Article
Biochemistry & Molecular Biology
Mariana F. Fragoso, Geysson J. Fernandez, Lisa Vanderveer, Harry S. Cooper, Michael Slifker, Margie L. Clapper
Summary: This study explored the miR expression profile of precancerous dysplastic lesions in the AOM/DSS mouse model, identifying early molecular changes associated with colitis-associated colorectal cancer (CAC). A miR signature was discovered that can distinguish inflamed non-neoplastic mucosa from dysplasia, providing novel insight into the development of CAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Rong Yan, Xinghua Liang, Juan Hu
Summary: This study aimed to identify specific miRNAs that could inhibit pyroptosis in colon epithelial cells and alleviate ulcerative colitis (UC). The results showed that miR-141-3p inhibits LPS-induced pyroptosis of colonic epithelial cells by targeting SUGT1 and alleviates the inflammatory phenotype of mouse colonic mucosa in the mouse DSS colitis model. Therefore, miR-141-3p may become a nucleic acid drug for the treatment of UC.
Article
Pathology
Samy A. Abdelazim, Olfat G. Shaker, Omaima Ali, Mai El-Tawil, Mahmoud A. Senousy
Summary: This study evaluated the diagnostic role of miR-486 and miR-25 in patients with inflammatory bowel disease (IBD) and found that miR-486 was upregulated in Crohn's disease (CD) patients, while miR-25 was decreased in both CD and ulcerative colitis (UC) patients. Serum miR-486 could distinguish CD and UC patients, while miR-25 showed potential for diagnosing both UC and CD.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Medicine, Research & Experimental
Chunhua Weng, Haojie Dong, Rongpan Bai, Jinghao Sheng, Guangdi Chen, Kefeng Ding, Weiqiang Lin, Jianghua Chen, Zhengping Xu
Summary: This study reveals that angiogenin (ANG) promotes proliferation, migration, tube formation, and angiogenesis of HUVECs by downregulating miR-141, consequently regulating CRC progression. Targeting ANG's nuclease activity may be valuable in treating angiogenesis-related diseases.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Immunology
Juan Zheng, Shengnan Wang, Tingting Zhang, Huaxin Li, Mengmeng Zhu, Xiaoning Wei, Yu Ge, Xiaoxiao Yang, Shuang Zhang, Hongmei Xu, Yajun Duan, Lipei Liu, Yuanli Chen
Summary: The study found that deficiency of Nogo-B can alleviate symptoms of ulcerative colitis (UC) and reduce the accumulation of inflammatory cells. The research revealed that inhibition of Nogo-B could serve as a new potential therapeutic candidate for the prevention and treatment of UC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Miruna Nemecz, Diana Simona Stefan, Ioana Karla Comarita, Alina Constantin, Gabriela Tanko, Cristian Guja, Adriana Georgescu
Summary: In this study, miR-218, miR-132, and miR-143 were identified as significantly up-regulated miRNAs in both circulating MVs and plasma from diabetic patients with dyslipidemia. These miRNAs showed significant correlations with important plasma markers representative of this pathology.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Plant Sciences
Xuanqing Chen, Tingting Xu, Xiangyu Lv, Jingwei Zhang, Shijia Liu
Summary: The study found that Rh2 exhibits potential application value in the treatment of ulcerative colitis (UC), and its mechanism is related to the downregulation of STAT3/miR-214 levels.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Oncology
Shuo Li, Miao Yu, Xiuying Wang, Bingyuan Fei
Summary: This study explored the role of miR-597-5p in colitis-associated colorectal cancer (CAC) and found that its deficiency aggravated macrophage recruitment and tumorigenesis in a mouse CAC model. miR-597-5p expression was decreased, while its target CXCL5 expression was increased in CAC tissues. In AOM/DSS-induced mice, miR-597-5p deficiency in intestinal epithelial cells resulted in decreased colon length, increased tumor numbers, and histologic colitis score, which were reversed by CXCL5 inhibition. These findings suggest that miR-597-5p agonists may have potential therapeutic effects in inflammatory bowel diseases and reducing the risk of developing CAC.
