Article
Multidisciplinary Sciences
Yuki Komatsu, Kiyoshi Aoyama, Mamoru Yoneda, Shogo Ito, Yusuke Sano, Yumeno Kawai, Xixi Cui, Yuichiro Yamada, Nozomi Furukawa, Katsuhide Ikeda, Kohzo Nagata
Summary: The removal of interscapular brown adipose tissue (iBAT) attenuated the exacerbation of cardiac inflammation and fibrosis induced by salt loading in DS/obese rats, but did not affect the development of hypertension. Salt loading led to adipocyte hypertrophy and increased inflammation in white adipose tissue, while the conversion of iBAT to white adipose tissue-like tissue contributed to elevated levels of circulating interleukin-6, exacerbating cardiac pathology.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Cell Biology
Xiao-Xi Pan, Kang-Li Yao, Yong-Feng Yang, Qian Ge, Run Zhang, Ping-Jin Gao, Cheng-Chao Ruan, Fang Wu
Summary: Aging-associated chronic inflammation is a key factor contributing to chronic metabolic disorders. Research shows an accumulation of T cells in adipose tissue in old mice, with a cross talk between T cells and preadipocytes contributing to tissue remodeling. Senescent T cells were found to inhibit brown adipocyte differentiation in adipose tissue, with increased production of IFN-gamma identified as a critical mechanism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Miriam A. Holzman, Abigail Ryckman, Tova M. Finkelstein, Kim Landry-Truchon, Kyra A. Schindler, Jenna M. Bergmann, Lucie Jeannotte, Jennifer H. Mansfield
Summary: Hoxa5 plays a critical role in embryonic BAT development and negatively regulates formation of epaxial muscle. The protein is expressed in embryonic adipocytes as early as day 12.5.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Peter Aldiss, Jo E. Lewis, Irene Lupini, Ian Bloor, Ramyar Chavoshinejad, David J. Boocock, Amanda K. Miles, Francis J. P. Ebling, Helen Budge, Michael E. Symonds
Summary: This study demonstrates that chronic suppression of adaptive thermogenesis leads to weight gain and increased fat mass in rodents. Living in a cool environment (20 degrees C) and treatment with a β3-adrenoreceptor agonist (YM-178) had minimal effects on metabolic health in obese rats raised at thermoneutrality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Francesca Molinari, Alessandra Feraco, Simone Mirabilii, Serena Saladini, Luigi Sansone, Enza Vernucci, Giada Tomaselli, Vincenzo Marzolla, Dante Rotili, Matteo A. Russo, Maria Rosaria Ricciardi, Agostino Tafuri, Antonello Mai, Massimiliano Caprio, Marco Tafani, Andrea Armani
Summary: The inhibition of SIRT5 stimulates brown adipogenesis in vitro, promoting the expression of brown adipocyte and mitochondrial markers and increasing lipolysis. This approach shows potential as a strategy to target obesity and type 2 diabetes by activating brown adipose tissue.
Article
Endocrinology & Metabolism
Sanna Laurila, Lihua Sun, Minna Lahesmaa, Katharina Schnabl, Kirsi Laitinen, Riku Klen, Yongguo Li, Miroslav Balaz, Christian Wolfrum, Katja Steiger, Tarja Niemi, Markku Taittonen, Mueez U-Din, Tommi Valikangas, Laura L. Elo, Olli Eskola, Anna K. Kirjavainen, Lauri Nummenmaa, Kirsi A. Virtanen, Martin Klingenspor, Pirjo Nuutila
Summary: The study demonstrated that secretin activates BAT, reduces central responses to appetizing food, and delays the motivation to refeed after a meal in humans, suggesting the potential for new clinical research avenues in treating obesity.
Article
Biochemistry & Molecular Biology
Sarah Abdul Majeed, Helene Dunzendorfer, Juliane Weiner, John T. T. Heiker, Wieland Kiess, Antje Korner, Kathrin Landgraf
Summary: Obesity in children is associated with adipose tissue dysfunction and metabolic disease, increasing the risk of premature death. The brown adipose tissue (BAT), known for its energy-dissipating function, has been suggested to protect against obesity and metabolic dysfunction. Through genome-wide expression profiling, we identified several genes, including COBL, MKX, and MYOC, which have not been previously characterized in BAT biology and examined their functional role in BAT development. Our findings also reveal an association between the expression of these genes and early metabolic dysfunction in children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Takuya Sakurai, Toshiyuki Fukutomi, Sachiko Yamamoto, Eriko Nozaki, Takako Kizaki
Summary: The study found that the abnormal expression of fluid factors in the BAT of obese mice can be alleviated through physical activity, and Lgals3 and Lgals3bp may be involved in brown adipocyte differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Henry S. Kahn
Summary: BMI does not provide information about the relative size of adipose tissue depots, while SAD is associated with visceral fat accumulation, which may contribute to the estimation of cardiometabolic risk. SADHtR is more strongly associated with intermediary predictors of cardiometabolic disease.
