Article
Biochemistry & Molecular Biology
Hussein Sakr, Zenat Khired, Marzieh Moghadas
Summary: This study examined the effect of a wheat grain diet on bone turnover markers in rats. The results showed that rats fed whole or refined grains had lower bone density and mineral content compared to the control group. Additionally, levels of bone turnover indicators in the blood were altered, indicating a decrease in bone turnover and mass with a grain diet.
Article
Nutrition & Dietetics
Nasser M. Al-Daghri, Syed Danish Hussain, Abdullah M. Alnaami, Naji Aljohani, Shaun Sabico
Summary: Osteoporosis is a significant public health concern in Saudi Arabia, particularly among the aging population. This study examined the association between dietary calcium intake and osteoporosis risk in Saudi adults. Results showed that the overall mean calcium intake was very low and that certain dietary factors, such as tea intake and consumption of fish and eggs, were associated with a lower risk of osteoporosis.
Article
Biochemistry & Molecular Biology
Ewa Jowko, Barbara Dlugolecka, Igor Cieslinski, Jadwiga Kotowska
Summary: The aim of this study was to identify relevant factors that affect bone mineral content (BMC) and bone mineral density (BMD) in young, healthy men reaching peak bone mass. The results showed that age, BMI, engaging in combat and team sports at a competitive level, and certain genetic polymorphisms were significant predictors of BMD/BMC at different skeletal sites. Specifically, the SOD2 AG genotype was associated with lower BMC values, while the VDR FokI GG genotype was associated with lower BMD. However, the CALCR AG genotype was linked to higher arm BMD. These findings suggest that sports training may mitigate the negative impact of genetic factors on bone tissue and reduce the risk of osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Elham Kazemian, Ali Pourali, Fatemeh Sedaghat, Mehrdad Karimi, Vahid Basirat, Zohreh Sajadi Hezaveh, Sayed Hossein Davoodi, Michael F. Holick
Summary: A systematic review and meta-analysis evaluated the effects of vitamin D-3 supplementation on bone health in adults. The results showed a protective effect of vitamin D-3 supplementation on bone mineral density (BMD) at the lumbar spine, femoral neck, and total hip. Dose-response analysis revealed a linear relationship between vitamin D-3 supplementation doses and BMD. However, no significant effect of vitamin D-3 supplementation on whole-body or total hip BMD was found. The relationship between vitamin D-3 supplement doses and markers of bone turnover was nonlinear.
Review
Biochemistry & Molecular Biology
Kathryn Frost, Amy J. Naylor, Helen M. McGettrick
Summary: Bone remodelling is a dynamically regulated process involving osteoblasts, osteoclasts, and their progenitors. Dysregulation of bone remodelling can lead to disorders like osteoporosis and Paget's disease. The sphingosine-1-phosphate (S1P) signaling pathway has been identified as an important regulator of bone remodelling and inflammatory responses. This review discusses the role of S1P in bone homeostasis and disease, highlighting its potential as a biomarker and therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Alicia R. Jones, Koen Simons, Susan Harvey, Vivian Grill
Summary: Individuals with primary hyperparathyroidism have reduced cortical bone mineral density, but relatively preserved trabecular bone density. However, their fracture risk is still increased. Trabecular bone score may provide a more accurate assessment of bone quality and fracture risk. This study compared the effectiveness of bone mineral density and trabecular bone score in describing bone quality in patients with primary hyperparathyroidism, and also evaluated changes in trabecular bone score following parathyroidectomy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Kazuyoshi Shigehara, Kouji Izumi, Yoshifumi Kadono, Atsushi Mizokami
