Article
Plant Sciences
Sheng-Tao Fang, Xiang-Hong Liu, Bing-Fei Yan, Feng-Ping Miao, Xiu-Li Yin, Wen-Zuo Li, Nai-Yun Ji
Summary: Novel terpenoids were isolated from the culture of a fungus derived from a red alga, showing inhibitory activities against microalgae.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Biotechnology & Applied Microbiology
Seto Windarto, Meng-Chou Lee, Happy Nursyam, Jue-Liang Hsu
Summary: ACE inhibitors generated from food proteins, such as the bioactive peptide VL-9 derived from the red alga Acrochaetium sp., have gained attention as potential alternatives to natural bioactive food components and synthetic drugs. VL-9 exhibited ACE inhibitory activity and was identified as a non-competitive inhibitor through molecular docking simulation. This discovery highlights the potential of Acrochaetium sp. as a source for developing functional foods targeting hypertension.
MARINE BIOTECHNOLOGY
(2022)
Article
Chemistry, Organic
Ke Xu, Ruijuan Li, Rongxiu Zhu, Xiaobin Li, Yuliang Xu, Qiaobian He, Fei Xie, Yanan Qiao, Xiaoyi Luan, Hongxiang Lou
Summary: Two pairs of diastereoisomeric isoindoline alkaloids, xylarins A-D, were isolated from the endolichenic fungus Xylaria sp. Their structures and biological activities were determined, with compound 1 showing significant anti-thrombotic activity.
Article
Chemistry, Medicinal
You-Jia Hao, Zheng-Biao Zou, Ming-Min Xie, Yong Zhang, Lin Xu, Hao-Yu Yu, Hua-Bin Ma, Xian-Wen Yang
Summary: Two new xanthones (1 and 2) were isolated from deep-sea-derived fungus Penicillium sp. MCCC 3A00126, along with 34 known compounds (3-36). The structures of the new compounds were determined using spectroscopic data. The absolute configuration of compound 1 was confirmed by comparing experimental and calculated ECD spectra. Cytotoxicity and ferroptosis inhibitory activities of all isolated compounds were evaluated. Compounds 14 and 15 showed potent cytotoxicity against CCRF-CEM cells, with IC50 values of 5.5 and 3.5 μM, respectively. Compounds 26, 28, 33, and 34 exhibited significant inhibitory effects on RSL3-induced ferroptosis, with EC50 values of 11.6, 7.2, 11.8, and 2.2 μM, respectively.
Article
Chemistry, Medicinal
Sheng-Tao Fang, Zhen-Zhen Shi, Yin-Ping Song, Xiu-Li Yin, Nai-Yun Ji
Summary: Further investigation of secondary metabolites from a marine-alga-derived fungus led to the discovery of new compounds with inhibitory effects on marine harmful microalgae.
Article
Biochemistry & Molecular Biology
Xin Qi, Weihao Chen, Liurong Chen, Yiwei Hu, Xueni Wang, Wenrong Han, Jiao Xiao, Xiaoyan Pang, Xingang Yao, Shuwen Liu, Yong Li, Jie Yang, Junfeng Wang, Yonghong Liu
Summary: Guided by Global Natural Products Social molecular networking, 14 new p-terphenyl derivatives, asperterphenyls A-N (1-14), together with 20 known p-terphenyl derivatives (15-34), were obtained from a sponge derived fungus Aspergillus sp. SCSIO41315. Among them, new compounds 2-8 and 15-17 were ten pairs of enantiomers. Comprehensive methods such as chiral-phase HPLC analysis, ECD calculations and X-ray diffraction analysis were applied to determine the absolute configurations. Asperterphenyls B (2) and C (3) represented the first reported natural p-terphenyl derivatives possessing a dicarboxylic acid system. Asperterphenyl A (1) displayed neuraminidase inhibitory activity with an IC50 value of 1.77 +/- 0.53 mu M and could efficiently inhibit infection of multiple strains of H1N1 with IC50 values from 0.67 +/- 0.28 to 1.48 +/- 0.60 mu M through decreasing viral plaque formation in a dose-dependent manner, which suggested that asperterphenyl A (1) might be exploited as a potential antiviral compound in the pharmaceutical fields.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Hui-Chun Wang, Tzu-Yi Ke, Ya-Chen Ko, Jue-Jun Lin, Jui-Sheng Chang, Yuan-Bin Cheng
Summary: The study discovered a new medical entity from edible marine algae through continuous natural product investigation, focusing on endophytes from marine macroalgae. Two new azaphilones were isolated from alga-derived fungus Penicillium sclerotiorum, along with five known azaphilones. The compounds showed bioactivity in cytotoxic, anti-inflammatory, and anti-fibrosis activities.
