Article
Chemistry, Organic
Hao-Feng Zhou, Wen-Yan Li, Li-Yan Peng, Xiao-Nian Li, Zhi-Li Zuo, Qin-Shi Zhao
Summary: Five new indole alkaloids, Rhynchines A-E, with a unique skeleton structure were isolated from Uncaria rhynchophylla. Among them, compounds 1 and 2 showed strong inhibitory activities against the Ca-v 3.1 calcium channel.
Article
Chemistry, Medicinal
Jiao Zhao, Fu-Rong Pang, Rui Luo, Fei Li, Dong-Bo Zhang
Summary: Three unprecedented indole alkaloids were isolated from the leaves of Winchia calophylla, and their structures and configurations were determined. Evaluation of their anti-inflammatory effects revealed that one of the compounds showed moderate activity.
Article
Plant Sciences
Nelson Jeng-Yeou Chear, Francisco Leon, Abhisheak Sharma, Siva Rama Raju Kanumuri, Grant Zwolinski, Khalil A. Abboud, Darshan Singh, Luis F. Restrepo, Avi Patel, Takato Hiranita, Surash Ramanathan, Aidan J. Hampson, Lance R. McMahon, Christopher R. McCurdy
Summary: This study isolated and characterized ten indole and oxindole alkaloids from Malaysian Kratom leaves, and assessed their binding affinity at opioid receptors. Certain oxindole alkaloids showed high binding affinity and greater analgesic efficacy than morphine in rats, indicating their potential therapeutic activity.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Rebeca Perez, Claudia Figueredo, Viviana Burgos, Jaime R. Cabrera-Pardo, Bernd Schmidt, Matthias Heydenreich, Andreas Koch, Jennifer R. Deuis, Irina Vetter, Cristian Paz
Summary: Maqui, a tree native to Chile, is used by the Mapuche people as an anti-inflammatory agent for the treatment of digestive ailments, fever, and skin lesions. Maqui fruits are considered a superfruit with potential health benefits, including antioxidant, cardioprotective, and anti-inflammatory properties. The leaves of maqui contain alkaloids, polyphenols, and terpenes. The alkaloids, aristoteline and hobartine, were found to inhibit Na(V)1.8, a key Na-V isoform involved in pain sensation, suggesting a potential mechanism for the reported analgesic properties of maqui.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Organic
Guanqun Zhan, Fuxin Zhang, Kailing Yang, Tao Yang, Ruixi Zhou, Xueqing Ma, Nan Wang, Zengjun Guo
Summary: A new compound and four known compounds were isolated from Alstonia scholaris. The new compound has a unique carbon skeleton and shows potential anti-inflammatory activity.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Qi-Ming Pan, Yu-Huan Li, Jian-Jun Zhang, Yong Li, Shuang-Gang Ma, Shi-Shan Yu
Summary: In this study, several undescribed monoterpenoid indole alkaloids were isolated from Strychnos cathayensis. (17S)-12-hydroxy-11-methoxydiaboline's absolute configuration was determined for the first time. Some of the isolated alkaloids showed potential analgesic and antiviral activities.
Article
Chemistry, Organic
Jiahang Yan, Yanxia Zhen, Pengyan Wang, Yimeng Han, Huanhuan Zou, Junhan Chen, Weigang He, Weiqing Xie
Summary: In this study, a de novo synthesis of the bisindole alkaloid geissolosimine was accomplished, along with the synthesis of related compounds and the demonstration of an innovative strategy. These findings provide new insights for further research.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Organic
An-Xiang Huang, Hu-Lin Zhu, Fan-Lin Zeng, Xiao-Lan Chen, Xian-Qiang Huang, Ling-Bo Qu, Bing Yu
Summary: 1-Acryloyl-2-cyanoindoles were discovered to be novel and efficient scaffolds in visible-light-induced persulfate-promoted cascade cyclization reactions. With this transition-metal-free photocatalytic procedure, various sulfonated/thiocyanated pyrrolo[1,2-a]indolediones were synthesized from 1-acryloyl-2-cyanoindoles with sulfonyl hydrazides/NH4SCN at room temperature under mild reaction conditions.
Article
Chemistry, Multidisciplinary
Ying-Ying Si, Wei-Wei Wang, Qing-Mei Feng, Zhen-Zhu Zhao, Gui-Min Xue, Yan-Jun Sun, Wei-Sheng Feng, Jun-Im Young, Xian-Shi Wang
Summary: This study isolated new monoterpene indole alkaloid glycosides and phenolic glycoside esters from Gardneria nutans extract, some of which showed significant inhibitory effects on NO production and inflammatory factor expression in microglial cells. Additionally, one compound exhibited stronger cytotoxicity against cancer cell lines than taxol.