Summary: Bone fracture due to osteoporosis is a significant issue for elderly men, and testosterone replacement therapy has shown benefits in improving bone mineral density in symptomatic hypogonadal men with osteopenia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Xiaojuan Xu, Manna Zhang, Zhaoliang Fei, Hui Sheng, Shen Qu, Ran Cui
Summary: The study found a significant association between lower extremity arterial calcification and osteoporosis in female patients with type 2 diabetes, but not in male patients. This suggests a potential gender difference in the relationship between arterial calcification and osteoporosis in individuals with type 2 diabetes.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Geriatrics & Gerontology
Xiaowen Zhang, Warrington W. Q. Hsu, Chor-Wing Sing, Gloria H. Y. Li, Kathryn C. B. Tan, Annie W. C. Kung, Janus S. H. Wong, Ian Chi-Kei Wong, Ching-Lung Cheung
Summary: This study investigated the relationship between bone mineral density (BMD) and the risk of incident dementia, and found that higher BMD was associated with a reduced risk of dementia, particularly in women. Further research is needed to evaluate the clinical usefulness of BMD in predicting and managing dementia.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Marta Galvez-Fernandez, Maria Grau-Perez, Tamara Garcia-Barrera, Sara Ramirez-Acosta, Jose L. Gomez-Ariza, Beatriz Perez-Gomez, Inaki Galan-Labaca, Ana Navas-Acien, Josep Redon, Laisa S. Briongos-Figuero, Antonio Duenas-Laita, Jose Luis Perez-Castrillon, Maria Tellez-Plaza, Juan Carlos Martin-Escudero
Summary: The study evaluated the association between arsenic, cadmium, and selenium biomarkers with bone mineral density. Results showed that selenium was associated with BMD-related disease, while arsenic and cadmium were not. The non-linear association of selenium with BMD-related disease included a strong positive association with osteoporosis-related bone fractures risk at higher selenium exposure levels.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Endocrinology & Metabolism
Chin-Hao Hsu, Sheng-Feng Sung, Hsin-Yi Yang, Wan-Ting Huang, Cheng-Yang Hsieh
Summary: Despite being at higher risk, stroke survivors are less likely to receive bone mineral density testing and osteoporosis treatment compared to non-stroke patients. Factors such as female sex, osteoporosis, prior BMD testing, and low-trauma fractures after stroke increase the likelihood of receiving these measures, while greater stroke severity reduces the likelihood.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Ming Qin, Yue Gao, Meichen Zhang, Junhua Wu, Yang Liu, Yuting Jiang, Xiaodi Zhang, Xin Wang, Yanmei Yang, Yanhui Gao
Summary: This study investigates the effects of fluorine and ADAMTS14_rs4747096 on bone mineral density (BMD). The findings suggest that fluoride exposure and mutation G allele in ADAMTS14_rs4747096 may be risk factors for decreased BMD, and there is an interaction between the two influencing factors.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Endocrinology & Metabolism
Y. Zhang, Z. Tian, S. Ye, Q. Mu, X. Wang, S. Ren, X. Hou, W. Yu, J. Guo
Summary: The study found that individuals with Down syndrome have significantly lower bone mineral density in total body and different regions (hip, lumbar spine, and femoral neck) compared to controls. It also showed a decreasing trend in lumbar spine volumetric bone mineral density and an elevated femoral neck volumetric bone mineral density in Down syndrome individuals versus controls.