Editorial Material
Endocrinology & Metabolism
Imke L. Lemmer, Alexander Bartelt
Summary: An elegant quantitative analysis of brown fat and skeletal muscle metabolite flux reveals that brown fat predominantly uses glucose and lactate and acts as a nitrogen scavenger during thermogenesis.
Article
Biotechnology & Applied Microbiology
Xin Liu, Jing Tang, Runan Zhang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Jiaxue Cao, Li Li, Hongping Zhang, Linjie Wang
Summary: Cold exposure activates gene expression and lipid metabolism in goat brown adipose tissue, resulting in decreased triglyceride content and increased phosphatidylcholine and phosphatidylethanolamine content.
Article
Medicine, General & Internal
Sean R. Millar, Ivan J. Perry, Catherine M. Phillips
Summary: This study found that predicted VAT equations explained a greater proportion of variance in inflammatory biomarkers compared to traditional anthropometric measures, suggesting that equations for assessing VAT levels may be useful for characterizing metabolic health. Further research is recommended to investigate the relationships between predicted VAT levels and disease and mortality outcomes.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Minh-Hanh Thi Nguyen, Dat Da Ly, Nhung Thi Nguyen, Xu-Feng Qi, Hyon-Seung Yi, Minho Shong, Seung-Kuy Cha, Sangkyu Park, Kyu-Sang Park
Summary: Short-term exposure to T-3 induces UCP1 upregulation and mitochondrial activation in brown adipocytes through PLC-mediated elevation of [Ca2+].
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Muhei Tanaka, Hiroshi Okada, Yoshitaka Hashimoto, Muneaki Kumagai, Hiromi Nishimura, Michiaki Fukui
Summary: This study found that intraperitoneal VAT (IVAT) and retroperitoneal VAT (RVAT) are differently associated with the prevalence of metabolic syndrome (MS) and its components. IVAT area index was independently associated with MS and its components, while RVAT area index was only associated with the blood pressure component.
CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Alana Deutsch, Kosaku Shinoda
Summary: Studies have shown that prolonged exposure to cold can increase the thermogenic capacity of brown adipose tissue through the recruitment of new brown adipocytes. Shamsi et al. and Angueira et al. have identified novel cellular origins of cold-induced brown adipocytes and elucidated the molecular mechanism regulating the expansion of brown adipose tissue.
Article
Cardiac & Cardiovascular Systems
Bertil Ladefoged, Tor Clemmensen, Anne Dybro, Charlotte Hartig-Andreasen, Lone Kirkeby, Lars Christian Gormsen, Peter Bomholt, Julian Gillmore, Steen Hvitfeldt Poulsen
Summary: The prevalence of ATTRwt was found to be 8.3% in a population of age and gender-selected patients with a recent history of CTS. Patients diagnosed with ATTRwt through screening had less cardiac involvement in terms of structure and function compared to clinical ATTRwt patients.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
David Lyse Overgaard, Lars Poulsen Tolbod, Lars Christian Gormsen, Michael Alle Madsen
Summary: A persistent left-sided superior vena cava (PLSVC) is a rare condition with a prevalence of 0.5% in the general population. It occurs when the left anterior cardinal vein fails to regress as the ligament of Marshall during embryologic development. Although usually asymptomatic and discovered incidentally, its recognition is important due to potential complications during invasive cardiovascular procedures. In this case report, we present an incidental finding of PLSVC in a patient referred for myocardial perfusion imaging using O-15-H2O PET/CT.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Mads Ryo Jochumsen, David Lyse Overgaard, Mikkel Holm Vendelbo, Michael Alle Madsen, Lars Poulsen Tolbod, Lars Christian Gormsen, Trine Orhoj Barkholt
Summary: The study examined extracardiac coincidental findings with increased perfusion using O-15-H2O PET MPI and found various malignant and benign conditions. It recommends evaluating the summed O-15-H2O PET images along with low-dose CT attenuation images.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Rheumatology
Berit Dalsgaard Nielsen, Philip Therkildsen, Kresten K. Keller, Lars C. Gormsen, Ib T. Hansen, Ellen-Margrethe Hauge
Summary: This study evaluated the sensitivity to change and discriminative abilities of vascular ultrasound scores in the follow-up of GCA patients. The OGUS score was found to be a feasible outcome measurement for treatment response assessment, and ultrasound scores showed potential in discriminating remission and relapse.
Letter
Rheumatology
Andreas Wiggers Nielsen, Line Lier Frolund, Christoffer Vaben, Asta Roos Bonde, Lars Christian Gormsen, Annette Ladefoged deThurah, Ellen-Margrethe Hauge, Kresten Krarup Keller
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Oncology
Mette Abildgaard Pedersen, Thomas Baad-Hansen, Lars C. Gormsen, Steen Baerentzen, Birgitte Sandfeld-Paulsen, Ninna Aggerholm-Pedersen, Mikkel Holm Vendelbo
Summary: This study aimed to evaluate the prognostic accuracy of combining PET parameters and circulating biomarkers in sarcoma patients. The results showed that adding PET parameters to existing prognostic models improved the prognostic value in all models. A new prognostic model, SBSpib, which includes albumin, lymphocytes, and metabolic tumor volume (MTV) as PET parameter, was developed. The study suggests that combining PET parameters and circulating biomarkers can enhance prognostic evaluation, but further validation is needed for SBSpib.
