Article
Immunology
Qi Huang, Wang-Dong Xu, Lin-Chong Su, Xiao-Yan Liu, An-Fang Huang
Summary: This study investigated CD40 gene polymorphisms in Chinese Han population with SLE and RA, finding associations between certain genotypes and alleles with susceptibility to the diseases. The findings suggest a potential role of CD40 gene polymorphisms in the pathogenesis of SLE and RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Yang-Yang Tang, Lu Fu, Xiao-Yan Liu, An-Fang Huang, Wang-Dong Xu
Summary: This study found an association between STAT3 gene polymorphisms and susceptibility to SLE. Specifically, certain gene mutations were found to be related to the clinical characteristics of SLE patients in the Chinese Han population.
Article
Multidisciplinary Sciences
Yuan-yuan Qi, Yan Cui, Hui Lang, Ya-ling Zhai, Xiao-xue Zhang, Xiao-yang Wang, Xin-ran Liu, Ya-fei Zhao, Xiang-hui Ning, Zhan-zheng Zhao
Summary: Genetic studies have linked the rs10947540 single-nucleotide polymorphism (SNP) in the ZNF76 gene with susceptibility to systemic lupus erythematosus (SLE) in Chinese populations. Carrier individuals of the C allele of rs10947540 were found to have a higher risk of developing SLE with elevated levels of serum creatinine. Bioinformatic analysis revealed a correlation between this SNP and decreased expression of ZNF76, suggesting a potential role in the pathogenesis of SLE.
SCIENTIFIC REPORTS
(2021)
Review
Biotechnology & Applied Microbiology
Marlene Pluess, Silvia Piantoni, Bjoern Tampe, Alfred H. J. Kim, Peter Korsten
Summary: Advances in the treatment and management of systemic lupus erythematosus have improved patient outcomes, but lupus nephritis remains a major complication. Belimumab has been shown to be superior as an add-on therapy for lupus nephritis, and personalized treatment options are expected with the development of new therapeutic agents.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Immunology
Jingquan He, Chiyu Ma, Donge Tang, Shaoyun Zhong, Xiaofang Yuan, Fengping Zheng, Zhipeng Zeng, Yumei Chen, Dongzhou Liu, Xiaoping Hong, Weier Dai, Lianghong Yin, Yong Dai
Summary: This study investigated the alteration of oxylipins in the serum of systemic lupus erythematosus (SLE) patients and identified potential biomarkers for SLE classification. The results showed that certain oxylipins were correlated with lupus nephritis (LN) and SLE disease activity. Additionally, a combination of 5 oxylipins was found to have high accuracy in classifying SLE patients. The findings provide insights into the characteristics of SLE and the development of new tools for classification.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Masahiro Nakano, Yukiko Iwasaki, Keishi Fujio
Summary: Studies on SLE have identified several disease-relevant signatures, including the IFN signature, myeloid lineage/neutrophil and plasma cell signatures, and the exhaustion signature in CD8(+) T cells, which are correlated with disease activity, nephritis, and complications of pregnancy. Further research is needed to identify treatment targets and patient stratification in SLE, as well as to understand the molecular heterogeneity and distinct subpopulations involved in the pathogenesis of SLE.
