Article
Infectious Diseases
Samuel Bourassa-Blanchette, Marit M. M. Biesheuvel, John C. C. Lam, Alexander Kipp, Deirdre Church, Julie Carson, Bruce Dalton, Michael D. D. Parkins, Herman W. W. Barkema, Daniel B. B. Gregson
Summary: This study aimed to determine the burden of illness, the population it affects, and the resistance profile of candidemia in our region. The annual incidence of candidemia in the Calgary Region was 3.8 per 100,000 persons, with C. albicans being the most common species. More than 50% of individuals with candidemia died within a year. The common Candida species in Calgary remains susceptible to fluconazole.
BMC INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Anna Dudakova, Claudia Blei, Uwe Gross, Marco H. Schulze
Summary: This study analyzes the impact of bedside antifungal stewardship (AFS) on clinical management and prognosis of patients with candidemia at a university hospital in Germany. The results show that bedside AFS significantly improves adherence to recommendations for antifungal treatment and follow-up in patients with Candida fungemia. However, improving the prognosis of patients with candidemia remains a huge challenge.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Microbiology
Luz Alejandra Vargas-Espindola, Sonia I. Cuervo-Maldonado, Jose L. Enciso-Olivera, Julio C. Gomez-Rincon, Leydy Jimenez-Cetina, Ricardo Sanchez-Pedraza, Katherine Garcia-Guzman, Maria Jose Lopez-Mora, Carlos A. alvarez-Moreno, Jorge Alberto Cortes, Javier R. Garzon-Herazo, Samuel Martinez-Vernaza, Claudia R. Sierra-Parada, Bryan A. Murillo-Sarmiento
Summary: Fungemia in hematologic malignancies has a high mortality rate. This retrospective cohort study analyzed adult patients with hematologic malignancies and fungemia in Bogota, Colombia from 2012 to 2019. The study described the epidemiological, clinical, and microbiological characteristics and identified risk factors associated with mortality. The findings revealed that non-albicans Candida species were the most frequent, and lymphoma or multiple myeloma and ICU admission were predictors of mortality.
Article
Medicine, General & Internal
Marcos Restrepo Arango, Juan Camilo Cadavid Usuga, Luis Fernando Velazquez Ossa, Jorge Hernando Donado Gomez, Laura Nataly Higuita Duque, Juan Pedro Neira Gomez
Summary: This study aims to describe the demographic clinical characteristics of patients with fungemia and secondary intraocular involvement, and identify risk factors. The findings suggest that there is no clear risk factor for subsequent ocular involvement in patients with fungemia, but patients with diabetes and history of HIV may have a risk trend.
ANNALS OF MEDICINE
(2022)
Article
Infectious Diseases
Sehnaz Alp, Dolunay Gulmez, Riza Can Kardas, Gizem Karahan, Zahit Tas, Gamze Gursoy, Caglayan Merve Ayaz-Ceylan, Sevtap Arikan-Akdagli, Murat Akova
Summary: Fungemia caused by uncommon Candida species is a rare but emerging threat with potential resistance to antifungal agents. The study found echinocandins and voriconazole to be effective against all tested isolates, but some species showed reduced susceptibility to fluconazole.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Microbiology
Ryan Mirchin, Jonathan M. Czeresnia, Erika P. Orner, Sudha Chaturvedi, Kerry Murphy, Joshua D. Nosanchuk
Summary: This article describes a case of a critically ill elderly woman with COVID-19 who developed a bloodstream infection caused by Candida blankii. The timely identification of the pathogen could have led to different treatment choices and possibly changed the outcome. The study highlights the challenges in correctly identifying C. blankii and the importance of understanding its susceptibility patterns to antifungal drugs.
Article
Infectious Diseases
Alessandra Leal Silva Chaves, Luciana Trilles, Gabriela Machado Alves, Maria Helena Galdino Figueiredo-Carvalho, Fabio Brito-Santos, Rowena Alves Coelho, Ianick S. Martins, Rodrigo Almeida-Paes
Summary: This study evaluated the clinical and microbiological aspects of six patients with bloodstream infections caused by the Meyerozyma guilliermondii species complex in Brazil, highlighting reduced antifungal susceptibility and variable production of virulence-related enzymes. Neutropenic patients with BSI caused by this emerging species complex had a poor prognosis.