Article
Chemistry, Organic
Wei Li, Jie Qiu, Hengyuan Li, Wanli Chen, Cheng Hou, Huaifeng Li
Summary: By utilizing the radical reactivity of neutral diazoacetates, we have developed a method for synthesizing indole compounds, especially valuable [a]-annulated indoles, without the need for transition metals, oxidants, or substrate prefunctionalization. This visible-light-driven transformation is enabled by a single organophotocatalyst, without the use of metals or additives.
Article
Biochemistry & Molecular Biology
Simon Urrea Florian, Beatriz Sepulveda, Alfredo Torres-Benitez, Mario J. Simirgiotis, Marcial Fuentes-Estrada, Carlos Areche, Olimpo Garcia-Beltran
Summary: This study reports the isolation of five alkaloids from the seeds of Erythrina rubrinervia, including four erythrinoid type alkaloids and one indolic alkaloid. The revision of the structure of one alkaloid and the chemotaxonomic significance of these findings in the genus Erythrina are discussed.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Manh Tuan Ha, Phuong Thao Tran, Huynh Nguyen Khanh Tran, Okwha Kim, Jeong Ah Kim, Jeong-Hyung Lee, Byung Sun Min
Summary: The alkaloid fraction of barley grass significantly inhibited osteoclast formation and protected bones. Compound 5 in particular showed strong suppression of osteoclast formation and related signaling pathways, making it a potential candidate for treating osteolytic bone diseases.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Kevin J. Gonzalez, Alexander W. Rand, Brian M. Stoltz
Summary: The Petasis-type reaction is a useful method for C-C bond formation in organic synthesis, but it has been limited by the need for a directing heteroatom. In this study, a non-directed Petasis-type reaction was developed, which allows for the coupling of trifluoroborate salts with alpha-hydroxyindoles. By disrupting aromaticity and using trifluoroborate nucleophiles, a new C-C bond can be generated without a directing group. This reaction is simple and efficient, and it has been applied as a bioconjugation strategy and for the synthesis of non-natural bisindole alkaloid analogs.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Plant Sciences
Elvis Otogo N. Nang, Pierre Le Pogam, Thiery Ndong Mba, Cedric Sima Obiang, Elisabeth Mouray, Philippe Grellier, Brice Kumulungui, Pierre Champy, Mehdi A. Beniddir
Summary: A new sulfur-containing vobasane-type indole alkaloid, hemitheion (1), was isolated from the stems of Mostuea brunonis Didr. (Gelsemiaceae), along with three known compounds. Hemitheion (1) showed moderate antiplasmodial activity and no cytotoxic activity against a specific cell line.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Chenzhe Li, Fengmei Zhang, Dong Gan, Chengyao Wang, Hao Zhou, Tianpeng Yin, Le Cai
Summary: Chemical investigation of the aconite-derived fungus Penicillium expansum WTJP1 led to the isolation of thirteen compounds, including six indole alkaloids (1-6), three quinoline alkaloids (7-9), two cyclopiane diterpenoids (10-11), a chroman derivative (12), and a naphthalenone (13). Among them, three compounds (2-4) were identified for the first time from the genus Penicillium, and six compounds (6, 9-13) have not previously been isolated from the species P. expansum. The chemotaxonomic significance of these compounds was discussed. Some of the isolated compounds showed limited distribution within the Penicillium fungi, which could serve as chemotaxonomic markers to facilitate strain identification of P. expansum. This work enriches the secondary metabolites of P. expansum and provides valuable information for chemotaxonomic studies on the genus Penicillium.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2023)
Article
Chemistry, Physical
Qian Yao, Yansong Zhu, Cheng Zheng, Nana Wang, Dongdong Wang, Fang Tian, Zhongchao Bai, Jian Yang, Yitai Qian, Shixue Dou
Summary: By molecular engineering of the polymer binders and cross-linking treatment, the mechanical properties and electrochemical stability of sodium-ion batteries can be improved, resulting in extended cycle life and enhanced Coulombic efficiency.
