Article
Medicine, General & Internal
Yanan Huo, Qi Wan, Xinzhu Hou, Zhiyong Zhang, Jinchuan Zhao, Zhiyi Wu, Xiuming Jin
Summary: This study evaluates the efficacy and safety of intense pulsed light (IPL) and meibomian gland expression (MGX) as polytherapy for Sjogren's Syndrome-related dry eye. The results show that this combined treatment significantly improves subjective and objective characteristics, representing a promising treatment strategy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Miki Hata-Mizuno, Yuichi Uchino, Miki Uchino, Shigeto Shimmura, Yoko Ogawa, Kazuo Tsubota, Kazuno Negishi
Summary: This study found a positive correlation between gal-3 concentration in tears and the severity of dry eye disease, as well as a negative correlation with tear film break-up time and Schirmer's test. The detection rate of gal-3C in tears was closely associated with the severity of dry eye disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
David Cui, Priya Mathews, Gavin Li, Shanna VanCourt, Esen Akpek
Summary: The study aimed to evaluate the long-term treatment outcomes of dry eye in patients with and without primary Sjogren's syndrome (SS). The results showed that both SS and non-SS dry eye patients demonstrated improvement in ocular surface staining score with similar rates of corneal complications leading to loss of vision.
Review
Medicine, General & Internal
Antonio Ballesteros-Sanchez, Clara Martinez-Perez, Cristina Alvarez-Peregrina, Miguel Angel Sanchez-Tena, Concepcion De-Hita-Cantalejo, Maria Carmen Sanchez-Gonzalez, Jose-Maria Sanchez-Gonzalez
Summary: The purpose of this study was to evaluate the efficacy and safety of trehalose tear-substitute treatment for dry eye disease. The results showed that trehalose tear-substitute treatment achieved greater improvement in all reported variables compared to the control group interventions. No adverse events were reported after trehalose tear-substitute treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Jose Loureiro-Amigo, Carlos Palacio-Garcia, Monica Martinez-Gallo, Fernando Martinez-Valle, Marc Ramentol-Sintas, Roser Solans-Laque
Summary: This study found that patients with pSS have imbalanced distribution of circulating T and B lymphocyte subsets. The ratio B-NSM/CD4(ACT) is useful in differentiating between pSS and sicca syndrome.
Article
Ophthalmology
Kimberley Yu, Penny A. Asbell, Roni M. Shtein, Gui-Shuang Ying
Summary: This study identified five clinically meaningful subtypes of dry eye disease which differed significantly in demographics, symptoms, signs, and systemic disease associations. The study also found that omega-3 was not significantly more effective than placebo for any subtype.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Anna Julia Dezsi, Csilla Erdei, Tamas Demeter, Alexandra Kovacs, Gabor Nagy, Karoly Mensch, Orsolya Nemeth, Peter Hermann, Gyorgy Toth, Agnes Fust, Emese Virag Kiss, Laszlo Kohidai, Attila Zalatnay, Krisztina Marton
Summary: One-third of the Hungarian population suffers from xerostomia. This study aimed to evaluate the prevalence of Sjogren's syndrome (SS) in Hungary. Results showed that approximately 1/5th-1/6th of patients with sicca symptoms have SS, with the majority being primary SS. Additionally, the number of new diagnoses and doctor-patient encounters for SS in Hungary has significantly decreased over the past decade.
Article
Immunology
Jehan Alam, Cintia S. de Paiva, Stephen C. Pflugfelder
Summary: Desiccating stress alters the myeloid cell populations in the conjunctiva, with increased recruitment of antigen-presenting cells and macrophages, and decreased monocytes. Gene expression analysis of conjunctival cells exposed to desiccating stress reveals changes in inflammatory gene expression and maturation of monocytes to antigen-presenting cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Chemistry, Medicinal
Julia Prinz, Nicola Maffulli, Matthias Fuest, Peter Walter, Frank Hildebrand, Filippo Migliorini
Summary: This systematic review and meta-analysis examined the effects of honey-related treatment strategies on patients with dry eye disease (DED). The results showed that these strategies significantly improved the symptoms and signs of DED in the included patients.
Review
Clinical Neurology
Larisa Ungureanu, K. Ray Chaudhuri, Stefania Diaconu, Cristian Falup-Pecurariu
Summary: A wide range of ocular and visual disorders are present in Parkinson's disease (PD) patients, including dry eye, which is characterized by tear film instability, ocular surface inflammation and dysfunction, and visual disturbance. This article discusses the frequency, pathogenesis, and impact on patients' quality of life of dry eye in PD based on a literature search, as well as reviews the available methods for diagnosis and management of dry eye. Improved awareness and recognition of dry eye are needed to provide suitable personalized therapeutic options for PD patients, aiming to enhance their quality of life, independence, and safety.