Article
Medicine, Research & Experimental
Katherine Miranda-Cadena, Cristina Marcos-Arias, Estibaliz Mateo, Jose Manuel Aguirre-Urizar, Guillermo Quindos, Elena Eraso
Summary: The study evaluated the effects of three phytocompounds on Candida planktonic and sessile cells, with cinnamaldehyde being the most active in inhibiting biofilm adhesion, while carvacrol and thymol significantly reduced both mature biofilm biomass and metabolic activity. These results highlight the potential of cinnamaldehyde, carvacrol, and thymol as promising alternatives for candidiasis treatment and emphasize the need for further research on their safety, toxicity, pharmacodynamics, and pharmacokinetics.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Infectious Diseases
Judith Diaz-Garcia, Aina Mesquida, Marina Machado, Carlos Sanchez-Carrillo, Patricia Munoz, Pilar Escribano, Jesus Guinea
Summary: During the COVID-19 pandemic, there was an increase in both fungemia incidence and cases caused by Candida auris or fluconazole-resistant C. parapsilosis. A study conducted from January 2020 to December 2022 analyzed the impact of the pandemic on fungemia incidence, species epidemiology, potential patient-to-patient transmission, and antifungal resistance. The results showed a decrease in fungemia incidence over time and changes in species distribution, but no significant increase in antifungal resistance.
Article
Immunology
Rozeen Abu Shqara, Imad Kassis, Ranaa Damouni Shalabi, Halima Dabaja Younis
Summary: This study aimed to investigate the clinical features, antibiotic susceptibility, mortality rate, and risk factors of mortality in children with Pseudomonas bacteremia. The results showed relatively lower mortality rate in children with Pseudomonas bacteremia, and younger age, multidrug-resistant isolates, and inappropriate antibiotic treatment were associated with higher mortality.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Mycology
Meini Chen, Dongmei Hu, Tianmin Li, Dongyan Zheng, Wanqing Liao, Xiaobo Xia, Cunwei Cao
Summary: This study conducted a retrospective descriptive analysis on the epidemiological and clinical characteristics of fungemia in southern China. It found that Talaromyces marneffei was the most frequently isolated agent causing fungemia, and Candida albicans was the most commonly isolated Candida spp. More than 70% of talaromycosis fungemia occurred in AIDS patients, while candidemia was most commonly associated with recent surgery. The study provides new guidance for the early diagnosis and prompt treatment of fungemia in similar geographic regions.
Article
Public, Environmental & Occupational Health
S. Umamaheshwari, M. N. Sumana
Summary: This study retrospectively analyzed the distribution of Candida in various clinical samples in a tertiary care hospital in India. It found that urine samples were the major source of Candida infection, and non-albicans Candida (NAC) was the predominant species. The susceptibility test revealed that about 75.44% of isolates were susceptible to the tested drugs, while about 24.56% were resistant to one or more drugs.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Infectious Diseases
Peng Xie, Wenqiang Wang, Maolong Dong
Summary: The predictive model for 30-day mortality risk in ICU patients with fungemia constructed in this study exhibits good predictive ability, potentially offering a practical screening tool for patients with fungemia.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Dermatology
Jiacheng Dong, Guanzhao Liang, Hailin Zheng, Siyue Kan, Nana Song, Meijie Zhang, Weida Liu
Summary: Ravuconazole showed good activity against C. auris and vaginal Candida isolates, suggesting it could be used as an effective treatment for drug-resistant candidiasis.
Article
Microbiology
Emilia Gomez-Molero, Iker De-la-Pinta, Jordan Fernandez-Pereira, Uwe Gross, Michael Weig, Guillermo Quindos, Piet W. J. de Groot, Oliver Bader
Summary: Candida parapsilosis is a common cause of fungal bloodstream infections, especially in critically ill neonates or immunocompromised patients. Biofilm formation increases the risk of infection and complicates treatment, making it an important clinical parameter for guiding therapeutic choices.
