Respiratory muscle contractile inactivity induced by mechanical ventilation in piglets leads to leaky ryanodine receptors and diaphragm weakness

Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical ventilation

(2016) Stefan Matecki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical Stretch-Induced Activation of ROS/RNS Signaling in Striated Muscle

(2013) Christopher W. Ward et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Dysfunction and Lipid Accumulation in the Human Diaphragm during Mechanical Ventilation

(2012) Martin Picard et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Ryanodine Receptor Oxidation Causes Intracellular Calcium Leak and Muscle Weakness in Aging

(2011) Daniel C. Andersson et al.   Cell Metabolism

Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: underlying mechanisms

(2011) Julien Ochala et al.   JOURNAL OF PHYSIOLOGY-LONDON

Diaphragm Muscle Weakness in an Experimental Porcine Intensive Care Unit Model

(2011) Julien Ochala et al.   PLoS One

Rapidly Progressive Diaphragmatic Weakness and Injury during Mechanical Ventilation in Humans

(2010) Samir Jaber et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Adaptive Support Ventilation Prevents Ventilator-induced Diaphragmatic Dysfunction in Piglet

(2010) Boris Jung et al.   ANESTHESIOLOGY

Prolonged mechanical ventilation alters diaphragmatic structure and function

(2010) Scott K. Powers et al.   CRITICAL CARE MEDICINE

Alteration of the Piglet Diaphragm Contractility In Vivo and Its Recovery after Acute Hypercapnia

(2009) Samir Jaber et al.   ANESTHESIOLOGY

Apocynin attenuates diaphragm oxidative stress and protease activation during prolonged mechanical ventilation

(2009) Joseph M. McClung et al.   CRITICAL CARE MEDICINE

Mechanical ventilation induces diaphragmatic mitochondrial dysfunction and increased oxidant production

(2009) Andreas N. Kavazis et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of the respiratory muscles in acute respiratory failure of COPD: lessons from weaning failure

(2009) Martin J. Tobin et al.   JOURNAL OF APPLIED PHYSIOLOGY

Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle

(2009) Andrew M Bellinger et al.   NATURE MEDICINE

Sympathetic Overstimulation During Critical Illness: Adverse Effects of Adrenergic Stress

(2009) Martin W. Dünser et al.   JOURNAL OF INTENSIVE CARE MEDICINE

Rapid Disuse Atrophy of Diaphragm Fibers in Mechanically Ventilated Humans

(2008) Sanford Levine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Remodeling of ryanodine receptor complex causes "leaky" channels: A molecular mechanism for decreased exercise capacity

(2008) A. M. Bellinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of Mechanical Ventilation in Response to Clinical Research

(2007) Andrés Esteban et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE