Hemorrhagic fever of bunyavirus etiology: disease models and progress towards new therapies

Rift Valley Fever: An Emerging Mosquito-Borne Disease

(2016) Kenneth J. Linthicum et al.   Annual Review of Entomology

A chronological review of experimental infection studies of the role of wild animals and livestock in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus

(2016) Jessica R. Spengler et al.   ANTIVIRAL RESEARCH

Targeting a Novel RNA-Protein Interaction for Therapeutic Intervention of Hantavirus Disease

(2016) Nilshad N. Salim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse model for the Rift Valley fever virus MP12 strain infection

(2016) Yuekun Lang et al.   VETERINARY MICROBIOLOGY

What Do We Know about How Hantaviruses Interact with Their Different Hosts?

(2016) Myriam Ermonval et al.   Viruses-Basel

Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea

(2016) Daouda Sissoko et al.   PLOS MEDICINE

Inhibition of the Hantavirus Fusion Process by Predicted Domain III and Stem Peptides from Glycoprotein Gc

(2016) Gonzalo P. Barriga et al.   PLoS Neglected Tropical Diseases

Short Interfering RNA Inhibits Rift Valley Fever Virus Replication and Degradation of Protein Kinase R in Human Cells

(2016) Bonto Faburay et al.   Frontiers in Microbiology

The GenusTospovirus: Emerging Bunyaviruses that Threaten Food Security

(2016) J.E. Oliver et al.   Annual Review of Virology

Efficacy of T-705 (Favipiravir) in the Treatment of Infections with Lethal Severe Fever with Thrombocytopenia Syndrome Virus

(2016) Hideki Tani et al.   mSphere

Serological Investigation of Heartland Virus (Bunyaviridae: Phlebovirus) Exposure in Wild and Domestic Animals Adjacent to Human Case Sites in Missouri 2012–2013

(2015) Angela M. Bosco-Lauth et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Phylogenetic Analysis of Severe Fever with Thrombocytopenia Syndrome Virus in South Korea and Migratory Bird Routes Between China, South Korea, and Japan

(2015) Yeojun Yun et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Evaluation of Crimean-Congo hemorrhagic fever virus in vitro inhibition by chloroquine and chlorpromazine, two FDA approved molecules

(2015) O. Ferraris et al.   ANTIVIRAL RESEARCH

Computational prediction and biochemical characterization of novel RNA aptamers to Rift Valley fever virus nucleocapsid protein

(2015) Mary Ellenbecker et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Recent advances in research on Crimean-Congo hemorrhagic fever

(2015) Anna Papa et al.   JOURNAL OF CLINICAL VIROLOGY

Disruption of Type I Interferon Signaling by the Nonstructural Protein of Severe Fever with Thrombocytopenia Syndrome Virus via the Hijacking of STAT2 and STAT1 into Inclusion Bodies

(2015) Yun-Jia Ning et al.   JOURNAL OF VIROLOGY

Crimean-Congo Hemorrhagic Fever Virus Subunit Vaccines Induce High Levels of Neutralizing Antibodies But No Protection in STAT1 Knockout Mice

(2015) Jeroen Kortekaas et al.   VECTOR-BORNE AND ZOONOTIC DISEASES

Laguna Negra Virus Infection Causes Hantavirus Pulmonary Syndrome in Turkish Hamsters (Mesocricetus brandti)

(2015) K. Hardcastle et al.   VETERINARY PATHOLOGY

Combination effects of ribavirin and interferons on severe fever with thrombocytopenia syndrome virus infection

(2015) Masayuki Shimojima et al.   Virology Journal

A National Assessment of the Epidemiology of Severe Fever with Thrombocytopenia Syndrome, China

(2015) Kun Liu et al.   Scientific Reports

Antiviral Biologic Produced in DNA Vaccine/Goose Platform Protects Hamsters Against Hantavirus Pulmonary Syndrome When Administered Post-exposure

(2015) Nicole Haese et al.   PLoS Neglected Tropical Diseases

MP-12 virus containing the clone 13 deletion in the NSs gene prevents lethal disease when administered after Rift Valley fever virus infection in hamsters

(2015) Brian B. Gowen et al.   Frontiers in Microbiology

Repurposing FDA-approved drugs as therapeutics to treat Rift Valley fever virus infection