FRONTIERS IN NEUROLOGY
(2023)
Article
Ophthalmology
Hassaam S. Choudhry, Shayan Hosseini, Hannaan S. Choudhry, Mahnaz Fatahzadeh, Reena Khianey, Mohammad H. Dastjerdi
Summary: This review summarizes recent advancements in the diagnosis and treatment of Sjogren's syndrome (SS), an autoimmune disorder that primarily affects secretory glands, leading to dry eye and dry mouth. The review also explores the correlations between oral and ocular manifestations of SS, highlighting the importance of understanding these connections for further research on SS pathogenesis and the development of new standards for diagnosis and treatment.
Article
Clinical Neurology
Joao Sergio Ignacio Hora, Maria Clara Rangel da Silva, Cicero Luiz Souza Braga, Arli Moreira Loureiro, Adriana Terezinha Neves Novellino Alves, Simone de Queiroz Chaves Lourenco, Claudia Cristina Ferreira Vasconcelos
Summary: This study investigates the frequency of dry oral and ocular manifestations and autoantibodies characteristic of primary Sjodgren's Syndrome in patients with Multiple Sclerosis. It found that even in the absence of comorbidities and the use of medications that can cause dry symptoms, MS patients may report xerostomia and/or xerophthalmia, which may fulfill the diagnostic criteria for pSS. The study suggests that there may be a link between these two diseases, but further research is needed to confirm this.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Ophthalmology
Mingjun Gao, Lin Zhao, Ran Liang, Qing Zhu, Qi Zhao, Xiaodan Kong
Summary: This study evaluated the efficacy and safety of 0.05% cyclosporine eye drops for the treatment of primary Sjogren's syndrome-associated dry eye. The results showed that 0.05% cyclosporine effectively reduced symptoms and improved signs without serious adverse events.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Review
Endocrinology & Metabolism
Yu-Kai Kuo, Shih-Chieh Shao, Erh-Tsan Lin, Li-Yen Pan, Ling Yeung, Chi-Chin Sun
Summary: The aim of this study was to examine tear function in patients with diabetes mellitus (DM). Through a systematic review and meta-analysis, it was found that patients with DM had worse tear function compared to those without DM. The study also indicated that glycemic control is critical for maintaining tear function.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Pharmacology & Pharmacy
Julia Prinz, Nicola Maffulli, Matthias Fuest, Peter Walter, Frank Hildebrand, Filippo Migliorini
Summary: This meta-analysis investigated the impact of placebo administration in the treatment of dry eye disease (DED). The results showed that placebo treatment did not significantly improve the symptoms of DED, but it can be used to evaluate the efficacy of active treatments.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2022)
Article
Ophthalmology
Ming Ming Zhu, Bonnie N. K. Choy, Qi Sheng You, Jonathan Cheuk Hung Chan, Alex L. K. Ng, Kendrick Shih, Janice Jing Chee Cheung, Jasper Ka Wai Wong, Jennifer Shum, Michael Y. Ni, Jimmy Shiu-Ming Lai, Gabriel M. Leung, Ian Y. Wong
Summary: This study investigated optic disc and peripapillary vessel density in healthy adult Chinese population, finding that decreased NFLP VD is significantly associated with older age, male gender, longer axial length, and lower signal strength index.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Allergy
Ruby Pawankar, Bernard Yu-Hor Thong, Marysia Tiongco-Recto, Jiu-Yao Wang, Amir Hamzah Abdul Latiff, Ting Fan Leung, Philip Hei Li, Rommel Crisenio M. Lobo, Michela Lucas, Jae-Won Oh, Wasu Kamchaisatian, Mizuho Nagao, Iris Rengganis, Zarir F. Udwadia, Raja Dhar, Sonomjamts Munkhbayarlakh, Logii Narantsetseg, Duy Le Pham, Yuan Zhang, Luo Zhang
Summary: This study investigates the changes in COVID-19 epidemiology, clinical profile, therapeutics, and public health measures in the Asia Pacific region. The findings indicate that mild-to-moderate cases predominate, thanks to vaccination programs and new treatment options. Public health measures are transitioning from containment to endemicity.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Review
Medicine, General & Internal
Yasutsugu Akasaki, Takenori Inomata, Jaemyoung Sung, Masahiro Nakamura, Koji Kitazawa, Kendrick Co Shih, Takeya Adachi, Yuichi Okumura, Kenta Fujio, Ken Nagino, Akie Midorikawa-Inomata, Mizu Kuwahara, Kunihiko Hirosawa, Tianxiang Huang, Yuki Morooka, Hurramhon Shokirova, Atsuko Eguchi, Akira Murakami
