Article
Immunology
Adriana Dominguez-Flores, Gloria M. Rodriguez Lopez, Rodolfo Soria-Castro, Ruben Lopez-Santiago, Octavio Rodriguez-Cortes, Sonia M. Perez-Tapia, Alma D. Chavez-Blanco, Sergio Estrada-Parra, Raul Flores-Mejia, Rommel Chacon-Salinas
Summary: Brucella abortus, a Gram-negative bacteria, is a major cause of brucellosis in animals and humans. This study analyzed the role of innate immune receptors TLR2 and TLR4 in mast cell activation during B. abortus infection. The results showed that B. abortus induced the synthesis of several cytokines and activated key cell signaling molecules in mast cells. Blockade of TLR2 and TLR4 receptors decreased the release of TNF-alpha and IL-6 by mast cells in response to B. abortus. Overall, mast cells are activated by B. abortus and may contribute to the inflammatory response during the initial phase of the infection.
MICROBIAL PATHOGENESIS
(2023)
Article
Immunology
Yan Liu, Li Liu, Wanying Xing, Yan Sun
Summary: Anesthetics have dual effects on inflammation and neuronal injury, with potential immune-modulation mechanisms involving TLR-mediated signaling regulation and nc RNA modulations. The review focuses on the immunomodulatory functions of anesthetics and the roles of nc RNAs in regulating TLR signaling induced by anesthetics.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Meenakshi Rani, Shannon R. Sayyadioskoie, Eva M. Galvan, Susannah E. Nicholson, Martin G. Schwacha
Summary: The study found that traumatic injury with hemorrhage leads to lung injury, activation of immune cells, and elevated cytokine production in the lungs. These cells play a key role in mediating inflammatory responses through TLRs.
Article
Medicine, Research & Experimental
Asal Katebi, Reyhaneh Varshochian, Farhad Riazi-rad, Mazdak Ganjalikhani-Hakemi, Soheila Ajdary
Summary: The combination of SLA with TLR1/2 and TLR7/8 agonists, either in NPs or in soluble forms, overcomes the suppression of L. major-infected macrophages. Encapsulation enhances the strength and duration of cytokines and iNOS expression, while reducing parasite load, indicating longer availability or delivery of NPs to macrophages. These findings suggest the advantages of particulate therapeutic vaccine formulations.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Immunology
Sagar Paudel, Laxman Ghimire, Liliang Jin, Duane Jeansonne, Samithamby Jeyaseelan
Summary: This article summarizes the mechanisms of how the hematopoietic system increases neutrophil generation rapidly during acute infectious and inflammatory conditions. Recent studies have identified new concepts, including the direct sensing of pathogens by BM resident or sentinel hematopoietic stem and progenitor cells, the crosstalk between hematopoietic stem and progenitor cells, endothelial cells, and stromal cells, and the direct effects of newly discovered inflammatory molecules on hematopoietic stem and progenitor cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Spela Knez, Mojca Narat, Jernej Ogorevc
Summary: Toll-like receptor 10 (TLR10) is a member of TLR family with unclear function and ligand. Its role as an immunomodulator appears to be cell type, pathogen, and TLR10 expression level-dependent. In this study, we overexpressed TLR10 in A549 lung epithelial cells and observed differential expression of TLR signaling genes activated by various TLR ligands. The overexpression of TLR10 suppressed proinflammatory cytokine expression and increased anti-inflammatory cytokine and antimicrobial peptide expression, suggesting its potential as an anti-inflammatory molecule in A549 cells.
Article
Biochemistry & Molecular Biology
Mary-Keara Boss, Remy Watts, Lauren G. Harrison, Sophie Hopkins, Lyndah Chow, Erin Trageser, Carina Easton, Susan M. LaRue, Daniel Regan, Mark W. Dewhirst, Steven Dow
Summary: This study investigated the immune responses within the tumor microenvironment (TME) following stereotactic body radiotherapy (SBRT) and the effects of local injection of immune modulatory antibodies on those responses using a canine spontaneous tumor model. The results showed that SBRT alone increased the density of immunosuppressive cells in the tumor, while the addition of immune therapy reduced these cells. Furthermore, increased concentrations of immune-related factors were observed in the serum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Harpreet Kaur, Syed Azmal Ali
Summary: Probiotics play an important role in maintaining gut health and preventing diseases through their interaction and modulation of the gut immune system.
Article
Biochemistry & Molecular Biology
Makram Merimi, Karolien Buyl, Dhouha Daassi, Robim M. Rodrigues, Rahma Melki, Philippe Lewalle, Tamara Vanhaecke, Hassan Fahmi, Vera Rogiers, Laurence Lagneaux, Joery De Kock, Mehdi Najar
Summary: This study investigates the response of AT-MSCs to inflammation and cell-passaging, revealing that inflammation leads to upregulation of specific cytokines and TLR, while cell-passaging increases the expression of other genes. These findings provide insights into the characteristics of AT-MSCs and potential therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Kunj Patel, R. Stokes Peebles
Summary: Prostacyclin is a metabolic product of the cyclooxygenase pathway with constitutive expression and anti-inflammatory effects. Evidence suggests that it may serve as an additional therapeutic target for treating allergic inflammation and asthma.
Article
Biochemistry & Molecular Biology
Heba R. Ghaiad, Shimaa O. Ali, Asmaa K. Al-Mokaddem, Maha Abdelmonem
Summary: This study demonstrates that sulbutiamine is a drug that can improve diabetic nephropathy by inhibiting multiple signaling pathways and providing renal protection.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Ashok Patidar, Sathishkumar Selvaraj, Mohona Chakravarti, Ipsita Guha, Avishek Bhuniya, Saurav Bera, Sukanya Dhar, Kamalika Roy, Rathindranath Baral, Debprasad Chattopadhyay, Chiranjib Pal, Bhaskar Saha
Summary: Activation of the tumor-eliminating immune response is a major challenge. Macrophages, a major component of solid tumors, play important roles in tumor development and regression. The interaction between Toll-Like Receptors (TLRs) and IL-27 has been found to enhance macrophage function and contribute to tumor regression by activating T cells. This study investigates the crosstalk between TLRs and IL-27 in a melanoma model and demonstrates the preventative role of TLR-induced IL-27 in aggressive and highly invasive melanoma.
Review
Chemistry, Multidisciplinary
Mei Jin, Jian Fang, Jiao-jiao Wang, Xin Shao, Suo-wen Xu, Pei-qing Liu, Wen-cai Ye, Zhi-ping Liu
Summary: Atherosclerosis, a life-threatening cardiovascular disease, is associated with chronic inflammation and immune processes. Toll-like receptors (TLRs) play a vital role in the occurrence and development of atherosclerosis. Targeting TLRs and their regulated inflammatory events could be a promising new strategy for the treatment of atherosclerotic CVDs.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Immunology
Dolly E. E. Montano, Susann Hartung, Melissa Wich, Rida Ali, Berit Jungnickel, Marie von Lilienfeld-Toal, Kerstin Voigt
Summary: This study reveals the interaction between invasive mucormycosis and human monocytes, providing new insights into the immune response of the host and potential therapies in the future.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Jose Donato, Frederick Wasinski, Isadora C. Furigo, Martin Metzger, Renata Frazao
Summary: Growth hormone plays a crucial role in regulating metabolism in the brain, affecting food intake, energy expenditure, blood sugar levels, and neuroendocrine changes. It acts as a hormonal factor that conveys homeostatic information to the brain to produce metabolic adjustments in order to promote energy homeostasis.