Article
Immunology
Chen-Yen Kuo, Shang-Yu Wang, Han-Po Shih, Kun-Hua Tu, Wen-Chi Huang, Jing-Ya Ding, Chia-Hao Lin, Chun-Fu Yeh, Mao-Wang Ho, Shi-Chuan Chang, Chi-Ying He, Hung-Kai Chen, Chen-Hsuan Ho, Chen-Hsiang Lee, Chih-Yu Chi, Cheng-Lung Ku
JOURNAL OF CLINICAL IMMUNOLOGY
(2017)
Article
Immunology
Chih-Yu Chi, Li-Na Liao, Cheng-Mao Ho, Chia-Huei Chou, Mao-Wang Ho, Jen-Hsein Wang
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2018)
Article
Immunology
Wei-Shuo Chang, Mao-Wang Ho, Po-Chang Lin, Cheng-Mao Ho, Chia-Hui Chou, Min-Chi Lu, Yen-Jen Chen, Hsien-Te Chen, Jen-Hsien Wang, Chih-Yu Chi
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2018)
Article
Multidisciplinary Sciences
Hsiu-Yin Chiang, Chih-Wei Chung, Chin-Chi Kuo, Yen-Chun Lo, Wei-Shuo Chang, Chih-Yu Chi
Review
Genetics & Heredity
Chen-Lung Ku, Chih-Yu Chi, Horst von Bernuth, Rainer Doffinger
Article
Medicine, Research & Experimental
Gaspard Kerner, Jeremie Rosain, Antoine Guerin, Ahmad Al-Khabaz, Carmen Oleaga-Quintas, Franck Rapaport, Michel J. Massaad, Jing-Ya Ding, Taushif Khan, Fatima Al Ali, Mahbuba Rahman, Caroline Deswarte, Ruben Martinez-Barricarte, Raif S. Geha, Valentine Jeanne-Julien, Diane Garcia, Chih-Yu Chi, Rui Yang, Manon Roynard, Bernhard Fleckenstein, Flore Rozenberg, Stephanie Boisson-Dupuis, Cheng-Lung Ku, Yoann Seeleuthner, Vivien Beziat, Nico Marr, Laurent Abel, Waleed Al-Herz, Jean-Laurent Casanova, Jacinta Bustamante
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Immunology
Wen-Hsin Hsih, Meng-Yu Cheng, Mao-Wang Ho, Chia-Huei Chou, Po-Chang Lin, Chih-Yu Chi, Wei-Chih Liao, Chih-Yu Chen, Lih-Ying Leong, Ni Tien, Huan-Cheng Lai, Yi-Chyi Lai, Min-Chi Lu
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2020)
Article
Microbiology
Chia-Huei Chou, Yi-Ru Lai, Chih-Yu Chi, Mao-Wang Ho, Chao-Ling Chen, Wei-Chih Liao, Cheng-Mao Ho, Yu-An Chen, Chih-Yu Chen, Yu-Tzu Lin, Chia-Der Lin, Chih-Ho Lai
Article
Immunology
Shih-Yi Lin, Shu-Woei Ju, Cheng-Li Lin, Cheng-Chieh Lin, Wu-Huei Hsu, Chia-Hui Chou, Chih-Yu Chi, Chung-Y Hsu, Chia-Hung Kao
CLINICAL INFECTIOUS DISEASES
(2020)
Article
Immunology
Meng-Yu Cheng, Wen-Hsin Hsih, Mao-Wang Ho, Yi-Chyi Lai, Wei-Chih Liao, Chih-Yu Chen, Tsung-Chia Chen, Yu-Lin Lee, Po-Yu Liu, Chih-Chuan Kao, Chia-Huei Chou, Po-Chang Lin, Chih-Yu Chi, Lih-Ying Leong, Chih-Jaan Tai, Min-Chi Lu
Summary: This study showed a higher prevalence of olfactory dysfunction in COVID-19 patients, especially among young adults. Olfactory dysfunction can serve as a specific screening criterion for early detection of COVID-19, and the TWSIT is a reliable testing tool for quantifying and qualifying olfactory dysfunction.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Medicine, General & Internal
Shih-Yi Lin, Shih-Sheng Chang, Cheng-Li Lin, Cheng-Chieh Lin, Wu-Huei Hsu, Chia-Hui Chou, Chih-Yu Chi, Chia-Der Lin, Chih-Yen Tu, Chung-Y. Hsu, Chia-Hung Kao
Summary: The study found that both ACEI and ARB use were associated with decreased risk of community-acquired pneumonia infection, regardless of age and sex. Patients using ARB for a shorter duration exhibited a greater reduction in risk, while those using ACEI for 121-450 days were more likely to have reduced risks of community-acquired pneumonia.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Immunology
Hsiu-Yin Chiang, Tsung-Chia Chen, Che-Chen Lin, Lu-Ching Ho, Chin-Chi Kuo, Chih-Yu Chi
Summary: This study investigated the trend of mortality and developed predictive models for adult patients with bacteremia at emergency departments. The study found a decrease in the cumulative incidence and mortality of bacteremia, but the mortality burden remains critical. The proposed ED-BM model had significantly better performance in predicting short-term mortality compared to other scoring systems.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Hui-Shan Hsieh, Yu-Nong Gong, Chih-Yu Chi, Sen-Yung Hsieh, Wei-Ting Chen, Cheng-Lung Ku, Hao-Tsai Cheng, Lyndsey Lin, Chang Mu Sung
Summary: This study reveals significant differences in gut microbiome between patients with anti-IFN-gamma AAbs and healthy controls, suggesting a potential association between gut dysbiosis and the immunodeficiency condition caused by anti-IFN-gamma AAbs.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Hsiu-Yin Chiang, Li-Ying Liang, Che-Chen Lin, Yi-Jin Chen, Min-Yen Wu, Sheng-Hsuan Chen, Pin-Hua Wu, Chin-Chi Kuo, Chih-Yu Chi
Summary: Integrating electronic medical record data significantly improves the accuracy of ICD-only approaches in phenotyping infective endocarditis, filling the gaps in ICD coding and enhancing the reliability and practicality of infective endocarditis research.
BIOMEDICINE-TAIWAN
(2021)