Article
Biochemistry & Molecular Biology
Jana Radosinska, Tomas Jasenovec, Dominika Radosinska, Peter Balis, Angelika Puzserova, Martin Skratek, Jan Manka, Iveta Bernatova
Summary: USPIONs administration improved erythrocyte deformability and nitric oxide production in normotensive rats but not in hypertensive rats. Hypertensive rats showed significantly lower levels of USPION-originated iron in erythrocytes and faster elimination of USPIONs compared to normotensive rats.
Article
Biochemistry & Molecular Biology
Neha Tyagi, Priya Gupta, Zafar Khan, Yub Raj Neupane, Bharti Mangla, Nikita Mehra, Tanya Ralli, Abdulsalam Alhalmi, Asgar Ali, Omkulthom Al Kamaly, Asmaa Saleh, Fahd A. Nasr, Kanchan Kohli
Summary: In this study, superparamagnetic iron-oxide nanoparticles were synthesized using green chemistry and coated with tamoxifen-conjugated bovine serum albumin. The nanoparticles showed suitable size, poly dispersity index and zeta potential. They exhibited superparamagnetic properties for therapeutic and diagnostic applications, effectively inhibited the proliferation of breast cancer cells, and were found to be safe for use in drug delivery systems according to acute toxicity study in rats.
Article
Chemistry, Physical
K. Gjorgjevikj, M. Bukleski, S. Dimitrovska-Lazova, S. Aleksovska
Summary: The interesting properties of perovskite materials, especially the organic-inorganic ones, are a result of their structural characteristics. Vibrational spectroscopy and X-ray powder diffraction were used to analyze several inorganic and organic-inorganic lead iodide perovskites, revealing differences in their Raman spectra based on their dimensionality. The bands below 200 cm-1 in the Raman spectra can be correlated to the octahedral connectivity of the PbI6 anions, influencing the dimensionality of the perovskites. Therefore, Raman spectroscopy can be used for fast and reliable identification of octahedral connectivity.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Review
Nanoscience & Nanotechnology
Hao Wei, Yangnan Hu, Junguo Wang, Xia Gao, Xiaoyun Qian, Mingliang Tang
Summary: Superparamagnetic iron oxide nanoparticles (SPIONs) are extensively studied and utilized in biomedicine due to their superb superparamagnetic properties and reliable traceability. However, different SPIONs exhibit variations in cytotoxicity, metabolism, and cellular behaviors. A comprehensive review of the construction and application of SPIONs is necessary to address these differences.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Green & Sustainable Science & Technology
Rajiv Periakaruppan, Xuan Chen, Kuberan Thangaraj, Anburaj Jeyaraj, Hoang Ha Nguyen, Ying Yu, Shunkai Hu, Li Lu, Xinghui Li
Summary: In this study, superparamagnetic biogenic iron oxide nanoparticles (SPBIONs) were successfully synthesized using an eco-friendly and low toxic approach with aqueous extract of tea-pruning waste as the reducing agent under alkaline conditions. The SPBIONs exhibited stable surface charge, average crystallite size of 20-35 nm, and high saturation magnetization value of 11 emu/g. Furthermore, the SPBIONs showed antioxidant properties by neutralizing the generation of free radicals and oxidative stress.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Multidisciplinary Sciences
Ali A. Mohammed, Jingqi Miao, Ieva Ragaisyte, Alexandra E. Porter, Connor W. Myant, Alessandra Pinna
Summary: Magnetic-stimuli responsive hydrogels show great potential in various fields such as biomedical devices, soft robotic actuators, and wearable electronics. By optimizing the method, superparamagnetic iron oxide nanoparticles were successfully infused into a photo-resin to create 3D printed starfish hydrogels with high mechanical stability and shape deformation control. These hydrogels can be actuated and regain their original shape through the application and removal of a remote magnetic field.
