Magnetic filtration of phase separating ferrofluids: From basic concepts to microfluidic device

In this work, we briefly review magnetic separation of ferrofluids composed of large magnetic particles (60 nm of the average size) possessing an induced dipole moment. Such ferrofluids exhibit field-induced phase separation at relatively low particle concentrations (similar to 0.8 vol%) and magnetic fields (similar to 10 kA/m). Particle aggregates appearing during the phase separation are extracted from the suspending fluid by magnetic field gradients much easier than individual nanoparticles in the absence of phase separation. Nanoparticle capture by a single magnetized microbead and by multi-collector systems (packed bed of spheres and micro-pillar array) has been studied both experimentally and theoretically. Under flow and magnetic fields, the particle capture efficiency Lambda decreases with an increasing Mason number for all considered geometries. This decrease may become stronger for aggregated magnetic particles (Lambda proportional to Ma(-1.7)) than for individual ones (Lambda proportional to Ma(-1)) if the shear fields are strong enough to provoke aggregate rupture. These results can be useful for development of new magneto-microfluidic immunoassays based on magnetic nanoparticles offering a much better sensitivity as compared to presently used magnetic microbeads. (C) 2016 Elsevier B.V. All rights reserved.