Review
Cell Biology
Nikita Thakkar, Ye Bin Shin, Hoon-Ki Sung
Summary: The mammary gland is a complex organ that can be regulated by nutritional stimuli, affecting glandular function and disease development. Obesity increases the risk of breast cancer, while fasting or calorie restriction may have a negative impact on mammary tumor progression. However, the specific effects of fasting on the mammary microenvironment are still not well understood.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yuan Wu, Xu Li, Qiong Li, Chienshan Cheng, Lan Zheng
Summary: The review examines mechanistic evidence for the connection between obesity and breast cancer, exploring the factors that promote tumor development or metastasis. It highlights the role of adipokines, metabolic pathways, inflammatory microenvironment, adipose stem cells, and miRNAs in breast cancer progression. The review also discusses possible therapeutic directions and the risks associated with autologous breast remodeling and fat transplantation. Furthermore, it explores the causes of the obesity paradox and the impact of enhanced immunity. Evaluating the balance between inflammation and immunity in obesity-induced breast cancer warrants further investigation.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Biochemistry & Molecular Biology
Gabriela Martinez-Chacon, Emrah Yatkin, Lauri Polari, Defne Deniz Dinc, Emilia Peuhu, Pauliina Hartiala, Niina Saarinen, Sari Makela
Summary: Obesity is a risk factor for postmenopausal breast cancer, as obesity-related inflammation upregulates aromatase expression in breast adipose tissue, leading to increased estrogen production and cancer risk. The pro-inflammatory factor CCL2 may regulate aromatase transcription through specific signaling pathways and contribute to the inflammatory environment and aromatase expression in obesity.
Article
Biochemistry & Molecular Biology
Genevra Kuziel, Brittney N. Moore, Grace P. Haugstad, Lisa M. Arendt
Summary: Obesity increases the risk of breast cancer, and this is partly due to chronic inflammation and fibrosis in the mammary gland. In this study, the researchers used a high-fat diet model and genetically modified mice to investigate the role of immune cells in obesity-induced fibrosis. They found that obesity increased the recruitment of a specific population of cells, called fibrocytes, which contributed to the formation of myofibroblasts and fibrosis in the mammary gland. Transplanting myeloid progenitor cells, which give rise to fibrocytes, into obese mice further increased myofibroblast formation. These findings suggest that obesity enhances the recruitment of fibrocytes and promotes fibrosis in the mammary gland.
Article
Endocrinology & Metabolism
Marina Chaves de Oliveira, Ana Leticia Malheiros Silveira, Amanda Carla Clemente de Oliveira, Jaqueline Pereira Lana, Katia Anunciacao Costa, Erica Leandro Marciano Vieira, Vanessa Pinho, Mauro Martins Teixeira, Fatiha Merabtene, Genevieve Marcelin, Karine Clement, Adaliene Versiani Matos Ferreira
Summary: This study evaluated the participation of eosinophils in metabolic and adipose tissue homeostasis in mice and humans, showing that eosinophils play a role in controlling systemic and adipose tissue metabolic homeostasis by modulating glucose metabolism, inflammation, and visceral fat expansion. These findings provide important insights into the pathogenesis of obesity and metabolic-related diseases.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Nutrition & Dietetics
Qian-Wen Sun, Chun-Fang Lian, Yan-Min Chen, Jun Ye, Wei Chen, Yue Gao, Hong-Liang Wang, Li-Li Gao, Yu-Ling Liu, Yan-Fang Yang
Summary: The study found that Ramulus Mori alkaloids can regulate lipid metabolism and alleviate obesity-induced adipose inflammation, showing potential in the treatment of obesity.