Article
Cardiac & Cardiovascular Systems
Jeyanthini Risikesan, Sara Heeboll, Indumathi Kumarathas, Kristian L. Funck, Esben Sondergaard, Rakel F. Johansen, Steffen Ringgaard, Lars P. Tolbod, Mogens Johannsen, Helle L. Kanstrup, Henning Gronbaek, Jan Frystyk, Lars C. Gormsen, Soren Nielsen
Summary: This study found that obese subjects with MAFLD have different myocardial free fatty acids oxidation (MOFFA), very low-density lipoprotein triglycerides (VLDL-TG) secretion, hepatic FFA utilization, and lactate production compared to obese subjects without MAFLD during exercise.
Article
Cardiac & Cardiovascular Systems
Laust Dupont Rasmussen, Line Emilie Brogger Albertsen, Louise Nissen, June Anita Ejlersen, Christin Isaksen, Theodore Murphy, Hanne Maare Sondergaard, Jane Kirk, Lau Brix, Lars Christian Gormsen, Steffen E. Petersen, Morten Bottcher, Simon Winther
Summary: This study investigated the ability of the ESC-PTP, RF-CL, and CACS-CL models to diagnose myocardial perfusion defects (MPDs). The results showed that compared with the ESC-PTP, the RF-CL and CACS-CL models can better classify patients into a low-risk group with a low prevalence of MPDs.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andre H. Dias, Mads R. Jochumsen, Helle D. Zacho, Ole L. Munk, Lars C. Gormsen
Summary: In this study, dynamic whole-body PET imaging was used to compare the pharmacokinetics of [Ga-68]Ga-PSMA-11 and [F-18]PSMA-1007 in different tissues and lesions. The study found that the two PSMA tracers exhibited different kinetics in organs and lesions, with [F-18]PSMA-1007 showing irreversible kinetics. Multiparametric PSMA images increased target-to-background ratios but did not lead to the detection of more lesions. For quantitative whole-body Ki imaging, [F-18]PSMA-1007 should be preferred over [Ga-68]Ga-PSMA-11.
Article
Chemistry, Medicinal
Thien Vinh Luong, Erik Nguyen Nielsen, Lise Falborg, Mette Louise Gram Kjaerulff, Lars Poulsen Tolbod, Esben Sondergaard, Niels Moller, Ole Lajord Munk, Lars Christian Gormsen
Summary: This study used positron emission tomography (PET) to investigate the uptake and tissue kinetics of the ketone tracer (R)-[1-C-11]beta-hydroxybutyrate -([C-11]OHB) in the human body. The results showed that intravenous administration of [C-11]OHB resulted in high uptake in the heart, liver, and kidneys, while oral ingestion led to rapid appearance in the blood and uptake in the heart, liver and kidneys. The study suggests that [C-11]OHB may serve as a safe and non-invasive imaging tool for exploring ketone metabolism in organs and tissues.
EJNMMI RADIOPHARMACY AND CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Simon Winther, Laust Dupont Rasmussen, Jelmer Westra, Salma Raghad Karim Abdulzahra, Jonathan Nortoft Dahl, Lars Christian Gormsen, Evald Hoj Christiansen, Gitte Stokvad Brix, Jesper Mortensen, June Anita Ejlersen, Hanne Maare Sondergaard, Nicolaj Christopher Lyng Hansson, Niels Ramsing Holm, Lars Lyhne Knudsen, Ashkan Eftekhari, Peter L. Moller, Palle Duun Rohde, Mette Nyegaard, Morten Bottcher
Summary: This study aims to evaluate the diagnostic accuracy of myocardial perfusion imaging using different tracers in patients with obstructive CAD. Approximately 1000 symptomatic patients without previous CAD will undergo a structured interview, blood samples, coronary CTA, and PET scans. The results of this study will be disseminated through international peer-reviewed journals.
Article
Radiology, Nuclear Medicine & Medical Imaging
Paul Cumming, Andre H. Dias, Lars C. Gormsen, Allan K. Hansen, Ian Alberts, Axel Rominger, Ole L. Munk, Hasan Sari
Summary: The study found strong relationships among different parameters of the input function derived from images, which enabled estimation of missing data and accurate calculation of FDG-Ki in the brain. The study also identified age-dependent aspects in the input function data, which was not previously reported in FDG pharmacokinetics. These findings support the quantitation of FDG-Ki in the brain using simplified methods with minimal error.
Article
Hematology
Mette Abildgaard Pedersen, Lars C. Gormsen, Lasse H. Jakobsen, Toby A. Eyre, Marianne T. Severinsen, Joachim Baech, Eldad J. Dann, Andrea Knapp, Denis Sahin, Peter Vestergaard, Tarec C. El-Galaly, Paw Jensen
Summary: This study aimed to compare the effects of different treatment regimens on bone mineral density in follicular lymphoma patients. The results showed that CHOP treatment was associated with a greater decrease in BMD and more frequent fractures.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
