Article
Endocrinology & Metabolism
Xuan Chen, Alison H. Affinati, Yungchun Lee, Adina F. Turcu, Norah Lynn Henry, Elena Schiopu, Angel Qin, Megan Othus, Dan Clauw, Nithya Ramnath, Lili Zhao
Summary: This study found that the risk of developing ICI-T1DM is associated with the type of ICI therapy, patient age, and preexisting non-T1DM diabetes. The development of ICI-T1DM does not seem to significantly impact patient survival.
Article
Chemistry, Analytical
Jihong Wang, Junqi Zhao, Yawen Liu, Zhen Meng, Xiaoxia Han, Baofeng Xu, Rui Liu, Chengyan He, Ziyi Cheng, Bing Zhao
Summary: A SERS-based immunoassay was developed for the detection of two autoantibodies, GADA and IAA, related to type 1 diabetes mellitus. The method showed potential for rapid, sensitive, and high-throughput screening of T1DM.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Endocrinology & Metabolism
Taylor M. Triolo, Laura Pyle, Hali Broncucia, Taylor Armstrong, Liping Yu, Peter A. Gottlieb, Andrea K. Steck
Summary: Objective Electrochemiluminescence (ECL) assays are high-affinity autoantibody tests used for risk screening and prediction of type 1 diabetes progression. This study analyzed the association of high-risk HLA haplotypes and genotypes with ECL positivity in relatives of individuals with type 1 diabetes, showing that ECL-GADA and ECL-IAA positivity are associated with HLA-DR3 and HLA-DR4 haplotypes, respectively.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Immunology
Xiongfeng Pan, Atipatsa C. Kaminga, Sanjay Kinra, Shi Wu Wen, Hongying Liu, Xinrui Tan, Aizhong Liu
Summary: This study summarized the associations of different chemokines with T1DM, revealing that circulating concentrations of CCL5 and CXCL1 were significantly higher in T1DM patients compared to controls. Circulating CCL5 ranked highest among all the chemokines investigated in T1DM.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Erin Strachan, Xavier Clemente-Casares, Sue Tsai
Summary: Maternal influences on the immune health and development of an infant begin in utero and continue after birth, shaping and educating the child's immune system. Two important provisions from the mother include early microbial colonizers and the transfer of antibodies. These provisions help educate the developing neonatal immune system, connecting with the microbiota and influencing disease development.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Carla Perego, Eliana S. Di Cairano, Alessandra Galli, Stefania Moretti, Elena Bazzigaluppi, Victoria Frolich Centonze, Amalia Gastaldelli, Emma Assi, Paolo Fiorina, Massimo Federici, Ottavia Porzio, Federico Bertuzzi, Alberto M. Davalli, Franco Folli
Summary: Islet cell surface autoantibodies have been found in subjects with type 1 diabetes mellitus (T1DM), but the specific antigens and mechanisms involved are still unknown. This study explored the potential immunological target of the glutamate transporter solute carrier family 1, member 2 (GLT1/EAAT2) in T1DM and the pathogenicity of autoantibodies against GLT1. The results showed the presence of autoantibodies against GLT1 in a significant percentage of T1DM patients and demonstrated that these autoantibodies caused beta-cell death through complement-dependent and independent mechanisms. GLT1 could be a promising therapeutic target for the prevention of beta-cell death in individuals with diabetes and prediabetes.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Luc Marchand, Meihang Li, Coralie Leblicq, Ibrar Rafique, Tugba Alarcon-Martinez, Claire Lange, Laura Rendon, Emily Tam, Ariane Courville-Le Bouyonnec, Constantin Polychronakos
Summary: It is hypothesized that about 1% of clinically diagnosed type 1 diabetes patients actually have non-autoimmune monogenic diabetes. By testing low genetic risk for type 1 diabetes, a significant percentage of patients with actionable monogenic variants can be identified, even in the absence of an affected parent. This approach could help in selecting patients for further screening studies and potentially change therapeutic strategies.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Annika Vestergaard Kvist, Mohamad I. Nasser, Peter Vestergaard, Morten Frost, Andrea M. Burden
Summary: A study in Denmark from 1997 to 2017 found that the incidence rates of fractures were higher in patients with type 1 and type 2 diabetes compared to those without diabetes, except for foot fractures. The incidence of hip fractures decreased by 35.2%, 47.0%, and 23.4% in patients with type 1 diabetes, type 2 diabetes, and without diabetes, respectively, over the last 5 years. However, vertebral fractures increased by 14.8%, 18.5%, and 38.9% in the same groups. After age adjustment, patients with type 1 diabetes still had a higher risk of fractures compared to those without diabetes, while patients with type 2 diabetes had a risk similar to those without diabetes.