ADVANCED ENERGY MATERIALS
(2023)
Article
Chemistry, Applied
Xinxin Song, Chenggang Wang, Dongdong Wang, Huili Peng, Cheng Wang, Chunsheng Wang, Weiliu Fan, Jian Yang, Yitai Qian
Summary: Cu-based cathodes in aqueous batteries have potential advantages but are hindered by serious side reactions caused by the spontaneous formation of Cu2O. In this study, Na2EDTA is introduced to reshape the solvation structure of Cu2+ and modify the electrode/electrolyte interface, reducing the redox potential of Cu2+/Cu2O and inhibiting Cu2O formation. The change in solvation structure also promotes high local concentration and uniform deposition. These findings provide insights for the application of rechargeable Cu-based batteries.
JOURNAL OF ENERGY CHEMISTRY
(2023)
Article
Chemistry, Physical
Jingjing Dong, Huili Peng, Jing Wang, Chenggang Wang, Dongdong Wang, Nana Wang, Weiliu Fan, Xuchuan Jiang, Jian Yang, Yitai Qian
Summary: In order to address the issues of severe electrolyte corrosion and dendrite growth in aqueous batteries, the electrolyte/Zn interface needs to be engineered. A new method of coating a dense and robust layer of polysilane functionalized by -NH2 on Zn has been developed. This layer provides alkalinity and interaction with Zn2+, enhancing hydrolysis and regulating Zn2+ flux. The results show superior mechanical property, suppressed side reactions, and uniform plating/stripping, leading to excellent electrochemical performance in both symmetrical and asymmetrical cells, even under high loading of MnO2 and limited electrolyte conditions.
ENERGY STORAGE MATERIALS
(2023)
Article
Plant Sciences
Biyun Sun, Dongdong Wang, Jinwei Ren, Chaojie Wang, Pengcheng Yan, Kirk R. Gustafson, Wei Jiang
Summary: Seven new eremophilane sesquiterpenoids, paraconulones A-G (1-7), were isolated from the EtOAc extract of the marine-derived fungus Paraconiothyrium sporulosum DL-16, along with three previously reported analogues. The structures of these compounds were elucidated through various techniques. Compounds 2-5, 7, and 10 exhibited inhibitory effects on NO production in BV2 cells, comparable to the positive control curcumin.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Xiaxia Di, Ingibjorg Hardardottir, Jona Freysdottir, Dongdong Wang, Kirk R. Gustafson, Sesselja Omarsdottir, Tadeusz F. Molinski
Summary: A new bromoindole alkaloid, Geobarrettin D (1), was isolated from the marine sponge Geodia barretti collected from Icelandic waters. Its structure was determined using NMR and HRESIMS data. Geobarrettin D (1) is a novel 6-bromoindole with an unusual purinium herbipoline moiety. It showed anti-inflammatory activity by reducing secretion of the pro-inflammatory cytokine IL-12p40 by human monocyte derived dendritic cells while not affecting secretion of the anti-inflammatory cytokine IL-10.
Article
Chemistry, Applied
Feifei Zhang, Yinlong Zhu, Yijun Zhong, Jing Zou, Yu Chen, Lianhai Zu, Zhouyou Wang, Jack Jon Hinsch, Yun Wang, Lian Zhang, Zongping Shao, Huanting Wang
Summary: This study enhances the ORR performance of Fe-N-C catalyst by integrating Fe2O3, achieving excellent activity, durability, and good methanol tolerance. By using M-Fe2O3/FeSA@NC catalyst in a zinc-air battery assembly, a peak power density of 155 mW cm-2 and specific capacity of 762 mA h gZn-1 were achieved, with superior cycling stability over 200 h. The introduction of Fe2O3 alters the crystal field and electron distribution on single Fe atoms, breaking the symmetric charge distribution and optimizing the adsorption energy of intermediates for O2 reduction.
JOURNAL OF ENERGY CHEMISTRY
(2023)
Article
Neurosciences
Juanning Si, Yi Yang, Long Xu, Tianshuai Xu, Hao Liu, Yujin Zhang, Rixing Jing, Jinglian Li, Dongdong Wang, Sijin Wu, Jianghong He
Summary: Accurate evaluation of consciousness for patients with prolonged disorders of consciousness (DOC) is crucial. This study used fNIRS to evaluate residual awareness in patients with DOC and investigated the differences in hemodynamic responses between the MCS and UWS groups. The results showed that the fNIRS-based command-driven MI tasks can be used as a promising tool for detecting residual awareness in patients with DOC.