CANCER BIOLOGY & THERAPY
(2023)
Article
Gastroenterology & Hepatology
Sarah C. Sasson, Stephanie M. Slevin, Vincent T. F. Cheung, Isar Nassiri, Anna Olsson-Brown, Eve Fryer, Ricardo C. Ferreira, Dominik Trzupek, Tarun Gupta, Lulia Al-Hillawi, Mari-lenna Issaias, Alistair Easton, Leticia Campo, Michael E. B. FitzPatrick, Joss Adams, Meenali Chitnis, Andrew Protheroe, Mark Tuthill, Nicholas Coupe, Alison Simmons, Miranda Payne, Mark R. Middleton, Simon P. L. Travis, Benjamin P. Fairfax, Paul Klenerman, Oliver Brain
Summary: Our study demonstrates that CD8(+) tissue resident memory T (T-RM) cells are the main activated T cell subset in ICI colitis. The pattern of gastrointestinal immunopathology in ICI colitis is distinct from ulcerative colitis at both the immune and epithelial-signaling levels. Activation of CD8+ T-RM cells correlates with clinical and endoscopic severity of ICI colitis.
Article
Endocrinology & Metabolism
Lingye Fan, Chunyan Wang, Ping Zhan, Yaofang Liu
Summary: The study found that miR-141-3p was downregulated in PCOS patients, showing a higher diagnostic value for PCOS and its association with glucose and lipid metabolism. Additionally, miR-141-3p may play a role in regulating glucose and lipid metabolism in PCOS-obese patients by targeting PTEN.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mehri Naghdalipour, Nariman Moradi, Reza Fadaei, Shekufe Rezghi Barez, Shirin Sayyahfar, Marjan Mokhtare, Toktam Kazemi Fard, Soudabeh Fallah, Aboulreza Esteghamati
Summary: This study evaluated the expression of TGF-beta signaling pathway genes and their regulatory microRNAs in patients with ulcerative colitis (UC). The results showed increased expression of TGF-beta 1 and SMAD3 in UC patients compared to controls. In addition, miR-21 and miR-433 were found to be higher in UC patients, while miR-590 was lower. Furthermore, miR-433 was positively correlated with SMAD3 and TGF-beta, while miR-21 was positively correlated with TGF-beta 1. MiR-590 was negatively correlated with SMAD2 and SMAD3. These findings suggest the importance of TGF-beta signaling pathway-related microRNAs in the pathogenesis of UC.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Lucy J. Newbury, Kate Simpson, Usman Khalid, Imogen John, Lluis Bailach de Rivera, Yueh-An Lu, Melisa Lopez-Anton, William J. Watkins, Robert H. Jenkins, Donald J. Fraser, Timothy Bowen
Summary: The study identified significant changes in urinary microRNAs in AKI patients, particularly increased levels of miR-21, miR-126, and miR-141, and decreased levels of miR-192 and miR-204. The upregulation of miR-141 in renal proximal tubular epithelial cells was associated with increased cell death and decreased viability, possibly through the targeting of the PTPRG gene. These findings suggest a potential new therapeutic target for AKI.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Alix Demaris, Ella S. K. Widigson, Johan F. K. F. Ilvemark, Casper Steenholdt, Jakob B. Seidelin, Wilhelm Huisinga, Robin Michelet, Linda B. S. Aulin, Charlotte Kloft
Summary: This review aims to analyze the population PK models of infliximab (IFX) in patients with ulcerative colitis (UC) and acute severe UC (ASUC), and assess the impact of disease activity on IFX PK. The results showed that there are still many gaps in the current research, such as a limited number of models specifically developed for UC patients, a lack of studies on severe UC patients, and a lack of evaluation of predictive performance for the models. Therefore, more comprehensive research and adequate reporting and evaluation of the models are needed for clinical application.
Article
Cell Biology
Artin Soroosh, Kai Fang, Jill M. Hoffman, Ivy K. M. Law, Elizabeth Videlock, Zulfiqar A. Lokhandwala, Jonathan J. Zhao, Sepehr Hamidi, David M. Padua, Mark R. Frey, Charalabos Pothoulakis, Carl R. Rankin
Summary: This study found that miR-24-3p restrains intestinal epithelial cell apoptosis by targeting BIM, and its loss of function is detrimental to epithelial restitution following intestinal inflammation.
CELL DEATH & DISEASE
(2022)