Article
Cell Biology
Wei Peng, Xingcheng Zhou, Tingting Xu, Yanwen Mao, Xiaohuan Zhang, Huiming Liu, Luqun Liang, Lingling Liu, Lirong Liu, Ying Xiao, Fan Zhang, Shuang Li, Mingjun Shi, Yuxia Zhou, Lei Tang, Yuanyuan Wang, Bing Guo
Summary: This study demonstrates that BMP-7 can upregulate the SnoN gene transcription through activating the Smad1/5 pathway, repairing the EMT and ECM deposition in renal tubular epithelial cells caused by diabetic kidney disease.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Patricia A. Miguez, Stephen A. Tuin, Adam G. Robinson, Joyce Belcher, Prapaporn Jongwattanapisan, Kimberly Perley, Vinicius de Paiva Goncalves, Arash Hanifi, Nancy Pleshko, Elisabeth R. Barton
Summary: Hesperidin has shown to enhance osteogenic markers and collagen matrix quality, potentially serving as an adjunct in regenerative bone therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Zhong Li, Shiqi Xiang, Zixuan Lin, Eileen N. Li, Haruyo Yagi, Lauren Yocum, La Li, Katherine K. Bruce, Madalyn R. Fritch, Huanlong Hu, Bing Wang, Peter G. Alexander, Khiam Aik Khor, Rocky S. Tuan, Hang Lin
Summary: This study successfully enhanced the osteogenic capability of hMSCs by incorporating graphene oxide-based nanosheets into GelMA. Both in vitro and in vivo experiments demonstrated the tremendous potential of this technology, providing new possibilities for bone tissue engineering applications.
Article
Endocrinology & Metabolism
Suni Tang, Dominique Cope, Yasmin M. Vasquez, Diana Monsivais
Summary: The biological processes that control endometrial receptivity and embryo implantation are critical for the successful outcome of pregnancy. Researchers found that the uterine epithelial BMP/SMAD1/5 signaling pathway plays a key role during early pregnancy and its deletion may lead to defects in endometrial receptivity and embryo implantation issues.
Article
Biochemistry & Molecular Biology
Helen Mok, Ahmed Al-Jumaily, Jun Lu
Summary: This study aimed to investigate the effect of PVT1 silencing on the progression of diabetic nephropathy in diabetic male C57BL/6 mice at different ages. The results showed that silencing of PVT1 reduced kidney hypertrophy, proteinuria, serum creatinine, TGF-beta 1, insulin levels, and increased creatinine clearance, while also decreasing ECM accumulation, TGF-beta 1 levels, and suppressing the upregulation of PAI-1, FN1, COL4A1.
Article
Environmental Sciences
Maryam A. Al-Ghamdi, Said S. Moselhy
Summary: Ferulic acid (FA) has anti-inflammatory, antioxidant, and antiglycation effects against streptozotocin-induced diabetic nephropathy. It reduces the release of inflammatory intermediates, improves kidney structure, and acts as a DPP4 inhibitor.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ariane G. Furlan, Chara E. S. Spanou, Alan R. F. Godwin, Alexander P. Wohl, Laura-Marie A. Zimmermann, Thomas Imhof, Manuel Koch, Clair Baldock, Gerhard Sengle
Summary: The study reveals a new MMP-dependent activation mechanism for BMP-7 from targeted ECM pools via specific prodomain degradation. Cleavage of prodomain by MMP-13 leads to disintegration of BMP-7 complex and release of bioactive growth factor, providing insights into pathomechanisms characterized by aberrant BMP activation and ECM destruction.
Article
Cell Biology
Noureldien H. E. Darwish, Khaled A. Hussein, Khaled Elmasry, Ahmed S. Ibrahim, Julia Humble, Mohamed Moustafa, Fatma Awadalla, Mohamed Al-Shabrawey
Summary: The study aimed to investigate the role of BMP4 in diabetic retinopathy. Immunofluorescence staining showed increased BMP4 expression in the retinas of diabetic humans and mice. In vitro experiments demonstrated that BMP4 treatment led to barrier disruption in human retinal endothelial cells.
Article
Multidisciplinary Sciences
Cheng-Kuei Wu, Man-Ting Wei, Hung-Chang Wu, Cheng-Lin Wu, Cheng-Ju Wu, Hungjiun Liaw, Wen-Pin Su
Summary: This study revealed the overexpression of BMP2 in lung adenocarcinoma patients with lymph node metastasis. In an in vivo mouse model, BMP2 was shown to promote lung adenocarcinoma metastasis. The activation of the SMAD1/5/8 signaling pathway was found to be involved in BMP2-mediated cell migration. Therefore, targeting the BMP2 signaling pathway could be a potential therapeutic strategy for treating metastatic lung adenocarcinoma.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Senem Aykul, Jordan Maust, Erik Martinez-Hackert
Summary: The study presents a novel approach to obtain significant quantities of pure and bioactive BMP-4 GF from Chinese hamster ovary cell cultures. The results provide insights into bioprocessing and biological function of human BMP-4, with implications for regenerating bone and cell culture applications.
