Article
Medicine, General & Internal
Dorota Grazyna Boron, Aleksy Swietlicki, Michal Potograbski, Grazyna Kurzawinska, Przemyslaw Wirstlein, Daniel Boron, Krzysztof Drews, Agnieszka Seremak-Mrozikiewicz
Summary: This study investigated the changes in maternal serum levels of galectin-1 and galectin-9 in patients with preterm prelabor rupture of membranes (pPROM) compared to uncomplicated pregnancies. The results showed that low levels of galectin-1 were associated with the incidence of pPROM, while galectin-9 levels were not significantly correlated with pPROM. Further clinical studies on larger groups are needed to investigate the potential of galectin-1 and galectin-9 levels as markers for pPROM.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Jenny Wu, Anna E. Denoble, Jeffrey A. Kuller, Sarah K. Dotters-Katz
Summary: Studies comparing retention versus removal of cervical cerclage in women with PPROM showed potential prolongation of latency to delivery with retention, but also potential increase in maternal infectious morbidity. Limited evidence found no significant differences in neonatal outcomes, with most studies limited by retrospective nature and small sample sizes.
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2021)
Article
Obstetrics & Gynecology
Ichchha Madan, Frank I. I. Jackson, Reinaldo Figueroa, Ray Bahado-Singh
Summary: This study aimed to investigate the effects of gestational age at delivery on the outcomes of maternal and neonatal in preterm prelabor rupture of membranes (PPROM). The study also examined various predictors of neonatal and infant mortality in these pregnancies. The results showed that there was a decrease in neonatal complications and death with advancing gestational age in PPROM. Gestational age at delivery was found to be the strongest predictor of mortality risk in PPROM.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Marian Kacerovsky, Lenka Pliskova, Radka Bolehovska, Daniel Lesko, Romana Gerychova, Petr Janku, Petr Matlak, Ondrej Simetka, Jaroslav Stranik, Tomas Faist, Jan Mls, Peter Vescicik, Bo Jacobsson, Ivana Musilova
Summary: This study found that the presence of cervical Gardnerella vaginalis was associated with microbial invasion of the amniotic cavity (MIAC) in pregnancies with preterm prelabor rupture of membrane (PPROM), particularly without the presence of intra-amniotic inflammation (IAI).
Article
Obstetrics & Gynecology
Michal Fishel Bartal, Lynda G. Ugwu, William A. Grobman, Jennifer L. Bailit, Uma M. Reddy, Ronald J. Wapner, Michael W. Varner, John M. Thorp, Steve N. Caritis, Mona Prasad, Alan T. N. Tita, George R. Saade, Dwight J. Rouse
Summary: The rate of preterm premature rupture of membranes (PROM) and the likelihood of composite maternal or neonatal morbidity after preterm PROM were similar for twin and singleton gestations in a large, diverse cohort.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Clara Murillo, Silvia Ferrero, Teresa Cobo, Montse Izquierdo Renau, Victoria Aldecoa, Laia Grau, Julia Ponce, Claudia Rueda, Montse Palacio
Summary: This study evaluated the outcomes of pregnant women with preterm prelabor rupture of membranes (PPROM) eligible for outpatient care. The results showed that women eligible for outpatient management had better prognosis and the neonatal outcomes were significantly better in the outpatient group.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Rachel D. Seaman, Rachel H. Kopkin, Mark A. Turrentine
Summary: This study suggests that for women with preterm prelabor rupture of membranes, administration of azithromycin is associated with a similar latency period but a lower rate of clinical chorioamnionitis compared to administration of erythromycin.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Jessica M. Hart, Dayna T. Neo, Anna M. Modest, Michele R. Hacker, Sarah Lambeth, Mary Vadnais
Summary: This study aimed to determine the incidence of discordant fetal presentation resulting from spontaneous version between admission and delivery among patients diagnosed with PPROM prior to 34 weeks' gestation. The results showed that the incidence of discordant presentation was 11.7% and 21.3% for cephalic to non-cephalic and non-cephalic to cephalic fetuses, respectively. Risk factors associated with spontaneous version after PPROM included earlier gestational age and longer latency period.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Environmental Sciences
Cheng Li, Jing-Jing Xu, Yi-Chen He, Lei Chen, Cindy-Lee Dennis, He-Feng Huang, Yan-Ting Wu
Summary: This study examined the acute effects of ambient pollutants on term PROM and preterm PROM, finding that PM2.5, PM10, SO2, and CO were associated with an increased risk for PPROM on lag days 2 and 3. Acute exposures to six air pollutants were not linked to an increased risk of TPROM.