(2015) Ashwini Benedict et al.   Frontiers in Microbiology

Rift Valley Fever Virus Infection in Golden Syrian Hamsters

(2015) Dionna Scharton et al.   PLoS One

Inhibition of Rift Valley Fever Virus Replication and Perturbation of Nucleocapsid-RNA Interactions by Suramin

(2014) Mary Ellenbecker et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

BCX4430, a Novel Nucleoside Analog, Effectively Treats Yellow Fever in a Hamster Model

(2014) Justin G. Julander et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model

(2014) Lisa Oestereich et al.   ANTIVIRAL RESEARCH

Animal models of viral hemorrhagic fever

(2014) Darci R. Smith et al.   ANTIVIRAL RESEARCH

One Health approach to Rift Valley fever vaccine development

(2014) Jeroen Kortekaas   ANTIVIRAL RESEARCH

Favipiravir (T-705) protects against peracute Rift Valley fever virus infection and reduces delayed-onset neurologic disease observed with ribavirin treatment

(2014) Dionna Scharton et al.   ANTIVIRAL RESEARCH

Heartland Virus-Associated Death in Tennessee

(2014) A. Muehlenbachs et al.   CLINICAL INFECTIOUS DISEASES

Seroprevalence of antibodies against SFTS virus infection in farmers and animals, Jiangsu, China

(2014) Zhifeng Li et al.   JOURNAL OF CLINICAL VIROLOGY

SFTS Virus Infection in Nonhuman Primates

(2014) Cong Jin et al.   JOURNAL OF INFECTIOUS DISEASES

Neutrophil Depletion Suppresses Pulmonary Vascular Hyperpermeability and Occurrence of Pulmonary Edema Caused by Hantavirus Infection in C.B-17 SCID Mice

(2014) T. Koma et al.   JOURNAL OF VIROLOGY

Severe fever with thrombocytopenia syndrome, an emerging tick-borne zoonosis

(2014) Quan Liu et al.   LANCET INFECTIOUS DISEASES

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430

(2014) Travis K. Warren et al.   NATURE

Small Interfering RNA Inhibition of Andes Virus Replication

(2014) Cheng-Feng Chiang et al.   PLoS One

Pathophysiology of hantavirus pulmonary syndrome in rhesus macaques

(2014) D. Safronetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Dose Intranasal Treatment with DEF201 (Adenovirus Vectored Consensus Interferon) Prevents Lethal Disease Due to Rift Valley Fever Virus Challenge

(2014) Brian Gowen et al.   Viruses-Basel

Bunyavirus-Vector Interactions

(2014) Kate Horne et al.   Viruses-Basel

Hantavirus Reservoirs: Current Status with an Emphasis on Data from Brazil

(2014) Renata de Oliveira et al.   Viruses-Basel

Broad Spectrum Antiviral Activity of Favipiravir (T-705): Protection from Highly Lethal Inhalational Rift Valley Fever

(2014) Amy L. Caroline et al.   PLoS Neglected Tropical Diseases

Evaluation of Antiviral Efficacy of Ribavirin, Arbidol, and T-705 (Favipiravir) in a Mouse Model for Crimean-Congo Hemorrhagic Fever

(2014) Lisa Oestereich et al.   PLoS Neglected Tropical Diseases

High Content Image-Based Screening of a Protease Inhibitor Library Reveals Compounds Broadly Active against Rift Valley Fever Virus and Other Highly Pathogenic RNA Viruses

(2014) Rajini Mudhasani et al.   PLoS Neglected Tropical Diseases

The Major Cellular Sterol Regulatory Pathway Is Required for Andes Virus Infection

(2014) Josiah Petersen et al.   PLoS Pathogens

Antiviral Efficacy of Favipiravir against Two Prominent Etiological Agents of Hantavirus Pulmonary Syndrome

(2013) David Safronetz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Post-exposure vaccination with MP-12 lacking NSs protects mice against lethal Rift Valley fever virus challenge

(2013) Brian B. Gowen et al.   ANTIVIRAL RESEARCH

Slit2-Robo4 receptor responses inhibit ANDV directed permeability of human lung microvascular endothelial cells

(2013) Elena E. Gorbunova et al.   ANTIVIRAL RESEARCH

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

(2013) Dennis A. Bente et al.   ANTIVIRAL RESEARCH

The molecular biology of nairoviruses, an emerging group of tick-borne arboviruses

