Article
Radiology, Nuclear Medicine & Medical Imaging
Rong Wen, Peng Lin, Yuquan Wu, Haihui Yin, Weiche Huang, Danxia Guo, Yuye Peng, Dun Liu, Yun He, Hong Yang
Summary: This study analyzed the CEUS manifestations of combined hepatocellular cholangiocarcinoma (CHC) and investigated the diagnostic value of CEUS LI-RADS and serum tumor markers in CHC. The results showed that CEUS LI-RADS and serum tumor markers can be useful tools for reducing the misdiagnosis of CHC, although CHC lacks specific CEUS features. Beginners in radiology need to learn more about the CEUS features involved in CHC due to their relative complexity.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Oncology
Yanling Chen, Qing Lu, Weibin Zhang, Jiaying Cao, Yi Dong, Wenping Wang
Summary: A predictive nomogram based on clinical and ultrasound findings was established to distinguish combined hepatocellular-cholangiocarcinoma (CHC) from other subtypes of primary liver cancers (PLCs). The nomogram showed promising performance and clinical usefulness in differentiating CHC from hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC).
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Si-Young Kim, Hee-Seung Lee, Seung-Min Bang, Dai-Hoon Han, Ho-Kyoung Hwang, Gi-Hong Choi, Moon-Jae Chung, Seung-Up Kim
Summary: Cholangiocarcinoma (CCC) is a rare cancer with poor prognosis when diagnosed in advanced stages. Dickkopf-related protein 1 (DKK-1) has been shown to have diagnostic and prognostic value in intrahepatic CCC (ICC) patients, and its combination with carbohydrate antigen 19-9 (CA 19-9) can improve diagnostic performance. High levels of DKK-1 and CA 19-9 are associated with shorter overall survival in CCC patients, indicating their potential as prognostic markers.
Article
Oncology
Yan Zhou, Shanshan Yin, Lin Zhao, Xiang Zhang, Meng Li, Jianmin Ding, Kun Yan, Xiang Jing
Summary: The combination of CEUS and CT/MRI LI-RADS with serum tumor markers shows promising diagnostic performance in differentiating cHCC-CCAs from HCCs.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biology
Wei Zhang, Yingying Wang, Xiang Dong, Bo Yang, Hongyuan Zhou, Lu Chen, Zewu Zhang, Qin Zhang, Guangtai Cao, Zhiqiang Han, Huikai Li, Yunlong Cui, Qiang Wu, Ti Zhang, Tianqiang Song, Qiang Li
Summary: The study investigated the prognostic value of preoperative CA19-9 in HBV-HCC patients and found that CA19-9 >= 39 U/mL was associated with poorer RFS and OS. Elevated CA19-9 indicated more severe inflammation and cirrhosis in the liver of HCC patients.
Article
Gastroenterology & Hepatology
Maria Reig, Giuseppe Cabibbo
Summary: The potential impact of DAAs in BCLC-B/C stage patients with HCC is understudied, as HCC patients have been excluded from DAA trials. The decision on using DAAs should be made based on individual patient profiles.
JOURNAL OF HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Aurelie Beaufrere, Julien Calderaro, Valerie Paradis
Summary: Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a tumor with both hepatocytic and biliary differentiation, whose diagnosis is primarily based on morphology and immunostaining, with a prognosis worse than hepatocellular carcinoma and treatment limited to surgery.