Summary: This systematic review aimed to determine the comorbid dry eye (DE) and allergic conjunctivitis (AC) prevalence. The results showed that the incidence of AC among individuals with DE ranged from 6.2% to 38.0%, while the incidence of DE among individuals with AC ranged from 0.9% to 97.5%. Furthermore, the meta-analysis revealed that approximately 47.2% of patients with AC had comorbid DE, and approximately 17.8% of patients with DE had comorbid AC. Therefore, complementary screening and treatment for patients with DE and AC may play a significant role in preventing chronic ocular damage and improving long-term outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Xin Rong Lim, Justina Wei Lynn Tan, Grace Yin Lai Chan, Jinfeng Hou, Linlin Xie, Vivian Hui Li Goh, Joewee Boon, Samuel Shang Ming Lee, Claire Min-Li Teo, Sze Chin Tan, Khai Pang Leong, Bernard Yu Hor Thong, Bernard Pui Lam Leung
Summary: During the initial rollout of COVID-19 vaccination in Singapore, patients with a history of vaccine allergy were recommended to be assessed for suitability. Testing and surveys showed that most patients tolerated the BNT162b2 vaccine without major allergic reactions.
Article
Medicine, General & Internal
Fan Huang, Jie Lian, Kei-Shing Ng, Kendrick Shih, Varut Vardhanabhuti
Summary: This study examined the association between retinal vascular changes and CAD-RADS scores as assessed on CCTA, and developed a GNN model for predicting CAD-RADS scores. The results showed significant associations between retinal vascular biomarkers and adverse CAD-RADS scores, and the GNN model outperformed traditional ML models in predicting CAD-RADS scores.
Article
Rheumatology
Khai Pang Leong, Joyce Ching-Wen Tan, Bernard Yu Hor Thong, Tsui Yee Lian, Ee Tzun Koh, Kok Ooi Kong, Weng Giap Law, Hiok Hee Chng, Grace Yin Lai Chan, Faith Li-Ann Chia, Justina Wei Lynn Tan, Hwee Siew Howe
Summary: This study aimed to analyze the effects of different drugs on the quality of life of SLE patients. By conducting questionnaire surveys and comparing scores before and after treatment, it was found that intravenous cyclophosphamide and mycophenolate had the greatest impact on the quality of life of SLE patients. Furthermore, SLEQOL may be a useful indicator for evaluating the results of SLE clinical trials.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Xin Rong Lim, Pamela Oi Khuan Chew, Gek Hsiang Lim, Yung Ling Low, June Wei Ping Lim, Huey Ni Ong, Weng Giap Law, Justina Wei Lynn Tan, Bernard Y. H. Thong, Faith Li-Ann Chia, Tsui Yee Lian, Grace Yin Lai Chan, Madelynn Tsu-Li Chan, Ee Tzun Koh, Kok Ooi Kong, Hwee Siew Howe
Summary: This study examined the performance of the Montreal Cognitive Assessment (MoCA) in identifying cognitive impairment (CI) in SLE patients. The results showed that MoCA could be a useful screening tool to identify the most frequently affected cognitive domain, executive functioning, in SLE patients without overt neuropsychiatric manifestations.
Article
Ophthalmology
Keke Liu, Ou Tan, Qi Sheng You, Aiyin Chen, Jonathan C. H. Chan, Bonnie N. K. Choy, Kendrick C. Shih, Jasper K. W. Wong, Alex L. K. Ng, Janice J. C. Cheung, Michael Y. Ni, Jimmy S. M. Lai, Gabriel M. Leung, Liang Liu, David Huang, Ian Y. H. Wong
Summary: The purpose of this study was to correct refractive error-associated bias in glaucoma diagnostic parameters of optical coherence tomography (OCT) and OCT angiography (OCTA). The results showed that myopic eyes tend to have lower measurements of nerve fiber layer thickness, ganglion cell complex thickness, and nerve fiber layer plexus capillary density. Adjustments based on axial eye length and spherical equivalent were effective in reducing this bias.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Immunology
Yashan Bu, Kendrick Co Shih, Ho Lam Wong, Sum Sum Kwok, Amy Cheuk-Yin Lo, Joseph Yau-Kei Chan, Alex Lap-Ki Ng, Tommy Chung-Yan Chan, Vishal Jhanji, Louis Tong
Summary: The effect of sustained hyperglycemia on corneal wound healing, immune response, and microbiome indices in diabetic mice after alkaline chemical injury of the eye was investigated. The diabetic mice showed delayed corneal wound healing and an inability to mount immune response. Additionally, differences in intestinal microbial diversity and abundance patterns were observed between diabetic mice and controls.
