Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.
Article
Endocrinology & Metabolism
Wei Wang, Rong Huang, Ping Tai Tang, Mei Tu, Xiu Li Guo
Summary: This study found that perirenal fat thickness is significantly associated with bone turnover markers, bone mineral density, and osteoporosis, suggesting that perirenal fat may play an important role in bone metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Izabela Michalus, Anna Lupinska, Izabela Woch, Katarzyna Wieczorek-Szukala, Danuta Chlebna-Soko, Andrzej Lewinski
Summary: This retrospective study explored the bone turnover and bone mass disorders in children with hypophosphatemic rickets. The results showed that bone metabolism disturbances and worse bone quality were found in these patients. It is crucial to monitor the progress and treatment effects by determining bone turnover markers, dual-energy X-ray absorptiometry findings, and indices of quantitative ultrasound examination.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Hai-yan Huang, Zhi-qi Huang, Ling-yan Hua, Wang-shu Liu, Feng Xu, Xiao-qin Ge, Chun-feng Lu, Jian-bin Su, Xue-qin Wang
Summary: The study found a significant association between low-normal serum sodium levels and low bone turnover, as well as a positive correlation between high serum sodium levels and high bone turnover.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Xiaowen Zhang, Suhas Krishnamoorthy, Casey Tze-Lam Tang, Warrington Wen-Qiang Hsu, Gloria Hoi-Yee Li, Chor-Wing Sing, Kathryn Choon-Beng Tan, Bernard Man-Yung Cheung, Ian Chi-Kei Wong, Annie Wai-Chee Kung, Ching-Lung Cheung
Summary: This study investigated the association between bone health and incident type-2 diabetes mellitus (T2DM). The results showed that higher bone density is associated with an increased risk of T2DM.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Mingwei Hu, Yifan Zhang, Jianjun Guo, Cuicui Guo, Xue Yang, Xue Ma, Hao Xu, Shuai Xiang
Summary: This study evaluated the changes in bone mineral density and bone turnover markers after denosumab and romosozumab therapies in patients with osteoporosis. The results showed that the romosozumab group exhibited greater changes in lumbar BMD and bone turnover markers at 3 months of treatment, while changes in BMD of total hip and femoral neck were relatively delayed. From 6 to 12 months of treatment, romosozumab showed greater changes in bone mineral density and markers of bone turnover.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Teresa Quattrin, Lucy D. Mastrandrea, Lucy S. K. Walker
Summary: Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic beta cells, and individuals with this disease rely on insulin for survival. Despite advancements, the burden of this disease remains high. Research shows that blocking the immune attack on beta cells holds promise in preserving endogenous insulin production.
Article
Endocrinology & Metabolism
Jakob Starup-Linde, Marie Juul Ornstrup, Thomas Nordstrom Kjaer, Simon Lykkeboe, Aase Handberg, Soren Gregersen, Torben Harslof, Steen Bonlokke Pedersen, Peter Vestergaard, Bente Lomholt Langdahl
Summary: This study compared bone structure, bone density, and bone turnover markers between non-diabetic overweight men with MetS and overweight men with T1D or T2D. The results showed lower bone turnover in men with T2D, but no clinically significant differences in bone density or structure.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Wei Wang, Zhe Yuan Chen, Fen Yan Lv, Mei Tu, Xiu Li Guo
Summary: This study evaluates the correlation of serum HDL-c and apolipoprotein A1 (APOA1) with bone metabolism in Chinese postmenopausal women with type 2 diabetes mellitus (T2DM). The results show that APOA1 is more strongly associated with bone metabolism compared to HDL-c.
FRONTIERS IN MEDICINE
(2023)
Article
Sport Sciences
Julie Abildgaard, Mette Yun Johansen, Kirsa Skov-Jeppesen, Lars Bo Andersen, Kristian Karstoft, Katrine Bagge Hansen, Bolette Hartmann, Jens Juul Holst, Bente Klarlund Pedersen, Mathias Ried-Larsen
Summary: The 12-month intensive exercise-based lifestyle intervention led to a significant increase in bone turnover in persons with T2D, primarily mediated by weight and fat mass loss. Bone mineral density was unaffected by the intervention, indicating improved bone health despite substantial weight loss. Further studies on the impact of exercise on fracture risk in persons with T2D are warranted.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Review
Nutrition & Dietetics
Minkyung Je, Kyeonghoon Kang, Jun-Il Yoo, Yoona Kim
Summary: This review aims to investigate the effects of macronutrients on bone health in elderly people based on human studies. The results suggest that carbohydrate intake has limited effects on bone fracture but further research is needed on its effects on bone mineral density and bone turnover markers. Additionally, inconsistent results were found regarding the beneficial effects of animal, vegetable, soy, or milk proteins on bone health. Further studies are required to establish a clear association between macronutrients and bone health in elderly people.
