Article
Biology
Holly E. Kinser, Matthew C. Mosley, Isaac B. Plutzer, Zachary Pincus
Summary: The study found that individual lifespan variability is high within populations across species and suggested that differences in expression of key regulatory genes are driving factors. Testing showed that gene expression can effectively predict future lifespan, with long-lived and short-lived individuals exhibiting divergent patterns of transgene expression and transcriptional regulation. Additionally, a hierarchy of redundancy in lifespan-predictive ability among different transgenes expressed in distinct tissues was demonstrated.
Article
Medicine, Research & Experimental
Yuan Gu, Gianni Pais, Vivien Becker, Christina Korbel, Emmanuel Ampofo, Elke Ebert, Johannes Hohneck, Nicole Ludwig, Eckart Meese, Rainer M. Bohle, Yingjun Zhao, Michael D. Menger, Matthias W. Laschke
Summary: The research demonstrates that miR-22 is highly expressed in ECs and significantly downregulated in NSCLC tissues. Endothelial miR-22 acts as an angiogenesis inhibitor by targeting sirtuin 1 and FGFR1 to inhibit ECs' angiogenic activities, thus suppressing NSCLC growth.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Multidisciplinary Sciences
Florian J. Bock, Egor Sedov, Elle Koren, Anna L. Koessinger, Catherine Cloix, Desiree Zerbst, Dimitris Athineos, Jayanthi Anand, Kirsteen J. Campbell, Karen Blyth, Yaron Fuchs, Stephen W. G. Tait
Summary: The study reveals that cells under apoptotic stress secrete the growth factor FGF2, which upregulates pro-survival BCL-2 proteins in neighboring cells, thereby promoting their survival.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Katherine M. Bland, Adam Aharon, Eden L. Widener, M. Irene Song, Zachary O. Casey, Yi Zuo, George S. Vidal
Summary: Fragile X syndrome (FXS) is the most common form of intellectual disability caused by the dysfunction of the Fmr1 gene. Neuroanatomical studies on cortical pyramidal neurons in Fmr1(+/-) and Fmr1(-/Y) mice reveal differences in dendritic spine density, with Fmr1(+/-) mice showing intermediate levels between wild type (WT) and Fmr1(-/Y) mice. The cell-autonomous contribution of Fmr1 on spine density was not assessed, but the regulation of the primary neuroanatomical defect of elevated spine density in FXS was found to be non-cell-autonomous.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Multidisciplinary Sciences
Jun Li, Melissa J. Hubisz, Ethan M. Earlie, Mercedes A. Duran, Christy Hong, Austin A. Varela, Emanuele Lettera, Matthew Deyell, Bernardo Tavora, Jonathan J. Havel, Su M. Phyu, Amit Dipak Amin, Karolina Budre, Erina Kamiya, Julie-Ann Cavallo, Christopher Garris, Simon Powell, Jorge S. Reis-Filho, Hannah Wen, Sarah Bettigole, Atif J. Khan, Benjamin Izar, Eileen E. Parkes, Ashley M. Laughney, Samuel F. Bakhoum
Summary: The study found that chromosomal instability is associated with endoplasmic reticulum stress signaling, immune suppression, and cancer metastasis, mediated by the cGAS-STING pathway. Inhibition of this pathway can reduce metastasis.
Review
Neurosciences
Alexandra C. M. Van Harten, Hemali Phatnani, Serge Przedborski
Summary: ALS, the most common adult-onset paralytic disorder, is characterized by the loss of motor neurons in the CNS. Recent research has shown that non-neuronal cells, particularly glial cells like astrocytes, play a role in the degeneration of motor neurons in ALS, potentially changing our understanding of the disease and treatment options.
TRENDS IN NEUROSCIENCES
(2021)
Article
Electrochemistry
Youngju Lee, Peng Bai
Summary: For the first time, a bipolar separator that utilizes distinct electroosmotic effects of negative and positive surface charges is reported. The impact of negative surface charge on zinc dendrite growth is observed through transparent capillary cells with operando video microscopy. By stacking the positively charged separator over the negatively charged separator, a uniform Zn-ion flux is achieved while preventing further metal growth that has penetrated the negative layer. Chronopotentiometry experiments show extended short-circuit time, and galvanostatic cycle-life experiments demonstrate excellent cycle life of 5,000 cycles at 10 C rate without metal penetration.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Article
Multidisciplinary Sciences
Christopher De Bono, Yang Liu, Alexander Ferrena, Aneesa Valentine, Deyou Zheng, Bernice E. Morrow
Summary: Disruption of cardiac neural crest cells (CNCCs) leads to congenital heart disease. The cell fate dynamics of CNCCs differentiating into vascular smooth muscle cells are not well understood. This study used single-cell RNA-sequencing to analyze the differentiation process of CNCCs in control mouse embryos and in embryos with inactivated Tbx1. The results reveal the dynamic transitions of CNCCs and the role of Tbx1 in this process, as well as the consequences of Tbx2 and Tbx3 inactivation on aortic arch branching and smooth muscle differentiation.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Serin Lee, Nicholas M. Schneider, Shu Fen Tan, Frances M. Ross
Summary: Liquid cell transmission electron microscopy is a powerful and increasingly accessible technique for in situ studies of nanoscale processes in liquid. By conducting crystal growth experiments and simulations at different temperatures, we observe strong changes in morphology and growth rate. A kinetic model is developed to predict the temperature-dependent solution composition, and the combined effect of temperature dependent chemistry, diffusion, and the balance between nucleation and growth rates on the morphology is discussed. This work may provide guidance in interpreting liquid cell TEM and potentially larger-scale synthesis experiments controlled by temperature.
Article
Multidisciplinary Sciences
Pei Kee Goh, Florian Wiede, Mara N. Zeissig, Kara L. Britt, Shuwei Liang, Tim Molloy, Nathan Goode, Rachel Xu, Sherene Loi, Mathias Muller, Patrick O. Humbert, Catriona McLean, Tony Tiganis
Summary: The tumor-suppressor gene PTPN2 is often diminished in a specific type of breast cancer. Surprisingly, the absence of PTPN2 in tumors or T cells can actually promote the recruitment and activation of T cells, leading to enhanced anti-tumor immunity. Targeting PTPN2 in tumor cells and T cells has therapeutic potential, as PTPN2 deficiency is associated with T cell infiltration and increased expression of PD-L1 in triple-negative breast cancers (TNBCs). Furthermore, deleting PTPN2 in mouse TNBC models can enhance T cell recruitment and PD-L1 expression, leading to suppressed tumor growth and improved efficacy of anti-PD-1 treatment. Additionally, deleting PTPN2 in both tumors and T cells can further facilitate T cell recruitment and activation, resulting in repression of tumor growth or even elimination of tumors dominated by exhausted T cells. Therefore, targeting PTPN2 in tumors and/or T cells can enhance T cell recruitment and alleviate inhibitory effects on T cells to combat TNBC.
Review
Cell Biology
Lei Dong, Da Han, Xinyi Meng, Mengchuan Xu, Chuwen Zheng, Qin Xia
Summary: Gain-of-function mutations in SHP2 play a central role in tumorigenesis and cancer progression through both cell-autonomous and non-autonomous mechanisms. Therapies targeting SHP2 could potentially enhance the efficacy of anti-tumor treatments, and the activating mutations of SHP2 are also involved in drug resistance in anti-tumor therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Mathematics, Applied
Tomas Caraballo, Javier Lopez-de-la-Cruz, Veronica Caraballo-Romero
Summary: In this paper, we investigate four non-autonomous chemostat models with non-monotonic consumption function, taking wall growth and nutrient recycling into account. We prove the existence and uniqueness of non-negative global solution in each case, generating a non-autonomous dynamical system. Additionally, we establish the presence of a unique (global) pullback attractor that provides detailed information about the long-term behavior of the state variables, including conditions for species extinction and persistence. Numerical simulations are provided to illustrate the theoretical results.
INTERNATIONAL JOURNAL OF COMPUTER MATHEMATICS
(2022)
Article
Oncology
Hyun-Jaung Sim, Yong-Chan Kim, Govinda Bhattarai, Sae-Young Won, Jeong-Chae Lee, Byung-Hoon Jeong, Sung-Ho Kook
Summary: PrPC-derived prion disease primarily affects neurodegeneration, but its impact on hematopoietic stem progenitor cells (HSPCs) has been poorly understood. In a study involving mice infected with prions, the presence of misfolded prion protein (PrPSc) was observed in bone marrow cells derived from infected mice, and these cells showed prion infectivity. Following infection, there was a significant decrease in the number of HSPCs, mainly due to increased apoptotic cell death in PrPC-positive HSPCs. Both PrPC-positive and PrPC-negative HSCs underwent cellular senescence, affecting their repopulation and self-renewal capacities. This study provides new evidence that prion infection modulates HSC fate through both cell-autonomous and non-autonomous mechanisms.
Article
Multidisciplinary Sciences
Agata Dutkowska, Bartosz Szmyd, Marcin Kaszkowiak, Daria Domanska-Senderowska, Dorota Pastuszak-Lewandoska, Ewa Brzezianska-Lasota, Jacek Kordiak, Adam Antczak
Summary: Tumours have the ability to avoid immune destruction and exhibit cancer-associated inflammation. The upregulation of interleukins IL-1 beta and IL-6 in non-small cell lung cancer (NSCLC) tissues suggests that inflammatory processes play a role in NSCLC, with a strong influence of smoking history on inflammation in tumourigenesis.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Yang Lu, Chen-Zi Zhao, Jiang-Kui Hu, Shuo Sun, Hong Yuan, Zhong-Heng Fu, Xiang Chen, Jia-Qi Huang, Minggao Ouyang, Qiang Zhang
Summary: This study uncovers the principles of interfacial void evolution in solid-state batteries and establishes a model for void nucleation and growth. Through electrochemical calculations and in situ observations, the microscopic features of void defects under different stripping conditions are studied, and the quantification of void-induced contact loss processes is conducted. The electrochemical-morphological relationship helps to understand and design solid-solid interfaces for advanced solid-state batteries.
Review
Biochemistry & Molecular Biology
Yue Mei, Yan Wang, Huiqian Chen, Zhong Sheng Sun, Xing-Da Ju
JOURNAL OF GENETICS AND GENOMICS
(2016)
Article
Biochemistry & Molecular Biology
Jianing Zhong, Xianfeng Li, Wanshi Cai, Yan Wang, Shanshan Dong, Jie Yang, Jian'an Zhang, Nana Wu, Yuanyuan Li, Fengbiao Mao, Cheng Zeng, Jinyu Wu, Xingzhi Xu, Zhong Sheng Sun
NUCLEIC ACIDS RESEARCH
(2017)
Article
Neurosciences
Zhuang Miao, Fengbiao Mao, Jialong Liang, Moshe Szyf, Yan Wang, Zhong Sheng Sun
MOLECULAR NEUROBIOLOGY
(2018)
Article
Genetics & Heredity
Yuwen Liu, Yanyu Liang, A. Ercument Cicek, Zhongshan Li, Jinchen Li, Rebecca Muhle, Martina Krenzer, Yue Mei, Yan Wang, Nicholas Knoblauch, Jean Morrison, Siming Zhao, Yi Jiang, Evan Geller, Iuliana Ionita-Laza, Jinyu Wu, Kun Xia, James Noonan, Zhong Sheng Sun, Xin He
AMERICAN JOURNAL OF HUMAN GENETICS
(2018)
Article
Cell Biology
Yan Wang, Cheng Zeng, Jinchen Li, Zikai Zhou, Xingda Ju, Shuting Xia, Yuanyuan Li, An Liu, Huajing Teng, Kun Zhang, Leisheng Shi, Cheng Bi, Wei Xie, Xin He, Zhengping Jia, Yonghui Jiang, Tao Cai, Jinyu Wu, Kun Xia, Zhong Sheng Sun
Article
Neurosciences
Zhuang Miao, Jianghong Zhang, Yuanyuan Li, Xianfeng Li, Wei Song, Zhong Sheng Sun, Yan Wang
Review
Endocrinology & Metabolism
Yan Wang, Haodo Wu, Zhong Sheng Sun
FRONTIERS IN NEUROENDOCRINOLOGY
(2019)
Article
Neurosciences
Jianghong Zhang, Meiying Xue, Yue Mei, Zhigang Li, Zeng Ceng, Yuanyuan Li, Yi Zhang, Na Li, Huajing Teng, Zhong Sheng Sun, Yan Wang
PSYCHOPHARMACOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Zhuang Miao, Yan Wang, Zhongsheng Sun
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Cell Biology
Kaifan Zhang, Yan Wang, Tianda Fan, Cheng Zeng, Zhong Sheng Sun
Summary: PAKs are main effectors of the Rho GTPases Cdc42 and Rac, linking complex cytoskeletal networks to neural activity. They play a crucial role in neuronal development, dendritic spine plasticity, and are implicated in neurodevelopmental and neurodegenerative disorders. Comprehensive understanding of PAKs' role in neural cytoskeletal remodeling can enhance our knowledge of neurological diseases and potentially provide therapeutic targets.
Letter
Neurosciences
Yue Mei, Huajing Teng, Zhigang Li, Cheng Zeng, Yuanyuan Li, Wei Song, Kaifan Zhang, Zhong Sheng Sun, Yan Wang
NEUROSCIENCE BULLETIN
(2021)
Article
Neurosciences
Zhuang Miao, Yuanyuan Li, Fengbiao Mao, Jianghong Zhang, Zhong Sheng Sun, Yan Wang
Summary: This study demonstrates that witnessing the defeat process of a mated partner during pregnancy can induce anxiety-like behaviors in male offspring, but not in female offspring, with these effects not present in the following generation. Transcriptome analysis revealed shared up-regulated and down-regulated genes in the maternal and male hippocampus, as well as potential candidate drugs for treating psychological stress. The study highlights the complexity of stress and sex factors on emotion and behaviors.
Article
Medicine, Research & Experimental
Lin Wang, Zhong Sheng Sun, Bingwu Xiang, Chi-ju Wei, Yan Wang, Kevin Sun, Guanjie Chen, Michael S. Lan, Gilberto N. Carmona, Abner L. Notkins, Tao Cai
JOURNAL OF TRANSLATIONAL MEDICINE
(2018)
Review
Biology
Yan Wang, Huijie Liu, Zhongsheng Sun
BIOLOGICAL REVIEWS
(2017)