Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis

mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function

(2017) Vivian A. Paschoal et al.   IMMUNOBIOLOGY

Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice

(2016) Juliana Magdalon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Raptor /mTORC1 loss in adipocytes causes progressive lipodystrophy and fatty liver disease

(2016) Peter L. Lee et al.   Molecular Metabolism

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Omega-3 fatty acids protect from diet-induced obesity, glucose intolerance, and adipose tissue inflammation through PPARγ-dependent and PPARγ-independent actions

(2015) Thiago Belchior et al.   MOLECULAR NUTRITION & FOOD RESEARCH

PPARγ activation attenuates glucose intolerance induced by mTOR inhibition with rapamycin in rats

(2014) William T. Festuccia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Macrophage mTORC1 disruption reduces inflammation and insulin resistance in obese mice

(2014) Hongfeng Jiang et al.   DIABETOLOGIA

Myeloid-Specific Rictor Deletion Induces M1 Macrophage Polarization and Potentiates In Vivo Pro-Inflammatory Response to Lipopolysaccharide

(2014) William T. Festuccia et al.   PLoS One

Beneficial Metabolic Effects of Rapamycin Are Associated with Enhanced Regulatory Cells in Diet-Induced Obese Mice

(2014) Kassem Makki et al.   PLoS One

Reactive oxygen species at the crossroads of inflammasome and inflammation

(2014) Anantha Harijith et al.   Frontiers in Physiology

Inflammasomes and Metabolic Disease

(2013) Jorge Henao-Mejia et al.   Annual Review of Physiology

mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

(2013) Masahiro Morita et al.   Cell Metabolism

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

DEPTOR Cell-Autonomously Promotes Adipogenesis, and Its Expression Is Associated with Obesity

(2012) Mathieu Laplante et al.   Cell Metabolism

Ceramide induces apoptosis via caspase-dependent and caspase-independent pathways in mesenchymal stem cells derived from human adipose tissue

(2011) Ji Yeon Park et al.   ARCHIVES OF TOXICOLOGY

Adipose tissue macrophages: phenotypic plasticity and diversity in lean and obese states

(2011) David L Morris et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

(2010) J. R. Ussher et al.   DIABETES

Uncoupling Protein 1 Decreases Superoxide Production in Brown Adipose Tissue Mitochondria

(2010) Rebecca Oelkrug et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mechanisms of Hepatic Steatosis and Insulin Resistance in the AGPAT2-Deficient Mouse Model of Congenital Generalized Lipodystrophy

(2009) Víctor A. Cortés et al.   Cell Metabolism

Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration

(2008) Pazit Polak et al.   Cell Metabolism

Remodeling Phenotype of Human Subcutaneous Adipose Tissue Macrophages

(2008) V. Bourlier et al.   CIRCULATION

Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice

(2008) I. Murano et al.   JOURNAL OF LIPID RESEARCH

Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity

(2008) Corneliu Henegar et al.   GENOME BIOLOGY