Review
Endocrinology & Metabolism
Marco Janner, Christoph Saner
Summary: This paper provides an overview of the impact of type 1 diabetes on bone health in children and adolescents. It discusses various methods, such as dual X-ray absorptiometry and modern non-invasive techniques, for assessing bone health. The paper also explores mechanisms responsible for diabetic bone disease in children and highlights the importance of microvascular disease in the pathophysiology.
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Article
Endocrinology & Metabolism
Yang Xu, Li Shen, Lianyong Liu, Zhenlin Zhang, Weiwei Hu
Summary: This study investigated the profile of serum undercarboxylated osteocalcin (ucOC) levels and their associations with bone mineral density (BMD), bone turnover markers (BTMs), and prevalence of osteopenia and osteoporosis in the Chinese population. The results showed that ucOC levels were higher in men than women and decreased with age until the age of 50, after which they increased. Higher ucOC levels were correlated with lower BMD values and higher levels of BTMs in both men and women. Furthermore, an increase in ucOC levels was associated with an increased risk of osteopenia and osteoporosis in both genders.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ian H. de Boer, Jye-Yu C. Backlund, Valerie Arends, Rose Gubitosi-Klug, Amisha Wallia, Naina Sinha Gregory, Annette Barnie, Andrew J. Burghardt, John M. Lachin, Barbara H. Braffett, Ann Schwartz
Summary: Poor glycemic control is associated with reduced bone formation in T1D patients, while reduced kidney function is associated with increased bone resorption and formation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Lilian Sewing, Laura Potasso, Sandra Baumann, Denis Schenk, Furkan Gazozcu, Kurt Lippuner, Marius Kraenzlin, Philippe Zysset, Christian Meier
Summary: Type 1 diabetes (T1DM) is associated with an increased risk of nonvertebral fractures, and the influence of glycemic control and microvascular disease on skeletal health in long-standing T1DM is not well understood. This study found that patients with long-standing T1DM had lower bone mineral density (BMD), decreased bone turnover, and weaker bones at the ultradistal tibia compared to non-diabetic controls. The presence of diabetic peripheral neuropathy was found to contribute to the altered cortical microarchitecture and reduced bone strength in T1DM patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Surgery
Pablo Quadri, Sofia Esposito, Adrian Coleoglou, Kirstie K. Danielson, Mario Masrur, Pier C. Giulianotti
JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
(2019)
Review
Surgery
Rebekah M. Zaluzec, Katherine A. Rodby, Perry S. Bradford, Kirstie K. Danielson, Pravin K. Patel, Janine Rosenberg
JOURNAL OF CRANIOFACIAL SURGERY
(2019)
Article
Surgery
Mario Masrur, Roberto Bustos, Lisa Sanchez-Johnsen, Luis Gonzalez-Ciccarelli, Alberto Mangano, Raquel Gonzalez-Heredia, Ronak Patel, Kirstie K. Danielson, Antonio Gangemi, Enrique Fernando Elli
Article
Multidisciplinary Sciences
Sirimon Reutrakul, Stephanie J. Crowley, Jason C. Park, Felix Y. Chau, Medha Priyadarshini, Erin C. Hanlon, Kirstie K. Danielson, Ben S. Gerber, Tracy Baynard, Jade J. Yeh, J. Jason McAnany
SCIENTIFIC REPORTS
(2020)
Article
Surgery
Perry S. Bradford, Moriyike Akinosun, Kirstie K. Danielson, Rebecca S. Monson, David. Morris, Janine Rosenberg
JOURNAL OF CRANIOFACIAL SURGERY
(2020)
Meeting Abstract
Endocrinology & Metabolism
Kirstie K. Danielson, Rebecca S. Monson, Yi Li, Jose Oberholzer
