.
Review
Chemistry, Multidisciplinary
Ana Laura de Cabral Sobreira, Janderson Barbosa Leite de Albuquerque, Wallace Amori Machado de Queiroz, Pedro Isaac Vanderlei de Souza, Diegina Araujo Fernandes, Maria de Fatima Vanderlei de Souza
Summary: The family Malvaceae sensu lato is a plant family consisting of about 245 genera and 4,465 species, primarily found in tropical and subtropical regions worldwide. These species contain alkaloids with various pharmacological effects, such as anti-inflammatory, antinociceptive, antiparasitic, antimicrobial, and anticancer properties. This review aims to provide an overview of the alkaloids isolated from Malvaceae species, evaluating their chemical profile and pharmacological potential.
Article
Plant Sciences
Moses K. Langat, Ncoza C. Dlova, Lauren E. Mulcahy-Ryan, Sianne L. Schwikkard, Elizabeth Opara, Neil R. Crouch, Jacob D. Hiles, Dulcie A. Mulholland
Summary: This study isolated and identified multiple compounds from the stem bark of Cassipourea flanaganii, with one previously unknown compound showing low cytotoxicity and a certain inhibitory effect on melanin production in melanocytes.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Linda Langat, Moses K. Langat, Wolfgang Wetschnig, Walter Knirsch, Dulcie A. Mulholland
Summary: The bulbs of South African Drimia altissima have produced a variety of previously undescribed bufadienolides, along with known bufadienolides, homoisoflavonoids, and sesquiterpenoids. Among them, some bufadienolides showed activity against human cancer cell lines at the nanomolar level in the NCI-60 screen.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Chemistry, Applied
Moses K. Langat, Yisau Mayowa, Nicholas Sadgrove, Mohammed Danyaal, Thomas A. K. Prescott, Teva Kami, Sianne Schwikkard, James Barker, Martin Cheek
Summary: The aromatic alkaloid-rich 'absolute' extract from Vepris gossweileri showed inhibitory effects on Saccharomyces cerevisiae and Bacillus subtilis, possibly due to synergistic effects. Specific combinations of compounds exhibited stronger antifungal activity when mixed with (Epsilon)-caryophyllene, indicating a multi-layered effect of the extract's antifungal properties.
NATURAL PRODUCT RESEARCH
(2022)
Article
Plant Sciences
Nicholas J. Sadgrove, Guillermo F. Padilla-Gonzalez, Alison Green, Moses K. Langat, Eduard Mas-Claret, Dane Lyddiard, Julian Klepp, Sarah V. A. -M. Legendre, Ben W. Greatrex, Graham L. Jones, Iskandar M. Ramli, Olga Leuner, Eloy Fernandez-Cusimamani
Summary: Endemic desert shrubs in Australia, particularly species from the Eremophila genus, exhibit rich chemical diversity with many compounds yet to be described. Research indicates high variability in chemical composition among species within the genus, with classification based on the expression of different compounds.
Article
Agriculture, Multidisciplinary
Guillermo F. Padilla-Gonzalez, Nicholas J. Sadgrove, Abigail Rosselli, Moses K. Langat, Rui Fang, Monique S. J. Simmonds
Summary: The study found the presence of two major diarylbutenedinitrile derivatives in commercial bamboo shoot extracts, which are produced by boiling the shoots of specific bamboo species and are associated with a decrease in taxiphyllin levels. These compounds can serve as markers for the authentication of boiled bamboo shoots obtained from edible bamboo species and organs containing taxiphyllin.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Infectious Diseases
Lidwine Ngah, Willifred Dongmo Tekapi Tsopgni, Judith Caroline Ngo Nyobe, Alain Tadjong Tcho, Moses K. Langat, Jean Claude Ndom, Eduard Mas-Claret, Nicholas John Sadgrove, Alain Francois Kamdem Waffo, Methee Phumthum
Summary: A chemical investigation of the leaves of Tabernaemontana inconspicua Stapf. led to the isolation of a new phenylpropanol derivative, irisdichototin G, along with nine known compounds. Among these compounds, irisdichototin G, 10-hydroxycoronaridine, and vobasine showed significant antimicrobial effects against Haemophilus influenzae, and irisdichototin G and vobasine exhibited significant antimicrobial effects against Pseudomonas aeruginosa. 10-hydroxycoronaridine also displayed significant antimicrobial activity against Klebsiella pneumoniae.