Article
Materials Science, Ceramics
Jae Won Lee, Do Kyung Kim
Summary: Monodispersed magnetic nanoparticles with high stability and biocompatibility were synthesized successfully, avoiding agglomeration of nanoparticles due to their magnetic force. A stepwise process for carboxymethyl activated cross-linked superparamagnetic iron oxide nanoparticles was developed, showing no significant adverse effects on cells. These findings suggest the potential biomedical applications of the developed CM-CL-SPIONs as versatile nanocarriers.
JOURNAL OF THE KOREAN CERAMIC SOCIETY
(2021)
Article
Biotechnology & Applied Microbiology
Mennatallah A. Gowayed, Lamiaa M. A. Ali, Maher A. Kamel, Ghaleb A. Oriquat, Rafael Pinol, Angel Millan, Rasha A. El-Tahan
Summary: In this study, the antidiabetic effect of superparamagnetic iron oxide nanoparticles (SPIONs)-PEG-550 was explored. It was found that SPIONs-PEG-550 could normalize glucose homeostasis, reverse insulin resistance, and improve abnormal expression of downstream effectors of the insulin signaling and WNT pathway in both muscle and kidney tissues. Histological examination also showed no significant adverse effects on kidney function.
Article
Multidisciplinary Sciences
Natalia Janik-Olchawa, Agnieszka Drozdz, Damian Ryszawy, Maciej Pudelek, Karolina Planeta, Zuzanna Setkowicz, Maciej Sniegocki, Magdalena Wytrwal-Sarna, Marta Gajewska, Joanna Chwiej
Summary: This study compared the impact of PEG-coated magnetite nanoparticles with different core sizes on six selected cell lines. It was found that exposure to these nanoparticles led to decreased cell viability, which was dependent on exposure time rather than core diameter. The nanoparticles not only increased the proliferation rate of macrophages but also stimulated tumor cell divisions. Additionally, the smallest nanoparticles mainly induced an increase in ROS levels in cells.
SCIENTIFIC REPORTS
(2021)
Article
Geochemistry & Geophysics
Nicolas Hoffmann, Gonzalo Tortella, Edward Hermosilla, Paola Fincheira, M. Cristina Diez, Isabella M. Lourenco, Amedea B. Seabra, Olga Rubilar
Summary: This study compares the toxicity of superparamagnetic iron oxide nanoparticles synthesized by biogenic and chemical routes. The experimental results demonstrate the different effects of these nanoparticles on aquatic organisms and plants.
Article
Immunology
Felix Pfister, Jan Doerrie, Niels Schaft, Vera Buchele, Harald Unterweger, Lucas R. Carnell, Patrick Schreier, Rene Stein, Marketa Kubankova, Jochen Guck, Holger Hackstein, Christoph Alexiou, Christina Janko
Summary: The influence of superparamagnetic iron oxide nanoparticles (SPIONs) on primary human T cells and their potential for magnetically targeted adoptive T cell therapy were investigated in this study. Results showed that SPION-loading did not affect the mechanics and functionality of T cells, indicating its potential for magnetically enriching T cells in solid tumors.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shigesaburo Ogawa, Isao Takahashi
Summary: In this study, the crystal structures of short-chain n-alkyl beta-D-glucosides (CnG) were investigated. It was found that C4G and C5G formed cubic crystal phases, while C6G formed a modulated lamellar structure, demonstrating the concept of glycolipid motif with a cubic crystal structure.
Article
Multidisciplinary Sciences
Gaesenngwe Gaesenngwe, Tirivaviri Mamvura, Gwiranai Danha, Vusumuzi Sibanda
Summary: This study investigated the comminution behavior of diorite rocks from two quarry locations in Botswana, comparing their structural similarities and mineral compositions. The experimental results showed that these factors significantly affect the cost of production and product application in the quarry industry of Botswana.
Article
Pharmacology & Pharmacy
Katarzyna Trzeciak, Ewelina Wielgus, Slawomir Kazmierski, Tomasz Pawlak, Marek J. Potrzebowski
Summary: The applicability of different solvent-free approaches leading to the amorphization of active pharmaceutical ingredients (APIs) was tested. Ethenzamide (ET) and two ethenzamide cocrystals were used as pharmaceutical models. Three methods (manual physical mixing, melting, and grinding) were used to prepare the samples. The amorphization process was determined using instrumental techniques, and the dissolution profiles showed significant differences for each sample. The nature and mechanism of this distinction were discussed.
