Article
Chemistry, Physical
Joanna Goscianska, Aleksander Ejsmont, Anita Kubiak, Dominika Ludowicz, Anna Stasilowicz, Judyta Cielecka-Piontek
Summary: The study demonstrated that amine grafting significantly modifies the surface chemistry and textural parameters of mesoporous carbons, enhancing their adsorption capability for benzocaine. Drug release kinetics are strongly influenced by the porosity of carbon carriers and the surface functional groups.
Article
Chemistry, Applied
Shuangying Li, Boyao Zhou, Yayan Tong, Jinghan Guo, Liushan Jiang, Ruochen Yang, Huanhuan Liu, Yue Zhang, Jingwen Niu, Shiyu Huang, Shuai Yuan, Qingxiang Zhou
Summary: In this study, an efficient and convenient magnetic solid phase extraction method using C60 modified magnetic polyamido-amine (PAMAM) dendrimers as sorbents was established for enriching trace amounts of PCBs in beverage samples. The results showed that the method was reliable for monitoring trace PCBs in beverage samples.
Article
Polymer Science
Mohanna Shokri, Mahsasadat Miralinaghi, Elham Moniri, Zahra Jafariazar
Summary: The aim of this study was to prepare and characterize a nanohybrid, CoFe2O4/SWCNT-PEI-PEG, for loading silibinin (SB) as a drug delivery platform. The prepared nanocomposite possessed a well-magnetic porous structure with functional groups and aggregates. The SB loading capacity was high and pH-responsive release was observed, demonstrating its potential for targeted drug delivery.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Materials Science, Ceramics
Zachary Kegley, Michael Makay, Joshua Rogers, Katrina Phelps, Colleen Malcom, David Hellmig, Anna Kroninger, Xiangdong Bi
Summary: The purpose of this research is to develop a hydrogel delivery system using PAMAM dendrimer to enhance the solubility and sustained release of hydrophobic drugs. The research shows that with the presence of PAMAM dendrimer, the solubility of diflunisal in water is significantly improved and the hydrogel system can achieve sustained release of the drug.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Ben S. Ou, Olivia M. Saouaf, Julie Baillet, Eric A. Appel
Summary: The immune system plays a crucial role in regulating and protecting human health. Sustained release technologies have shown potential in enhancing adaptive immune responses by prolonging exposure to immunogenic signals.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Materials Science, Multidisciplinary
Malvika Chawla, R. D. Kaushik, Mayank Kumar Malik, Vishakha Pundir, Jaspal Singh, Hafeezur Rehmaan
Summary: This study investigates the drug release dynamics and anti-inflammatory activity of the roflumilast analogue with dendrimer. The results show that the RofA-Dendrimer complex has high encapsulation potency and loading capability, and releases the drug progressively, making it suitable for sustained delivery. Drug release kinetics analysis indicates non-Fickian diffusion. Furthermore, the solubility of roflumilast increases with different dendrimer generations and pH levels.
MATERIALS TODAY COMMUNICATIONS
(2022)
Review
Pharmacology & Pharmacy
Elizabeth Magill, Sara Demartis, Elisabetta Gavini, Andi Dian Permana, Raghu Raj Singh Thakur, Muhammad Faris Adrianto, David Waite, Katie Glover, Camila J. Picco, Anna Korelidou, Usanee Detamornrat, Lalitkumar K. Vora, Linlin Li, Qonita Kurnia Anjani, Ryan F. Donnelly, Juan Dominguez-Robles, Eneko Larraneta
Summary: Implantable drug delivery systems (IDDS) are an attractive alternative to conventional drug administration routes, especially for the treatment of chronic conditions where patient adherence to conventional treatments can be challenging.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Chemistry, Medicinal
Malihe Pooresmaeil, Siamak Javanbakht, Hassan Namazi, Ahmad Shaabani
Summary: Nontoxic materials with natural origin, like citric acid, have shown promising potential in the design and preparation of new drug delivery systems. Research on citric acid-based platforms in various forms has demonstrated their efficiency as drug delivery systems.
MEDICINAL RESEARCH REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
E. Murugan, V. Yogaraj
Summary: In this study, poly (amidoamine) dendrimers (generation G2 and G3) were synthesized as drug carriers to enhance the solubility and sustained release of furosemide (FRSD). The dendrimers significantly increased the solubility and release time of FRSD compared with pure FRSD. Cytotoxicity studies indicated reduced toxicity and improved bioavailability of FRSD when delivered using these dendrimer-based drug carriers. The results suggest that the dendrimer-based drug carriers are promising for poorly soluble drugs and could be used for real-time drug delivery applications.