Review
Immunology
Yu Zhen, Wentao Shu, Xintong Hou, Yinan Wang
Summary: This study focuses on the role of innate immune cells in visceral adipose tissue (VAT) in maintaining tissue homeostasis and responding to changes induced by obesity, leading to chronic inflammation and metabolic diseases. The review emphasizes the importance of understanding the quantitative and functional changes in immune cells in the context of obesity-induced metabolic dysfunction, highlighting the need to consider complex interactive networks among different cell populations in the development of biotherapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
Dan Wu, Huiying Wang, Lijun Xie, Fang Hu
Summary: The increase in obesity and associated diseases is a major global health problem. The gut microbiota plays a significant role in maintaining energy balance and host immunity. Understanding the relationship between gut microbiota and adipose tissues may provide potential intervention strategies for treating obesity and associated diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alejandro Hinojosa-Moscoso, Anna Motger-Alberti, Elena De la Calle-Vargas, Marian Marti-Navas, Carles Biarnes, Maria Arnoriaga-Rodriguez, Gerard Blasco, Josep Puig, Diego Luque-Cordoba, Feliciano Priego-Capote, Jose Maria Moreno-Navarrete, Jose Manuel Fernandez-Real
Summary: Excess iron is associated with dysfunction in adipose tissue and insulin resistance. In this study, it was found that markers of iron status were linked to changes in abdominal adipose tissue over one year. These associations were mainly observed in women and non-obese subjects, and were independent of insulin sensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Sanil Patel, Njeri Z. R. Sparman, Douglas Arneson, Alexandra Alvarsson, Luis C. Santos, Samuel J. J. Duesman, Alessia Centonze, Ephraim Hathaway, In Sook Ahn, Graciel Diamante, Ingrid Cely, Chung Hwan Cho, Noble Kumar Talari, Abha K. K. Rajbhandari, Leigh Goedeke, Peng Wang, Atul J. J. Butte, Cedric Blanpain, Karthickeyan Chella Krishnan, Aldons J. J. Lusis, Sarah A. A. Stanley, Xia Yang, Prashant Rajbhandari
Summary: The mammary gland ductal epithelial cells regulate cold-induced adipocyte UCP1 expression and control adipose thermogenesis through the secretion of mammokines. These findings suggest that sympathetic nerve-activated glandular epithelium plays a crucial role in adipocyte UCP1 expression and has implications for energy expenditure and subcutaneous fat loss.
Review
Cell Biology
Jose Antonio Fagundes Assumpcao, Gabriel Pasquarelli-do-Nascimento, Mariana Saldanha Viegas Duarte, Martin Hernan Bonamino, Kelly Grace Magalhaes
Summary: Obesity is a complex disease associated with metabolic and cardiovascular conditions as well as cancer development. Recent evidence shows that mild obesity is paradoxically associated with better treatment outcomes in cancer patients, termed as the obesity paradox. Obesity also impacts the response to cancer treatments and has a positive association with immune checkpoint therapy.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Endocrinology & Metabolism
Georgia Colleluori, Jessica Perugini, Giorgio Barbatelli, Saverio Cinti
Summary: The mammary gland is an exocrine gland responsible for milk production in female mammals, composed mainly of epithelial cells and adipocytes. It displays highly plastic properties during different stages of the lactation cycle and requires close association with adipocytes for proper development. The role of adipocytes in mammary gland development and diseases like obesity and breast cancer deserves further investigation.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Kiran Shabir, James E. Brown, Islam Afzal, Seley Gharanei, Martin O. Weickert, Thomas M. Barber, Ioannis Kyrou, Harpal S. Randeva
Summary: White adipose tissue releases adipokines that regulate metabolic balance and physiological processes, with altered secretion profiles linked to obesity and cardio-metabolic diseases. Asprosin, a recently discovered adipokine, plays a key role in stimulating glucose secretion and appetite, and may have effects on various metabolic tissues.
CYTOKINE & GROWTH FACTOR REVIEWS
(2021)
Article
Multidisciplinary Sciences
Gemma Carreras-Badosa, Ariadna Gomez-Vilarrubla, Berta Mas-Pares, Silvia Xargay-Torrent, Anna Prats-Puig, Elsa Puerto-Carranza, Francis de Zegher, Lourdes Ibanez, Judit Bassols, Abel Lopez-Bermejo
Summary: GDF-15 is positively associated with immunoglobulin levels in apparently healthy children, especially in those with higher body mass index or renal fat accumulation, suggesting a potential role of GDF-15 in regulating the immune adaptive system in human obesity.
SCIENTIFIC REPORTS
(2021)
Review
Endocrinology & Metabolism
RuiYan Mei, WeiWei Qin, YanHua Zheng, Zhuo Wan, Li Liu
Summary: Exosomes secreted by adipose tissue play a crucial role in metabolic disorders, regulating specific mechanisms related to obesity, adipose inflammation, and diabetes. Adipose tissue is a major source of circulating exosomal miRNAs, which not only alter the state of patients with metabolic diseases but also affect the communication between metabolic organs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