Article
Microbiology
Virayu Suthiphasilp, Achara Raksat, Tharakorn Maneerat, Sarinya Hadsadee, Siriporn Jungsuttiwong, Stephen G. Pyne, Putarak Chomnunti, Wuttichai Jaidee, Rawiwan Charoensup, Surat Laphookhieo
Summary: Chemical investigation of the mycelia of the pathogenic fungus Curvularia sp. isolated from Dactyloctenium aegyptium revealed a new compound, curvulariahawadride (5), along with five known compounds. Compounds 1, 3, and 5 showed inhibitory activity towards nitric oxide production, while compounds 2 and 4 exhibited significant cytotoxicity against lung cancer, colorectal cancer, and leukemia cells.
Article
Chemistry, Medicinal
Ying Wang, Xiao-Ming Li, Sui-Qun Yang, Fan-Zhong Zhang, Bin-Gui Wang, Hong-Lei Li, Ling-Hong Meng
Summary: In this study, an endophytic fungus was isolated from a marine red alga and three novel compounds were identified from its culture extract. The structure of one compound was elucidated in detail, and the antimicrobial activities of all compounds were evaluated.
Article
Chemistry, Medicinal
Chunmei Chen, Xue Ren, Huaming Tao, Wenteng Cai, Yuchi Chen, Xiaowei Luo, Peng Guo, Yonghong Liu
Summary: A new linear polyketide named aspormisin A, along with five known polyketides, was isolated from the alga-derived fungus Aspergillus ochraceopetaliformis SCSIO 41020. The structures of these compounds were determined and their anti-inflammatory activities were evaluated. Compound 2 showed promising inhibitory effects on the release of pro-inflammatory cytokines both in vitro and in vivo. These findings provide a basis for the further development of linear polyketides as potential anti-inflammatory agents.
Article
Microbiology
Zhuang Li, Lu Meng, Qingyun Ma, Zhen Wang, Youxing Zhao, Duqiang Luo
Summary: In this study, five new polyketides were isolated from a desert-plant-derived fungus and two of them were found to have unprecedented structural cores. Furthermore, compounds 1, 2, and 4 exhibited inhibitory activities against IDH1 R132h, while seven compounds showed potent inhibitory activity against PTP1B.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Neak Muhammad, Ho Le Han, Yong -Jae Lee, Jaeho Ko, Tra T. H. Nguyen, Song-Gun Kim
Summary: A Gram-stain-negative, rod-shaped bacterial strain WSW3-B6T was isolated from red alga samples collected from the West Sea, Republic of Korea. This strain, belonging to the genus Flavobacterium, has distinct physiological and genetic characteristics, and represents a novel species within the Flavobacterium genus.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Shun-Zhi Liu, Guang-Xin Xu, Feng-Ming He, Wei-Bo Zhang, Zhen Wu, Ming-Yu Li, Xi-Xiang Tang, Ying-Kun Qiu
Summary: In this study, several sorbicillinoid derivatives with potent inhibitory activity against tea-pathogenic fungus were isolated from the fungal strain Hypocrea jecorina H8. These compounds displayed low toxicity and high potential as antifungal agents.
Article
Biochemistry & Molecular Biology
Fei Zhang, Li Yang, Qing-Yi Xie, Jiao-Cen Guo, Qing-Yun Ma, Lu-Ting Dai, Li-Man Zhou, Hao-Fu Dai, Fan-Dong Kong, Du-Qiang Luo, You-Xing Zhao
Summary: Eight previously undescribed indole-diterpenoids were isolated from the marine soft coral-derived fungus Aspergillus sp. ZF-104, along with seven known analogues. Their structures and absolute configurations were determined through spectroscopic data, ECD analysis, and quantum ECD and NMR calculations. Several of these compounds showed comparable protein tyrosine phosphatase 1B inhibitory activity to the positive control.
Article
Plant Sciences
Marcelo R. de Amorim, Camila de S. Barbosa, Tiago A. Paz, Laura P. Ioca, Karen J. Nicacio, Lucianne F. P. de Oliveira, Mirian O. Goulart, Julia M. Paulino, Mateus O. da Cruz, Antonio G. Ferreira, Maysa Furlan, Simone P. de Lira, Raquel A. dos Santos, Andre Rodrigues, Rafael V. C. Guido, Roberto G. S. Berlinck
Summary: Bioassay-guided investigation of the EtOAc-soluble extract of a culture of the marine-derived fungus Peroneutypa sp.M16 led to the discovery of seven new polyketide- and terpenoid-derived metabolites (1, 2, 4-8), alongside known polyketides (3, 9-13). The structures of compounds 1, 2, and 4-8 were determined through analysis of spectroscopic data, while the absolute configurations of compounds 1, 2, 4, 6, 7, and 8 were determined by comparing experimental ECD spectra with calculated CD data. Compound 5 exhibited moderate antiplasmodial activity against both chloroquine-sensitive and -resistant strains of Plasmodium falciparum.