Article
Endocrinology & Metabolism
Jamie L. Felton, David Cuthbertson, Megan Warnock, Kuldeep Lohano, Farah Meah, John M. Wentworth, Jay Sosenko, Carmella Evans-Molina
Summary: The study suggests that HOMA2-B may be used as a single-time-point measurement to stratify the risk of developing type 1 diabetes in Aab+ individuals. Lower HOMA2-B values were associated with higher risk and faster progression to type 1 diabetes.
Article
Endocrinology & Metabolism
Charanya Muralidharan, Abass M. Conteh, Michelle R. Marasco, Justin J. Crowder, Jeroen Kuipers, Pascal de Boer, Amelia K. Linnemann
Summary: The study provides evidence of impaired islet macroautophagy/crinophagy in human type 1 diabetes, as well as accumulation of telolysosomes with peripheral nitrogen in beta cells of autoantibody-positive donors, indicating altered lysosome content associated with lysosome dysfunction before clinical hyperglycemia. Similar macroautophagy impairments are also present in the NOD mouse model of type 1 diabetes.
Article
Endocrinology & Metabolism
Noora Nurminen, Damiano Cerrone, Jussi Lehtonen, Anirudra Parajuli, Marja Roslund, Maria Lonnrot, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Mikael Knip, Juho Rajaniemi, Olli H. Laitinen, Aki Sinkkonen, Heikki Hyoty
Summary: This study found that early exposure to an agricultural environment is inversely associated with the risk of type 1 diabetes, possibly mediated by early exposure to environmental microbial diversity.
Article
Endocrinology & Metabolism
Kaat Beunen, Lies Vercauter, Paul Van Crombrugge, Carolien Moyson, Johan Verhaeghe, Sofie Vandeginste, Hilde Verlaenen, Chris Vercammen, Toon Maes, Els Dufraimont, Nele Roggen, Christophe De Block, Yves Jacquemyn, Farah Mekahli, Katrien De Clippel, Annick van den Bruel, Anne Loccufier, Annouschka Laenen, Roland Devlieger, Chantal Mathieu, Katrien Benhalima
Summary: This study aimed to characterize and evaluate the risk of long-term glucose intolerance in women with gestational diabetes mellitus (GDM) positive for type 1 diabetes-related autoimmune antibodies (T1D-related autoantibodies) in pregnancy. The results showed that women with autoantibodies had some adverse characteristics during pregnancy and in their newborns. Long-term follow-up revealed that some women developed glucose intolerance, but only a few still had autoantibodies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Bum Chul Kwon, Vibha Anand, Peter Achenbach, Jessica L. Dunne, William Hagopian, Jianying Hu, Eileen Koski, Ake Lernmark, Markus Lundgren, Kenney Ng, Jorma Toppari, Riitta Veijola, Brigitte Frohnert
Summary: The development of islet autoimmunity in children with type 1 diabetes can be predicted, but the presence of autoantibodies does not always result in noticeable symptoms. Through long-term sampling and analysis of clinical characteristics, it was found that disease progression follows three distinct trajectories, with the ability to further predict disease onset based on age, sex, and HLA-DR status.
NATURE COMMUNICATIONS
(2022)
Article
Ophthalmology
James Rafferty, David R. Owens, Stephen D. Luzio, Patrick Watts, Ashley Akbari, Rebecca L. Thomas
Summary: This study found that 37.4% of the study cohort had DR at the first screening, with the risk increasing with longer diabetes duration, higher HbA(1c), and diastolic blood pressure. Additionally, individuals diagnosed with T1DM at 12 years or older were more likely to develop DR with each additional year of diabetes duration.
Article
Immunology
Sefina Arif, Irma Pujol-Autonell, Yogesh Kamra, Evangelia Williams, Norkhairin Yusuf, Clara Domingo-Vila, Yasaman Shahrabi, Emily Pollock, Leena Khatri, Mark Peakman, Timothy Tree, Anna Lorenc
Summary: T cell responses to both native and neoepitopes in patients with type 1 diabetes and high-risk unaffected family members are similar in terms of frequency and phenotype. This suggests that neoepitopes are comparable to native epitopes for immune-monitoring studies.
FRONTIERS IN IMMUNOLOGY
(2021)