Article
Medicine, General & Internal
Elzbieta Kozlowska, Ewa Brzezinska-Blaszczyk, Adam Wysokinski, Paulina Zelechowska
Summary: It has been suggested that immune-inflammatory processes might be involved in the etiopathogenesis of schizophrenia, and growing evidence indicates that adipokines, particularly apelin, may play a role in the disease. This study found that there was no significant difference in levels of resistin and chemerin between schizophrenia patients and healthy individuals, but apelin levels were significantly lower in patients with schizophrenia. Apelin may be involved in the pathogenesis of schizophrenia.
JOURNAL OF INVESTIGATIVE MEDICINE
(2021)
Article
Medicine, General & Internal
Jean-Eric Tarride, Aristithes G. Doumouras, Dennis Hong, J. Michael Paterson, Semra Tibebu, Francis Nguyen, Richard Perez, Valerie H. Taylor, Feng Xie, Vanessa Boudreau, Eleanor Pullenayegum, David R. Urbach, Mehran Anvari
Summary: This study compared 4-year health care expenditures after RYGB and sleeve gastrectomy, finding no significant differences in all-cause mortality and number of hospital admissions between the two procedures, but more frequent nonelective hospitalizations with RYGB. Patients who underwent RYGB had a lower rate of subsequent bariatric procedures.
Article
Medicine, General & Internal
Viviana Aursulesei Onofrei, Ecaterina Anisie, Carmen Lacramioara Zamfir, Alexandr Ceasovschih, Mihai Constantin, Florin Mitu, Elena-Daniela Grigorescu, Antoneta Dacia Petroaie, Daniel Vasile Timofte
Summary: The study investigated the correlations between two adipokines (chemerin, adiponectin), PVAT morphological changes (adipocyte size, blood vessel wall thickness) and arterial stiffness (AS) parameters in patients with morbid obesity. The findings suggest that chemerin and adipocyte size could be predictive biomarkers for AS in patients with morbid obesity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Lei Zhao, Lawrence L. Leung, John Morser
Summary: Chemerin, produced by the RARRES2 gene, undergoes activation and inactivation processes to exert its biological activity. It signals through various receptors and is expressed in multiple tissues. Methods for identifying different forms of Chemerin provide a means to study its biological function, and its levels in circulation may serve as a biomarker.
Article
Clinical Neurology
Russell Yanofsky, Carina Sancho, Karina Gasbarrino, Huaien Zheng, Robert J. Doonan, Fanny Jaunet, Samantha Steinmetz-Wood, John P. Veinot, Chi Lai, Stella S. Daskalopoulou
Summary: The study found that mRNA expression of resistin and chemerin was lower in unstable plaques compared to stable plaques, while protein expression of resistin and chemerin was higher in unstable plaques. There was no difference in ChemR23 mRNA expression. The results suggest that these adipokines may play different roles in the pathogenesis of carotid atherosclerotic plaques.
Review
Endocrinology & Metabolism
Yiming Gao, Caihong Xin, Huaying Fan, Xin Sun, Hongli Wang
Summary: In this meta-analysis, it was found that the levels of chemerin, a newly identified adipokine, were significantly higher in patients with PCOS compared to healthy controls. However, there was no significant difference in the levels of apelin, another adipokine, between the two groups.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Joanna Sulicka-Grodzicka, Andrzej Surdacki, Marcin Surmiak, Marek Sanak, Barbara Wizner, Wojciech Sydor, Magdalena Strach, Mariusz Korkosz, Lubomir Skladany, Ivica Grgurevic, Kristian Podrug, Michal Kukla, Monika Bociasa-Jasik
Summary: This study evaluated the sequence of inflammatory responses in COVID-19 survivors and found that chemerin concentrations decreased one week after infection onset but increased on the 28-day follow up in patients with moderate/severe disease. In contrast, pro-inflammatory cytokines and adipokines did not show similar changes. This suggests enhanced vascularization as a consequence of acute SARS-CoV2 infection.
