Article
Cardiac & Cardiovascular Systems
Andreas S. Papazoglou, Anastasios Kartas, Athanasios Samaras, Ioannis Vouloagkas, Eleni Vrana, Dimitrios V. Moysidis, Evangelos Akrivos, Georgios Kotzampasis, Amalia Baroutidou, Anastasios Papanastasiou, Evangelos Liampas, Michail Botis, Efstratios Karagiannidis, Nikolaos Stalikas, Haralambos Karvounis, Apostolos Tzikas, George Giannakoulas
Summary: The presence of diabetes mellitus on top of atrial fibrillation was associated with increased risk of all-cause mortality and cardiovascular mortality. Lower HbA1c levels were independently related to better survival rates in patients with atrial fibrillation and diabetes mellitus.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ying X. Gue, Arnaud Bisson, Alexandre Bodin, Julien Herbert, Gregory Y. H. Lip, Laurent Fauchier
Summary: This study found that male atrial fibrillation patients born in spring or summer have a higher risk of cardiovascular mortality, while there is no such association in female patients. The underlying reasons for this gender difference require further investigation.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2021)
Article
Multidisciplinary Sciences
Juntae Kim, Pil-Sung Yang, Byoung-Eun Park, Tae Soo Kang, Seong-Hoon Lim, Sungsoo Cho, Su-Yeon Lee, Myung-Yong Lee, Gregory Y. H. Lip, Dongmin Kim, Boyoung Joung
Summary: This study found that proteinuria is associated with a higher risk of atrial fibrillation in diabetic patients, with a dose-dependent relationship. Assessment of proteinuria through a simple urine dipstick test could be a useful tool in evaluating the risk of atrial fibrillation in elderly diabetic population.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Yong Wei, Qingye Zeng, Lidong Cai, Xingjie Wang, Bin Wang, Chaoying Shen, Chao Li, Caihong Wang, Yahong Shen, Shunhong Yang, Xiaoyu Wu, Yan Liu, Juan Xu, Xiaofeng Lu, Songwen Chen, Genqing Zhou, Shaowen Liu
Summary: Ischemic stroke remains a leading cause of death in Chinese atrial fibrillation (AF) patients. Oral anticoagulants (OAC) are underused in this population. Age, AF subtype, previous tumor, prior myocardial infarction, hypoglycemic therapy, low body weight, and lack of calcium channel blocker (CCB) use are independent risk factors for death.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Husam Abdel-Qadir, Madison Gunn, Iliana C. Lega, Andrea Pang, Peter C. Austin, Sheldon M. Singh, Cynthia A. Jackevicius, Karen Tu, Paul Dorian, Douglas S. Lee, Dennis T. Ko
Summary: The longer the duration of diabetes and the higher the glycated hemoglobin level, the significantly higher the stroke rate in patients with AF and diabetes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Clinical Neurology
Alvi A. Rahman, Jonathan Michaud, Sophie Dell'Aniello, Erica E. M. Moodie, James M. Brophy, Madeleine Durand, Jason R. Guertin, Jean-Francois Boivin, Christel Renoux
Summary: In patients with nonvalvular atrial fibrillation (NVAF), the use of oral anticoagulants (OACs) is associated with a decreased risk of dementia, particularly in elderly individuals.
Article
Medicine, General & Internal
Cecilia Johansson, Lina Ortendahl, Marcus M. Lind, Jonas Andersson, Lars Johansson, Mattias Brunstrom
Summary: This study investigated the association between diabetes and different prediabetic states as independent risk factors for atrial fibrillation (AF). The results showed a significant association between glycemic status and AF in all groups except the impaired glucose tolerance group. However, this association disappeared after controlling for potential confounders.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
So-Ryoung Lee, Eue-Keun Choi, Jin-Hyung Jung, Kyung-Do Han, Seil Oh, Gregory Y. H. Lip
Summary: This study found that patients with newly diagnosed atrial fibrillation who abstained from alcohol or were non-drinkers had a lower risk of ischemic stroke compared to current drinkers.
EUROPEAN HEART JOURNAL
(2021)
Article
Oncology
Daniele Pastori, Amelie Marang, Arnaud Bisson, Danilo Menichelli, Julien Herbert, Gregory Y. H. Lip, Laurent Fauchier
Summary: This study investigated the impact of cancer on clinical outcomes in atrial fibrillation (AF) patients, as well as the performance of HAS-BLED and CHA(2)DS(2)-VASc scores. The results showed that cancer increased all-cause mortality, major bleeding, and intracranial hemorrhage risk in AF patients. The risk of ischemic stroke varied among different cancer types, with some showing higher bleeding risk compared to thromboembolic risk.