Article
Chemistry, Inorganic & Nuclear
Emily L. Arnold, Sarah Gosling, Samantha K. Davies, Hannah L. Cross, Paul Evans, Dean S. Keeble, Charlene Greenwood, Keith D. Rogers
Summary: This study analyzes the local structure of synthetic hydroxyapatite samples using X-ray total scattering, providing a better understanding of its nanocrystalline nature. The results demonstrate a significant relationship between time and temperature during heat treatment, suggesting a process occurring slower than thermal expansion. This research has implications for various sectors, including forensic, biomedical, and clinical settings, particularly in the study of implant coatings and bone diseases.
JOURNAL OF SOLID STATE CHEMISTRY
(2022)
Article
Chemistry, Analytical
Sahraneshin Samani Somayeh, Seyed Mohammad Taghdisi, Sayed Ali Mortazavi, Tabatabaei Yazdi Farideh, Khalil Abnous
Summary: In this study, a novel U-shaped electrochemical biosensor was designed for the detection of Micrococcal nuclease (MNase). The biosensor utilized a gold electrode, thiol-modified oligonucleotide strands and their complementary strand (CS). The presence of MNase resulted in the digestion of the oligonucleotide sequences, allowing the redox agent to access the electrode surface and generate a current peak. The biosensor showed satisfactory results for MNase recognition in spiked milk samples.
Article
Engineering, Environmental
Zahra Sabouri, Mohammad Sabouri, Samaneh Sadat Tabrizi Hafez Moghaddas, Majid Darroudi
Summary: The goal of this study was to synthesize amino-functionalized Fe3O4@SiO2 core-shell magnetic nanoparticles as an efficient photocatalyst for removing organic dyes from water. The core-shell structure of magnetic Fe3O4@SiO2 was obtained through the co-precipitation method using a silica source. The nanoparticles were then functionalized with 3-Aminopropyltriethoxysilane (APTES) via a post-synthesis link. XRD, VSM, FT-IR, FESEM, EDAX, and DLS/Zeta potential analyses were used to characterize the chemical structure, magnetic properties, and shape of the manufactured photocatalyst (Fe3O4@SiO2-NH2). The nanoparticles showed high photocatalytic activity for MB degradation, with a degradation performance of approximately 90% under optimum conditions. Furthermore, the cytotoxicity of the nanoparticles was evaluated on CT-26 cells, and they exhibited potential for inhibiting cancer cell growth.
JOURNAL OF ENVIRONMENTAL HEALTH SCIENCE AND ENGINEERING
(2023)
Article
Materials Science, Ceramics
Zahra Sabouri, Reza Kazemi Oskuee, Sajjad Sabouri, Samaneh Sadat Tabrizi Hafez Moghaddas, Saeed Samarghandian, Hadi Sajid Abdulabbas, Majid Darroudi
Summary: Ag-doped ZnO-MgO-CaO nanocomposite (NCPs) was successfully synthesized using Ocimum Basilicum L seeds extract, demonstrating a green and efficient method. The NCPs showed a crystalline nature with an average size of 40 nm, as confirmed by XRD analysis. The triangular-shaped NCPs with a size of 59 nm displayed a dye degradation percentage of 93% for methylene blue (MB) dye under UV light. The cytotoxicity evaluation revealed IC50 values of approximately 250 and 500 μg/mL for cancer HeLa cells at 48 and 72 hours, respectively.