ENVIRONMENTAL POLLUTION
(2021)
Article
Multidisciplinary Sciences
Marian Kacerovsky, Jaroslav Stranik, Jana Matulova, Martina Chalupska, Jan Mls, Tomas Faist, Helena Hornychova, Rudolf Kukla, Radka Bolehovska, Pavel Bostik, Bo Jacobsson, Ivana Musilova
Summary: This study examined the clinical characteristics of preterm prelabor rupture of membranes (PPROM) complicated by colonization of the amniotic cavity. The presence of colonization, mainly caused by microorganisms from the lower genital tract, was associated with a weaker intra-amniotic inflammatory response.
SCIENTIFIC REPORTS
(2022)
Article
Health Care Sciences & Services
Chunmei Yan, Xiaohui Deng, Fanzhen Hong
Summary: This study retrospectively analyzed maternal and neonatal outcomes among different latency periods of patients with preterm prelabor rupture of membranes (PPROM). The results showed that prolonging the latency period was beneficial for newborns in the gestational week range of 28-31(+6) weeks, but not for those beyond 32 weeks. Increased infection index before labor was a common maternal complication in all groups, while neonatal hyperbilirubinemia and neonatal pneumonia were common neonatal complications.
JOURNAL OF HEALTHCARE ENGINEERING
(2022)
Review
Microbiology
Nathalia M. Noda-Nicolau, Ourlad Alzeus G. Tantengco, Jossimara Polettini, Mariana C. Silva, Giovana F. C. Bento, Geovanna C. Cursino, Camila Marconi, Ronald F. Lamont, Brandie D. Taylor, Marcia G. Silva, Daniel Jupiter, Ramkumar Menon
Summary: This study determined the association between genital mycoplasmas and adverse pregnancy outcomes such as preterm labor, preterm birth, and preterm prelabor rupture of membranes. The results showed that women with these adverse pregnancy outcomes had significantly higher odds of presence with genital mycoplasmas compared to women who delivered at term.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Obstetrics & Gynecology
Lu Zhuang, Zhan-Kui Li, Yuan-Fang Zhu, Rong Ju, Shao-Dong Hua, Chun-Zhi Yu, Xing Li, Yan-Ping Zhang, Lei Li, Yan Yu, Wen Zeng, Jie Cui, Xin-Yu Chen, Jing-Ya Peng, Ting Li, Zhi-Chun Feng
Summary: This study conducted a prospective study on 1001 preterm infants born from mothers with pPROM and identified several important factors associated with SNO risk. A predicting model was developed and showed good discrimination and calibration performance.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Environmental Sciences
Cuiping Wang, Guoqi Yu, Ramkumar Menon, Nanbert Zhong, Chong Qiao, Jing Cai, Weidong Wang, Huijuan Zhang, Ming Liu, Kang Sun, Haidong Kan, Jun Zhang
Summary: This study found that both acute and chronic maternal exposure to ambient PM2.5 during pregnancy are risk factors for PROM, with a stronger association found between PM2.5 exposure and preterm PROM. Women who are less educated, obese, or give birth in a cold season appear to be more sensitive to ambient PM2.5 exposure.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Rabia Zehra Bakar, Nadiye Koroglu, Lale S. Turkgeldi, Esra N. Tola, Berna Aslan Cetin, Ali Gedikbasi
Summary: This study aimed to determine the efficacy of maternal serum procalcitonin levels in early prediction of chorioamnionitis in women with PPROM. While proCT was not found to be predictive, higher levels of WBC and CRP were associated with chorioamnionitis in PPROM patients. Further research is needed to confirm the role of proCT in predicting clinical chorioamnionitis, considering conflicting results in existing literature.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Veterinary Sciences
Osman Safa Terzi, Erdal Kara, Yasin Senel, Ebubekir Ceylan, Salim Neselioglu, Ozcan Erel
Summary: The study investigates the TDH parameters and IMA levels in calves with neonatal diarrhea compared to healthy controls. The results show that calves with neonatal diarrhea have significantly decreased levels of native thiol and total thiol compared to healthy controls. The study also finds that IMA levels are increased in calves with neonatal diarrhea due to oxidative stress.
ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI
(2023)
Article
Medical Laboratory Technology
Elif Guler Kazanci, Muhammet Furkan Korkmaz, Funda Eren, Ozcan Erel
Summary: This study aimed to evaluate the oxidant/antioxidant balance in individuals with beta-thalassemia major (beta-TM) and healthy children, and found that thiol/disulfide homeostasis was weakened in beta-TM patients. The study also revealed that the oxidant imbalance worsened when beta-TM patients did not receive regular chelation therapy.
LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Yunus H. Polat, Sukran Erten, Ahmet Kor, Ismail Dogan, Yuksel Maras, Orhan Kucuksahin, Guniz Y. Ustuner, Ozcan Erel
Summary: This study aimed to evaluate the thiol/disulfide balance in patients with rheumatoid arthritis (RA) compared to healthy controls, and to examine its relationship with Disease Activity Score-28 (DAS28). The results showed that RA patients had lower thiol levels and higher disulfide levels compared to controls. Additionally, the group in remission had higher thiol levels and lower disulfide levels compared to other DAS28 groups. These findings suggest that the antioxidant defense system is impaired in RA patients, leading to oxidative stress and imbalance.
CLINICAL BIOCHEMISTRY
(2023)
Article
Neurosciences
Birsen Can Demirdogen, Osman Oguzhan Kilic, Ata Ayhan Yilmaz, Semra Mungan, Salim Neselioglu, Ozcan Erel
Summary: This study aimed to investigate the association between cognitive impairment and oxidative stress biomarkers TDH and IMA in multiple sclerosis patients. The results showed that plasma native thiol and total thiol levels were significantly decreased in patients with SPMS. The study also found significant correlations between TDH, BICAMS scores, clinical indices of disease severity, and MRI parameters.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Muhammed Emin Demirkol, Gulali Aktas, Murat Alisik, Ozgur Mehmet Yis, Musa Kaya, Derya Kocadag
Summary: This study aimed to investigate the prognostic nutritional index (PNI) in outpatient and inpatient subjects with confirmed Covid-19 and compare the PNI between deceased and survived patients. The results showed that inpatients had significantly lower PNI values compared to outpatients, and deceased patients had significantly lower PNI values than survivors. Therefore, PNI could serve as a reliable prognostic marker in Covid-19 patients.
MALAWI MEDICAL JOURNAL
(2023)
Article
Clinical Neurology
Tugba Alisik, Murat Alisik, Sirzat Cogalgil
Summary: This study evaluated the relationship between the clinical outcome of subacute stroke patients and extracellular thiol-disulphide (SH-SS) and intracellular oxidized-reduced glutathione (GSSG-GSH) homeostasis and the effect of the rehabilitation program on these homeostasis. The results showed that patients had higher SH-SS and GSSG-GSH ratios compared to the control group, and these ratios decreased significantly after rehabilitation. Furthermore, the baseline ratios were correlated with clinical scores before and after rehabilitation. This suggests that active thiol groups may contribute to better outcomes in subacute stroke patients, and rehabilitation treatment can improve clinical scores and shift thiol groups towards the antioxidant side.