FRONTIERS IN IMMUNOLOGY
(2023)
Letter
Allergy
Philip H. Li, Ruby Pawankar, Bernard Y. H. Thong, Hugo W. F. Mak, Grace Chan, Wen-Hung Chung, Meng Juan, Hye-Ryun Kang, Byung-Keun Kim, Rommel Crisenio M. Lobo, Michaela Lucas, Duy Le Pham, Thushali Ranasinghe, Iris Rengganis, Ticha Rerkpattanapipat, Munkhbayarlakh Sonomjamts, Yi-Giien Tsai, Jiu-Yao Wang, Masao Yamaguchi, James Yun
Article
Ophthalmology
Fiona Stapleton, Juan Carlos Abad, Stefano Barabino, Anthea Burnett, Geetha Iyer, Kaevalin Lekhanont, Tianjing Li, Yang Liu, Alejandro Navas, Chukwuemeka Junior Obinwanne, Riaz Qureshi, Danial Roshandel, Afsun Sahin, Kendrick Shih, Anna Tichenor, Lyndon Jones
Summary: A framework was used to map societal factors associated with ocular surface diseases, considering the individual, health, and environment. The impact of the COVID-19 pandemic and mitigating factors on ocular surface diseases were reviewed systematically. Age and sex effects are well-characterized for various types of ocular surface diseases. Sex and gender, genetic factors, race, smoking, and co-morbidities have interdependencies with geographical, employment, and socioeconomic factors. Living and working conditions, as well as regional and global socio-economic, cultural, and environmental conditions, play a role in the prevalence and severity of ocular surface diseases. Digital technology, conflicts, natural disasters, and the pandemic influence access to health services. The COVID-19 pandemic and related strategies have increased the risk of developing or worsening ocular surface diseases.
Review
Ophthalmology
Zhang Zhe Thia, Yik To Ho, Kendrick Co Shih, Louis Tong
Summary: A persistent epithelial defect (PED) refers to a corneal epithelial defect that fails to heal within two weeks, with unsatisfactory treatment outcomes. More research is needed to establish reliable treatment modalities and advance new therapies.
SURVEY OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Yan Kiu Li, Nicholas Siu-Kay Fung, Jonathan C. H. Chan, Bonnie N. K. Choy, Loraine L. W. Chow, Kendrick C. Shih, Jasper K. W. Wong, Ian Y. H. Wong
Summary: This study collected optical coherence tomography angiography (OCTA) data from 4188 healthy individuals aged 50 and above through an eye screening program. The results showed that high foveal avascular zone (FAZ) area, low FAZ circularity, low superficial vessel density (MSVD) in the outer ring, particularly in the nasal and temporal quadrants, and low capillary perfusion density (MCPD) in the outer superior quadrant were associated with decreased visual acuity. These parameters can be used as biomarkers in predicting visual acuity decline in adults aged 50 and above.
Article
Engineering, Biomedical
Qinyu Li, Ho Lam Wong, Yan Lam Ip, Wang Yee Chu, Man Shek Li, Chinmoy Saha, Kendrick Co Shih, Yau Kei Chan
Summary: According to the World Health Organization, corneal blindness constitutes 5.1% of global blindness population. Surgical outcomes have been improved significantly in the treatment of corneal blindness. However, corneal transplantation is limited by global shortage of donor tissue, prompting researchers to explore alternative therapies such as novel ocular pharmaceutics to delay corneal disease progression.
MATERIALS TODAY BIO
(2023)
Review
Rheumatology
Thomas Khoo, James B. Lilleker, Bernard Yu-Hor Thong, Valerie Leclair, Janine A. Lamb, Hector Chinoy
Summary: Idiopathic inflammatory myopathies (IIMs) are a group of systemic autoimmune diseases that affect skeletal muscles and other body parts. The incidence and prevalence of IIM are influenced by various factors, including age, gender, and geographical location. Although genetic and environmental factors have been identified, more research is needed to understand the differences in different ethnic groups.
NATURE REVIEWS RHEUMATOLOGY
(2023)