CERAMICS INTERNATIONAL
(2023)
Article
Chemistry, Analytical
Ehsan Shamloo, Farshid Nickfar, Maryam Mahmoudzadeh, Mansour Sarafraz, Amir Salari, Majid Darroudi, Zohreh Abdi-Moghadam, Mohammad Reza Amiryosefi, Alieh Rezagholizade-Shirvan, Zeinab Rezaei
Summary: The study found that the release of heavy metals increases in old cookware due to frequent use and damage or abrasion. Cooking time had a significant relationship with the release of metals in food, especially in old cookware. Therefore, the use of high-risk damaged cookware should be restricted.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2023)
Article
Materials Science, Ceramics
Atefeh Omidtorshiz, Mohammad Reza Benam, Mehdi Momennezhad, Majid Darroudi
Summary: This study synthesized lead oxide nanoparticles (PbO-NPs) in a green manner using Trigonella feonumgraecum extracts for stabilization and capping. The synthesized nanoparticles were evaluated using UV-Vis, FTIR, TGA-DTA, FESEM, EDX, and XRD techniques. UV-Vis spectrophotometry confirmed the optical features of PbO-NPs, while XRD patterns indicated their tetragonal and orthorhombic crystallized structures. FESEM images showed a cubic form and a size of around 30 nm for the synthesized nanoparticles. The cytotoxicity of PbO-NPs on Huh-7 cell line and their photocatalytic functionality in degrading methylene blue dye under UVA light were also examined, with approximately 90% degradation observed after 180 minutes.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Masood Barzegar, Davoud Ahmadvand, Zahra Sabouri, Majid Darroudi
Summary: This study describes a green chemistry method for synthesizing magnesium oxide nanoparticles (MgO-NPs) using chitosan polymer as a stabilizer and reducing agent. Characterization techniques such as TGA/DTA, FTIR, UV-Vis, XRD, and FESEM/EDX/PSA were used to analyze the prepared MgO-NPs. The results confirmed the successful synthesis of MgO-NPs with essential functional groups, cubic crystallinity framework, spherical morphology, and presence of magnesium and oxygen elements. Furthermore, the cytotoxic effects on cancer cell lines and photocatalytic activity for pigment degradation were also investigated.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Chemistry, Analytical
Zahra Khoshbin, Seyed Mohammad Taghdisi, Noor Mohammad Danesh, Parirokh Lavaee, Ali Khakshour Abdolabadi, Khalil Abnous
Summary: A simple colorimetric strategy was developed for the monitoring of lead ion (Pb2+) using gold nanoparticles (AuNPs) regulated by aptamer strands. The aptamers masked the surface of AuNPs, preventing their peroxidase-like activity and the oxidation of TMB. The aptamer-Pb2+ complex, formed by adding Pb2+, released the aptamer from the AuNPs surface, enabling the oxidation of TMB and resulting in a color change from colorless to blue. The aptasensor showed a linear concentration range of 0.2 to 200 nM and a LOD of 0.056 nM for Pb2+ detection, successfully monitoring Pb2+ in drinking water, milk, and human serum, making it suitable for various applications.
ANALYTICAL LETTERS
(2023)
Article
Physics, Multidisciplinary
Mahin Velayati, Hassan Hassani, Hasan Ali Hosseini, Zahra Sabouri, Asma Mostafapour, Majid Darroudi
Summary: In this paper, Selenium nanoparticles (Se-NPs) were synthesized using a green approach and their morphology, structure, and properties were characterized. The results showed that the Se-NPs had excellent photocatalytic performance for dye degradation and exhibited certain toxicity against the cell line.
EUROPEAN PHYSICAL JOURNAL PLUS
(2023)
Article
Biotechnology & Applied Microbiology
Mohammad Javad Javid-Naderi, Zahra Sabouri, Amin Jalili, Hossein Zarrinfar, Saeed Samarghandian, Majid Darroudi
Summary: Copper oxide nanoparticles (CuO-NPs) were synthesized using okra fruit extract as a stabilizer and reducing agent. The resulting CuO-NPs exhibited a monoclinic structure with a size of about 25 nm. The CuO-NPs showed effective photocatalytic and anticancer properties.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2023)
Review
Multidisciplinary Sciences
Zohreh Abdi-Moghadam, Yeganeh Mazaheri, Alieh Rezagholizade-shirvan, Maryam Mahmoudzadeh, Mansour Sarafraz, Mahnaz Mohtashami, Samira Shokri, Ahmad Ghasemi, Farshid Nickfar, Majid Darroudi, Hedayat Hossieni, Zahra Hadian, Ehsan Shamloo, Zeinab Rezaei
Summary: Essential oils derived from plants possess antioxidant and antimicrobial properties, and have been extensively studied for their potential applications in the food industry, agriculture, and skin health. In particular, essential oils have demonstrated antifungal activity against various species of Aspergillus and other fungal pathogens. These findings suggest the potential of essential oils as alternative preservatives to enhance the shelf life of food products.