Article
Biology
Hauke Koch, Vita Welcome, Amy Kendal-Smith, Lucy Thursfield, Iain W. Farrell, Moses K. Langat, Mark J. F. Brown, Philip C. Stevenson
Summary: Antimicrobial nectar secondary metabolites can support pollinator health by preventing or reducing parasite infections. This study found that the antiparasitic activity of nectar metabolites can be modulated through chemical modification by the host or resident microbiome during gut passage.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Biology
Winnie Rotich, Eduard Mas-Claret, Nicholas Sadgrove, Anastasia Guantai, Guillermo F. Padilla-Gonzalez, Moses K. Langat
Summary: In this study, the anti-HIV activity of compounds in CareVid(TM) was investigated. Pellitorine, oleuropein, magnoflorine, and crotepoxide showed high inhibitory effects against HIV-1 integrase in vitro. However, ellagic acid had poor bioavailability. Urolithin A and urolithin B demonstrated lower activity compared to ellagic acid. The docking study revealed that oleuropein had the best binding affinity.
Article
Biochemistry & Molecular Biology
Ermias Mergia Terefe, Faith Apolot Okalebo, Solomon Derese, Moses K. Langat, Eduard Mas-Claret, Kamal Ahmad Qureshi, Mariusz Jaremko, Joseph Muriuki
Summary: This study reported three new anti-HIV eudesmane-type sesquiterpenes isolated from the bark of Croton megalocarpus, one of which demonstrated the highest antiviral activity by inhibiting 93% of viral replication.
Article
Multidisciplinary Sciences
Douglas Kemboi, Moses K. Langat, Xavier Siwe-Noundou, Tendamudzimu Tshiwawa, Rui W. M. Krause, Candace Davison, Christie Jane Smit, Jo-Anne de la Mare, Vuyelwa Jacqueline Tembu
Summary: New 13-amino derivatives of dehydrocostus lactone were synthesized and screened for their activity against breast cancer cells. The derivatives showed high selectivity for breast cancer cells and promising ADME properties, suggesting their potential as drug candidates.
Article
Biochemistry & Molecular Biology
Fanny-Aimee Essombe Malolo, Ariane Dolly Kenmogne Kouam, Judith Caroline Ngo Nyobe, Lidwine Ngah, Marcel Frese, Jean Claude Ndom, Moses K. K. Langat, Bruno Ndjakou Lenta, Dulcie A. A. Mulholland, Norbert Sewald, Jean Duplex Wansi
Summary: A phytochemical investigation of the roots of Citrus x paradisi Macfad. led to the identification of two new compounds along with ten known compounds. Compound 3 and 4 from the genus Citrus were reported for the first time. The MeOH extract of the roots and compounds 1-7 showed significant activity against cancer cells.
Article
Chemistry, Applied
Antoine Salvial Tcheuko, Bernard Samuel Fotso Hodjie, Alain Tadjong Tcho, Foundikou Nsangou Mohammed, Flaure Rosette Ehawa Essoung, Mohammed S. Isyaka, Eduard Mas-Claret, Moses K. Langat, Jean Duplex Wansi, Alain Francois Waffo Kamdem
Summary: A new 30-norfriedelane triterpenoid, laphocarpanol, was discovered in the methanol extract of Caloncoba lophocarpa roots, along with seven known compounds. Compound 1 showed weak antibacterial activity against Shigella flexineri, while all isolates were inactive against tested fungal strains.
NATURAL PRODUCT RESEARCH
(2023)
Review
Chemistry, Medicinal
Mandisa Mangisa, Douglas Kemboi, Gerda Fouche, Rudzani Nthambeleni, Moses Kiprotich Langat, Clemence Tarirai, Martin Cheek, Odwa Gonyela, Vuyelwa Jacqueline Tembu
Summary: The compounds from Suregada Roxb. ex Rottler plants are used in traditional medicine to treat various ailments and have shown pharmacological activities such as anticancer and antioxidant properties. However, the chemical composition and medicinal uses of many species in this genus are still unknown.
Article
Multidisciplinary Sciences
S. G. Mewaba, E. N. Happi, B. M. N. Nangmou, M. K. Langat, H. Siddique, N. Sadgrove, A. F. W. Kamdem, J. C. Vardamides, E. Mas-Claret, S. M. Isyaka, W. Rotich, B. G. A. Azebaze
Summary: The stems and leaves of robusta coffee contain various compounds, among which ursolic acid exhibits good antibacterial activity against methicillin-resistant Staphylocccus aureus.
SCIENTIFIC AFRICAN
(2022)