JOURNAL OF HEPATOLOGY
(2021)
Article
Oncology
Leijuan Gan, Shaohua Ren, Mengran Lang, Guangtao Li, Feng Fang, Lu Chen, Yayue Liu, Ruyu Han, Kangwei Zhu, Tianqiang Song
Summary: This study aimed to investigate the relationship between tumor marker score (TMS) and postoperative recurrence of single small hepatocellular carcinoma (HCC). The results showed that TMS can divide patients into groups with different prognoses, and high TMS was associated with worse recurrence-free survival. TMS was identified as an independent prognostic factor for postoperative recurrence and could be used for risk stratification.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2022)
Article
Oncology
Hui Li, Yuan Feng, Chang Liu, Jiawang Li, Jiaxin Li, Hong Wu, Genshu Wang, Dewei Li
Summary: The study revealed that elevated preoperative CA19-9 that normalized after surgery does not lead to a poor prognosis in ICC patients, while those with persistently elevated postoperative CA19-9 are at higher risk of recurrence and death.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jie Zhang, Shang Dong Qin, Yan Li, Fei Lu, Wen Feng Gong, Jian Hong Zhong, Liang Ma, Jing Fei Zhao, Guo Hua Zhan, Peng Zhan Li, Bin Song, Bang De Xiang
Summary: This study evaluated the predictive role of preoperative serum levels of AFP and CA19-9 on the prognosis of HCC patients after hepatectomy. The results showed that the combination of serum AFP and CA19-9 levels can serve as a useful prognostic marker for HCC patients after hepatectomy.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Oncology
Matteo Renzulli, Daryl Ramai, Jameel Singh, Samridhi Sinha, Nicolo Brandi, Anna Maria Ierardi, Elisa Albertini, Rodolfo Sacco, Antonio Facciorusso, Rita Golfieri
Summary: Cholangiocarcinoma and combined hepatocellular cholangiocarcinoma are aggressive primary malignancies with liver resection as the main treatment modality. Locoregional therapies can provide local tumor control and increase chances of survival.
Article
Acoustics
Y. A. N. L. I. N. G. Chen, Q. I. N. G. Lu, Y. U. L. Zhu, B. E. I. J. I. A. N. Huang, Y. Dong, W. E. N. P. I. N. G. Wang
Summary: The study aimed to evaluate the predictive value of pre-operative clinical information and contrast-enhanced ultrasound (CEUS) imaging characteristics in diagnosing microvascular invasion (MVI) in combined hepatocellular-cholangiocarcinoma (CHC) patients. The results showed that heterogeneous enhancement and marked washout on CEUS were independent predictors of MVI in CHC. Patients with MVI had earlier recurrence after hepatectomy.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Oncology
Jiawei Zhang, Qiming Huang, Yi Yang, Jiahui Zhang, Xueting Fang, Yubin Yang, Huifang Liang, Wei Wang, Yanjun Wang
Summary: The role of carbonic anhydrase II (CAII) in intrahepatic cholangiocarcinoma (ICC) was investigated and a novel prognostic system combining CAII and preoperative carbohydrate antigen 19-9 (CA19-9) was established to predict the survival of patients with ICC after curative resection.
Article
Acoustics
Yi Dong, Sheng Chen, Kathleen Moeller, Yi-Jie Qiu, Xiu-Yun Lu, Qi Zhang, Christoph F. Dietrich, Wen-Ping Wang
Summary: The objective of this study was to investigate the value of dynamic contrast-enhanced ultrasound (DCE-US) and quantitative analysis in the pre-operative differential diagnosis of intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) in non-cirrhotic liver. The results showed that DCE-US with quantitative analysis is helpful in the pre-operative differential diagnosis of ICC and HCC lesions.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Article
Medicine, General & Internal
Ling Gao, Jia-Yan Huang, Zi-Jian Lu, Qiang Lu
Summary: The CEUS characteristics of synchronous CHC and HCC are different. CEUS features in combination with clinical information could help in effective diagnosis, clinical decision-making and better prognosis.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yang Huang, Meng-Fei Xian, Wen-Xuan Xie, Kang-Ming Pan, Dan Zeng, Hui Huang, Ming-De Li, Xiao-Yan Xie, Ming Kuang, Ming-De Lu, Li-Da Chen, Wei Wang
Summary: The presence of chaotic vessels and/or peripheral circular artery can help detect HCC among LR-M observations. Other explored criteria based on major features did not have higher specificity or PPV.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hui Huang, Si-Min Ruan, Meng-Fei Xian, Ming-De Li, Mei-Qing Cheng, Wei Li, Yang Huang, Xiao-Yan Xie, Ming-De Lu, Ming Kuang, Wei Wang, Hang-Tong Hu, Li-Da Chen
Summary: This study aimed to construct a prediction model based on contrast-enhanced ultrasound (CEUS) ultrasomics features and investigate its efficacy in predicting early recurrence of primary hepatocellular carcinoma (HCC). The combined model performed best in predicting recurrence within 2 years, with high efficacy in predicting early recurrence of HCC. The study highlights the potential of CEUS ultrasomics in diagnosing and predicting HCC recurrence.