Article
Endocrinology & Metabolism
Konsta Teppo, Elis Kouki, Birgitta Salmela, Leo Niskanen, Jussi Jaakkola, Olli Halminen, Jari Haukka, Jukka Putaala, Miika Linna, Pirjo Mustonen, Juha Hartikainen, K. E. Juhani Airaksinen, Mika Lehto
Summary: The prevalence of diabetes among patients with atrial fibrillation (AF) has increased from 2007 to 2018. However, during this period, there has been a decrease in rates of ischemic stroke (IS) and mortality among both patients with and without diabetes. Diabetes is found to be a significant risk factor for IS and mortality in this patient population.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Cardiac & Cardiovascular Systems
Bisan Shweikialrefaee, Dennis T. Ko, Jiming Fang, Andrea Pang, Peter C. Austin, Paul Dorian, Sheldon M. Singh, Cynthia A. Jackevicius, Karen Tu, Douglas S. Lee, Husam Abdel-Qadir
Summary: This study found that statin use is associated with a lower stroke rate in patients with atrial fibrillation (AF), while higher levels of low-density lipoprotein are associated with a higher stroke rate.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Nan Young Bae, So-Ryoung Lee, Eue-Keun Choi, Hyun Jin Ahn, Hyo-Jeong Ahn, Soonil Kwon, Kyung-Do Han, Kyu-Na Lee, Seil Oh, Gregory Y. H. Lip
Summary: This study investigates whether patients with diabetes who have mental disorders are at an increased risk for atrial fibrillation (AF). The results show that mental disorders, especially depression, insomnia, and anxiety, are associated with an increased risk for AF in patients with diabetes.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Wajd Alkabbani, Colleen J. J. Maxwell, Ruth Ann Marrie, Suzanne L. L. Tyas, Iliana C. C. Lega, John-Michael Gamble
Summary: This study reevaluates the association between insulin use and dementia risk in type 2 diabetes patients, considering confounding factors. The results showed no significant association between insulin use and all-cause dementia in patients previously treated with two noninsulin antihyperglycemic medications.
Article
Endocrinology & Metabolism
Nami Lee, So Jeong Park, Dongwoo Kang, Ja Young Jeon, Hae Jin Kim, Dae Jung Kim, Kwan-Woo Lee, Edward J. Boyko, Seung Jin Han
Summary: DEP is more likely to require insulin therapy than type 2 diabetes. Hypoglycemia, micro- and macrovascular complications, and all-cause mortality events are higher in DEP compared with type 2 diabetes.
Article
Endocrinology & Metabolism
Arvid Engstroem, Viktor Wintzell, Mads Melbye, Anders Hviid, Bjoern Eliasson, Soffia Gudbjoernsdottir, Kristian Hveem, Christian Jonasson, Henrik Svanstroem, Bjoern Pasternak, Peter Ueda
Summary: Using nationwide registers data from Denmark, Norway, and Sweden, this study demonstrates an association between the use of SGLT2 inhibitors and the risk of new-onset atrial fibrillation. Compared to GLP-1 receptor agonists, SGLT2 inhibitors are associated with a modestly reduced risk of new-onset atrial fibrillation.