Article
Medicine, General & Internal
Georgios-Ioannis Verras, Francesk Mulita, Sjaak Pouwels, Chetan Parmar, Nikolas Drakos, Konstantinos Bouchagier, Charalampos Kaplanis, George Skroubis
Summary: Morbid obesity is a chronic disease with a rising incidence, and surgical treatment has shown superior outcomes compared to conventional weight loss measures. This study evaluated the long-term weight loss outcomes, comorbidity reduction, and adverse effects of Roux-en-Y Gastric Bypass (RYGB), Biliopancreatic Diversion (BPD), and Sleeve Gastrectomy (SG) at 10 years. RYGB and BPD resulted in significant weight loss, with no observed differences in diabetes resolution and adverse outcomes. Longer follow-up reports are important for comparing the outcomes of different bariatric operations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Karolina Hoffmann, Dorota Kopciuch, Michal Michalak, Wieslaw Bryl, Krzysztof Kus, Kinga Marzec, Jonas Raakow, Matthias Pross, Rafael Berghaus, Elzbieta Nowakowska, Magdalena Kostrzewska, Tomasz Zaprutko, Piotr Ratajczak, Anna Paczkowska
Summary: This study compared patient adherence in morbid obesity treatment between Poland and Germany, finding higher adherence among Polish patients but no statistically significant difference. Adherence was associated with various factors including gender, age, education level, duration of obesity, healthcare professionals involved, and type of treatment. Adherent patients had better weight loss outcomes and lower levels of anxiety, stress, and depression.
Article
Endocrinology & Metabolism
Ville A. Palomaki, Petri Lehenkari, Sanna Merilainen, Tuomo J. Karttunen, Vesa Koivukangas
Summary: This case-control study analyzed the macrophage infiltration in subcutaneous adipose tissue after bariatric surgery or conservative treatment of obesity, and investigated whether these features could predict weight loss outcome. The study found a significant decline in crown-like structures (CLS) density after surgery, regardless of weight loss. However, surgery had no effect on the infiltration of single-cell macrophages, and the abundance of these macrophage populations before surgery did not predict weight loss or response to surgery.
Article
Surgery
B. K. Wolnerhanssen, R. Peterli, S. Hurme, M. Bueter, M. Helmio, A. Juuti, A. C. Meyer-Gerspach, M. Slawik, P. Peromaa-Haavisto, P. Nuutila, P. Salminen
Summary: After 5 years of follow-up, it was found that LRYGB resulted in greater weight loss and better improvement in hypertension compared to LSG, but there was no significant difference in remission of T2DM, obstructive sleep apnoea, or quality of life. The complication rate was higher after LRYGB, but the individual burden for patients with complications was similar after both operations.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Endocrinology & Metabolism
Michael Semyonov, Anastasiya Bartulovic, Nir Cohen, Baruch Berzon, Ekaterina Fedorina, Sofia Lerman, Anastasia Semionov, Michael Friger, Asaf Acker, Alexander Geftler, Alexander Zlotnik, Evgeni Brotfain
Summary: This study compared the effects of pre- and postincisional intravenous paracetamol administration in bariatric surgery patients. The results showed that early administration of intravenous paracetamol before surgical incision resulted in lower postoperative pain scores and reduced the need for additional analgesics.
Article
Reproductive Biology
Borhan Shokrollahi, Jiang-Hua Shang, Nazila Saadati, Hafiz Ishfaq Ahmad, Chun-Yan Yang
Summary: Adipose tissue plays a significant role in mammalian reproduction by secreting adipokines that influence energy regulation, metabolism, and cardiovascular diseases. Studies have shown that adipokines are crucial for protecting the reproductive axis, promoting ovulation, and successful embryo implantation, with different adipokines having diverse functions in the reproductive system.
