Review
Immunology
Samantha L. Tucker, Demba Sarr, Balazs Rada
Summary: Cystic Fibrosis is a genetic disease that causes chronic lung inflammation and infections, leading to high mortality rates. Immune system disruption in CF results in impaired immune responses, chronic infections with pathogens, and alterations in T cell and neutrophil functions. The role of P. aeruginosa and gMDSCs in T cell suppression and immune evasion in CF remains a subject of ongoing research.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ash Lee Manley, Jichun Chen, Wendy Fitzgerald, Xingmin Feng, Neal S. Young
Summary: This study demonstrates that G-MDSC-exos attenuate immune bone marrow failure by modulating the delivery of immunosuppressive miRNAs into activated T lymphocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medical Laboratory Technology
Ari Ahn, Chan-Jeoung Park, Min-sun Kim, Young-Uk Cho, Seongsoo Jang, Mi Hyun Bae, Jung-Hee Lee, Je-Hwan Lee, Kyung-Nam Koh, Ho Joon Im
Summary: Myeloid-derived suppressor cells (MDSCs) are heterogeneous populations that suppress tumor-specific T-cell responses and are increased in several hematologic malignancies, including chronic myeloid leukemia (CML). In CML patients, differences in levels and prognostic significance of MDSCs are evaluated according to clinical status. High levels of peripheral blood granulocytic MDSCs (gMDSCs) are associated with better prognosis, while monocytic MDSCs (mMDSCs) may be related to malignant conditions and poor prognosis.
ANNALS OF LABORATORY MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Rashi Sehgal, Navkiran Kaur, Gayatri Ramakrishna, Nirupma Trehanpati
Summary: This review focuses on understanding the key molecules involved in the expansion and regulation of MDSCs in liver diseases and their immunosuppressive mechanisms. The key message is that modulated MDSCs can be used for therapeutic purposes in inflammation, cancer, and sepsis.
DIGESTIVE DISEASES
(2022)
Review
Medicine, General & Internal
Iosif Papafragkos, Efrosyni Markaki, Christina Kalpadakis, Panayotis Verginis
Summary: Myeloid-derived suppressor cells (MDSCs) are potent regulators of the immune system, playing a role in cancer but their specific contribution to lymphomas remains unclear. This review focuses on MDSCs in lymphomas, discussing literature and lessons learned from animal models, and highlights future research directions and challenges in understanding the immune system complexities in malignancies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cell Biology
Tianmiao Ma, Bernhard W. Renz, Matthias Ilmer, Dominik Koch, Yuhui Yang, Jens Werner, Alexandr V. Bazhin
Summary: Myeloid-derived suppressor cells (MDSCs) play a crucial role in the tumor microenvironment (TME) and have been linked to poor prognosis and drug resistance in cancer. Further research is needed to fully understand the definition and phenotypes of MDSCs in humans.
Review
Immunology
Hui Zhang, Qi-Wei Li, Yuan-Yuan Li, Xue Tang, Ling Gu, Han-Min Liu
Summary: Pulmonary hypertension (PH) is characterized by increased pulmonary vascular resistance and pressure, and the relationship between myeloid-derived suppressor cells (MDSCs) and PH has been studied. MDSCs are a group of cells that can suppress T-cell responses and potentially exacerbate the development of diseases. Understanding the relationship between MDSCs and PH can help identify potential therapeutic targets for the treatment of PH.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Suncica Kapor, Juan F. Santibanez
Summary: This review discusses the main features of MDSCs and MSCs in myeloid malignancies, revealing that MDSCs are elevated in numbers and exhibit strong immunosuppressive capabilities, while MSCs not only have immunosuppressive properties but also regulate the growth, apoptosis, and chemotherapy resistance of myeloid leukemia cells.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Taosan Li, Fang Zheng, Fanjun Cheng
Summary: This article analyzes the role of MDSCs in lymphopenia in COVID-19 patients and discusses their immunopathologic changes and potential therapeutic targets.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Xidan Gao, Hongshu Sui, Shang Zhao, Xingmei Gao, Yanping Su, Peng Qu
Summary: MDSCs, a heterogeneous population of immature myeloid cells accumulating in tumor-bearing hosts, play a critical role in promoting tumor immune escape. Therapeutic strategies targeting MDSCs have shown potential in enhancing the efficacy of tumor immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Yuliya V. Perfilyeva, Yekaterina O. Ostapchuk, Raikhan Tleulieva, Aykin Kali, Nurshat Abdolla, Vladimir K. Krasnoshtanov, Anastassiya V. Perfilyeva, Nikolai N. Belyaev
Summary: This article reviews the current findings on myeloid-derived suppressor cells (MDSCs) in COVID-19 and discusses the complex role of these cells in the immunopathology of the disease.
CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Xueping Yu, Jian Sun, Feifei Yang, Richeng Mao, Zhiqing Shen, Lan Ren, Songhua Yuan, Qian He, Linxia Zhang, Yu Yang, Xiangqing Ding, Yongquan He, Haoxiang Zhu, Zhongliang Shen, Mengqi Zhu, Chao Qiu, Zhijun Su, Jiming Zhang
Summary: This study found that the proportion of granulocytic myeloid-derived suppressor cells (gMDSC) increased significantly in patients with Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF), and this increase was associated with disease severity, prognosis, and infection. Further experiments revealed that TNF-alpha induced gMDSC expansion and inhibited T cell proliferation and interferon-gamma production through the IDO signaling pathway. These findings have important implications for understanding the pathogenesis of HBV-ACLF and developing potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ching-Chuan Hsieh, Cheng-Chih Chang, Yung-Chien Hsu, Chun-Liang Lin
Summary: In the development of diabetic kidney disease, the dysregulation of glomerular cell types is crucial, and MDSCs exhibit anti-inflammatory activities that help improve renal fibrosis in diabetic mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Yanan Li, Hongdan He, Ribu Jihu, Junfu Zhou, Rui Zeng, Hengxiu Yan
Summary: MDSCs are a heterogeneous group of cells generated in various pathologic conditions, known to be key components of the tumor microenvironment promoting tumor growth, and partially restoring antitumor immunity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Yi Ren, Henrik Baecker, Michael Mueller, Arne Kienzle
Summary: The immune system has a significant impact on bone metabolism in various pathological and inflammatory conditions. Myeloid-derived suppressor cells (MDSCs) are a group of cells that can suppress immune responses and mediate bone remodeling. They can both cause bone erosion through differentiation into osteoclasts and alleviate immune reactions. This review discusses the influence of MDSCs on bone metabolism and potential therapeutic targets for improving bone health.
FRONTIERS IN IMMUNOLOGY
(2023)