Article
Neurosciences
Zahra Golmohammadi, Reza Boostani, Morteza Saeidi, Ehsan Aryan, Aida Gholoobi, Mojtaba Meshkat, Amin Hooshyar Chechaklou, Mahdieh Khoshakhlagh, Samaneh Abolbashari, Zahra Meshkat
Summary: This study found no presence of HIV antibodies in the serum of both MS patients and non-MS individuals. While HTLV-I/II antibodies were detected in the control group, no statistically significant difference was found between the presence of HTLV-I/II antibodies and MS.
ARCHIVES OF NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Samaneh Hashemi Ghoochani, Hasan Ali Hosseini, Zahra Sabouri, Mohammad Hasan Soheilifar, Hoda Keshmiri Neghab, Alireza Hashemzadeh, Mahin Velayati, Majid Darroudi
Summary: The study involves the use of photodynamic treatment to remove specific cancer cells by activating a photosensitizer with specific light. Zinc porphyrin (Zn[TPP]) was prepared and encapsulated into MIL-101 (Zn[TPP]@MIL-101) for use in photodynamic therapy against MCF-7 breast cancer cells under red light-emitting diode. Various characterization methods were used to investigate the changes in structure, morphology, surface area, and composition. The MTT assay demonstrated an IC50 of 14.3 and 81.6 mg/mL for light and dark groups respectively, indicating the efficient eradication of cancer cells using Zn[TPP]@MIL-101 in photodynamic therapy.
LASERS IN MEDICAL SCIENCE
(2023)
Article
Chemistry, Physical
Samaneh Ghazal, Mahdi Mirzaee, Majid Darroudi, Zahra Sabouri, Sara Khadempir
Summary: In this study, pure tungsten oxide nanoparticles and silver-doped tungsten oxide nanoparticles were synthesized using chitosan as the reducing and stabilizing agent. The nanoparticles were characterized using various techniques and their cytotoxicity and photocatalytic properties were evaluated. The results showed that the silver-doped tungsten oxide nanoparticles exhibited inhibitory effects on cancer cells and had a higher photocatalytic degradation efficiency compared to the pure tungsten oxide nanoparticles.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2024)
Review
Materials Science, Biomaterials
Ali Aliabadi, Maliheh Hasannia, Masoume Vakili-Azghandi, Fatemeh Araste, Khalil Abnous, Seyed Mohammad Taghdisi, Mohammad Ramezani, Mona Alibolandi
Summary: The formation of polymeric micelles via self-assembly is a versatile approach for improving the solubility and permeability of hydrophobic drugs. Polymer-based micelles have advantages in terms of size, morphology, and scalability. Various techniques have been employed to synthesize copolymers that can self-assemble into well-defined micellar structures with tunable drug release patterns. This review summarizes important polymerization techniques and recent achievements in the field of drug delivery using micellar systems, and proposes new visions for designing and synthesizing potent amphiphilic polymers.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Materials Science, Biomaterials
Ali Aliabadi, Maliheh Hasannia, Masoume Vakili-Azghandi, Fatemeh Araste, Khalil Abnous, Seyed Mohammad Taghdisi, Mohammad Ramezani, Mona Alibolandi
Summary: Polymeric micelles formed through self-assembly of amphiphilic polymers in aqueous environments have been explored as a versatile platform for enhancing the solubility and permeability of hydrophobic drugs. Compared to other self-assembly-based vehicles, polymeric micelles commonly have smaller size, spherical morphology, and simpler scale-up process. The synthesis of various amphiphilic polymers using different polymerization techniques has led to the development of smart copolymers that can form micelles, load therapeutics, and respond to external stimuli. This review summarizes important polymerization techniques and recent achievements in the field of drug delivery using micellar systems, and proposes new visions for the design and synthesis of innovative amphiphilic polymers for drug delivery applications. ROP, ATRP, RAFT, and combined methods were employed for copolymer synthesis, resulting in copolymers with proficiency of self-assembly into micellar structures.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Physical