Review
Cardiac & Cardiovascular Systems
Davide Olivari, Daria De Giorgio, Lidia Irene Staszewsky, Francesca Fumagalli, Antonio Boccardo, Deborah Novelli, Martina Manfredi, Giovanni Babini, Anita Luciani, Laura Ruggeri, Aurora Magliocca, Davide Danilo Zani, Serge Masson, Angelo Belloli, Davide Pravettoni, Giuseppe Maiocchi, Roberto Latini, Giuseppe Ristagno
Summary: This study presents a novel porcine model of decompensated acute heart failure (AHF) that combines chronic and acute myocardial infarction, volume overload, and pressure overload. The model successfully replicates all typical clinical signs of AHF in a consistent and reproducible manner.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Letter
Medicine, General & Internal
Alessandra Bandera, Alessandro Nobili, Mauro Tettamanti, Sergio Harari, Silvano Bosari, Pier Mannuccio Mannucci
INTERNAL AND EMERGENCY MEDICINE
(2022)
Letter
Medicine, General & Internal
Raffaella Rossio, Mauro Tettamanti, Alessandro Nobili, Sergio Harari, Pier Mannuccio Mannucci, Alessandra Bandera, Flora Peyvandi
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Geriatrics & Gerontology
Andrea Corsonello, Luca Soraci, Mirko Di Rosa, Silvia Bustacchini, Anna Rita Bonfigli, Rosamaria Lisa, Rosa Liperoti, Mauro Tettamanti, Antonio Cherubini, Roberto Antonicelli, Giuseppe Pelliccioni, Demetrio Postacchini, Fabrizia Lattanzio
Summary: Multimorbidity and functional impairment have a prognostic impact on long-term mortality among older patients. Functional impairment may better predict prognosis compared with multimorbidity.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Xavier Rossello, Sergio Raposeiras-Roubin, Roberto Latini, Alberto Dominguez-Rodriguez, Jose A. Barrabes, Pedro L. Sanchez, Manuel Anguita, Felipe Fernandez-Vazquez, Domingo Pascual-Figal, Jose M. De la Torre Hernandez, Stefano Ferraro, Alfredo Vetrano, Jose A. Perez-Rivera, Oscar Prada-Delgado, Noemi Escalera, Lidia Staszewsky, Gonzalo Pizarro, Jaume Aguero, Stuart Pocock, Filippo Ottani, Valentin Fuster, Borja Ibanez
Summary: The REBOOT trial aims to provide guidance on the use of beta-blockers for patients discharged after MI without reduced LVEF, with a lack of evidence in this area.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Giuseppe Vergaro, Alberto Aimo, James L. Januzzi, A. Mark Richards, Carolyn S. P. Lam, Roberto Latini, Lidia Staszewsky, Inder S. Anand, Thor Ueland, Hans-Peter Brunner-La Rocca, Antoni Bayes-Genis, Josep Lupon, Rudolf A. de Boer, Akiomi Yoshihisa, Yasuchika Takeishi, Ida Gustafsson, Kai M. Eggers, Kurt Huber, Greg D. Gamble, Kui Toh Gerard Leong, Poh Shuan Daniel Yeo, Hean Yee Ong, Fazlur Jaufeerally, Tze P. Ng, Richard Troughton, Robert N. Doughty, Michele Emdin, Claudio Passino
Summary: This study assessed the influence and prognostic value of three biomarkers (NT-proBNP, hs-TnT, and sST2) in patients with HF and COPD. The results showed that patients with COPD had higher levels of NT-proBNP and hs-TnT, but no significant difference in sST2 levels. Regardless of COPD status, all three biomarkers were predictive of prognosis in HF patients.
JOURNAL OF CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Federico Carbone, Jennifer Meessen, Marco Magnoni, Daniele Andreini, Aldo Pietro Maggioni, Roberto Latini, Fabrizio Montecucco
Summary: Inflammation may play a role in the development of coronary artery disease (CAD) in different cardiovascular risk factor categories. Osteopontin (OPN) levels were highest in the low risk factor group and associated with CAD. Other biomarkers, such as myeloperoxidase (MPO) and resistin, did not differ based on CAD presence.
Article
Cardiac & Cardiovascular Systems
Blerim Mujaj, Zhen-Yu Zhang, Wen-Yi Yang, Lutgarde Thijs, Fang-Fei Wei, Peter Verhamme, Christian Delles, Javed Butler, Peter Sever, Roberto Latini, John G. F. Cleland, Faiez Zannad, Jan A. Staessen
Summary: This study found that aspirin use was associated with incident HF in patients at risk, independent of other risk factors. In the absence of conclusive trial evidence, caution should be exercised in prescribing aspirin to patients at risk of HF or with HF.