MOLECULAR BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Yinbo Xiao, Hannah Donnelly, Mark Sprott, Jiajun Luo, Vineetha Jayawarna, Leandro Lemgruber, P. Monica Tsimbouri, R. M. Dominic Meek, Manuel Salmeron-Sanchez, Matthew J. Dalby
Summary: In the field of bone tissue regenerative medicine, the use of MSC-based tissue engineering strategies combined with growth factors (GFs) and biomaterials has drawn great interest. However, the optimization of interactions between biomaterials and MSCs, as well as the efficient delivery of GFs, remains a challenge. This study demonstrates that through plasma polymerization, tissue culture plates coated with poly (ethyl acrylate) (PEA) can provide an optimal environment for MSCs, with enhanced adhesion and binding of GFs. The combination of fibronectin (FN) and vitronectin (VN) on PEA surfaces results in the formation of a heterogeneous, open ECM network, promoting MSC differentiation into osteoblasts and inducing osteogenic intracellular signaling.
MATERIALS TODAY BIO
(2022)
Review
Endocrinology & Metabolism
Ming Yang, Shilu Luo, Jinfei Yang, Wei Chen, Liyu He, Di Liu, Li Zhao, Xi Wang
Summary: This review discusses the changes in bone composition and function in diabetic nephropathy (DN) and the role of bone-derived proteins in the progression of the disease. The bone-kidney axis is speculated to be a potential target for early diagnosis and treatment of DN.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Mitsugi Ookawara, Yasunori Nio
Summary: Phosphodiesterase subtype 4 (PDE4) plays key roles in inflammatory and fibrotic responses by hydrolyzing cyclic AMP, but its inhibition with PDE4 inhibitors can also lead to adverse effects. Studies have shown that PDE4 inhibitors may have beneficial effects on improving symptoms of diabetes, particularly in relation to hyperglycemia and insulin resistance, yet the mechanisms of action in diabetic nephropathy are still unknown.
CELLULAR SIGNALLING
(2022)
Article
Biochemistry & Molecular Biology
Somesh Banerjee, Parul Katiyar, Lokesh Kumar, Vijay Kumar, Shashank Sagar Saini, Vengadesan Krishnan, Debabrata Sircar, Partha Roy
Summary: The study shows that black pepper and its major bioactive alkaloid piperine can effectively reduce the expression of hepcidin induced by inflammation and improve anemia of inflammation.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Tzila Davidov, Yael Efraim, Rotem Hayam, Jacopo Oieni, Limor Baruch, Marcelle Machluf
Summary: Comparing pECM hydrogels derived from different tissues revealed differences in composition, structure, and mechanical properties, as well as unique attributes. Through protein and gene expression analyses, it was shown for the first time that each pECM hydrogel supports the differentiation of induced pluripotent stem cells towards cells of its original tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Geriatrics & Gerontology
Helio Coelho-Junior, Emanuele Marzetti, Riccardo Calvani, Anna Picca, Hidenori Arai, Marco Uchida
Summary: The present study found that resistance training (RT) has a positive impact on overall cognitive function in older adults with different cognitive statuses. Both cognitively healthy and cognitively impaired older adults showed improved cognitive function after engaging in RT. However, short-term memory was only improved in the cognitively healthy group.