Xinlei Chen, Shiyi Chen, Xuele Lin, Jingxuan Zhou, Xingjun Gao, Yaoqi Zhen, Xiaodan Ma, Shouwen Jin, Linfang Shi, Hui Liu, Daqi Wang
Summary: Nine mixed-ligand Cd2+ complexes with different geometric structures were synthesized and characterized. The complexes exhibit various coordination modes and form both intra- and intermolecular hydrogen bonds.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Rupali Mahajan, Abhishek Sharma, Bhagyashree Patra, Lijo Mani, Parul Grover, Sandeep Kumar, Santosh Kumar Guru, Gananadhamu Samanthula, Amol G. Dikundwar, Amit Asthana
Summary: This research article provides a comprehensive characterization and toxicological assessment of a photoisomeric impurity of the antianemic drug Roxadustat. The impurity has a distinct structure compared to the drug and its formation due to light exposure is a concern. Through various experiments, including single crystal XRD, physicochemical characterization, and in vitro cytotoxicity assays, the researchers confirmed the structure of the impurity, evaluated its conversion with Roxadustat, and assessed its toxicological activity. These findings contribute to the understanding of drug stability, safety, and formulation development.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Laila S. Alqarni, Azzah M. Alghamdi, Nuha Y. Elamin, A. Rajeh
Summary: The solution casting method was used to produce a new type of nanocomposites made of chitosan, gelatin, and co-doped ZnO nanoparticles. The addition of 3.5% co-doped ZnO nanoparticles improved the physicochemical characteristics and antimicrobial effects of the nanocomposites, indicating their significant potential in food packaging and energy storage.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ruchi Gaur
Summary: The structure and intermolecular interactions of a newly synthesized bis-chalcone THXA were studied using experimental and computational methods. The importance of non-covalent interactions such as pi center dot center dot center dot pi, C-H center dot center dot center dot S, and C-H center dot center dot center dot pi was revealed.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Andrii Bazylevich, Leonid Patsenker, Sarit Aviel-Ronen, Gary Gellerman
Summary: Drug combination therapy is commonly used for treating various skin disorders, but its effectiveness is often limited. In this study, researchers synthesized conjugates of anti-pigmenting drugs and hyaluronic acid (HA) to improve treatment efficacy. These HA-drug conjugates exhibited measurable drug release profiles and demonstrated superior depigmentation effects compared to control groups in a swine model.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Xiaodan Ma, Xinlei Chen, Yaoqi Zhen, Xunjie Zheng, Chengzhe Shi, Shouwen Jin, Bin Liu, Bin Chen, Daqi Wang
Summary: Cocrystallization experiments between minoxidil and aryl acids coformers resulted in the successful formation of multi-component samples. The nature of these samples was determined using various techniques and their structural and supramolecular aspects were investigated. The outcomes revealed the importance of nonbonding contacts and different types of interactions in stabilizing and expanding the crystal structures.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Najla A. Alshaye, Magdy A. Ibrahim, Al-Shimaa Badran
Summary: The chemical behavior of 3-substituted-6,8-dimethylchromones towards phenylhydrazine was examined. Different reaction conditions produced various products, and the molecular geometries and reactivity descriptors of the compounds were also investigated. The results suggest that these compounds are suitable for nonlinear optical applications.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Hayette Alliouche, Houria Bouria, Rafik Bensegueni, Mounia Guergouri, Abdelmalek Bouraiou, Ali Belfaitah
Summary: In this paper, a combined experimental and theoretical study was conducted to synthesize and characterize new 2-quinolone-piperidine and -morpholine hybrids. The results from experiments were validated using computational calculations, and the affinity between these compounds and Acetylcholinesterase/Butyrylcholinesterase was estimated through molecular docking.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Wei-Min Chen, Juan-Juan Shao, Yi Zhang, Zhen-Dong Xue, Peng-Lai Liu, Jian-Ling Ni, Li-Zhuang Chen, Qiang Gao, Fang-Ming Wang