Article
Clinical Neurology
Yvonne Leung, Nir Barzilai, Agnieszka Batko-Szwaczka, Nina Beker, Kathrin Boerner, Carol Brayne, Henry Brodaty, Karen Siu-Lan Cheung, Maria M. Corrada, John D. Crawford, Alessia A. Galbussera, Yasuyuki Gondo, Henne Holstege, Marc Hulsman, Yoshiko Lily Ishioka, Daniela Jopp, Claudia H. Kawas, Jeff Kaye, Nicole A. Kochan, Bobo Hi-Po Lau, Darren M. Lipnicki, Jessica W. Lo, Ugo Lucca, Steve R. Makkar, Gabriella Marcon, Peter Martin, Kenichi Meguro, Sofiya Milman, Leonard W. Poon, Angela Recchia, Oscar Ribeiro, Emma Riva, Christoph Rott, Sietske Am Sikkes, Ingmar Skoog, Blossom Stephan, Jan Szewieczek, Laetitia Teixeira, Mauro Tettamanti, Krzysztof Wilczynski, Perminder Sachdev
Summary: This study investigated the prevalence of dementia in centenarians and near-centenarians and found that the prevalence increases with age. Education and hypertension may have a protective effect against dementia, but further research is needed to understand other factors affecting dementia in this age group.
ALZHEIMERS & DEMENTIA
(2022)
Review
Biochemistry & Molecular Biology
Calogero Caruso, Gabriella Marcon, Giulia Accardi, Anna Aiello, Anna Calabro, Mattia Emanuela Ligotti, Mauro Tettamanti, Claudio Franceschi, Giuseppina Candore
Summary: In this paper, the role of age and sex in the fatal outcome of COVID-19 was analyzed, and conflicting results in the literature were discussed. The findings showed that women are more resilient than men, centenarians overall did not have lower mortality rates compared to other older individuals, and centenarians over the age of 101 showed greater resilience to COVID-19 compared to younger centenarians in the first wave of the pandemic in 2020. The potential relationship with the 1918 Spanish flu epidemic is still unclear, and further research is needed to understand the underlying mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Alessandro Nobili, Barbara D'Avanzo, Mauro Tettamanti, Alessia Antonella Galbussera, Giuseppe Remuzzi, Ida Fortino, Olivia Leoni, Sergio Harari, Pier Mannuccio Mannucci
Summary: By analyzing the administrative claims database of Lombardy, the first region heavily affected by the SARS-CoV-2 pandemic in Italy, we investigated the healthcare impact of the post-COVID-19 condition. We used drug and diagnostic test dispensation as proxies and compared the data of 46,574 recovered COVID-19 cases with their pre-COVID period. The findings suggest that the post-COVID condition remains active and clinically relevant in a substantial proportion of recovered cases even 18 months after the acute disease, with certain drug categories still showing higher dispensation rates compared to the pre-COVID period.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Review
Health Care Sciences & Services
Cosimo Tuena, Francesca Borghesi, Francesca Bruni, Silvia Cavedoni, Sara Maestri, Giuseppe Riva, Mauro Tettamanti, Rosa Liperoti, Lorena Rossi, Maurizio Ferrarin, Marco Stramba-Badiale
Summary: Cognitive-motor dual-task (CMDT) is essential in daily life and can be challenging for older adults with chronic age-related conditions. Technology-assisted CMDT rehabilitation has shown to be effective in improving motor-cognitive functions, particularly for dual-task performances, falls, gait, and cognition. However, further research is needed to explore its application in different chronic conditions and frailty status.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Chemistry, Medicinal
Ersilia Lucenteforte, Marco Finocchietti, Antonio Addis, Mauro Tettamanti, Monica Varano, Mariacristina Parravano, Gianni Virgili
Summary: This study aimed to describe the polytherapy and multimorbidity pattern of patients receiving anti-VEGF and dexamethasone drugs for the treatment of retinal conditions. The results revealed that patients receiving intravitreal injections have a high prevalence of multimorbidity and polytherapy, leading to a significant burden of care.
Letter
Medicine, General & Internal
Luisa Ojeda-Fernandez, Marta Baviera, Giulia Macaluso, Simone Schena, Mauro Tettamanti, Massimo Cartabia, Andreana Foresta, Pier Manuccio Manucci, Alessandro Nobili, Giuseppe Remuzzi, Carla Roncaglioni
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Urology & Nephrology
Boris Bikbov, Ida Fortino, Olivia Leoni, Alessandro Nobili, Mauro Tettamanti
Summary: This study analyzed the healthcare system in the Lombardy region of Italy from 2000 to 2019 and evaluated the incidence, mortality, healthcare resource utilization, and cost of acute kidney injury (AKI) in the population aged 40 and older. The results showed an increase in AKI incidence, a decrease in mortality and years of life lost (YLLs), higher incidence rates in males, and significant geographical differences. The study also found that AKI imposes a substantial burden and cost on the healthcare system.