OSTEOPOROSIS INTERNATIONAL
(2022)
Review
Endocrinology & Metabolism
Panagiotis Anagnostis, Kalliopi Lampropoulou-Adamidou, Julia K. Bosdou, Georgios Trovas, Petros Galanis, Efstathios Chronopoulos, Dimitrios G. Goulis, Symeon Tournis
Summary: The optimal management of pregnancy and lactation-associated osteoporosis (PLO) has not been determined. Existing studies have found that calcium/vitamin D, bisphosphonates, and teriparatide can improve bone mineral density, with teriparatide showing better efficacy. However, due to heterogeneity and lack of robust comparative data, safe conclusions cannot be drawn regarding the optimal therapeutic intervention in women with PLO.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Orthopedics
Jiemei Gu, Hao Zhang, Qingyun Xue, Li Wang, Zhifeng Cheng, Yawei Zhang, Qifu Li, Lingqing Yuan, Yukun Li, Jin Dong, Yanan Huo, Xin Tang, Ling Hu, Xinjia Wang, Fei Hua, Lin Shen, Jinluo Cheng, Huimin Zhou, Youjia Xu, Tao Yang, Chuansuo Wang, Jin Xu, Jie Shen, Ying Zhang, Xiaomei Zhang, Dun Hong, Xiaoling Guan, Xinhua Xiao, Guang Wang, Yonghua Liu, Liujun Fu, Jianting Chen, Xigao Cheng, Yue Ding, Lijun Liu, Qi Yao, Xinchao Zhang, Lixin Li, Panjun Zhang, Chunying Deng, Chengyan Jiang, Li You, Kai Wang, Shimin Zhang, Jianzhong Xiao, Wei Liu, Xiaohong Du, Xianwen Shang, Tianrong Pan, Chen Lei, Shuren Guo, Zhenlin Zhang
Summary: This study assessed the efficacy, safety, pharmacokinetics, and immunogenicity of a denosumab biosimilar (LY06006) in Chinese postmenopausal women with osteoporosis. The results showed that LY06006 significantly increased bone mineral density and reduced bone resorption. The safety and tolerability of LY06006 were comparable to the reference drug Prolia(R).
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Psychology, Clinical
Kayoung Lee
Summary: This study found that weight misperception is associated with estimated cardiovascular disease (CVD) risk independently in both men and women, and moderates the association between obesity indices and estimated CVD risk in women.
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Joo-Hyun Park, Jung Yong Hong, Kyungdo Han, Jay J. Shen
Summary: The study found a dose-response association between glycemic status and kidney cancer risk in men and women. Diabetes was associated with an increased risk in men, while both diabetes and prediabetes were associated with an increased risk in women. This highlights the importance of monitoring for kidney complications even in women with prediabetes.
Article
Oncology
Joo-Hyun Park, Jung Yong Hong, Kyungdo Han
Summary: This study investigated the association between smoking and gallbladder cancer risk and found that smoking is associated with an increased risk of gallbladder cancer, with a higher risk for those who smoke more pack-years. The study also showed that smoking and diabetes or pre-diabetes together increase the risk of gallbladder cancer.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Public, Environmental & Occupational Health
Yong Jin Gil, Jong Hyun Park, Joohon Sung
Summary: This study evaluated the impact of body weight status and sleep duration on the hazard of menarche in Korean schoolgirls. The results showed that being overweight or sleeping less than the recommended duration increased the risk of menarche, while being underweight decreased the risk.
JOURNAL OF PREVENTIVE MEDICINE & PUBLIC HEALTH
(2023)
Article
Endocrinology & Metabolism
Hyungwoo Lee, Kyung-Do Han, Jinyoung Shin
Summary: This study investigated the risk of dry and wet age-related macular degeneration (AMD) based on fasting glucose levels and disease duration of type 2 diabetes. The results showed that diabetes patients, especially those with a duration of more than 5 years, had a higher risk of developing AMD compared to those with normal glycemic status. New-onset diabetes patients also had an increased risk of wet AMD.