Summary: This study synthesized and characterized a novel Mn-based LMOF, and achieved good results in detecting heavy metal Al3+ in water, showing good stability, high selectivity and sensitivity. This provides new insights into the potential applications of Mn-based MOFs in chemical sensing.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Jun-Xia Li, Yi-Jing Lu, Ke-Ying Quan, Li-Bing Wu, Xun Feng, Wei-Zhou Wang
Summary: This study synthesized two cobalt(II) complexes and analyzed their crystal structures using single-crystal X-ray diffraction. The results showed that the crystal structures of these complexes were different, and they exhibited different crystal packing and magnetic properties.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Yang Li, Yan Zhang, Hong Xu, Min Li, Zhen Li, Zi-yu Song, Ji-shi Chen, Yan-Jun Liu, Yong Sun, Zhao Yang
Summary: This study reports the synthesis and solid-state characterization of a new pharmaceutical cocrystal, PRO-BPE, which can enhance the solubility of the highly water-insoluble prodrug probenecid. The PRO-BPE cocrystals were found to have superior water solubility compared to pure PRO. This research provides valuable insights into improving the solubility of poorly soluble drugs.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Lucas G. B. Felicio, Bianca B. M. Vieira, Ivana S. Lula, Renata Diniz, Frank Alexis, Flavio B. Miguz, Frederico B. De Sousa
Summary: A novel spiropyran derivative was synthesized for heavy metals sensing in water. The results demonstrated that the new derivative can serve as a rapid, sensitive, and simple tool for detecting Hg2+ ions in water with high selectivity.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Junqing Meng, Jie Wang, Lijuan Wang, Chunhui Lyu, Haiyan Chen, Yingpei Lyu, Baisheng Nie
Summary: Material modification with low surface energy can achieve lower surface free energy on micro-and nano-rough structures, which is crucial for developing superhydrophobic surfaces. In this study, attapulgite (APT) was modified with alkylamine, alkylammonium salt, and stearic acid, and the interaction between low surface materials and attapulgite was explained. The results showed that the hydrophobicity of APT was significantly modified by the modifiers, and the surface free energy of the composites first decreased and then increased with increasing molecular number of low surface energy monomers.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Karan Goswami, Dipak Das, Parthasarathi Bera, Sounak Roy, Md. Motin Seikh, Prasanta Kumar Sinha, Arup Gayen
Summary: This work presents the development of a simple and highly active heterogeneous Pd catalyst for Suzuki-Miyaura carbon-carbon cross-coupling reaction. The NiPdFe-1 catalyst shows the best activity and stability among the prepared catalysts. It efficiently promotes the coupling reaction between aryl bromide and phenyl boronic acid under mild reaction conditions with high isolated yields.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ekta Pardhi, Devendra Singh Tomar, Rahul Khemchandani, Gananadhamu Samanthula, Pankaj Kumar Singh, Neelesh Kumar Mehra
Summary: The main aim of this study was to prepare a drug-drug coamorphous system to improve the physiochemical properties, solubility and stability of Apremilast and Indomethacin. Various solid-state characterization techniques were used to characterize the prepared system. Molecular level interactions were studied using molecular modeling and ATR-FTIR and 1H NMR. Solubility and dissolution studies showed the benefits of the coamorphous system. The system was found to be stable for a period of five months. Permeation study also demonstrated improved flux for both drugs compared to their crystalline forms. The coamorphous system showed anti-psoriatic and anti-melanogenic activity based on molecular docking results. Overall, the developed CAM-based supersaturated system exhibited improved physicochemical properties and physical stability.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
