Journal
JOURNAL OF NATURAL PRODUCTS
Volume 80, Issue 12, Pages 3081-3093Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.6b00921
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Funding
- National Natural Science Foundation of China [U1403102, 81473330, 81673323, U1603125]
- Shenyang Science and Technology Research Project [F15-199-1-26]
- Research Project for Key Laboratory of Liaoning Educational Committee [LZ2015067]
- Natural Science Foundation of Liaoning Province [2015020732]
- Innovation Team Project of Liaoning Province [LT2015027]
- project of the State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources [CMEMR2017-B03]
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Twenty compounds, including 14 new a-acid derivatives, a new chromone, and five known compounds, were identified from the pistillate inflorescence of Humulus lupulus (hops), and their structures were elucidated via physical data analysis. The absolute configurations of new a-acid derivatives 1-11b were determined by comparing their computed and experimental electronic circular dichroism spectra using TDDFT and NMR spectroscopic data. A putative biosynthetic pathway for the identified components was deduced. Their antineuroinflammatory effects were assayed systematically, and their structure-activity relationships are discussed briefly. Among the identified compounds, compound 14 displayed moderate inhibitory effects against nitric oxide production with an IC50 value of 7.92 mu M.
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