Article
Biochemistry & Molecular Biology
Zhigang Wang, Zhiwei Chen, Xiang Zhang, Qiuxing Wei, Yafeng Xin, Baolei Zhang, Fuhang Liu, Jixing Xia
Summary: OsCASP1 is essential for the formation of the Casparian strip in the rice endodermis, and overexpression of OsCASP1 enhances Ca tolerance in rice. It promotes the formation of Casparian strip in endodermal cells, inhibits Ca transport, and restricts Ca accumulation under high Ca conditions. The results suggest that OsCASP1 overexpression is an effective strategy for improving rice adaptation to high Ca environments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Seung-Won Jung, Gi Hyun Park, Eunjung Kim, Kang Min Yoo, Hea Won Kim, Jin Soo Lee, Min Youl Chang, Kyong-Oh Shin, Kyungho Park, Eung Ho Choi
Summary: This study discovered that creams containing NHE1 activators, such as rosmarinic acid, can improve skin barrier functions. Through in vitro screening, a plant extract was found to activate NHE1, and it was confirmed that the component rosmarinic acid could increase the expression levels and production of NHE1. Clinical study results showed that application of the cream containing NHE1 activator significantly improved skin barrier functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mariko Takada, Yuko Ishikawa, Kayoko Numano, Shinichi Hirano, Genji Imokawa
Summary: The study found that using a nano-emulsion containing POLG can effectively improve the symptoms of atopic dry skin in patients with AD, especially dryness, itching, and irritation. After treatment for 3 and 6 weeks, the skin's water content significantly increased, and roughness and smoothness were significantly improved.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Hu Zhang, Juntao Wang, Mingrong Qian, Yuanxiang Jin
Summary: This study exposed mice to the azole fungicide Mefentrifluconazole (MFZ) to evaluate its toxic effects on liver and gut tissues. The results showed that MFZ exposure disrupted liver structure, lipid metabolism, and gut barrier function, leading to inflammation. The study also revealed changes in gut microbiota, suggesting a potential link between gut microbiota function and liver lipid metabolism disruption caused by MFZ exposure. This research provides new insights for risk assessment of MFZ and highlights the importance of studying novel fungicides.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Dermatology
Erle Dang, George Man, Dale Lee, Debbie A. Crumrine, Theodora M. Mauro, Peter M. Elias, Mao-Qiang Man
Summary: The deficiency of 3 beta-hydroxysteroid-delta 8, delta 7-isomerase does not compromise epidermal permeability barrier in mice, suggesting compensatory mechanisms through other pathways. Whether these findings can be extrapolated to humans remains to be determined.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Microbiology
E. Y. Lim, E-J Song, J. G. Kim, S. Y. Jung, S-Y Lee, H. S. Shin, Y-D Nam, Y. T. Kim
Summary: Studies have shown that treatment with L. intestinalis YT2 significantly alleviates symptoms of menopause, including increased fat mass, decreased bone density, heightened pain sensitivity, reduced depression-like behavior, and cognitive impairment. Additionally, this probiotic restores intestinal microbial balance by increasing the Firmicutes/Bacteroides ratio and promoting gut barrier integrity. These findings suggest that L. intestinalis YT2 may be a therapeutic probiotic for menopausal women.
BENEFICIAL MICROBES
(2021)
Article
Agriculture, Dairy & Animal Science
Shanchuan Cao, Wenjie Tang, Hui Diao, Shuwei Li, Honglin Yan, Jingbo Liu
Summary: This study examined the effects of feeding frequency on growth performance, nutrient digestibility, carcass quality, and lipid metabolism in growing-finishing pigs. The results showed that reducing feeding frequency improved feed conversion ratio and had an impact on fat deposition and carcass composition. This study provides a new approach to feeding and management of growing-finishing pigs.
Article
Dermatology
Yuki Umino, Sari Ipponjima, Mitsuhiro Denda
Summary: The study showed that EPDME increases lipid ordering in the stratum corneum at a depth of approximately 3 μm, leading to improved barrier function. PEG and PPG, on the other hand, had no effect on lipid ordering.
SKIN RESEARCH AND TECHNOLOGY
(2021)
Review
Plant Sciences
Olga Serra, Niko Geldner
Summary: This article discusses the use of different bio-polymers in outer protective barriers of animals and plants, focusing on the plant cell wall structure involving suberin and cutin. Suberin provides protective functions for plants and may assist in carbon sequestration from the atmosphere.
Article
Dermatology
Qingwei Geng, Guoqi Wei, Yebei Hu, Jinhui Xu, Xiuzu Song
Summary: This study aims to investigate the role of autophagy in the formation of lamellar bodies in keratinocytes and the regulation of keratinocyte lipids. The results showed that the autophagy inducer promoted autophagy activation and formation of lamellar bodies in keratinocytes, while the inhibitor inhibited autophagy signals and the formation of lamellar bodies in keratinocytes. In addition, the lipidomics results revealed a significant change in glycerophospholipids after autophagy induction and autophagy inhibition.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2023)
Article
Dermatology
Ali Narangifard, Christian L. Wennberg, Lianne den Hollander, Ichiro Iwai, HongMei Han, Magnus Lundborg, Sergej Masich, Erik Lindahl, Bertil Daneholt, Lars Norlen
Summary: This study reveals two cryo-electron microscopy patterns representing intermediate stages in the skin lipid lamellae's maturation process, contributing to a tentative molecular model for the complete skin barrier formation process.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Dermatology
Li Ye, Qingsong Lai, Xiaohua Wang, Si Wen, Aiqi Chen, Yulin Lai, Bin Yang, Mao-Qiang Man
Summary: The study found that there are changes in transepidermal water loss rates (TEWL), stratum corneum hydration, and skin surface pH in Chinese children aged 1 month to 17 years. Overall, TEWL and stratum corneum hydration levels decrease, while skin surface pH increases. These changes vary with age, gender, and body site.
SKIN RESEARCH AND TECHNOLOGY
(2023)
Article
Cell Biology
Raffaella di Vito, Carmela Conte, Giovanna Traina
Summary: This study investigated the effects of a commercially available probiotic formulation on intestinal barrier integrity and found that it can prevent inflammatory damage. The findings provide new insights into the mechanisms by which probiotics prevent damage to the gut epithelial barrier.
Article
Chemistry, Medicinal
Hongtao Gao, Xue Wang, Hao Wu, Yuan Zhang, Wenxiao Zhang, Zuobin Wang, Xin Liu, Xiaokun Li, Haiyan Li
Summary: This study demonstrates that Camelina lipid droplets (CLDs) can promote the absorption of hFGF2 and accelerate burn healing. The research found that CLDs can change the structure and content of lipids and keratin, increasing the permeability of hFGF2 in skin tissue. CLDs are also more easily taken up by keratinocytes without damaging cell integrity.
Article
Pharmacology & Pharmacy
Maria Ines Teixeira, Carla Martins Lopes, Hugo Goncalves, Jose Catita, Ana Margarida Silva, Francisca Rodrigues, Maria Helena Amaral, Paulo C. Costa
Summary: Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease with a very poor prognosis, is hindered by the blood-brain barrier (BBB), which restricts the access of drugs commonly used in ALS to the brain. In this study, riluzole-loaded nanostructured lipid carriers (NLC) functionalized with lactoferrin (Lf) were prepared to overcome this limitation and increase brain targeting. The results showed that Lf-functionalized NLC exhibited a promising ability to target riluzole to the brain without causing significant toxicity to cells.