FRONTIERS IN CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Hadeel Kheraldine, Ousama Rachid, Abdella M. Habib, Ala-Eddin Al Moustafa, Ibrahim F. Benter, Saghir Akhtar
Summary: Traditional drug delivery systems typically use carriers to improve drug efficacy, but recent research has shown that polymeric drug delivery systems may have intrinsic biological actions.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Chester E. Markwalter, Robert F. Pagels, Ava N. Hejazi, Kurt D. Ristroph, Jiping Wang, Ke Chen, Jian Li, Robert K. Prud'homme
Summary: This study introduces a scalable technique to encapsulate water-soluble therapeutics into polymeric nanocarriers, demonstrating improved therapeutic effect and reduced toxicity. The results establish the potential of this technique as a platform for nanocarrier delivery of water-soluble therapeutics, particularly in pulmonary administration.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Xiaowen Xu, Yu Ran, Chengyuan Huang, Zongning Yin
Summary: A novel nanocomplex was constructed to deliver insulin in response to hyperglycemia. The nanocomplex showed potential in insulin self-regulation delivery.
Article
Chemistry, Physical
Mohammad Fahimizadeh, Pooria Pasbakhsh, Lee Sui Mae, Joash Ban Lee Tan, R. K. Singh Raman
Summary: This report presents the preparation and characterization of Halloysite nanotubes (Hal) loaded with yeast extract (YE) as a multifunctional nanocomposite carrier of microbiological nutrients. The results show that the HY nanocomposite effectively supports spore germination and bacterial growth.
APPLIED CLAY SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Manling Wu, Min Wang, Haoyuan Jia, Peipei Wu
Summary: Increasing evidence shows that unmodified extracellular vesicles (EVs) can effectively inhibit the malignant progression of different types of tumors by delivering bioactive molecules, making them a promising emerging anticancer drug. Researchers are actively exploring ways to engineer EVs as a translational therapy platform, broadening their therapeutic capability and enhancing specificity and effectiveness through targeted modifications. This review focuses on the latest research progress of functionalized EVs and highlights their superior biological functions and therapeutic potential, aiming to inspire new design concepts and develop next-generation nanomedicine therapeutic platforms.
Review
Pharmacology & Pharmacy
Junqi Wu, Sawnaz Shaidani, Sophia K. Theodossiou, Emily J. Hartzell, David L. Kaplan
Summary: This article provides an overview of naturally derived biopolymer-based drug delivery systems for localized, sustained, and on-demand treatment. These systems offer advantages such as high drug concentrations at the treatment site, enhanced treatment efficiency, and reduced systemic side effects. However, they also face challenges in terms of encapsulation, delivery, and controlled release of therapeutics.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Review
Chemistry, Analytical
Yadiris Garcia, Myleidi Vera, Juan D. Giraldo, Karla Garrido-Miranda, Veronica A. Jimenez, Bruno F. Urbano, Eduardo D. Pereira
ANALYTICAL CHEMISTRY
(2022)
Article
Polymer Science
Carola F. Diaz, Leonardo Guzman, Veronica A. Jimenez, Joel B. Alderete
Summary: The study demonstrated successful conjugation of PAMAM-G3 with chlorin e6 to form PAMAM-G3-Ce6 nanoconjugates, which showed reduced cytotoxicity and efficient photodynamic activity against HeLa cancer cells. Molecular dynamics simulations indicated the spherical structure and dendritic cavities of the system, which facilitate drug encapsulation.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Chemistry, Analytical
Yadiris Garcia, Myleidi Vera, Veronica A. Jimenez, Luis F. Barraza, Joao Aguilar, Susana Sanchez, Eduardo D. Pereira
Summary: This study developed a simple and optimized Molecularly Imprinted Nanoparticle-Based Assay (MINA) for the detection of microcystin-leucine-arginine (MC-LR) in water. Molecularly imprinted nanoparticles (MINs) were prepared by solid-phase polymerization and immobilized onto a polystyrene microplate. The MINs showed strong binding affinity for MC-LR and exhibited a limit of detection of 2.49 x 10(-4) nmol L-1.