(2013) Lidia Lasecka et al.   ARCHIVES OF VIROLOGY

Human Antibody Neutralizes Severe Fever with Thrombocytopenia Syndrome Virus, an Emerging Hemorrhagic Fever Virus

(2013) Xiling Guo et al.   Clinical and Vaccine Immunology

Lethal Crimean-Congo Hemorrhagic Fever Virus Infection in Interferon α/β Receptor Knockout Mice Is Associated With High Viral Loads, Proinflammatory Responses, and Coagulopathy

(2013) Marko Zivcec et al.   JOURNAL OF INFECTIOUS DISEASES

Aerosolized Rift Valley Fever Virus Causes Fatal Encephalitis in African Green Monkeys and Common Marmosets

(2013) A. L. Hartman et al.   JOURNAL OF VIROLOGY

Characterization of the Bhanja Serogroup Viruses (Bunyaviridae): a Novel Species of the Genus Phlebovirus and Its Relationship with Other Emerging Tick-Borne Phleboviruses

(2013) K. Matsuno et al.   JOURNAL OF VIROLOGY

A Lethal Disease Model for Hantavirus Pulmonary Syndrome in Immunosuppressed Syrian Hamsters Infected with Sin Nombre Virus

(2013) R. L. Brocato et al.   JOURNAL OF VIROLOGY

Hamster-Adapted Sin Nombre Virus Causes Disseminated Infection and Efficiently Replicates in Pulmonary Endothelial Cells without Signs of Disease

(2013) D. Safronetz et al.   JOURNAL OF VIROLOGY

Structure of Severe Fever with Thrombocytopenia Syndrome Virus Nucleocapsid Protein in Complex with Suramin Reveals Therapeutic Potential

(2013) L. Jiao et al.   JOURNAL OF VIROLOGY

The Pathogenesis of Severe Fever with Thrombocytopenia Syndrome Virus Infection in Alpha/Beta Interferon Knockout Mice: Insights into the Pathologic Mechanisms of a New Viral Hemorrhagic Fever

(2013) Y. Liu et al.   JOURNAL OF VIROLOGY

Ribavirin Protects Syrian Hamsters against Lethal Hantavirus Pulmonary Syndrome — After Intranasal Exposure to Andes Virus

(2013) Monica Ogg et al.   Viruses-Basel

Aerosol Exposure to Rift Valley Fever Virus Causes Earlier and More Severe Neuropathology in the Murine Model, which Has Important Implications for Therapeutic Development

(2013) Christopher Reed et al.   PLoS Neglected Tropical Diseases

A Fusion-Inhibiting Peptide against Rift Valley Fever Virus Inhibits Multiple, Diverse Viruses

(2013) Jeffrey W. Koehler et al.   PLoS Neglected Tropical Diseases

A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion

(2013) Frederic Vigant et al.   PLoS Pathogens

Extended Protection against Phlebovirus Infection Conferred by Recombinant Adenovirus Expressing Consensus Interferon (DEF201)

(2012) Brian B. Gowen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Syrian hamster model of hantavirus pulmonary syndrome

(2012) David Safronetz et al.   ANTIVIRAL RESEARCH

Pathogenic effects of Rift Valley fever virus NSs gene are alleviated in cultured cells by expressed antiviral short hairpin RNAs

(2012) Tristan Scott et al.   ANTIVIRAL THERAPY

A New Phlebovirus Associated with Severe Febrile Illness in Missouri

(2012) Laura K. McMullan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model

(2012) C. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemotactic and Inflammatory Responses in the Liver and Brain Are Associated with Pathogenesis of Rift Valley Fever Virus Infection in the Mouse

(2012) Kimberly K. Gray et al.   PLoS Neglected Tropical Diseases

Choice of inbred rat strain impacts lethality and disease course after respiratory infection with Rift Valley Fever Virus

(2012) Jacquelyn M. Bales et al.   Frontiers in Cellular and Infection Microbiology

Identification of an antioxidant small-molecule with broad-spectrum antiviral activity

(2011) Rekha G. Panchal et al.   ANTIVIRAL RESEARCH

Human pathogenic hantaviruses and prevention of infection

(2011) Detlev H. Krüger et al.   Human vaccines & immunotherapeutics

Ribavirin for patients with Crimean–Congo haemorrhagic fever: a systematic review and meta-analysis

(2011) Sibel Ascioglu et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Hazara virus infection is lethal for adult type I interferon receptor-knockout mice and may act as a surrogate for infection with the human-pathogenic Crimean-Congo hemorrhagic fever virus