Meeting Abstract
Endocrinology & Metabolism
Sirimon Reutrakul, Bharati Prasad, Ashima Sahni, Sara Matani, Urmi Sheth, Kirstie K. Danielson, Rebecca S. Monson, Melissa Carlucci, Tomas Mercado, Maureen Smith
Article
Clinical Neurology
Urmi Sheth, Rebecca S. Monson, Bharati Prasad, Ashima S. Sahni, Sara Matani, Tomas Mercado, Maureen A. Smith, Melissa A. Carlucci, Kirstie K. Danielson, Sirimon Reutrakul
Summary: The study revealed that among patients with type 2 diabetes, CPAP adherence was associated with significantly lower blood pressure. Greater CPAP use within adherent patients was linked to lower systolic blood pressure.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2021)
Meeting Abstract
Endocrinology & Metabolism
Kirstie K. Danielson, Brett Rydzon, Yuval Eisenberg, Brian T. Layden, Janet Lin
Article
Nursing
Pablo Quadri, Lisa Sanchez-Johnsen, Gabriela Aguiluz-Cornejo, Mario Masrur, David Sigmon, Kirstie K. Danielson, Antonio Gangemi, Chandra Hassan
Summary: This study aims to describe hospital readmissions following bariatric surgery (sleeve gastrectomy and Roux-en-Y gastric bypass) in an urban academic medical center. The study also examines the association between specific sociodemographic and clinical variables with bariatric surgery hospital readmissions. The findings indicate that patients with chronic kidney disease, hypertension, a greater number of comorbidities before surgery, and postoperative complications have higher 30-day readmission rates.
BARIATRIC SURGICAL PRACTICE AND PATIENT CARE
(2023)
Article
Gastroenterology & Hepatology
Kathleen M. Dungan, Phil A. Hart, Dana K. Andersen, Marina Basina, Vernon M. Chinchilli, Kirstie K. Danielson, Carmella Evans-Molina, Mark O. Goodarzi, Carla J. Greenbaum, Rita R. Kalyani, Maren R. Laughlin, Ariana Pichardo-Lowden, Richard E. Pratley, Jose Serrano, Emily K. Sims, Cate Speake, Dhiraj Yadav, Melena D. Bellin, Frederico G. S. Toledo
Summary: This article describes the objectives, hypotheses, and methods of the DREAM study, which aims to comprehensively assess the metabolic and endocrine changes that precede and follow the development of diabetes mellitus after acute pancreatitis.
Meeting Abstract
Endocrinology & Metabolism
W. K. M. Wong, M. V. Joglekar, V. Saini, C. X. Dong, P. S. Kunte, B. L. Anderson, K. Z. Dajani, A. M. Simpson, P. E. MacDonald, P. A. Senior, K. K. Danielson, A. M. J. Shapiro, A. A. Hardikar
Meeting Abstract
Gastroenterology & Hepatology
Sarang Thaker, Mitali Agarwal, Karla J. Castellanos, Haya Rashdan, Yongchao Huang, Brian R. Boulay, Paul Grippo, H. Rex Gaskins, Kirstie K. Danielson, Georgios Papachristou, Lisa Tussing-Humphreys, Yang Dai, Ece Mutlu, Brian Layden, Cemal Yazici
Article
Medicine, Research & Experimental
Sirimon Reutrakul, Pamela Martyn-Nemeth, Lauretta Quinn, Brett Rydzon, Medha Priyadarshini, Kirstie K. Danielson, Kelly G. Baron, Jennifer Duffecy
Summary: This study aimed to explore the feasibility of sleep extension in women with a history of gestational diabetes (GDM) and its effects on glucose metabolism. The results showed that sleep duration increased in the sleep extension group, while decreased in the control group. Fasting glucose levels increased less in the sleep extension group compared to the control group, and there was no difference in glucose levels after an oral glucose tolerance test (OGTT).
PILOT AND FEASIBILITY STUDIES
(2022)
Meeting Abstract
Clinical Neurology
Sirimon Reutrakul, Pamela Martyn-Nemeth, Laurie Quinn, Kirstie Danielson, Brett Rydzon, Kelly Baron, Jennifer Duffecy