Article
Plant Sciences
Eun A. Kim, Ju-Hwan Yang, Eun-Hye Byeon, Woong Kim, Dawon Kang, Jaehee Han, Seong-Geun Hong, Deok-Ryong Kim, Sang-Je Park, Jae-Won Huh, Hyeonsook Cheong, Seung-Pil Yun, Dong-Kun Lee
Summary: The study demonstrates that pine needle extract inhibits obesity by increasing hypothalamic POMC neuronal activity and improving physiological conditions after high-fat diet-induced obesity. Additionally, PNE also suppresses lipogenesis in white adipose tissue.
Article
Medicine, Research & Experimental
Seyyed Mohammad Reza Hashemnia, Reza Meshkani, Fahimeh Zamani-Garmsiri, Maryam Shabani, Maryam Tajabadi-Ebrahimi, Iraj Ragerdi Kashani, Seyed Davar Siadat, Samaneh Mohassel Azadi, Solaleh Emamgholipour
Summary: New evidence suggests that B. coagulans can be a promising alternative for treating metabolic disorders. However, its effects on obesity-induced adipose tissue inflammation are still unknown.
Article
Food Science & Technology
Di Wang, Jilong Yin, Zixin Zhou, Yan Tao, Yufeng Jia, Haipeng Jie, Jingyuan Zhao, Ruiyu Li, Yuan Li, Chun Guo, Faliang Zhu, Haiting Mao, Lining Zhang, Qun Wang
Summary: Oral supplementation with spermidine can attenuate obesity and metabolic disorders through hypothalamus-dependent or -independent BAT activation and skeletal muscle adaptation. Spermidine promotes UCP-1 and PGC-1 alpha expression in brown adipocytes and myotubes, as well as tyrosine hydroxylase expression and norepinephrine production in neurocytes, leading to CREB activation and UCP-1 induction.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Hematology
Mark Colin Gissler, Nathaly Anto-Michel, Jan Pennig, Philipp Scherrer, Xiaowei Li, Timoteo Marchini, Katharina Pfeiffer, Carmen Haerdtner, Tijani Abogunloko, Timothy Mwinyella, Lucia Sol Mitre, Lisa Spiga, Christoph Koentges, Christian Smolka, Dominik von Elverfeldt, Natalie Hoppe, Peter Stachon, Bianca Dufner, Timo Heidt, Sven Piepenburg, Ingo Hilgendorf, Jan-Inge Bjune, Simon N. Dankel, Gunnar Mellgren, Gabriel Seifert, Steffen U. Eisenhardt, Heiko Bugger, Constantin von zur Muhlen, Christoph Bode, Andreas Zirlik, Dennis Wolf, Florian Willecke
Summary: Genetic deficiency of TRAF5 exacerbates diet-induced obesity and metabolic dysregulation by promoting a proinflammatory response in adipocytes, indicating a potential role of TRAF5 in anti-inflammatory and obesity-preventing signaling events in adipose tissue.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Chaowei Li, Qi Chen, Yanrong Liu, Zhuwen Sun, Zhentong Shen, Shuhan Li, Dingrui Cha, Chao Sun
Summary: In this study, it was found that MetEnk effectively prevented obesity and improved glucose tolerance and insulin sensitivity. It also improved mitochondrial function, promoted lipolysis and thermogenesis through the activation of the cAMP/PKA pathway.
Article
Nutrition & Dietetics
Yu Wang, Xuyang Gao, Xiaoyou Chen, Qiang Li, Xinrui Li, Junxing Zhao
Summary: Sea buckthorn powder intake has a preventive effect on high-fat diet-induced obesity, reducing body weight, fat mass, and circulating lipid levels, and improving insulin sensitivity. Additionally, it alleviates hepatic steatosis and lipid accumulation, exhibits anti-inflammatory capacity in white adipose tissue, promotes thermogenesis in brown adipose tissue, and induces beige adipocyte formation.
Review
Nutrition & Dietetics
Muhammed Mustafa Atakan, Sukran Nazan Kosar, Yasemin Guzel, Hiu Tung Tin, Xu Yan
Summary: Calorie restriction, regular exercise, or a combination of the two are accepted as effective strategies in preventing or treating obesity. The benefits of exercise in combating obesity are not only attributed to reducing adiposity but also to releasing proteins, peptides, enzymes, and metabolites that are beneficial for overall health.