JOURNAL OF NATURAL PRODUCTS
(2023)
Review
Plant Sciences
E. B. Gareth Jones, Ka-Lai Pang
Summary: The sand dunes of Gronhoj, Jutland, Denmark, introduced by Jorgen Koch, is a unique habitat for marine fungi. The high diversity of marine fungi obtained from this site has provided valuable resources for various research areas in marine mycology. A list of 102 species of marine fungi documented for Denmark is also provided in this review.
Article
Biochemistry & Molecular Biology
Yu-Hsuan Kuo, Yi-Xuan Wang, Wan-Hua Peng, Nian-Yu Chi, Tzong-Huei Lee, Chi-Chung Wang
Summary: Lung cancer is a leading cause of cancer-related deaths globally, and in Taiwan, lung adenocarcinoma is the most common form. Current lung cancer therapies have limited clinical outcomes, necessitating the search for new pharmaceutical compounds. In this study, researchers discovered that coriloxin, derived from fungal metabolites, efficiently inhibits the proliferation, migration, and clonogenic abilities of lung adenocarcinoma cells. These effects are achieved through ERK/AKT inactivation, regulation of epithelial-mesenchymal transition, and HLJ1 expression. The findings suggest that coriloxin may be a promising multitarget anticancer agent, potentially serving as an adjuvant therapy in lung cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Multidisciplinary
Yuh-Hwa Liu, Yeh-Lin Lu, Ya-Chih Chang, Jong-Ho Chyuan, Tzong-Huei Lee, Wen-Chi Hou
Summary: This study found that two compounds isolated from wild bitter gourd have anti-adipogenic activities, reducing lipid accumulation and showing higher toxicity towards differentiated adipocytes. These compounds are commonly found in other vegetables or edible seaweeds, providing potential resources for further research on their anti-obesity effects.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Biochemistry & Molecular Biology
Jih-Jung Chen, Tzong-Huei Lee, Ming-Jen Cheng
Summary: Five new compounds and one known compound were isolated from the solid cultures of Herbidospora daliensis from Taiwan. Their structures were determined through spectroscopic analyses, and their anti-inflammatory activities were evaluated.
Article
Biochemistry & Molecular Biology
Jih-Jung Chen, Ming-Jen Cheng, Tzong-Huei Lee, Yueh-Hsiung Kuo, Chao-Tsen Lu
Summary: The genus Cimicifuga, one of the smallest genera in the Ranunculaceae family, has been used in Chinese traditional medicine as anti-inflammatory, analgesic, and antipyretic remedies. Phytochemical investigation of Cimicifuga taiwanensis roots led to the isolation of six new compounds with potent anti-inflammatory activity.
Article
Microbiology
E. B. Gareth Jones, Sundari Ramakrishna, Sabaratnam Vikineswary, Diptosh Das, Ali H. Bahkali, Sheng-Yu Guo, Ka-Lai Pang
Summary: This review explores the response mechanisms of marine fungi and fungal-like organisms to salinity variations, and reveals that marine fungi have a greater capacity to adapt to higher salinities compared to terrestrial and freshwater fungi. They require a range of physiological and genetic characteristics to respond to the challenges brought by climate change.