BRITISH JOURNAL OF RADIOLOGY
(2022)
Article
Acoustics
Jiakang Zhou, Fengxin Pan, Wei Li, Hangtong Hu, Wei Wang, Qinghua Huang
Summary: In this study, a feature fusion method was proposed and evaluated to address the problem of distinguishing atypical hepatocellular carcinoma from focal nodular hyperplasia in CEUS videos. The results showed that the fused features achieved excellent performance and had better interpretability compared to general CNNs.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Acoustics
Huan-Ling Guo, Xiao-Zhou Lu, Hang-Tong Hu, Si-Min Ruan, Xin Zheng, Xiao-Yan Xie, Ming-De Lu, Ming Kuang, Shun-Li Shen, Li-Da Chen, Wei Wang
Summary: The study suggests that the CEUS-clinical nomogram is a reliable tool for early recurrence prediction in hepatocellular-cholangiocarcinoma, aiding in postoperative risk stratification.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dan Zeng, Ming Xu, Jin-Yu Liang, Mei-Qing Cheng, Hui Huang, Jia-Ming Pan, Yang Huang, Wen-Juan Tong, Xiao-Yan Xie, Ming-De Lu, Ming Kuang, Li-Da Chen, Hang-Tong Hu, Wei Wang
Summary: By adjusting the early washout onset and the time of marked washout, the diagnostic performance of liver imaging reporting and data system (LI-RADS) in distinguishing between hepatocellular carcinoma (HCC) and non-HCC malignancies can be improved.
Article
Oncology
Bo-Wen Zhuang, Wei Li, Bin Qiao, Nan Zhang, Man-Xia Lin, Wei Wang, Ming Kuang, Ming-De Lu, Xiao-Yan Xie, Xiao-Hua Xie
Summary: This study examined the prognostic value of preoperative alfa-fetoprotein (AFP) density and other clinical factors in patients undergoing percutaneous radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). The results showed that high AFP density was associated with prolonged progression-free survival (PFS) and overall survival (OS). Multivariate analysis identified AFP density as a predictor of PFS and OS.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2022)
Article
Endocrinology & Metabolism
Junzhao Ye, Xiaodong Zhuang, Xin Li, Xiaorong Gong, Yanhong Sun, Wei Wang, Shiting Feng, Tingfeng Wu, Bihui Zhong
Summary: This study proposes a new classification system for MAFLD that accurately identifies the risk of complications using metabolic parameters. The study found that MAFLD patients in different clusters have different risks of diabetes, heart disease, stroke, and mortality.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wen-juan Tong, Mei-qing Cheng, Man-xia Lin, Hang-tong Hu, Jia-min Pan, Hui Huang, Ying Wang, Xiao-yan Xie, Ming-de Lu, Ming Kuang, Yang Huang, Wei Wang
Summary: This study compares the diagnostic performance of CEUS LI-RADS v2016 and v2017 in identifying the origin of tumor in vein (TIV). The results show that CEUS LI-RADS v2016 has higher diagnostic accuracy and positive predictive value in identifying the origin of TIV, while v2017 has lower diagnostic accuracy.