Article
Endocrinology & Metabolism
Rinki Murphy, Lindsay D. Plank, Michael G. Clarke, Nicholas J. Evennett, James Tan, David D. W. Kim, Richard Cutfield, Michael W. C. Booth
Summary: SR-LRYGB provided superior diabetes remission and weight loss compared with LSG at 5 years, with similar low risks of complications.
Article
Health Care Sciences & Services
Mohammad Muzaffar Mir, Rashid Mir, Mushabab Ayed Abdullah Alghamdi, Javed Iqbal Wani, Zia Ul Sabah, Mohammed Jeelani, Vijaya Marakala, Shahzada Khalid Sohail, Mohamed O'haj, Muffarah Hamid Alharthi, Mohannad Mohammad S. Alamri
Summary: The study found significantly altered concentrations of four adipokines, adiponectin, leptin, visfatin and chemerin, in the T2DM patient group compared to the controls, with more pronounced alterations in the obese and highly obese patients. This suggests that these four adipokines play a significant role in the onset, progression, and associated complications of T2DM. More research on a larger sample size is needed to further explore the relationship between adipokines and T2DM.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Acoustics
Seda Aladag Kurt, Lebriz Uslu Besli, Yasemin Kayadibi, Cesur Samanci, Azizullah Nazari, Tulin Ozturk, Pinar Kocael, Haluk Sayman
Summary: Quantitative imaging and metabolic parameters can be used to predict high proliferation in invasive breast carcinomas, but they are not eligible to be used as independent biomarkers. Visual assessment of microvascular morphology can improve prognostic efficiency.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Article
Respiratory System
Gulseren Sagcan, Dildar Konukoglu, Hafize Uzun, Orhan Arseven, Gulfer Okumus, Caglar Cuhadaroglu
Summary: The study found that AOPPs and PAB levels were significantly higher, while FRAP levels were significantly lower in low-risk and moderate-risk PE patients. In high-risk PE patients, AOPPs and IMA levels were significantly higher. There were significant correlations between AOPPs levels and IMA levels, as well as PAB levels.
BMC PULMONARY MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Aykut Oruc, Kadriye Yagmur Oruc, Karolin Yanar, Murat Mengi, Aysel Caglar, Bahar Ozturk Kurt, Mehmet Altan, Osman Fuat Sonmez, Ufuk Cakatay, Hafize Uzun, Gonul Simsek
Summary: Through studying rats with glutamate-induced neurotoxicity, it was found that metformin may exert neuroprotective effects and increase neuronal survival through zinc-dependent inhibition of GSK-3 beta.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Pediatrics
Yusuf Elgormus, Omer Okuyan, Hafize Uzun
Summary: This study aimed to evaluate the relationship between vitamin D status and systemic inflammatory markers NLR, LMR, and PLR in newborns. The results suggest that vitamin D deficiency in newborns may be associated with inflammation and changes in NLR, LMR, and PLR. NLR and other hematologic indices may serve as non-invasive, simple, easily measurable, and cost-effective markers of inflammation in newborns.
Article
Virology
Omer Okuyan, Yusuf Elgormus, Seyma Dumur, Ugurcan Sayili, Hafize Uzun
Summary: This study examined the relationship between SII, NLR, and PLR with clinical findings of RSV infection in children with LRTI. The results showed that CRP levels were higher in RSV positive cases, while NLR, PLR, and SII were lower in these cases. CRP performed better than other blood parameters as a marker. Determining the cause of the disease using these parameters can aid in disease management and avoid unnecessary antibiotic use.
Article
Immunology
Omer Okuyan, Yusuf Elgormus, Ugurcan Sayili, Seyma Dumur, Ozlem Erkan Isik, Hafize Uzun
Summary: This study evaluated the impact of the RV vaccine on the natural course of RV infections. The results showed that children who received the RV vaccine had lower rates of fever and hospitalization for acute gastroenteritis (AGE), and breastfeeding was also associated with a lower risk of infection. The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and systemic immune inflammatory index (SII) were significantly higher in the RV-unvaccinated group.
