Journal
DIABETES-METABOLISM RESEARCH AND REVIEWS
Volume 31, Issue 3, Pages 221-233Publisher
WILEY
DOI: 10.1002/dmrr.2568
Keywords
diabetic nephropathy; signalling pathway; renal fibrosis; glomerular mesangial cell; podocyte
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Funding
- National Natural Science Foundation of China [81102864]
- Chinese traditional medical research of Anhui Province (China) [2012zy48]
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Diabetic nephropathy, a lethal diabetic complication, is a leading cause of end-stage renal disease, which is pathologically characterized by thickened tubular basal and glomerular membranes, accumulated extracellular matrix, and progressive mesangial hypertrophy. Growing evidence indicates that diabetic nephropathy is induced by multiple conditions, such as glucose metabolism disorder, oxidative stress, numerous inflammatory factors and cytokines, and haemodynamic changes that lead to the occurrence and development of diabetic nephropathy based on genetic susceptibility. A variety of abnormalities in the signalling pathway may interact to produce these pathologic processes. Research has aimed to highlight the signalling pathway mechanisms that lead to diabetic nephropathy so that preventative strategies and effective therapies might be developed. In this review, important pathways that appear to be involved in driving these processes are discussed. Copyright (C) 2014 John Wiley & Sons, Ltd.
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