BMC MEDICAL IMAGING
(2022)
Article
Gastroenterology & Hepatology
Ming-De Li, Ze-Rong Huang, Quan-Yuan Shan, Shu-Ling Chen, Ning Zhang, Hang-Tong Hu, Wei Wang
Summary: The aim of this study was to analyze the performance of different artificial intelligence models in endoscopic colonic polyp detection and classification and compare them with doctors of different experience. The results showed that the performance of AI group in detecting and classifying colonic polyps was similar to that of the expert group, with high sensitivity and moderate specificity. Different tasks may have an impact on the performance of deep learning models and human experts, especially in terms of sensitivity and specificity.
BMC GASTROENTEROLOGY
(2022)
Article
Acoustics
Meng-Fei Xian, Wei Li, Wen-Tong Lan, Dan Zeng, Wen-Xuan Xie, Ming-De Lu, Yang Huang, Wei Wang
Summary: This study aimed to develop an effective strategy for accurate diagnosis of focal liver lesions (FLLs) in patients with non-high risk for hepatocellular carcinoma (HCC). The combination of clinical risk stratification criteria and CEUS criteria showed high accuracy in identifying benign lesions and HCCs in the intermediate-risk group.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Biology
Qinghua Huang, Liangrun Zhao, Guanqing Ren, Xiaoyi Wang, Chunying Liu, Wei Wang
Summary: Cardiovascular diseases (CVD) are a major threat to human health and the leading cause of death worldwide. This paper proposes a nested attention-guided deep learning model, NAG-Net, for accurate segmentation of carotid Lumen-intima interface (LII) and Media-adventitia interface (MAI). NAG-Net incorporates task-related clinical domain knowledge and allows for direct obtaining of fine contours without complicated post-processing steps.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Medicine, General & Internal
Wen-Juan Tong, Shao-Hong Wu, Mei-Qing Cheng, Hui Huang, Jin-Yu Liang, Chao-Qun Li, Huan-Ling Guo, Dan-Ni He, Yi-Hao Liu, Han Xiao, Hang-Tong Hu, Si-Min Ruan, Ming-De Li, Ming-De Lu, Wei Wang
Summary: To optimize the integration of AI decision aids and reduce workload in thyroid nodule management, personalized AI needs to be incorporated into radiologists' decision-making processes. The study compares the diagnostic performance and workload reduction of an optimized AI strategy with a traditional all-AI strategy.
Article
Acoustics
Ze-Rong Huang, Lv Li, Hui Huang, Mei-Qing Cheng, Ming- De Li, Huan-Ling Guo, Rui-Fang Lu, Wei Wang, Wei Li, Li- Da Chen
Summary: The objective of this study was to evaluate the value of pre-operative multimodal data in predicting early and late recurrence of hepatocellular carcinoma after curative treatment. Clinical parameters, 2-D shear wave elastography, and contrast-enhanced ultrasound were found to be independently associated with early recurrence. Contrast-enhanced ultrasound and 2-D shear wave elastography were significant predictors of early recurrence at different time points. The multimodal model performed the best in predicting early recurrence of hepatocellular carcinoma.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhong Liu, Wei Li, Ziqi Zhu, Huiying Wen, Ming-de Li, Chao Hou, Hui Shen, Bin Huang, Yudi Luo, Wei Wang, Xin Chen
Summary: This study developed a deep learning model that integrates ultrasound contrast-enhanced micro-flow (CEMF) cines, B-mode images, and clinical parameters to improve the diagnosis of significant liver fibrosis (>= F2) in patients with chronic hepatitis B (CHB).
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Si-min Ruan, Hui Huang, Mei-qing Cheng, Man-xia Lin, Hang-tong Hu, Yang Huang, Ming-de Li, Ming-de Lu, Wei Wang
Summary: This study established a shear-wave elastography combined with contrast-enhanced ultrasound algorithm for the differentiation of focal liver lesions. The results showed that the algorithm had higher accuracy and clinical benefits in detecting malignant lesions, and it also showed promising results in patients with normal liver backgrounds.