Article
Medicine, General & Internal
Pelin Uysal, Arzu Yuksel, Sinem Durmus, Caglar Cuhadaroglu, Remise Gelisgen, Hafize Uzun
Summary: In this study, the relationship between NF-kappa B, oxidative stress, and disease severity in new COVID-19 patients was investigated. LOX-1, NF-kappa B, and oxLDL levels were found to be higher in COVID-19 patients compared to healthy subjects. oxLDL showed the highest discrimination power in distinguishing COVID-19 patients.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Derya Ozturk, Adem Melekoglu, Ertugrul Altinbilek, Mustafa Calik, Arzu Kosem, Hakan Kilci, Naile Fevziye Misirlioglu, Hafize Uzun
Summary: This study aimed to investigate the associations between serum irisin levels and acute myocardial infarction (AMI). The findings showed that STEMI patients had significantly lower irisin levels compared to control subjects, and these levels were correlated with cTi levels and QTc interval.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Nevin Fazlioglu, Pelin Uysal, Sinem Durmus, Sibel Yurt, Remise Gelisgen, Hafize Uzun
Summary: This study investigated the relationship between plasma irisin, RBP-4, and adiponectin levels and the severity of OSAS. The results showed that these biomarkers were associated with the disease and could be used for diagnosis in the absence of polysomnography. Patients with an AHI score greater than thirty should be closely monitored for metabolic abnormalities.
Article
Medicine, General & Internal
Gulseren Sagcan, Zeki Dogan, Hafize Uzun, Caglar Cuhadaroglu, Gulfer Okumus, Orhan Arseven
Summary: This study found that higher levels of NT-proBNP and GDF-15 were associated with the severity, prognosis, and mortality of acute pulmonary embolism.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Z. Dogan, S. Durmus, D. D. Ergun, R. Gelisgen, H. Uzun
Summary: This study evaluated the effectiveness of ranolazine on hypoxia-inducible factor-1 alpha (HIF-1 alpha) and oxidative stress in H9c2 cardiomyocyte cells. The results showed that ranolazine can protect cardiomyocytes from oxidative damage induced by methotrexate (MTX) by reducing oxidative stress and increasing antioxidant capacity markers. The antioxidant properties of ranolazine may contribute to these protective effects.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Zeki Dogan, Gokhan Bektasoglu, Seyma Dumur, Hafize Uzun, Ismail Erden, Mustafa Yurtdas
Summary: This study aimed to evaluate the monocyte count and high-density lipoprotein cholesterol levels and their ratio in patients with deep venous thrombosis and investigate whether this ratio can indicate thrombus burden in terms of thrombus location. The results showed a significantly higher monocyte/high-density lipoprotein ratio in deep venous thrombosis patients compared to the control group. This ratio was associated with thrombus location and the number of vein segments involved.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2023)
Meeting Abstract
Physiology
Emine Uygur, Hakki Oktay Seymen, Hafize Uzun, Matem Tuncdemir, Aysim Buge Oz, Elif Polat, Ahsen Yilmaz, Elif Yaman
Meeting Abstract
Physiology
Emine Uygur, Hakki Oktay Seymen, Hafize Uzun, Matem Tuncdemir, Aysim Buge Oz, Elif Polat, Ahsen Yilmaz, Elif Yaman
Article
Medicine, General & Internal
Yusuf Elgormus, Omer Okuyan, Seyma Dumur, Ugurcan Sayili, Hafize Uzun
Summary: This study aimed to investigate the vitamin B12 levels and risk factors in preschool children. The results showed that B12 deficiency was significantly higher in the 6-11-month group compared to other age groups. Children with insufficient B12 levels had higher homocysteine levels. There was no significant difference in weekly dairy and meat consumption levels among different age groups. The study concluded that low vitamin B12 levels and increased homocysteine levels could be important risk factors in preschool children, especially those starting to consume additional foods from the age of 6 months.
MEDICINA-LITHUANIA
(2023)