Article
Chemistry, Physical
Daniela Correa-Muriel, Hoover Valencia-Sanchez, Hector Cortes-Hernandez, Daniela Gonzalez-Vera, Javiera Herrera, Cristian H. Campos, Monica L. Casella, Luis E. Arteaga-Perez, Paula Osorio-Vargas
Summary: In this study, the catalytic pyrolysis of waste tires using NiTiO3 and CoTiO3 ilmenites as catalysts was evaluated. The nature of the catalysts was found to have a significant effect on the product distribution. The presence of metal in reduced-ilmenite enhanced the selectivity of target compounds.
Article
Chemistry, Medicinal
Jeisson D. Corredor, Camilo Febres-Molina, Gonzalo A. Jana, Veronica A. Jimenez
Summary: In this study, molecular dynamics simulations were used to reveal a novel water-mediated mechanism for the covalent inhibition of dipeptidyl peptidase-4 (DPP4) by Vildagliptin (VIL). The findings have important implications for understanding the molecular features of DPP4 inhibition by VIL and for the development of new derivatives with improved structural or mechanistic profiles.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Food Science & Technology
Myleidi Vera, Claudio Mella, Yadiris Garcia, Veronica A. Jimenez, Bruno F. Urbano
Summary: The packaging industry is a major contributor to plastic waste pollution globally. To address this issue, the scientific community has been working on developing sustainable packaging materials, with tannins being a promising natural polyphenolic substance for food packaging applications. This review discusses the challenges, opportunities, and recent advances in tannin-containing biodegradable polymers for multifunctional food packaging and preservation.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Editorial Material
Chemistry, Medicinal
Veronica A. Jimenez
Summary: Dipeptidyl peptidase-like protein 9 (DPP9) is a promising drug target for hematological diseases. Two novel DPP9 inhibitors with nanomolar affinity and unprecedented selectivity over DPP8 have been discovered, opening the way for future DPP9-mediated treatments.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Carola F. Diaz, Diego L. Cifuentes, Maximiliano Oyarzun, Veronica A. Jimenez, Leonardo Guzman
Summary: The cell internalization kinetics of surface-modified PAMAM dendrimers were examined, and the solvent accessibility of cationic surface charges was found to be the key factor affecting cell internalization capacity.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Engineering, Biomedical
Nuria Lafuente-Gomez, Irene de Lazaro, Monica Dhanjani, David Garcia-Soriano, Miguel C. Sobral, Gorka Salas, David J. Mooney, Alvaro Somoza
Summary: A novel immunotherapy based on magnet nanoparticles is described in this study, which significantly enhances immune response and combats melanoma cells. Covalently modified nanoparticles exhibit a more potent and sustained immune response in vivo.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Organic
Carola F. Diaz, Diego L. Cifuentes, Maximiliano Oyarzun, Veronica A. Jimenez, Leonardo Guzman
Summary: This study investigates the role of surface functionalization on the cell internalization capacity of PAMAM dendrimers. The accessibility of surface cationic charges is found to be a key determinant for cell internalization. Dendrimers with 25% functionalization exhibit slower rates and lower maximum uptakes, while those with 50% functionalization show negligible internalization capacities.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Nuria Lafuente-Gomez, Shiqi Wang, Flavia Fontana, Monica Dhanjani, David Garcia-Soriano, Alexandra Correia, Milagros Castellanos, Ciro Rodriguez Diaz, Gorka Salas, Helder A. Santos, Alvaro Somoza
Summary: In this study, magnetic nanoparticles with different coatings were synthesized and their interactions with red blood cells, plasma proteins, and macrophages were investigated. CMD-MNP, chosen for its biosafety profile and ability to promote a pro-inflammatory response in macrophages, was proposed as a smart miRNA delivery system for cancer immunotherapy. It was demonstrated that CMD-MNP-miRNA155 and CMD-MNP-miRNA125b nanoparticles could induce a pro-inflammatory response in human macrophages by increasing the expression of CD80 and the levels of TNF-alpha and IL-6.
Article
Chemistry, Multidisciplinary
David Cabrera, Takashi Yoshida, Teresa Rincon-Dominguez, J. L. F. Cunado, Gorka Salas, Alberto Bollero, Maria del Puerto Morales, Julio Camarero, Francisco J. Teran
Summary: This study reports experimental and theoretical evidence regarding the superparamagnetism observed in magnetic iron oxide nanoparticle suspensions at room temperature. The transition from superparamagnetic to blocked states was unambiguously demonstrated through AC magnetization measurements and supported by a theoretical model based on the stochastic Landau-Liftshitz-Gilbert equation. An empirical expression to determine the effective magnetic anisotropy was proposed.