DIABETES & METABOLISM
(2023)
Editorial Material
Public, Environmental & Occupational Health
Joohon Sung, John L. Hopper
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
John L. Hopper, James G. Dowty, Tuong L. Nguyen, Shuai Li, Gillian S. Dite, Robert J. MacInnis, Enes Makalic, Daniel F. Schmidt, Minh Bui, Jennifer Stone, Joohon Sung, Mark A. Jenkins, Graham G. Giles, Melissa C. Southey, John D. Mathews
Summary: This article introduces a unified model (VALID) to explain the extent of differences in disease risk among people of the same age. The model takes into account genetic and non-genetic familial risk factors and converts familial risk ratios into variance components of risk. Application of VALID to female breast cancer shows that much is still unknown about genetic and familial aspects of risk, especially for young women.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Oncology
Joo-Hyun Park, Jung Yong Hong, Jay J. Shen, Kyungdo Han, Joon Oh Park, Young Suk Park, Ho Yeong Lim
Summary: Young adults with NAFLD have an increased risk of young-onset digestive tract cancers. This study investigates the association between NAFLD and these cancers and finds that NAFLD is a modifiable risk factor for young-onset digestive tract cancers.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Joo-Hyun Park, Jung Yong Hong, Kyungdo Han
Summary: This study investigated the association between smoking status and the risk of intrahepatic and extrahepatic cholangiocarcinoma (iCCA and eCCA), and found that quitting smoking was associated with a reduced risk of CCA. However, current smokers with diabetes and prediabetes had a synergistically increased risk of CCA. Therefore, smoking cessation is crucial for reducing the risk of CCA.
Article
Health Care Sciences & Services
Kyungah Park, Hyeongsu Kim, Jeehye Lee, Jinyoung Shin, AhHyun Park
Summary: Although regulations have been implemented for medical school admission in Korea, the unequal distribution of healthcare personnel across regions remains a problem. This study examines the distribution and retention rate of physicians in different regions based on their experience staying in the current practice area during high school, medical school, and residency training. The highest retention rate was observed when physicians completed their education and training in the same region they currently practice, indicating the importance of continued training in the same area for increasing retention rates.
Article
Clinical Neurology
Keon-Joo Lee, Hakyung Kim, Soo Ji Lee, Marie-Gabrielle Duperron, Stephanie Debette, Hee-Joon Bae, Joohon Sung
Summary: The study did not find a significant causal effect of serum 25(OH)D concentration on cSVD-related phenotypes, suggesting that the previously reported association may be partly due to reverse causation.
Article
Nutrition & Dietetics
Junhee Park, Jiyoung Kim, Dong Wook Shin, Jinyoung Shin, Belong Cho, Yun-Mi Song
Summary: The current nutritional guidelines for stomach cancer survivors mainly focus on the influence of surgery, but do not provide sufficient guidance on a wider range of food options. This study aimed to investigate factors associated with healthier dietary changes in Korean adult stomach cancer survivors. The study found that approximately 60% of participants reported dietary changes in a healthier direction for three or more food categories, while 9.1% reported no changes. The study also found that factors such as age, education, income, and psychological characteristics were associated with the dietary pattern changes.
Article
Nutrition & Dietetics
Seonghye Kim, Yohwan Yeo, Jinyoung Shin, Dong Wook Shin, Belong Cho, Yun-Mi Song
Summary: The factors associated with the use of dietary supplements by Asian breast cancer survivors vary depending on the duration of use and the specific type of supplement. Long-term use is more frequently associated with cancer-related factors.
Article
Primary Health Care
Hyeonjin Cho, Wonyoung Jung, Dong Wook Shin, Jinyoung Shin, Yun-Mi Song
Summary: This study aimed to evaluate the prevalence and factors associated with sleep disorder among Korean adult cancer survivors. The results showed that one-fifth of cancer survivors had sleep disorder, and age, menopausal status, fear of cancer recurrence, anxiety, living with a spouse or partner, and quality of life were independently associated with sleep disorder.
KOREAN JOURNAL OF FAMILY MEDICINE
(2023)
Article
Nutrition & Dietetics
Hyun Jeong Cho, Akinkunmi Paul Okekunle, Ga-Eun Yie, Jiyoung Youn, Moonil Kang, Taiyue Jin, Joohon Sung, Jung Eun Lee
Summary: This study used Mendelian randomization to test the causal association between genetically predicted coffee consumption and type 2 diabetes. The results showed that genetically predicted increased coffee consumption was associated with a reduced prevalence of type 2 diabetes. In addition, genetically predicted coffee consumption was also associated with lower levels of fasting blood glucose and 2-hour postprandial glucose.
NUTRITION RESEARCH AND PRACTICE
(2023)