Article
Nanoscience & Nanotechnology
Yun Wang, Oscar J. Allen, Jian Kang
Summary: With increasing energy demands, nanoscale group VA monolayers have been proven to be promising passivator candidates, despite limitations in their commercial applications due to defect formation and instability.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Applied
Dan Lv, Huili Peng, Cheng Wang, Hongxia Liu, Dongdong Wang, Jian Yang, Yitai Qian
Summary: This study proposes a method for screening metal coatings on zinc anodes based on theoretical evaluation of depolarization effect and dendrite suppression. Experimental results show that cadmium (Cd) coating on zinc anodes exhibits an ultra-long cycle life and high cumulative capacity at high current density. This work not only presents the first report of Cd coating for stabilizing zinc anodes, but also provides a feasible way to screen promising metal materials for other metal anodes.
JOURNAL OF ENERGY CHEMISTRY
(2023)
Article
Chemistry, Physical
Yuan Li, Xinyao Wang, Hong Wang, Xiaoyao Tan, Dan Liu, Jianzhou Gui, Jian Gao, Zhen Yin, Na Ma, Yun Wang
Summary: Metal-air batteries rely on the slow oxygen reduction reaction (ORR) for their operation. The high cost and limited availability of Pt-based catalysts required for ORR have led to the development of metal-free catalysts. This study utilized sugar, melamine, and a polymerizable ionic liquid to prepare heteroatom-doped carbons with desired composition and structure, which exhibited comparable performance to a commercial Pt/C catalyst in terms of onset potential, half-wave potential, and stability. The synthesized carbon catalyst was successfully applied in a Zn-air battery, achieving a high power density of 90 mW cm(-2).
Article
Electrochemistry
Xin Wang, Seokgyun Ham, Hongwei Zhang, Yun Wang, Rui Qiao
Summary: This study investigates the adsorption behavior of perfluorooctanoic acid (PFOA), a model PFAS molecule, on gold substrates using simulations. The results show that PFOA molecules can adsorb on neutral gold surfaces with the lowest free energy in a co-planar orientation, indicating strong enrichment of PFOA near the electrode. Van der Waals interactions between PFOA and gold are the primary driving force for adsorption, while entropic effects associated with interfacial water molecules are the secondary driving force. These findings have important implications for the electrochemical detection and analysis of PFAS molecules.
Article
Chemistry, Physical
Chongyan Hao, Xiaoning Li, Haoliang Huang, Liangbing Ge, Zhengping Fu, Yalin Lu, Yun Wang, Shujun Zhang, Zhenxiang Cheng
Summary: It was found that only tetrahedral (Td) sites are highly active in Co2Mo3O8 while the octahedral (Oh) sites are activated by introducing Fe. The dual activation of different sites improves the efficiency of the oxygen evolution reaction (OER) and the unique structure increases the number of active sites, produces synergistic effects, optimizes the adsorption of intermediates, and creates an unobstructed spin channel for electron transfer.
ACS ENERGY LETTERS
(2023)
Article
Energy & Fuels
Nanjun Lai, Dongdong Wang, Junqi Wang, Lei Tang
Summary: Polymer gels have been used in Enhanced Oil Recovery for many years, but there is a lack of methods for tracing and positioning them within the layers. Traditional tracers are affected by the differences in size, potential, and viscosity with polymer gels, resulting in variations between monitoring results and actual movement. By synthesizing fluorescent components with polymer gels, driving and tracking can be integrated, acting as a tracer while flooding. The stability of fluorescent CQDs@PPG has been tested under reservoir conditions, showing unaffected fluorescence peak value and promising performance in a specific reservoir condition.
CHEMISTRY AND TECHNOLOGY OF FUELS AND OILS
(2023)
Article
Electrochemistry
Qiang Yuan, Bo Li, Yu Liu, Qingxin Li, Yang Zhang, Dongdong Wang, Hewei Wang, Wei Li, Jichen Dong, Xintao Bai, Yonghui Xing, Mengqi Zhang, Yaxu Zhao
Summary: In this study, an engineering strategy was proposed to enhance the performance of thermal batteries by constructing a NiCl2 cathode with a specific structure and improved electrochemical activity. The cathode successfully increased the plateau voltage and specific energy of the battery, and it is industrially feasible. This study provides new insight into the design of high-performance cathodes.
ELECTROCHIMICA ACTA
(2023)
Article
Engineering, Multidisciplinary
Zeng Lin, Fawang Liu, Junchao Wu, Dongdong Wang, Yuantong Gu
Summary: In this work, a meshfree technique is used to analyze the time-Caputo and space-Laplacian fractional diffusion equations in three dimensions. The proposed method employs the stabilized conforming nodal integration and lumped mass matrix techniques to increase computational efficiency. The spatial discretization is achieved using a three-dimensional reproducing kernel particle method. Numerical examples demonstrate the accuracy and effectiveness of the proposed method.
ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS
(2023)