AGING & MENTAL HEALTH
(2022)
Letter
Geriatrics & Gerontology
Minoru Yamada, Hidenori Arai
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2022)
Article
Geriatrics & Gerontology
Yoshinori Fujiwara, Katsunori Kondo, Wataru Koyano, Hiroshi Murayama, Shoji Shinkai, Koji Fujita, Hidenori Arai, Fuki Horiuchi
Summary: This article discusses the concept and definition of social frailty that has not been established. However, using the term can draw attention to professionals using social factors to support older adults. By recognizing that social factors may interact with other factors and lead to functional decline, it can increase healthy life expectancy. Interventions should be pursued to address these factors. Further research and discussion are needed to clarify the academic significance and usefulness of social frailty for disability prevention.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2022)
Letter
Geriatrics & Gerontology
Jiaqi Li, Mikako Yasuoka, Kaori Kinoshita, Keisuke Maeda, Marie Takemura, Yasumoto Matsui, Hidenori Arai, Shosuke Satake
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2022)
Letter
Geriatrics & Gerontology
Kaori Kinoshita, Shosuke Satake, Kenta Murotani, Jiaqi Li, Mikako Yasuoka, Hidenori Arai
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Susumu Sato, Shinjiro Miyazaki, Akira Tamaki, Yoshihiro Yoshimura, Hidenori Arai, Dai Fujiwara, Hideki Katsura, Atsuyoshi Kawagoshi, Ryo Kozu, Keisuke Maeda, Sumito Ogawa, Jun Ueki, Hidetaka Wakabayashi
Summary: Respiratory sarcopenia, characterized by respiratory muscle weakness and decreased respiratory muscle mass, is an important condition that has not been adequately evaluated in clinical practice. This position paper provides an overview of the basic knowledge, diagnostic and assessment methods, mechanisms, involvement in respiratory diseases, intervention and treatment methods, and future perspectives on respiratory sarcopenia. The consensus on respiratory sarcopenia is also summarized, with recommendations for evaluating respiratory muscle strength and mass. Further research is needed to establish cutoff values for defining decreased respiratory muscle mass.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Yuto Nakao, Koki Kawamura, Taku Iwase, Aiko Osawa, Shinichiro Maeshima, Hidenori Arai
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Mihoko Ogita, Mika Okura, Ryo Katayose, Naomi Miyamatsu, Hidenori Arai
Summary: This study aimed to examine the association between participation in health and frailty check-ups and functional outcomes and mortality among Japanese community-dwelling older adults. The results showed that long-term care and mortality risks were significantly lower among those aged <75 years who used health screening. In those aged >= 75 years, the risk for long-term care was lower in individuals participating in both health and frailty check-ups and in those who participated in the frailty check-ups only.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Tomoki Tanaka, Hirohiko Hirano, Kazunori Ikebe, Takayuki Ueda, Masanori Iwasaki, Maki Shirobe, Shunsuke Minakuchi, Masahiro Akishita, Hidenori Arai, Katsuya Iijima
Summary: To assess oral frailty in older adults, a five-item checklist called OF-5 was developed and found to have predictive validity for physical frailty, physical disability, and mortality.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Wei-Min Chu, Hsin-En Ho, Chih-Jung Yeh, James Cheng-Chung Wei, Hidenori Arai, Meng-Chih Lee
Summary: This study explores the association between multimorbidity patterns with/ without frailty and future mortality among Taiwanese middle-aged and older adults. Frailty plays an important role in mortality among middle-aged and older adults with distinct multimorbidity patterns.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Shinichiro Maeshima, Aiko Osawa, Koki Kawamura, Takako Yoshimura, Eri Otaka, Yayoi Sato, Ikue Ueda, Naoki Itoh, Izumi Kondo, Hidenori Arai
Summary: The study investigated assessment tools used by dementia specialists, reasons for their use, and related factors. Most specialists use neuropsychological tests for diagnosis and to assess behavioral and psychological symptoms. Screening tools like the Hasegawa Dementia Scale-Revised and Mini-Mental State Examination are commonly used, while direct assessments include the Mini-Mental State Examination, Clock Drawing Test, and Cube Copying Test. Quality of life and care burden assessments are less common in clinical practice.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Sayuri Sable-Morita, Saiko Sugiura, Hirokazu Suzuki, Hideki Fukuoka, Yasumoto Matsui, Hidenori Arai
Summary: This study aimed to clarify the relationship between frailty and the senses of sight, hearing, smell, and taste. Olfactory impairment had the strongest correlation with frailty. Although the sense of smell decreases with disease and aging, olfactory impairment may be correlated with frailty as a symptom of neurodegenerative diseases.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Letter
Geriatrics & Gerontology
Yasuhiro Yamaguchi, Jiro Okochi, Tomohiko Urano, Takae Ebihara, Takafumi Kadono, Hidenori Arai, Katsuya Iijima, Shinya Ishii, Masafumi Kuzuya, Hiromi Rakugi, Masahiro Akishita, Kentaro Higashi, Koichi Kozaki
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Letter
Geriatrics & Gerontology
Minoru Yamada, Hidenori Arai
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Wei-Min Chu, Yukiko Nishita, Chikako Tange, Shu Zhang, Kanae Furuya, Hiroshi Shimokata, Meng-Chih Lee, Hidenori Arai, Rei Otsuka
Summary: Smoking, especially when combined with secondhand smoke exposure, is associated with future physical frailty among older adults.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)