Correction
Biochemistry & Molecular Biology
Jih-Jung Chen, Ming-Jen Cheng, Tzong-Huei Lee, Yueh-Hsiung Kuo, Chao-Tsen Lu
Article
Agriculture, Multidisciplinary
Ho-Cheng Wu, Hsiao-Yang His, George Hsiao, Chia-Hung Yen, Jyh-Yih Leu, Chin-Chung Wu, Szu-Hsing Chang, Shu-Jung Huang, Tzong-Huei Lee
Summary: This study examined the phytochemical and pharmacological properties of corn galls and the fermentate of Ustilago maydis MZ496986. It identified six new chemical entities and 17 known components. Compounds 3, 5, and 9 showed potent inhibitory activities against nitric oxide production, and compound 9 also attenuated NF-KB activation. Ustilagol G exhibited potent antiplatelet aggregation. These findings suggest that corn galls and Ustilago maydis MZ496986 fermentate have potential as functional foods for improving inflammation-related discomforts and vascular obstruction.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Plant Sciences
Chia-Hao Chang, Yi-Chieh Lee, George Hsiao, Li-Kwan Chang, Wei-Chiung Chi, Yuan-Chung Cheng, Shu-Jung Huang, Tai-Chou Wang, Yi-Shan Lu, Tzong-Huei Lee
Summary: This study investigated the liquid-state fermented products produced by the fungal strain Alternaria alstroemeriae Km2286 isolated from the medicinal herb Atriplex maximowicziana Makino. Chromatographic separation resulted in the isolation of compounds 1-9, including four undescribed perylenequinones. Compound 1-6 exhibited antiviral activities against Epstein-Barr virus and compounds 1-4, 6, and 7 showed inhibitory activity of nitric oxide production in lipopolysaccharide-induced microglial BV-2 cells without significant cytotoxicity. This is the first report of perylenequinone-type compounds with potent anti-EBV and anti-neuroinflammatory activities.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Hsiao-Yang Hsi, Shih-Wei Wang, Chia-Hsiung Cheng, Ka-Lai Pang, Jyh-Yih Leu, Szu-Hsing Chang, Yen-Tung Lee, Yueh-Hsiung Kuo, Chia-Ying Huang, Tzong-Huei Lee
Summary: In this study, a fungal strain Penicillium sumatraense SC29 isolated from the marine brown alga Sargassum cristaefolium was identified, and six compounds were isolated from its liquid fermented products. Among them, penisterine D (4) showed anti-angiogenic activity without cytotoxic effects. This makes it a promising candidate for further preclinical investigation.
Article
Plant Sciences
Ka-Lai Pang, I-An Chen, Michael Wai-Lun Chiang, Ami Shaumi, Sung-Yuan Hsieh, Sheng-Yu Guo
Summary: This study explored the morphological diversity of arenicolous marine fungi at 11 sandy beaches in Taiwan. Phylogenetic analysis revealed four previously unknown clades of Corollospora spp., with differences in ascospore morphology. A total of 13 species of arenicolous marine fungi were identified, with Taan Beach having the highest species richness and diversity.
Review
Plant Sciences
Mark S. Calabon, E. B. Gareth Jones, Ka-Lai Pang, Mohamed A. Abdel-Wahab, Jing Jin, Bandarupalli Devadatha, Resurreccion B. Sadaba, Carlo Chris Apurillo, Kevin D. D. Hyde
Summary: This article revises the diversity of known marine fungi, presenting new species and taxonomic changes. A total of 1898 species from nine phyla, 33 classes, 107 orders, 273 families, 767 genera are documented. The first marine member of Aphelidiomycota, Pseudaphelidium drebesii, is reported, along with additions to the Mortierellomycota phylum and six subclasses. The checklist also includes 641 new species in 228 genera, with four new combinations proposed.
Article
Agriculture, Multidisciplinary
Sheng-Chia Chen, Bo-Chen Jiang, Yen-Ju Lu, Chia-Hao Chang, Tsung-Han Wu, Sheng-Wei Lin, Hua-Wen Yin, Tzong-Huei Lee, Chun-Hua Hsu
Summary: Antrodia cinnamomea is a medicinal plant found only in Taiwan, with various health benefits such as treating inflammation, diarrhea, and abdominal pain. It contains terpenoids that have multiple bioactivities, making them potential food additives.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Plant Sciences
Ho-Cheng Wu, Lung-Lin Shiu, Shih-Wei Wang, Chia-Ying Huang, Tzong-Huei Lee, Ping-Jyun Sung, Yueh-Hsiung Kuo
Summary: This study investigated the chemical profiles and anti-lymphangiogenic activity of Juniperus chinensis var. tsukusiensis, a type of Taiwan juniper. Several new compounds were successfully isolated and evaluated for their anti-lymphangiogenic effects in human lymphatic endothelial cells. The results showed that one compound, totarolone, displayed the most potent anti-lymphangiogenic activity. These findings suggest the promising potential of Juniperus chinensis var. tsukusiensis in developing therapeutics targeting tumor lymphangiogenesis.
Article
Plant Sciences
Chia-Hao Chang, George Hsiao, Shih-Wei Wang, Juei-Yu Yen, Shu-Jung Huang, Wei-Chiung Chi, Tzong-Huei Lee
Summary: This study isolated and identified three previously unreported compounds and eleven known compounds from the fermented products of Chaetomium globosum Km1226 isolated from Atriplex maximowicziana Makino. Mollipilin A (5) and chaetoglobosin D (10) showed potential as lead drugs for anti-inflammatory and anti-angiogenic purposes.