INFLAMMATION AND REGENERATION
(2021)
Article
Rheumatology
Antonis Fanouriakis, Myrto Kostopoulou, Jeanette Andersen, Martin Aringer, Laurent Arnaud, Sang-Cheol Bae, John Boletis, Ian N. Bruce, Ricard Cervera, Andrea Doria, Thomas Doerner, Richard A. Furie, Dafna D. Gladman, Frederic A. Houssiau, Luis Sousa Ines, David Jayne, Marios Kouloumas, Laszlo Kovacs, Chi Chiu Mok, Eric F. Morand, Gabriella Moroni, Marta Mosca, Johanna Mucke, Chetan B. Mukhtyar, Gyoergy Nagy, Sandra Navarra, Ioannis Parodis, Jose M. Pego-Reigosa, Michelle Petri, Bernardo A. Pons-Estel, Matthias Schneider, Josef S. Smolen, Elisabet Svenungsson, Yoshiya Tanaka, Maria G. Tektonidou, Y. K. Onno Teng, Angela Tincani, Edward M. Vital, Ronald F. van Vollenhoven, Chris Wincup, George Bertsias, Dimitrios T. Boumpas
Summary: The EULAR recommendations for the management of systemic lupus erythematosus (SLE) have been updated based on emerging new evidence. The updated recommendations provide consensus guidance on the use of various medications and treatment strategies to control the disease, as well as recommendations for assessing treatment response and tapering therapy.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Microbiology
Ping Yang, Rui Xu, Fei Chen, Shanshan Chen, Adeel Khan, Liang Li, Xiaoshan Zhang, Yanbo Wang, Zhipeng Xu, Han Shen
Summary: This study investigates the gut fungal dysbiosis and ecology in patients with SLE and demonstrates the applicability of fungal species as diagnostic tools for SLE. It suggests that the interaction between the gut fungal mycobiome and the host may contribute to the pathogenesis of the disease.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Jessica S. Kleer, Pascal A. Rabatscher, Jessica Weiss, Joel Leonardi, Severin B. Vogt, Andrea Kieninger-Grafitsch, Carlo Chizzolini, Uyen Huynh-Do, Camillo Ribi, Marten Trendelenburg
Summary: The study found that epitope-specific anti-C1q in SLE patients is associated with specific disease manifestations, providing more diagnostic value than conventional anti-C1q.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
Robert Silver, Sabrina Craigo, Flint Porter, Sarah S. Osmundson, Jeffrey A. Kuller, Mary E. Norton
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by relapses and remission. It can affect various organs, with the kidneys, joints, and skin being commonly affected. Immunologic abnormalities, such as the production of antinuclear antibodies, are also characteristic of the disease. This document provides recommendations for the treatment and management of SLE during pregnancy, including the use of medications and the prevention of complications.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Immunology
Xiaoyuan Li, Ying Tan, Feng Yu, Minghui Zhao
Summary: The proportion of successfully withdrawn from glucocorticoids (GC) in lupus nephritis patients is low, and it requires a long duration and meticulous monitoring. There is no risk of relapse after GC withdrawal.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Urology & Nephrology
Momin H. Alkhatib, Sam Kant, Steven Menez, Laila Lakhani, Christopher John Sperati, Derek M. Fine, Lois J. Arend, Mohamed G. Atta
Summary: This study compared the clinical and prognostic characteristics of thrombotic microangiopathy (TMA) with class IV lupus nephritis in SLE patients. TMA patients showed significant abnormalities in certain laboratory markers and had a worse prognosis.
JOURNAL OF NEPHROLOGY
(2021)
Article
Environmental Sciences
Heming Bai, Lei Jiang, Ting Li, Chong Liu, Xiaoxia Zuo, Yi Liu, Shaoxian Hu, Linyun Sun, Miaojia Zhang, Jin Lin, Weiguo Xiao, Qingwen Wang, Dongbao Zhao, Huaxiang Wu, Xiaodan Kong, Wenkang Gao, Wanxin Hou, Myeongsu Seong, Yuanpeng Zhang, Fangfang Chen, Sheng Chen, Xin Wu, Chunde Bao, Li Wang, Huji Xu
Summary: The study found that air pollutants PM2.5 and NO2 may be risk factors for lupus nephritis (LN), while short-term exposure to CO and O-3 does not generally have an association with LN. Furthermore, negative associations of LN with SO2 were observed for the entire region and east China.
ENVIRONMENTAL RESEARCH
(2021)
Article
Rheumatology
Yoshiya Tanaka
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease that causes damage to multiple organs. Current treatments mainly involve glucocorticoids and immunosuppressants, but the development of molecular target drugs with minimal side effects is desired. Research is focused on finding new approaches such as targeted therapies and drugs that modulate the innate and adaptive immune systems.
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Fatma A. Hisham, Samar Tharwat, Nouran E. Samra, Nora Mostafa, Mohammed K. Nassar, Manal M. El-Desoky
Summary: This study evaluated the effects of HMGB1 protein levels and gene polymorphisms on the development of SLE and their connection to LN. Higher levels of HMGB1 in both serum and urine were found in SLE patients, and there was a marginal association between HMGB1 gene variations and SLE. In addition, specific HMGB1 genotypes were significantly associated with a greater risk of LN in the Egyptian population.