Article
Medicine, General & Internal
Kadriye Erdogan, Nazli Tunca Sanlier, Emine Utlu Ozen, Sueleyman Erol, Inci Kahyaoglu, Salim Neselioglu, Ozcan Erel, Serra Akar, Yaprak Engin Ustun
Summary: This study evaluates the role of oxidative stress in unexplained infertility (UEI) by assessing dysfunctional high-density lipoprotein (HDL) through the myeloperoxidase (MPO) and paraoxonase (PON) ratio. The results show that patients with UEI have higher total dosages of gonadotropin, lower number of Grade 1 embryos and quality of blastocysts, and higher serum MPO/PON ratio. Serum MPO/PON ratio can significantly predict the duration of infertility.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Sukru Alperen Korkmaz, Sadice Kizgin, Esra Firat Oguz, Salim Neselioglu, Ozcan Erel
Summary: This study found significant differences in levels of thiol-disulphide parameters, ischemia-modified albumin (IMA), and C-reactive protein (CRP) between bipolar disorder (BD) patients in acute mania and early remission compared to healthy controls. Additionally, during the manic phase, markers such as neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammatory index (SII), platelet-to-albumin ratio (PAR), and CRP levels were significantly higher. These findings highlight the importance of inflammation in bipolar disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Cetin Turan, Guliz Senormanci, Salim Neselioglu, Yasemin Budak, Ozcan Erel, Omer Senormanci
Summary: This study aimed to investigate the differences in oxidative stress and systemic inflammation biomarkers between methamphetamine users and the control group. Serum thiol/disulfide balance and ischemia-modified albumin levels were used to assess oxidative stress, while serum interleukin-6 (IL-6) levels and complete blood count (CBC) were used to evaluate inflammation.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Article
Neurosciences
Almila Senat, Esra Kabadayi-Sahin, Ibrahim Sogut, Tomris Duymaz, Ozcan Erel
Summary: This study aimed to evaluate oxidative contributors of atherosclerotic risk factors in patients with Alcohol Use Disorder (AUD). The results showed significantly elevated oxidative markers in AUD patients and decreased antioxidant capacity. Atherosclerotic markers were also higher and correlated with alcohol intake. Thus, oxidative markers may serve as indicators for atherosclerotic risk and therapeutic interventions targeting oxidative load may help prevent clinical manifestation of atherosclerotic diseases.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Yasemin Dogan, Yucel Yilmaz, Saban Kelesoglu, Bekir Calapkorur, Salim Neselioglu, Ozcan Erel, Nihat Kalay
Summary: The aim of this study was to investigate the relationship between thiol, the main component of the antioxidant system, and coronary collateral circulation (CCC). The results showed that patients with stable coronary artery disease (sCAD) who developed poor CCC had lower levels of native thiol, total thiol, and disulfide compared to those with good CCC. Additionally, DM, total thiol, and disulfide were identified as independent predictors of poor CCC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
K. Cetinkaya, M. Atasever, Z. Erisgin, C. Sonmez, C. Ozer, B. Coskun, M. Alisik
Summary: This study aimed to determine the role of oxidative stress in carboplatin-induced gonadotoxicity and whether Nigella Sativa oil (NSO) has a protective effect on ovarian apoptosis, oxidative stress, and anti-Mullerian hormone (AMH) level in rats. The results showed that NSO pretreatment may protect ovarian tissue and decrease chemotherapy-induced ovarian injury by reducing oxidative stress and apoptosis, but its protective effect on AMH is limited.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Medical Laboratory Technology
Ozgur M. Yis, Murat Alisik, Guler Bugdayci, Mehmet A. Sert, Utku G. Erdogan, Merve Ates
Summary: This study evaluated the analytical performance of osmolality measurement using the Sysmex UF-5000 and found that it can effectively assess the concentration ability and conductivity of urine. The results suggest that the UF-5000 can be used to determine if urine osmolality is within reference range, and more accurate measurements can be done using methods based on colligative properties.
CLINICAL LABORATORY
(2023)
Article
Neurosciences
Meyri Arzu Yoldas, Mervan Bekdas, Aysegul Danis, Ayhan Cetinkaya, Selma Erdogan Duzcu, Murat Alisik, Huseyin Kocabey, Idris Turel, Gokce Kaya Dincel
Summary: The study aimed to investigate the protective and therapeutic effects of okra seed extract against acute non-traumatic brain damage resulting from acetaminophen intoxication. The extract is known for its antioxidant, immunomodulatory, and anti-inflammatory properties.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Gamze Yilmaz, Salim Neselioglu, Fatma Nur Ceylan, Burak Elmas, Fatmanur Ece Aydogdu, Ozcan Erel, Ozlem Uzunlar, Esma Sarikaya, Ozlem Moraloglu Tekin
Summary: This study reveals that the highest level of antioxidant status can be observed in full-term pregnancies, and it is correlated with better APGAR scores in newborns. However, no significant difference in maternal oxidant balance was found between different gestational stages.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2023)