(2011) S. D. Dowall et al.   JOURNAL OF GENERAL VIROLOGY

Development of a Novel Nonhuman Primate Model for Rift Valley Fever

(2011) D. R. Smith et al.   JOURNAL OF VIROLOGY

Fever with Thrombocytopenia Associated with a Novel Bunyavirus in China

(2011) Xue-Jie Yu et al.   NEW ENGLAND JOURNAL OF MEDICINE

In Vitro and In Vivo Activity of Ribavirin against Andes Virus Infection

(2011) David Safronetz et al.   PLoS One

A DNA vaccine encoding ubiquitinated Rift Valley fever virus nucleoprotein provides consistent immunity and protects IFNAR−/− mice upon lethal virus challenge

(2011) Hani Boshra et al.   VACCINE

Re-Evaluation of 400 Crimean-Congo Hemorrhagic Fever Cases in an Endemic Area: Is Ribavirin Treatment Suitable?

(2011) Fazilet Duygu et al.   VECTOR-BORNE AND ZOONOTIC DISEASES

Inhibition of Hazara nairovirus replication by small interfering RNAs and their combination with ribavirin

(2011) Olivier Flusin et al.   Virology Journal

The Pathogenesis of Rift Valley Fever

(2011) Tetsuro Ikegami et al.   Viruses-Basel

Small molecule inhibitors of hantavirus infection

(2010) Pamela R. Hall et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Global Perspective on Hantavirus Ecology, Epidemiology, and Disease

(2010) C. B. Jonsson et al.   CLINICAL MICROBIOLOGY REVIEWS

Crimean-Congo hemorrhagic fever virus infection is lethal for adult type I interferon receptor-knockout mice

(2010) S. Bereczky et al.   JOURNAL OF GENERAL VIROLOGY

A New Mouse Model Reveals a Critical Role for Host Innate Immunity in Resistance to Rift Valley Fever

(2010) T. Z. do Valle et al.   JOURNAL OF IMMUNOLOGY

Andes Virus Disrupts the Endothelial Cell Barrier by Induction of Vascular Endothelial Growth Factor and Downregulation of VE-Cadherin

(2010) P. Shrivastava-Ranjan et al.   JOURNAL OF VIROLOGY

Pathogenesis and Immune Response of Crimean-Congo Hemorrhagic Fever Virus in a STAT-1 Knockout Mouse Model

(2010) D. A. Bente et al.   JOURNAL OF VIROLOGY

A broad-spectrum antiviral targeting entry of enveloped viruses

(2010) M. C. Wolf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protection against lethal Rift Valley fever virus (RVFV) infection in transgenic IFNAR−/− mice induced by different DNA vaccination regimens

(2010) Gema Lorenzo et al.   VACCINE

The pathogenesis of Rift Valley fever virus in the mouse model

(2010) Darci R. Smith et al.   VIROLOGY

Development of a broad-spectrum antiviral with activity against Ebola virus

(2009) M. Javad Aman et al.   ANTIVIRAL RESEARCH

Efficacy of favipiravir (T-705) and T-1106 pyrazine derivatives in phlebovirus disease models

(2009) Brian B. Gowen et al.   ANTIVIRAL RESEARCH

Rift Valley fever virus

(2009) Brian H. Bird et al.   JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION

Efficacy of oral ribavirin treatment in Crimean-Congo haemorrhagic fever: A quasi-experimental study from Turkey

(2009) Nazif Elaldi et al.   JOURNAL OF INFECTION

Phage Display Selection of Cyclic Peptides That Inhibit Andes Virus Infection

(2009) P. R. Hall et al.   JOURNAL OF VIROLOGY

Rift Valley fever vaccines

(2009) Tetsuro Ikegami et al.   VACCINE

Synthesis of 1-β-d-ribofuranosyl-3-ethynyl-[1,2,4]triazole and its in vitro and in vivo efficacy against Hantavirus

(2008) Dong-Hoon Chung et al.   ANTIVIRAL RESEARCH

Molecular strategies to inhibit the replication of RNA viruses

(2008) Pieter Leyssen et al.   ANTIVIRAL RESEARCH

Experience with intravenous ribavirin in the treatment of hemorrhagic fever with renal syndrome in Korea

(2008) Janice M. Rusnak et al.   ANTIVIRAL RESEARCH