Article
Endocrinology & Metabolism
Hui Wang, Monja Willershaeuser, Yongguo Li, Tobias Fromme, Katharina Schnabl, Andrea Bast-Habersbrunner, Samira Ramisch, Sabine Mocek, Martin Klingenspor
Summary: While UCP1 is essential for cold-induced thermogenesis, its presence alone does not protect mice from diet-induced obesity. A new mouse model with low UCP1 levels demonstrates that impaired cold-induced thermogenic capacity does not increase susceptibility to diet-induced obesity. Pharmacological activation of brown fat is necessary to promote negative energy balance in diet-induced obese mice.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biology
Haruchika Masuda, Atsuko Sato, Kumiko Miyata, Tomoko Shizuno, Akira Oyamada, Kazuo Ishiwata, Yoshihiro Nakagawa, Takayuki Asahara
Summary: MHW intake alleviated oxidative stress and improved cardiovascular function in DIO mice, promoting energy expenditure in adipose tissues and maintaining vascular homeostasis. This indicates that drinking MHW could be a potential prophylactic strategy against cardiovascular disorders in metabolic syndrome.
Article
Biochemistry & Molecular Biology
Sara Becerril, Carlota Tuero, Javier A. Cienfuegos, Amaia Rodriguez, Victoria Catalan, Beatriz Ramirez, Victor Valenti, Rafael Moncada, Xabier Unamuno, Javier Gomez-Ambrosi, Gema Fruhbeck
Summary: This study compares Sleeve Gastrectomy (SG) and Single Anastomosis Duodenoileal Bypass with SG (SADI-S) in obese rats and finds that SADI-S surgery results in better control of lipid and glucose metabolism and improved adipose tissue function compared to SG surgery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Bynvant Sandhu, Maria C. Perez-Matos, Stephanie Tran, Garima Singhal, Ismail Syed, Linda Feldbruegge, Shuji Mitsuhashi, Julie Pelletier, Jinhe Huang, Yusuf Yalcin, Eva Csizmadia, Shilpa Tiwari-Heckler, Keiichi Enjyoji, Jean Sevigny, Eleftheria Maratos-Flier, Simon C. Robson, Z. Gordon Jiang
Summary: This study investigated the impact of NTPDase3 deficiency on diet-induced obesity and metabolism in mice. The results showed that global NTPDase3 deletion led to resistance to obesity and glucose intolerance, with metabolic changes in adipocytes playing a key role rather than NTPDase3 expression in pancreatic beta-cells.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Biochemistry & Molecular Biology
Sabrina Folie, Bernhard Radlinger, Georg Goebel, Karin Salzmann, Gabriele Staudacher, Claudia Ress, Herbert Tilg, Susanne Kaser
Summary: The study suggests that switching from a metabolically harmful Western diet to a balanced standard diet can improve adipose tissue inflammation, while long-term consumption of a Western diet negatively impacts the thermogenic capacity of brown adipose tissue and inhibits beiging of white adipose tissue.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Yen-Ju Chiu, Ho-Hsiang Tu, Mei-Lang Kung, Hung-Ju Wu, Yun-Wen Chen
Summary: Patients with type 2 diabetes mellitus have a higher risk of developing depression, and fluoxetine (FLX) has been shown to alleviate high fat diet-induced metabolic dysfunctions and depressive phenotypes in mice. FLX improves systemic glucose homeostasis by enhancing insulin signaling in visceral white adipose tissue (vWAT), and reduces circulating plasma leptin levels as well as the expression of adipose triglyceride lipase (ATGL) and peroxisome proliferator-activated receptor gamma (PPAR gamma) in vWAT.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biology
Reabetswe R. Pitere, Marlene B. van Heerden, Michael S. Pepper, Melvin A. Ambele
Summary: Obesity development can be attributed to adipocyte hypertrophy or hyperplasia, which lead to increased adiposity. Targeting the SLC7A8 gene in a mouse model of diet-induced obesity significantly protects against weight gain and improves glucose metabolism by reducing lipid accumulation in multiple organs.Deleting SLC7A8 attenuates adipocyte hypertrophy, reduces inflammation, and protects against diet-induced obesity.
Article
Endocrinology & Metabolism
Sebastian Dieckmann, Akim Strohmeyer, Monja Willershauser, Stefanie F. Maurer, Wolfgang Wurst, Susan Marschall, Martin Hrabe de Angelis, Ralf Kuehn, Anna Worthmann, Marceline M. Fuh, Joerg Heeren, Nikolai Koehler, Josch K. Pauling, Martin Klingenspor
Summary: This study demonstrates that UCP1 does not protect against diet-induced obesity at thermoneutrality, and provides evidence that the abundance of UCP1 does not influence energy metabolism, highlighting the importance of a new knockout model for further understanding the contribution of UCP1 in energy metabolism in different cell types or life stages.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Peripheral Vascular Disease
Andrea G. Maria, Mari Suzuki, Annabel Berthon, Crystal Kamilaris, Andrew Demidowich, Justin Lack, Mihail Zilbermint, Fady Hannah-Shmouni, Fabio R. Faucz, Constantine A. Stratakis
AMERICAN JOURNAL OF HYPERTENSION
(2020)
Editorial Material
Pediatrics
Constantine A. Stratakis, Scott A. Rivkees
PEDIATRIC RESEARCH
(2020)
Editorial Material
Endocrinology & Metabolism
Constantine A. Stratakis
HORMONE AND METABOLIC RESEARCH
(2020)
Article
Oncology
Ivana Jochmanova, April Melody T. Abcede, Ruby Jane S. Guerrero, Chandy Lou P. Malong, Robert Wesley, Huynh Thanh, Melissa K. Gonzales, Katherine I. Wolf, Abhishek Jha, Marianne Knue, Tamara Prodanov, Naris Nilubol, Leilani B. Mercado-Asis, Constantine A. Stratakis, Karel Pacak
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2020)
Article
Endocrinology & Metabolism
Amit Tirosh, Harish RaviPrakash, Georgios Z. Papadakis, Christina Tatsi, Elena Belyavskaya, Lyssikatos Charalampos, Maya B. Lodish, Ulas Bagci, Constantine A. Stratakis
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Cell Biology
Marie Helene Schernthaner-Reiter, Giampaolo Trivellin, Constantine A. Stratakis
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Afrouz Anderson, Andrea Gropman, Cynthia Le Mons, Constantine Stratakis, Amir Gandjbakhche
MOLECULAR GENETICS AND METABOLISM
(2020)
Review
Medicine, General & Internal
Christina Tatsi, Constantine A. Stratakis
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Oncology
Emilia Modolo Pinto, Fabio R. Faucz, Luana Z. Paza, Gang Wu, Elizabeth S. Fernandes, Jerome Bertherat, Constantine A. Stratakis, Enzo Lalli, Raul C. Ribeiro, Carlos Rodriguez-Galindo, Bonald C. Figueiredo, Gerard P. Zambetti
Review
Endocrinology & Metabolism
Fady Hannah-Shmouni, Constantine A. Stratakis
HORMONE AND METABOLIC RESEARCH
(2020)
Article
Pediatrics
Amanda C. Swart, Therina du Toit, Evgenia Gourgari, Martin Kidd, Meg Keil, Fabio R. Faucz, Constantine A. Stratakis
Summary: Using UPC2-MS/MS technology, a distinct subgroup of PCOS patients with adrenal abnormalities has been successfully identified, showing significant changes in steroid ratios. The newly discovered steroid metabolites may serve as novel biomarkers for diagnosing PCOS patients with adrenal abnormalities.
PEDIATRIC RESEARCH
(2021)
Editorial Material
Endocrinology & Metabolism
Sarantis Livadas, Constantine A. Stratakis, Djuro Macut
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Medicine, Research & Experimental
Edra London, Jason C. Wester, Michelle Bloyd, Shelby Bettencourt, Chris J. McBain, Constantine A. Stratakis
Article
Endocrinology & Metabolism
Rachel Wurth, Crystal Kamilaris, Naris Nilubol, Samira M. Sadowski, Annabel Berthon, Martha M. Quezado, Fabio R. Faucz, Constantine A. Stratakis, Fady Hannah-Shmouni
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS
(2020)
Meeting Abstract
Medicine, General & Internal
M. Rescigno, C. Tatsi, C. Lyssikatos, E. Belyavskaya, M. Keil, G. Papadakis, C. Stratakis
JOURNAL OF INVESTIGATIVE MEDICINE
(2020)